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Javid Hussain,Najeeb Ur Rehman,Ahmed Al-Harrasi,Abdul Latif Khan,Tania Shamim Rizvi,Faryal Vali Mohammad,Mehjabeen,Liaqat Ali 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
The plant species of genus Nepeta are used totreat various human diseases and for ornamental purposesas well. Nepethalate B (1) was isolated as a result ofphytochemical investigations of Nepeta clarkei and wassubjected in the present study for investigation of analgesic,anti-inflammatory, and central nervous system (CNS)depressant activities. The percentage inhibition in phase Iof the acetic acid induced writhing test of compound 1(dose of 0.1, 0.2 and 0.4 mg/kg of body weight) was 53.3,58.0 and 86.7 % respectively. These results were foundsignificantly higher (P\0.01) as compared to the negativecontrol. Moreover, the percentage inhibitions of threephases for 0.1, 0.2 and 0.4 mg/kg were higher than thevalues obtained for Aspirin (positive control). In formalintest, the percentage pain inhibition between 0 and 5 min(early phase) was 68.0, 25.5, and 75.5 % for 0.1, 0.2 and0.4 mg/kg intra-peritoneal doses of compound 1 respectively. In case of late phase (20–30 min) it was 63.0, 66.7and 48.1 %, respectively. In comparison to aspirin, overallpercentage inhibition of compound 1 was significantlyhigher in early and late phases. Interestingly, at all dosescompound 1 showed more potent anti-inflammatory effectsin terms of intensity and duration as compared to aspirin. The gross behavioral study of nepethalate B (1) was alsocarried out and the results revealed that it exhibited CNSdepression in the mice and showed a prominent decrease inlocomotor activity.
Relative Expression of Apocarotenoid Biosynthetic Genes in Developing Stigmas of Crocus sativus L.
Javid IqbaLMzr,Raies Ahmad Qadri,Nazeer Ahmed,Tassem Ahmad Mokhdomi,Asrar Hussain Wafai,Sajad Hassan Wani,Shoiab Bukhari,Asif Amin 한국작물학회 2013 Journal of crop science and biotechnology Vol.16 No.3
Saffron, the desiccated stigmas of Crocus sativus, is recognized for its attractive color, flavor, and aroma which are due to the accumulation of crocin, picrocrocin, and safranal, respectively. HPLC analysis demonstrated maximum apocarotenoid accumulation during the fully developed scarlet stage of stigma development followed by the orange and yellow stages of stigma development. Reverse Transcription-PCR analysis revealed a concurrent expression pattern of CsZCD and CsLYC genes in a developmental stagespecific manner. However, CsBCH and CsGT2 genes were specifically expressed during the mature, scarlet stage of stigma development. Real-Time PCR analysis showed a sharp increase in gene expression of CsLYC gene during stigma development indicative of its possible regulatory role in apocarotenoid biosynthesis or stigma development. Results suggest that genetic manipulation of this gene can help to improve the quality of stigma in saffron; besides highlighting its potential to monitor stigma development during in vitro experimentation
Relative Expression of Apocarotenoid Biosynthetic Genes in Developing Stigmas of Crocus sativus L.
IqbaLMzr, Javid,Ahmed, Nazeer,Mokhdomi, Tassem Ahmad,Wafai, Asrar Hussain,Wani, Sajad Hassan,Bukhari, Shoiab,Amin, Asif,Qadri, Raies Ahmad 한국작물학회 2013 Journal of crop science and biotechnology Vol.16 No.3
Saffron, the desiccated stigmas of Crocus sativus, is recognized for its attractive color, flavor, and aroma which are due to the accumulation of crocin, picrocrocin, and safranal, respectively. HPLC analysis demonstrated maximum apocarotenoid accumulation during the fully developed scarlet stage of stigma development followed by the orange and yellow stages of stigma development. Reverse Transcription-PCR analysis revealed a concurrent expression pattern of CsZCD and CsLYC genes in a developmental stage-specific manner. However, CsBCH and CsGT2 genes were specifically expressed during the mature, scarlet stage of stigma development. Real-Time PCR analysis showed a sharp increase in gene expression of CsLYC gene during stigma development indicative of its possible regulatory role in apocarotenoid biosynthesis or stigma development. Results suggest that genetic manipulation of this gene can help to improve the quality of stigma in saffron; besides highlighting its potential to monitor stigma development during in vitro experimentation.
Induced Magnetic Properties of BN Nanotubes by the Adsorption of First-row Adatoms
Fayyaz Hussain,Muhammad Imran,Nimra Fatima,Anwar Manzoor Rana,R. M. Arif Khalil,Arshad Javid,Muhammad Ismail 한국자기학회 2018 Journal of Magnetics Vol.23 No.1
This work is performed to study the effect of adsorption of various first row adatoms (such as Be, C, F, Li and O) on (8, 0) zigzag boron nitride nanotubes (BNNTs) on their structural, electronic and magnetic properties. These calculations are based on density functional theory using pseudopotentials technique. For this purpose, five different sites namely axial, hexagonal, zigzag, on top of N and/or B (which are the most preferred available sites for adatoms on (8, 0) BNNTs) were utilized. The energetically stable sites for each of the first-row adatoms are found to be different because of their different electronic configurations caused by the charge transfer/ rearrangements between s-p or p-p orbitals. The binding energies of all adatoms on (8, 0) BNNTs have been calculated through structural optimization process after adsorbing these five adatoms at the above said sites on the BNNTs and are found to be in the energy range from -2.04 to 2.96 eV. It is further elaborated that F, Be and C adatoms on (8, 0) BNNTs show strong induced magnetization at specific localized sites depending upon the nature of adatom, whereas weak magnetization is noticed for Li and O adatoms on the BNNTs. Such localized induced magnetization could be associated with the hybridization of s-p or p-p orbitals of adatoms and B and/or N atoms.
Algorithm of Common Solutions to the Cayley Inclusion and Fixed Point Problems
Dar, Aadil Hussain,Ahmad, Mohammad Kalimuddin,Iqbal, Javid,Mir, Waseem Ali Department of Mathematics 2021 Kyungpook mathematical journal Vol.61 No.2
In this paper, we develop an iterative algorithm for obtaining common solutions to the Cayley inclusion problem and the set of fixed points of a non-expansive mapping in Hilbert spaces. A numerical example is given for the justification of our claim.
Muhammad Ashraf Javid,Nazam Ali,Muhammad Abdullah,Syed Arif Hussain Shah 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.7
Many accidents happen on roads due to the risky behaviour of drivers including speeding. The rate of fatalities and injuries is high in those accidents where speeding is the reason for the accident. This study aims to identify the significant predictors of drivers’ speeding behaviour considering the theoretical background of the Norm-Activation Model (NAM) theory. The social, cultural, and road environment-related factors were also considered in the design of the questionnaire. This survey was conducted in Lahore city and 556 usable samples were collected. A factor analysis was conducted to confirm the association of observed variables with their latent variables according to NAM theory. Exploratory Factor Analysis (EFA) resulted in factors of personal speeding traits, the effectiveness of traffic enforcements, speeding propensity, situational constraints, drivers’ compliance with speed limits, social and environmental influence. The results of Structural Equation Modelling (SEM) revealed that driver’s Awareness of the Consequences (AC), the Ascription of Responsibility (AR) of behavioural outcomes, and compliance with speed limits are good predictors of Personal Norms (PN) (R2 = 0.62). The factors of personal speeding traits, situational constraints, personal norms, and social and environmental influence have significant correlations with drivers’ speeding propensity (R2 = 0.36). The PN, effectiveness of traffic enforcements, compliance with speed limits, and speeding propensity factors are a direct predictor of drivers’ speeding behaviour (R2 = 0.21). These results implicate that drivers’ ability to comply with speed limits and present traffic enforcements are effective in controlling speedy drivers. However, different situations, specific personality attributes, road driving environment, and culture have a positive influence on speeding propensity.
Endophytic fungi: resource for gibberellins and crop abiotic stress resistance
Khan, Abdul Latif,Hussain, Javid,Al-Harrasi, Ahmed,Al-Rawahi, Ahmed,Lee, In-Jung Informa Healthcare USA, Inc. 2015 Critical reviews in biotechnology Vol.35 No.1
<P>The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recently they have been found to produce physiologically active gibberellins as well. The symbiosis of gibberellins producing endophytic fungi with crops can be a promising strategy to overcome the adverse effects of abiotic stresses. The association of such endophytes has not only increased plant biomass but also ameliorated plant-growth during extreme environmental conditions. Endophytic fungi represent a trove of unexplored biodiversity and a frequently overlooked component of crop ecology. The present review describes the role of gibberellins producing endophytic fungi, suggests putative mechanisms involved in plant endophyte stress interactions and discusses future prospects in this field.</P>
Diversity and habitat preferences of amphibians and reptiles in Pakistan: a review
Waqas Ali,Arshad Javid,Ali Hussain,Syed Mohsin Bukhari 국립중앙과학관 2018 Journal of Asia-Pacific Biodiversity Vol.11 No.2
Geographical position of Pakistan is unique, and country harbors two out of six zoogeographical regions. The country can be divided into 15 habitat types in three major divisions: the mountainous region, foothills, and Indus plains. Overall, 219 species including 24 amphibians and 195 reptiles have been reported so far. Out of these, nine amphibian and 13 reptilian species are endemic to Pakistan. Despite this richness, there is paucity of knowledge regarding diversity of amphibians and reptiles as very few species have been thoroughly studied and very small area has been explored. This has led to the uncertainties regarding distribution and taxonomy of these taxa in the country. The herpetofauna is not protected by law in the country, and their conservation status is yet to be evaluated. Furthermore, distribution ranges of amphibians and reptiles have been changed and systemized survey work is required to update baseline information in the country.
( Khan Abdul Latif ),( Muhammad Hamayun ),( Nadeem Ahmad ),( Javid Hussain ),( Sang Mo Kang ),( Yoon Ha Kim ),( Muhammad Adnan ),( Dong Sheng Tang ),( Muhammad Waqas ),( Ramalingam Radhakrishnan ),( Y 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.9
Endophytic fungi are little known for their role in gibberellins (GAs) synthesis and abiotic stress resistance in crop plants. We isolated 10 endophytes from the roots of field-grown soybean and screened their culture filtrates (CF) on the GAs biosynthesis mutant rice line - Waito-C. CF bioassay showed that endophyte GMH-1B significantly promoted the growth of Waito-C compared with controls. GMH-1B was identified as Penicillium minioluteum LHL09 on the basis of ITS regions rDNA sequence homology and phylogenetic analyses. GC/MS-SIM analysis of CF of P. minioluteum revealed the presence of bioactive GA4 and GA7. In endophyte-soybean plant interaction, P. minioluteum association significantly promoted growth characteristics (shoot length, shoot fresh and dry biomasses, chlorophyll content, and leaf area) and nitrogen assimilation, with and without sodium chloride (NaCl)-induced salinity (70 and 140 mM) stress, as compared with control. Field-emission scanning electron microcopy showed active colonization of endophyte with host plants before and after stress treatments. In response to salinity stress, low endogenous abscisic acid and high salicylic acid accumulation in endophyte-associated plants elucidated the stress mitigation by P. minioluteum. The endophytic fungal symbiosis of P. minioluteum also increased the daidzein and genistein contents in the soybean as compared with control plants, under salt stress. Thus, P. minioluteum ameliorated the adverse effects of abiotic salinity stress and rescued soybean plant growth by influencing biosynthesis of the plant`s hormones and flavonoids.