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RISS 인기검색어
- 검색키워드
- 저자 : Yousseu Nana William (검색결과 3 건)
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Yousseu Nana William,Ateufack Gilbert,Abdul Jabbar Shah,Mbiantcha Marius,Tchoumba Tchoumi Liliane Mireille,Matah Mba Marthe Vanessa,Adjouzem Carine Flore,Teboukeu Boungo Gires,Awouafack Maurice Ducret 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
Distemonanthus benthamianus is used in Cameroon to treat diarrhoeal episodes. The study aimed to evaluate its antidiarrhoeal potential in Wistar rats and BALB/c mice. Extracts were preliminary investigated for phytochemical components, total phenols quantifcation and DPPH scavenging activity. Their efects were also evaluated against castor oil-induced diarrhoea, prostaglandin-E1-induced fuid accumulation, charcoal meal motility test, as well as against magnesium sulphateinduced diarrhoea and electrolytes regulation. The methanolic extract contains alkaloids, favonoids, polyphenols, saponins, sterols, tannins and triterpenes while aqueous extract was devoid of sterols and triterpenes. Phenolic compounds were more concentrated in methanolic extract, which also developed signifcant DPPH scavenging efects. In castor oil-induced diarrhoea, signifcant (p<0.001) reduction in diarrhoeal stools frequency was observed with 100, 200 and 300 mg/kg of aqueous extract, while 400 mg/kg of methanolic extract exhibited maximum efect. Total stools frequency was signifcantly (p<0.001) reduced with doses of 300 and 400 mg/kg of extracts. Maximum protection was obtained with 400 mg/kg of both extracts in magnesium sulphate-induced diarrhoea. That dose signifcantly (p<0.001) reduced Na+ excretion, while Ca2+ excretion was signifcantly (p<0.001) increased with 100 mg/kg of aqueous extract. Both extracts signifcantly (p<0.01, p<0.001) reduced the intestinal fuids mass and volume similarly compared to the negative control groups. The gut motility was signifcantly (p<0.001) reduced with 100 and 200 mg/kg of methanolic and aqueous extracts, respectively. Extracts are therefore antidiarrhoeal remedies candidates, since they provoked a decrease in intestinal motility, associated with fuid and electrolytes regulation across the gut.
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Marius Mbiantcha,Rauf Khalid,Donatien Albert Atsamo,Isaac S. Njoku,Arif Mehreen,Gilbert Ateufack,Dar Hamza,William Yousseu Nana,Rehman Ur Naeem,Ahmad Izhar 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Painful neuropathy that can cause hyperalgesia and allodynia is the most common and debilitating complication of diabetes. Both hyperglycemia and oxidative stress clearly play a key role in the progression of diabetic neuropathy. The search for new natural products with combined anti-inflammatory, antioxidant, hypoglycemic and antinociceptive properties is important in the treatment of this disease. The purpose of this study was to evaluate the anti-hypernoceptive effect of the methanolic extract of Boswellia dalzielii in streptozotocin-induced diabetic mice. Thus, the mice were injected with 200 mg/kg of streptozotocin to produce hyperglycemia. Von Frey filaments, hotplate, acetone and formalin tests were used to evaluate anti-nociceptive activity. Assays of catalase, SOD, MDA and NO determined the antioxidant properties. When administered, methanolic extract of Boswellia dalzielii (250 and 500 mg/kg, p.o.) significantly reduced licking/biting behavior during the first and second phase of the formalin test in a dose-dependent manner. Moreover, this extract significantly improved the glycemia of diabetic mice, it also significantly decreased the levels of TNF alpha, IL-1 beta in the serum and the sciatic nerve, decreased the levels of MDA and NO, and then increased the activity of SOD and catalase enzymes. Our results suggest that methanolic extract of Boswellia dalzielii can be a useful therapeutic agent, presumably for both prevention and reversal of pathophysiologic pain. This effect seems to imply hyperglycemic and antioxidant properties of this plant.
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Mbiantcha Marius,Djami Marcelle Bejoutance,Ateufack Gilbert,Atsamo Donatien Albert,Tsafack Gonzal Eric,Yousseu William Nana,Djuichou Flore Stéphanie Nguemnang,Matah Vanessa Marthe Mba,Kenmogne Liliane 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2
Nauclea diderrichii, is a common woody plant in Africa where it is traditionally used for the relief and treatment of multiple pain-related conditions. The aim was to evaluate the inflammatory and anti-arthritic properties of the aqueous extract of N. diderrichii stem bark. Carrageenan and formalin were used to induce inflammation while zymosan A was used to induce monoarthritis in rats. The extract was given orally at doses of 100, 200 and 400 mg/kg. The extract significantly reduced carrageenan-induced edema up to 6 h, with 61.94% (6th hour). The extract induces a significant inhibition of the formalin-induced edema from the 2nd to the 8th hour with 61.50% (2nd hour). In continuous treatment, the activity of the extract remains significant from the 2nd to the 10th day of treatment with 63.85% (9th day). The extract (400 mg/kg) induces a significant decrease of the organ weight while the body weight increases significantly. At 400 mg/kg, the extract significantly increases the levels of red blood cells, hemoglobin and proteins, as well as the catalase and SOD activities, then a significant decrease of the levels of white blood cells, lymphocytes, hematocrit, MDA and NO. Furthermore, the extract significantly inhibited zymosan A-induced edema from the 1st to the 5th day with 60.99% (5th day). The joints of the treated animals show a close to normal architecture compared to that of the untreated animals. These results demonstrate the anti-inflammatory and anti-arthritic properties of N. diderrichii and confirm its traditional use to relieve pain and inflammation.
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