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RISS 인기검색어
- 검색키워드
- 저자 : Abdul Jabbar Shah (검색결과 5 건)
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Abdul Jabbar Shah,Anwarul-Hassan Gilani,Kanza Abbas,Munawwer Rasheed,Amir Ahmed,Viqar Uddin Ahmad 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8
This study describes the chemical composition of the essential oil of Artemisia maritima (Am.Oil) and the pharmacological basis for its medicinal use in gut and airways disorders. Twenty five compounds, composing 93.7% of the oil, were identified; among these, chrysanthenyl propionate and elixene were identified for the first time from any Artemisia species. The Am.Oil (0.3-1.0 mg/mL) suppressed spontaneous and high K^+ (80 mM)-induced contractions in isolated rabbit jejunum, suggestive of an antispasmodic effect mediated possibly through calcium channel blockade. The calcium channel blockade activity was confirmed when pre-treatment of the tissue with Am.Oil (0.01-0.03 mg/mL) shifted the Ca^++ concentration-response curves to the right, similar to verapamil and papaverine. In isolated tracheal strips, Am.Oil inhibited carbachol (CCh; 1 μM)-induced contractions more than that induced by K^+ and shifted the isoprenaline-induced inhibitory CRCs to the left, similar to papaverine, suggestive of potentiation, while, verapamil was more potent against K^+ than CCh-induced contractions and had no potentiating effect on isoprenaline-induced inhibitory CRCs. These data indicate that the Am.Oil exhibited spasmolytic and bronchodilator activities mediated possibly through dual blockade of calcium channels and phosphodiesterase, which provides the pharmacological basis to the medicinal use of Artemisia maritima in colic, diarrhea and possibly asthma.
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Yousseu Nana William,Ateufack Gilbert,Abdul Jabbar Shah,Mbiantcha Marius,Tchoumba Tchoumi Liliane Mireille,Matah Mba Marthe Vanessa,Adjouzem Carine Flore,Teboukeu Boungo Gires,Awouafack Maurice Ducret 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Distemonanthus benthamianus is used in Cameroon to treat diarrhoeal episodes. The study aimed to evaluate its antidiarrhoeal potential in Wistar rats and BALB/c mice. Extracts were preliminary investigated for phytochemical components, total phenols quantifcation and DPPH scavenging activity. Their efects were also evaluated against castor oil-induced diarrhoea, prostaglandin-E1-induced fuid accumulation, charcoal meal motility test, as well as against magnesium sulphateinduced diarrhoea and electrolytes regulation. The methanolic extract contains alkaloids, favonoids, polyphenols, saponins, sterols, tannins and triterpenes while aqueous extract was devoid of sterols and triterpenes. Phenolic compounds were more concentrated in methanolic extract, which also developed signifcant DPPH scavenging efects. In castor oil-induced diarrhoea, signifcant (p<0.001) reduction in diarrhoeal stools frequency was observed with 100, 200 and 300 mg/kg of aqueous extract, while 400 mg/kg of methanolic extract exhibited maximum efect. Total stools frequency was signifcantly (p<0.001) reduced with doses of 300 and 400 mg/kg of extracts. Maximum protection was obtained with 400 mg/kg of both extracts in magnesium sulphate-induced diarrhoea. That dose signifcantly (p<0.001) reduced Na+ excretion, while Ca2+ excretion was signifcantly (p<0.001) increased with 100 mg/kg of aqueous extract. Both extracts signifcantly (p<0.01, p<0.001) reduced the intestinal fuids mass and volume similarly compared to the negative control groups. The gut motility was signifcantly (p<0.001) reduced with 100 and 200 mg/kg of methanolic and aqueous extracts, respectively. Extracts are therefore antidiarrhoeal remedies candidates, since they provoked a decrease in intestinal motility, associated with fuid and electrolytes regulation across the gut.
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The Analgesic, Anti-inflammatory and Calcium Antagonist Potential of Tanacetum artemisioides
Bukhari, Ishfaq Ali,Gilani, Anwar-Ul Hassan,Shah, Abdul Jabbar,Hussain, Javid,Khan, Rafeeq Alam 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Several species of the genus Tanacetum are traditionally used in a variety of health conditions including pain, inflammation, respiratory and gastrointestinal disorders. In the current investigation, we evaluated the plant extract of T atemisioides and some of its pure compounds (flavonoids) for analgesic, anti-inflammatory and calcium antagonist effects in various in-vivo and in vitro studies. Using the actetic acid induced writhing test, intraperitoneal (i.p) administration of the plant extract (25-50 mg/kg) and its flavonoid compounds TA-1 and TA-2 (1-5 mg/kg) exhibited significant analgesic activity. The maximum analgesic effect observed with the crude extract of the plant was 71% at 50 mg/kg, while that of compounds TA-1 and TA-2 (5mg/kg i.p)was 75 and 47%, respectively. The plant extract and its pure compounds caused inhibition of formalin induced paw licking in mice predominatly in the second phase of the test. Diclofenac sodium, a standard reference compound, showed a similar effect in these chemical induced pain models. In the carrgeenan induced rat paw edema assay, the plant extract (50-200 mg/kg i.p) demonstrated significant (P<0.01) anti-inflmmatory activity which was comparable to that obtained with diclofenac sodium and indomethacin. In isolated rabbit jejunum preprations the piant extract showed an atropine sensitive dose-dependant (0.10-1.0 mg/mL) spasmogenic activity followed by a spasmolytic effect at the next higher doses (3-5 mg/mL). The crude extract of the plant also inhibited the high K$^+$-induced contractions, indicating a calcium channel blocking (CCB) activity, which was further confirmed when the plant extract caused a right-ward shift in the Ca$^{++}$ concentration response curves in the isolated rabbit jejunum preparations, similar to that seen with verapamil. The flavonoid compounds isolated from the plant were devoid of any activity in the isolated tissue preparations. These results indicate that the plant extract of T. artemisioides possesses analgesic, anti-inflammatory and CCB activities. The flavonoid compounds of the plant may have a role in its observed analgesic and anti-inflammatory activities, while the CCB activity of the plant may be attributed to some other chemical constituents present. Moreover the findings support the traditional reputation of the genus Tanacetum for its therapeutic benefits in pain and inflammatory conditions.
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Daim Asif Raja,Syed Ghulam Musharraf,Muhammad Raza Shah,Abdul Jabbar,Muhammad Iqbal Bhanger,Muhammad Imran Malik 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.87 No.-
Polymer capped metal nanoparticles have been used for numerous biomedical and analyticalapplications. In present study, highly stable gold nanoparticles (AuNPs) capped with polypropyleneglycol (PPG) were synthesized using chemical reduction method. The characterization of PPG-AuNPs wasaccomplished by atomic force microscopy (AFM), zetasizer, fourier transform infrared spectroscopy (FT-IR) and UV–vis spectroscopy. Furthermore, PPG-AuNPs were utilized as colorimetric probe for thirdgeneration cephalosporin antibiotic, ceftriaxone (CEF). PPG-AuNPs permitted efficient, selective,quantitative and rapid recognition in concentration range of 0.1–100 mM in presence of numerousother drugs and salts. PPG-AuNPs have great potential for quantitative recognition of ceftriaxone inbiological and environmental samples. Moreover, the developed sensor has capacity to be applied asquality control of pharmaceutical formulations containing ceftriaxone. The PPG-AuNPs based sensorpermits quantitative and fast recognition of ceftriaxone away from a sophisticated laboratory setup.
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