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RISS 인기검색어
- 검색키워드
- 저자 : Abbasali Keshtkar (검색결과 3 건)
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Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women
Pooneh Salari,Abbasali Keshtkar,Shapour Shirani,Leila Mounesan 대한골대사학회 2017 대한골대사학회지 Vol.24 No.1
Background: Since 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity between arterial calcified plaque and bone matrix and involvement of similar cells and mediators provide a special field of research. Therefore in the present study, we aimed to evaluate the relationship between coronary artery calcium score (CACS) as a surrogate marker of atherosclerosis and bone mediators and parameters in postmenopausal women. Methods: Eleven postmenopausal women who had CACS higher than 80 were enrolled into the study and underwent bone densitometry. In addition, their serum and urine samples were taken for measuring osteoprotegerin, osteocalcin, and β cross laps. Patients’ 10- year probability of fracture was calculated by the World Health Organization fracturerisk assessment tool (FRAX). Results: The regression analysis of our results showed the association between CACS and OC (std β=0.66, 95% confidence interval [CI] 5.47-72.27, P=0.027), femoral bone density (std β=-0.6, 95% CI -6864.34-14.27, P=0.05) and T-score (std β=-0.6, 95% CI -773.08-1.28, P=0.05) which remained significant after adjustment for age, weight, years since menopause and body mass index. No association was found between CACS and osteoprotegerin, spinal bone density and FRAX score. Conclusions: In conclusion, this pilot study with small sample size showed the potential association between CACS and osteocalcin, femoral bone density and T-score. However, the relationship between CACS and osteoprotegerin, receptor activator of nuclear factor-kappa B ligand, FRAX score and other bone parameters remain to be clarified in larger sample size studies.
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Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level
Mohammad Tabaeizadeh,Vahid Haghpanah,Abbasali Keshtkar,Shahryar Semnani,Gholamreza Roshandel,Khadijeh Adabi,Ramin Heshmat,Davood Rohani,Alireza Kia,Ehsan Hatami,Ataollah Jahangirrad,Ramin Nabizadeh,Ba 대한위암학회 2013 Journal of gastric cancer Vol.13 No.2
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.
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Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level
Tabaeizadeh, Mohammad,Haghpanah, Vahid,Keshtkar, Abbasali,Semnani, Shahryar,Roshandel, Gholamreza,Adabi, Khadijeh,Heshmat, Ramin,Rohani, Davood,Kia, Alireza,Hatami, Ehsan,Jahangirrad, Ataollah,Nabizad The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.2
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.
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