Slide Session : OS-HEM-03 ; Hematology : Hemophagocytic Syndrome in Internal Medicine: Iden-tification of Infectious Triggers, Therapeutic Manage-ment and Mortality in 88 Patients (REGHEM-GEAS-SEMI)

( Pilar BRITO ZERÓN ),( Marta PEREZ DE LIS NOVO ),( Roberto PÉREZ ALVAREZ ),( Pedro MORAL MORAL ),( Aleida MARTÍNEZ ZAPICO ),( Guadalupe FRAILE ),( Eva FONSECA ),( María VAQUERO HERRERO ),( Angela RUI 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: To analyze the therapeutic management and the main epidemiological and clinical characteristics related to survival in a large series of patients with hemophagocytic syndrome (HS) diagnosed in Departments of Internal Medicine. Methods: In June 2013, the Study Group of Autoimmune Diseases (GEAS-SEMI) creates a national registry of patients with HS. Patients were diagnosed according to the fulfillment of the criteria of the Histiocytosis Society in 1991 and updated in 2004. Results: At June 15, 2014, the REGHEM registry included 88 patients with HS, 35 (40%) men and 55 (60%) women, with a mean age at diagnosis of 49.16 years (range 12- 84 years). During the admission that led to the diagnosis of SH, acute infections were identified in 50 (57%) patients, including viruses (n=20), bacteria (n=13), mycobacteria (n=8) and parasites/fungi (n=13). Patients were treated with corticosteroids (n=40), etoposide (n=12), cyclosporin A (n=12), methotrexate (n=4), tacrolimus (n=2) rituximab (n=3), intravenous immunoglobulins (n=2) and chemotherapy (n=5). A total of 44 (50%) patients died. The main factors associated with mortality were analytical parameters at diagnosis such as the presence of severe anemia (Hb <9 g/L, 89% vs 66%, p=0.01), platelet count <100,000/mm3 (96% vs 64%, p<0.001), neutropenia <1000/mm3 (59% vs 39%, p=0.044), and bacterial infections as precipitating agent (77% vs 45%, p=0.034); a clinical presentation including lymphadenopathy was associated with a lower mortality (59% vs 39%, p=0.044). Conclusions: Hemophagocytic syndrome is a severe multisystemic disease associated in nearly 50% of cases with an acute infection, and usually requires vital support in intensive care units. Despite this and the use of a complex therapeutic approach, half of the patients died. The main prognostic factor identified is the presence at diagnosis of severe cytopenias and the coexistence of bacterial infections.

Electrocatalytic reduction of CO2 with N/B co-doped reduced graphene oxide based catalysts

María Isabel Cerrillo,Carlos Jiménez,Miguel Ángel Ortiz,Rafael Camarillo,Jesusa Rincón,Fabiola Martínez 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-

Metal based materials are frequently used in electrocatalytic processes for the mitigation ofCO2 emissions, increasing the cost of the technology and the toxicity of the material. Metal-free catalystsappear as an interesting alternative. This work focusses on the synthesis of nitrogen and boron dopedreduced graphene oxide (rGO) for the electrocatalytic reduction of CO2 in gas phase in continuous operationmode in a PEM type cell. The main reaction products observed have been formic acid and CO, beingthe first one mainly formed. Results obtained with rGONB have been compared with the undoped rGOand with copper-based catalysts (Cu/rGO and Cu/rGONB). The non-metal doped material (rGONB) ismuch more active in the CO2 electrocatalytic reduction as compared with the undoped material (rGO). The catalytic activity of rGONB is very similar to those obtained with Cu/rGO and Cu/rGONB catalysts,pointing out rGONB as a very promising material for the electrocatalytic reduction of CO2. This is especiallyrelevant considering that rGONB has been tested in a relatively high geometric area (comparedwith most works in literature), in gas phase and in continuous operation mode, which is an importantstep to carry out the further scale-up of the process for industrial applications.

Development of a gamma irradiation loop to evaluate the performance of a EURO-GANEX process

I. Sanchez-García,H. Galan,A. Núnez,J.M. Perlado,J. Cobos 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.5

A new irradiation loop design has been developed, which provides the ability to carry out radiolyticresistance studies of extraction systems simulating process relevant conditions in an easy and simpleway. The step-by-step loop configuration permits an easy modification of settings and has a relative lowvolume requirement. This irradiation loop has been initially set up to test the main EURO-GANEX processsteps: the lanthanide (Ln) and actinide (An) co-extraction followed by the transuranic (TRU) stripping. The performance and changes in the composition have been analyzed during the irradiation experimentby different techniques: gamma spectroscopy and ICP-MS for the extraction and corrosion behavior ofthe full system, and HPLC-MS and Raman spectroscopy to determine the degradation of the organic andaqueous solvents, respectively. The Ln and An co-extraction step and the corrosion that occurred duringthe first irradiation step revealed the favorable expected results according to literature. The effects ofacidity changes occurred during the irradiation process, the presence of stainless corrosion products insolution as well as the new possible degradation compounds have been explored in the An stripping step. The results obtained demonstrate the importance of developing realistic irradiation experiments wheredifferent factors affecting the performance can be easily studied and isolated

Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance

Luis A Gaytán Martínez,Luis A Sánchez-Ruiz,Laura Y Zuñiga,Manuel González-Ortiz,Esperanza Martínez-Abundis 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1

Gymnema sylvestre, a plant typical of India, has long been known for its hypoglycemic effects. The objective of this study was to evaluate the effect of G. sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance (IGT). A randomized, double-blind, placebo-controlled clinical trial was conducted in 30 patients with IGT. Fifteen patients randomly received G. sylvestre in doses of 300 mg b.i.d. and the other 15 received placebo in the same way. Before and after the intervention, anthropometric and metabolic measurements were taken, including 2-h oral glucose tolerance test (2-h OGTT), fasting plasma glucose, glycated hemoglobin A1c (A1C), and the lipid profile panel. Areas under the curve of glucose and insulin were calculated, as well as the insulinogenic, Stumvoll, and Matsuda indices. Wilcoxon, Mann–Whitney U, and chi-square or Fisher's exact tests were performed, and a P-value ≤.05 was considered statistically significant. There was a significant reduction in 2-h OGTT (9.1 ± 1.2 vs. 7.8 ± 1.7 mmol/L, P = .003), A1C (5.8 ± 0.3% vs. 5.4 ± 0.4%, P = .025), body weight, body mass index, and low-density lipoprotein cholesterol levels in the G. sylvestre group, with an increment in the Matsuda index (1.8 ± 0.8 vs. 2.4 ± 1.2, P = .008). At the end of the intervention, 46.7% of the patients obtained normal values in A1C. In conclusion, G. sylvestre administration in patients with IGT decreased 2-h OGTT and A1C, increasing insulin sensitivity. There were also improvements in anthropometric measures and the lipid profile.

Adsorption of Graphene Oxide onto Synthetic Fibers: Experimental Conditions

E. Giménez-Martín,J. A. Moleón-Baca,A. Ontiveros-Ortega,I. Plaza 한국섬유공학회 2018 Fibers and polymers Vol.19 No.11

Comparative studies on the adsorption capacity of two synthetic fibers, polyamide (PA 66) and polyester (PET) pre-treated with N-cetylpyridinium chloride (PET-NCPCl), towards graphene oxide (GO) have been carried out. The fiber samples were characterized by scanning electron microscopy (FE-SEM) and Raman spectroscopy. The results of adsorption isotherms, kinetics, and zeta potential determinations as a function of the GO concentration, pH, and temperature show that at a low pH of 2.5 and a high temperature of 323 K, almost 99 % of the 75 mg/l GO solution is adsorbed onto PA 66 and 70 % onto the PET-NCPCl fibers. The interaction should be first attributed to electrostatic forces, also the adsorption data exhibited a good fit to the Freundlich isotherm model and the free energy value of 10 kJ/mol was in the range of physical adsorption, which could suggest that the interaction is driven mainly by physical forces. Due to the increasing development of wastewater treatments based on the GO reactivity with metals and cationic contaminants, synthetic fibers coated with GO could be considered an adsorbent for environmental applications.

Association between cigarette smoking and the prevalence of post-endodontic periapical pathology: a systematic review and meta-analysis

Ríos-Osorio Néstor,Muñoz-Alvear Hernan Darío,Jiménez-Castellanos Fabio Andrés,Quijano-Guauque Sara,Jiménez-Peña Oscar,García-Perdomo Herney Andrés,Caviedes-Bucheli Javier 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.3

Objectives This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans. Materials and Methods We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3). Results 6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%). Conclusions Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure. Objectives This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans. Materials and Methods We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3). Results 6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%). Conclusions Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure.

Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

Ambar Oyarzábal-Yera,Sandra Rodríguez-Salgueiro,Nelson Merino-García,Leyanis Ocaña-Nápoles,Lucía González-Núñez,Licet Mena-Valdés,Zullyt Zamora-Rodríguez,José A. Medina-Pírez,Sonia Jiménez-Despaigne,V 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.4

Background: Acute kidney injury (AKI) induced by renal ischemia/reperfusion (IR) is associated with enhanced production of reactive oxygen species in renal tissues. D-005, a lipid extract obtained from Acrocomia crispa fruit, has previously shown antioxidant effects. The aim of this work was to evaluate the effects of D-005 on renal IR-induced AKI in rats. Methods: Rats were randomized into seven groups including a negative control group (vehicle) without AKI and six groups with renal IR-induced AKI as follows: a positive control (vehicle); D-005 treatment at 25, 100, 200, or 400 mg/kg; and dexamethasone at 3 mg/kg. All treatments were orally administered as single doses 1 hour before AKI induction. Biomarkers (serum creatinine, urea, and uric acid concentrations), oxidative variables, and histopathological AKI changes were evaluated in blood and kidney tissues. Results: All D-005 doses protected against IR-induced AKI in rats by significantly decreasing biomarkers and histopathological AKI changes as assessed by reduced serum concentrations of creatinine, urea, and uric acid. In addition, all D-005 doses decreased tubular damage, as shown by fewer detached cells and casts in the tubular lumen. D-005 reversed oxidation disturbance markers by decreasing malondialdehyde and sulfhydryl group concentrations in plasma and in kidney homogenates and by increasing kidney catalase activity. Dexamethasone, the reference substance, protected against IR-induced AKI in rats by reducing biochemical and histological variables of renal damage in a similar manner. Conclusion: Administration of single oral doses of D-005 markedly and significantly protected against renal IR-induced AKI, possibly due to its known antioxidant effects.

Analyzing Nursing Leadership at an Academic Historical Event: A Descriptive Study Based On Social Networks

Marqués-Sánchez Pilar,Cummings Greta,Martínez-Fernández María Cristina,Martínez-Gimeno María Lara,López María,Serrano-Fuentes Néstor 한국간호과학회 2020 Asian Nursing Research Vol.14 No.2

Purpose: To analyze the leadership network structure among nursing leaders in Spain identified through the Grupo40Enfermeras y Universidad event. Methods: A descriptive cross-sectional study using social network analysis was used. Study sample consisted of 210 individuals, of whom 119 received nominations as referents. Structural analysis of the network was conducted using centrality and cohesion. Results: A network structure was generated in which different leadership strategies were identified through InDegree, Eigenvector, and Betweenness Centrality. Five leaders were identified as bridges to other individuals using Betweenness. The whole network presented little cohesion although two highly cohesive cores were detected by K-core measurements. Conclusion: A strategy is needed to support nursing leaders with high degree of Betweenness to serve as bridges to connect other nursing leaders

Probing Quantum Confinement within Single Core–Multishell Nanowires

Martí,nez-Criado, Gema,Homs, Alejandro,Alé,n, Benito,Sans, Juan A.,Segura-Ruiz, Jaime,Molina-Sá,nchez, Alejandro,Susini, Jean,Yoo, Jinkyoung,Yi, Gyu-Chul American Chemical Society 2012 NANO LETTERS Vol.12 No.11

<P>Theoretically core–multishell nanowires under a cross-section of hexagonal geometry should exhibit peculiar confinement effects. Using a hard X-ray nanobeam, here we show experimental evidence for carrier localization phenomena at the hexagon corners by combining synchrotron excited optical luminescence with simultaneous X-ray fluorescence spectroscopy. Applied to single coaxial n-GaN/InGaN multiquantum-well/p-GaN nanowires, our experiment narrows the gap between optical microscopy and high-resolution X-ray imaging and calls for further studies on the underlying mechanisms of optoelectronic nanodevices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-11/nl303178u/production/images/medium/nl-2012-03178u_0007.gif'></P>

Biochemical characterization of a semi-purified aspartic protease from sea catfish Bagre panamensis with milk-clotting activity

Idalia Osuna-Ruiz,Marı´a Fernanda Espinoza-Marroquin,Jesu´ s Aaro´n Salazar-Leyva,Emyr Pen˜a,Carlos Alfonso A ´ lvarez-Gonza´lez,Isaura Ban˜uelos-Vargas,Emmanuel Martı´nez-Montan˜o 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.6

Pepsin from stomach of Bagre panamensis wassemi-purified and biochemically characterized. The acidproteolytic activity and purification fold were 3875 U/mgprotein and 91.85, respectively, after purification process. The optimum pH and temperature for semi-purified proteasewere 2–3 and 65 C, respectively. The enzymeactivity was stable after heating proteases at 50 C for120 min, but only 30% residual activity was detected afterheating at 65 C for 30 min. SDS-PAGE analysis showedtwo proteins bands after dialysis (26.1 and 38.6 kDa). Onlythe band of 38.6 kDa had proteolytic activity, which wasinhibited using pepstatin A. Organic solvents, surfactantsand reducing agents affect the proteolytic activity at differentextent; however, metal ions or EDTA have noimpact on protease activity. The semi-purified proteaseexhibited milk coagulant activity, with a maximum activityat 45 C. The obtained results highlight the potentialbiotechnological use of B. panamensis pepsin.