Spread of Efflux Pump Overexpressing-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa by using an Efflux Pump Inhibitor

Maryam Adabi,Mahshid Talebi-Taher,Leila Arbabi,Mastaneh Afshar,Sara Fathizadeh,Sara Minaeian,Niloufar Moghadam-Maragheh,Ali Majidpour 대한감염학회 2015 Infection and Chemotherapy Vol.47 No.2

Background: Fluoroquinolone resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression and/or target mutations. We designed this study to investigate the efflux pump mediated fluoroquinolone resistance and check the increasing effectiveness of fluoroquinolones in combination with an efflux pumps inhibitor among P. aeruginosa isolates from burn wounds infections. Materials and Methods: A total of 154 consecutive strains of P. aeruginosa were recovered from separate patients hospitalized in a burn hospital, Tehran, Iran. The isolates first were studied by disk diffusion antibiogram for 11 antibiotics and then minimum inhibitory concentration (MIC) experiments were performed to detect synergy between ciprofloxacin and the efflux pump inhibitor, carbonyl cyanide- m-chlorophenyl hydrazone (CCCP). Then to elucidate the inducing of multi drug resistance due to different efflux pumps activation in Fluoroquinolone resistant isolates, synergy experiments were also performed in random ciprofloxacin resistant isolates which have overexpressed efflux pumps phenotypically, using CCCP and selected antibiotics as markers for Beta-lactams and Aminoglycosides. The isolates were also tested by polymerase chain reaction (PCR) for the presence of the MexA, MexC and MexE, which encode the efflux pumps MexAB-OprM, MexCD-OprJ and MexEF-OprN. Results: Most of the isolates were resistant to 3 or more antibiotics tested. More than half of the ciprofloxacin resistant isolates exhibited synergy between ciprofloxacin and CCCP, indicating the efflux pump activity contributed to the ciprofloxacin resistance. Also increased susceptibility of random ciprofloxacin resistant isolates of P. aeruginosa to other selected antibiotics, in presence of CCCP, implied multidrug extrusion by different active efflux pump in fluoroquinolones resistant strains. All of Ciprofloxacin resistant isolates were positive for MexA, MexC and MexE genes simultaneously. Conclusion: In this burn hospital, where multidrug resistant P. aeruginosa isolates were prevalent, ciprofloxacin resistance and multidrug resistance due to the overexpression of fluoroquinolones mediated efflux pumps has also now emerged. Early recognition of this resistance mechanism should allow the use of alternative antibiotics and use an efflux pumps inhibitor in combination with antibiotic therapy.

Parallel Array InAs Nanowire Transistors for Mechanically Bendable, Ultrahigh Frequency Electronics

Takahashi, Toshitake,Takei, Kuniharu,Adabi, Ehsan,Fan, Zhiyong,Niknejad, Ali M.,Javey, Ali American Chemical Society 2010 ACS NANO Vol.4 No.10

<P>The radio frequency response of InAs nanowire array transistors on mechanically flexible substrates is characterized. For the first time, GHz device operation of nanowire arrays is demonstrated, despite the relatively long channel lengths of ∼1.5 μm used in this work. Specifically, the transistors exhibit an impressive maximum frequency of oscillation, <I>f</I><SUB>max</SUB> ∼ 1.8 GHz, and a cutoff frequency, <I>f</I><SUB>t</SUB> ∼ 1 GHz. The high-frequency response of the devices is due to the high saturation velocity of electrons in high-mobility InAs nanowires. The work presents a new platform for flexible, ultrahigh frequency devices with potential applications in high-performance digital and analog circuitry.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2010/ancac3.2010.4.issue-10/nn1018329/production/images/medium/nn-2010-018329_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn1018329'>ACS Electronic Supporting Info</A></P>

A Coordinated Heuristic Approach for Virtual Network Embedding in Cloud Infrastructure

( Nahid Hamzehee Nia ),( Sepideh Adabi ),( Majid Nikougoftar Nategh ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.5

A major challenge in cloud infrastructure is the efficient allocation of virtual network elements on top of substrate network elements. Path algebra is a mathematical framework which allows the validation and convergence analysis of the mono-constraint or multi-constraint routing problems independently of the network topology or size. The present study proposes a new heuristic approach based on mathematical framework "paths algebra" to map virtual nodes and links to substrate nodes and paths in cloud. In this approach, we define a measure criterion to rank the substrate nodes, and map the virtual nodes to substrate nodes according to their ranks by using a greedy algorithm. In addition, considering multi-constraint routing in virtual link mapping stage, the used paths algebra framework allows a more flexible and extendable embedding. Obtained results of simulations show appropriate improvement in acceptance ratio of virtual networks and cost incurred by the infrastructure networks.

Socioeconomic Inequalities in the Oral Health of People Aged 15-40 Years in Kurdistan, Iran in 2015: A Cross-sectional Study

Moradi, Ghobad,Moinafshar, Ardavan,Adabi, Hemen,Sharafi, Mona,Mostafavi, Farideh,Bolbanabad, Amjad Mohamadi The Korean Society for Preventive Medicine 2017 Journal of Preventive Medicine and Public Health Vol.50 No.5

Objectives: The aim of this study was to evaluate socioeconomic inequalities in the prevalence of dental caries among an urban population. Methods: This study was conducted among 2000 people 15-40 years of age living in Kurdistan, Iran in 2015. Using a questionnaire, data were collected by 4 trained dental students. The dependent variable was the decayed, missing, and filled teeth (DMF) index. Using principal component analysis, the socioeconomic status (SES) of families was determined based on their household assets. Inequality was measured using the concentration index; in addition, the Oaxaca analytical method was used to determine the contribution of various determinants to the observed inequality. Results: The concentration index for poor scores on the DMF index was -0.32 (95% confidence interval [CI], -0.40 to -0.36); thus, poor DMF indices had a greater concentration in groups with a low SES (p<0.001). Decomposition analysis showed that the mean prevalence of a poor DMF index was 43.7% (95% CI, 40.4 to 46.9%) in the least privileged group and 14.4% (95% CI, 9.5 to 9.2%) in the most privileged group. It was found that 85.8% of the gap observed between these groups was due to differences in sex, parents' education, and the district of residence. A poor DMF index was less prevalent among people with higher SES than among those with lower SES (odds ratio, 0.31; 95% CI, 0.19 to 0.52). Conclusions: An alarming degree of SES inequality in oral health status was found in the studied community. Hence, it is suggested that inequalities in oral health status be reduced via adopting appropriate policies such as the delivery of oral health services to poorer groups and covering such services in insurance programs.

Socioeconomic Inequalities in the Oral Health of People Aged 15-40 Years in Kurdistan, Iran in 2015: A Cross-sectional Study

Ghobad Moradi,Ardavan Moinafshar,Hemen Adabi,Mona Sharafi,Farideh Mostafavi,Amjad Mohamadi Bolbanabad 대한예방의학회 2017 Journal of Preventive Medicine and Public Health Vol.50 No.5

Objectives: The aim of this study was to evaluate socioeconomic inequalities in the prevalence of dental caries among an urban population. Methods: This study was conducted among 2000 people 15-40 years of age living in Kurdistan, Iran in 2015. Using a questionnaire, data were collected by 4 trained dental students. The dependent variable was the decayed, missing, and filled teeth (DMF) index. Using principal component analysis, the socioeconomic status (SES) of families was determined based on their household assets. Inequality was measured using the concentration index; in addition, the Oaxaca analytical method was used to determine the contribution of various determinants to the observed inequality. Results: The concentration index for poor scores on the DMF index was -0.32 (95% confidence interval [CI], -0.40 to -0.36); thus, poor DMF indices had a greater concentration in groups with a low SES (p<0.001). Decomposition analysis showed that the mean prevalence of a poor DMF index was 43.7% (95% CI, 40.4 to 46.9%) in the least privileged group and 14.4% (95% CI, 9.5 to 9.2%) in the most privileged group. It was found that 85.8% of the gap observed between these groups was due to differences in sex, parents’ education, and the district of residence. A poor DMF index was less prevalent among people with higher SES than among those with lower SES (odds ratio, 0.31; 95% CI, 0.19 to 0.52). Conclusions: An alarming degree of SES inequality in oral health status was found in the studied community. Hence, it is suggested that inequalities in oral health status be reduced via adopting appropriate policies such as the delivery of oral health services to poorer groups and covering such services in insurance programs.

Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran

Fariba Keramat,Mohammad Mehdi Majzobi,Jalal Poorolajal,Zohreh Zarei Ghane,Maryam Adabi 질병관리본부 2017 Osong Public Health and Research Persptectives Vol.8 No.4

Objectives: Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in Hamadan Province in the west of Iran. Methods: A total of 157 HIV-infected patients were screened through standard serological tests, including Wright’s test, Coombs’ Wright test, and 2-mercaptoethanol Brucella agglutination test (2ME test), blood cultures in Castaneda media, and CD4 counting. Data were analyzed using Stata version 11. Results: Wright and Coombs’ Wright tests were carried out, and only 5 (3.2%) patients had positive serological results. However, all patients had negative 2ME results, and blood cultures were negative for Brucella spp. Moreover, patients with positive serology and a mean CD4 count of 355.8 ± 203.11 cells/mL had no clinical manifestations of brucellosis, and, and the other patients had a mean CD4 count of 335.55 ± 261.71 cells/mL. Conclusion: Results of this study showed that HIV infection is not a predisposing factor of acquiring brucellosis.

A promising treatment for HIV-1 using biosynthesis of metal nanoparticles

Farahnaz Behzad,Fateme Najafi Kalyani,Azam Samadi,Mahdi Adabi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

Human immunodeficiency virus (HIV) is the aetiological agent of acquired immunodeficiency diseasesyndrome (AIDS). A noticeable public health worry is associated with the fast growth of drug resistanceto the present treatments and also the drugs with negative side effects because of their long-term use. Lately, there has been a quick progress in using metal nanoparticles (MNPs) due to their anti-virus activities. On the other hand, physicochemical procedures for synthesizing MNPs create some problems owingto use of toxic solvents, high consumption of energy, and formation of non-ecofriendly by-products. Therefore, it is vital to develop environment-friendly methods to synthesize MNPs. This study presentsa review of anti-virus effects of MNPs on HIV/AIDS. In addition, we studied the potential of greenMNPs especially silver (Ag), gold (Au), and zinc oxide (ZnO) NPs, to supply a method for treating HIVand future challenges.

Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

Mohammad Tabaeizadeh,Vahid Haghpanah,Abbasali Keshtkar,Shahryar Semnani,Gholamreza Roshandel,Khadijeh Adabi,Ramin Heshmat,Davood Rohani,Alireza Kia,Ehsan Hatami,Ataollah Jahangirrad,Ramin Nabizadeh,Ba 대한위암학회 2013 Journal of gastric cancer Vol.13 No.2

Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.

Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

Tabaeizadeh, Mohammad,Haghpanah, Vahid,Keshtkar, Abbasali,Semnani, Shahryar,Roshandel, Gholamreza,Adabi, Khadijeh,Heshmat, Ramin,Rohani, Davood,Kia, Alireza,Hatami, Ehsan,Jahangirrad, Ataollah,Nabizad The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.2

Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.