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- 저자 : Adjouzem Carine Flore (검색결과 1 건)
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Yousseu Nana William,Ateufack Gilbert,Abdul Jabbar Shah,Mbiantcha Marius,Tchoumba Tchoumi Liliane Mireille,Matah Mba Marthe Vanessa,Adjouzem Carine Flore,Teboukeu Boungo Gires,Awouafack Maurice Ducret 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Distemonanthus benthamianus is used in Cameroon to treat diarrhoeal episodes. The study aimed to evaluate its antidiarrhoeal potential in Wistar rats and BALB/c mice. Extracts were preliminary investigated for phytochemical components, total phenols quantifcation and DPPH scavenging activity. Their efects were also evaluated against castor oil-induced diarrhoea, prostaglandin-E1-induced fuid accumulation, charcoal meal motility test, as well as against magnesium sulphateinduced diarrhoea and electrolytes regulation. The methanolic extract contains alkaloids, favonoids, polyphenols, saponins, sterols, tannins and triterpenes while aqueous extract was devoid of sterols and triterpenes. Phenolic compounds were more concentrated in methanolic extract, which also developed signifcant DPPH scavenging efects. In castor oil-induced diarrhoea, signifcant (p<0.001) reduction in diarrhoeal stools frequency was observed with 100, 200 and 300 mg/kg of aqueous extract, while 400 mg/kg of methanolic extract exhibited maximum efect. Total stools frequency was signifcantly (p<0.001) reduced with doses of 300 and 400 mg/kg of extracts. Maximum protection was obtained with 400 mg/kg of both extracts in magnesium sulphate-induced diarrhoea. That dose signifcantly (p<0.001) reduced Na+ excretion, while Ca2+ excretion was signifcantly (p<0.001) increased with 100 mg/kg of aqueous extract. Both extracts signifcantly (p<0.01, p<0.001) reduced the intestinal fuids mass and volume similarly compared to the negative control groups. The gut motility was signifcantly (p<0.001) reduced with 100 and 200 mg/kg of methanolic and aqueous extracts, respectively. Extracts are therefore antidiarrhoeal remedies candidates, since they provoked a decrease in intestinal motility, associated with fuid and electrolytes regulation across the gut.
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