하악 편측 유리단 국소의치의 직접유지장치 형태에 따른 3차원적 광탄성 응력분석 연구

김병무,유광희,Kim Byeong-Moo,Yoo Kwang-Hee 대한치과보철학회 1994 대한치과보철학회지 Vol.32 No.4

The extent and direction of movement of removable partial dentures during function are influenced by the nature of the supporting structures and and the design of the prosthesis. Since forces are transmitted to the abutment teeth through occlusal rests, guide planes and direct retainers during functional movements, proper design based on the avaialble research data will maintain the health of abutment teeth and their supporting structures. The purpose of this in vitro study is evaluating stress distribution clinically around the abutment teeth prepared following 4-type clasping systems for unilateral free-end removable partial dentures. Three-Dimensional Photoelastic Stress Analysis method was used because it shows a visual display of stresses of the simulated abutment teeth and residual ridges and reveals stress concentration that can be read at any given points in terms of direction and magnitude. For this study, the author fabricated 4 mandibular photoelastic epoxy models missing left 1st and End molar. Epoxy models were duplicated and 4 unilateral removable partial dentures were construe- ted in accordance with 4-type direct retainers. Unilateral free-end removable partial dentures were positioned on their own models. 6kg force was loaded on the every removable partial dentures of the epoxy model on the central fossa of mandibular left 1st molar vertically by the loading device. After the stress was frozen in a stress freezing furnace, 6 specimens of 6-mm thickness were made from every epoxy model and examined with the circular polariscope. The results were as follows : 1. Generally I-bar clasp revealed the most favorable stress distribution around the abutment teeth. 2. At the end portion of the free-end ridge, Back action clasp showed the highest stress concentration at the bucco-lingual and top portions of the residual alveolar ridge. 3. At the distal area of the abutment teeth, Akers clasp and Roach clasp showed higher stress concentration bucco-lingually and apically than the others. 4. To the abutment tooth, I-bar clasp showed the least stress distribution bucco-lingually but the others showed irregular stress distribution. 5. At the mesial area of the abutment teeth, the order of effective stress distribution was I-bar clasp, Back-action clasp, Akers clasp and Roach clasp. There was big difference of stress distribution between them. 6. At the right 2nd premolar and 1st molar, the stress concentration of Akers clasp was a little high but that of I-bar clasp was low.

치과환자의 상하악 골융기의 임상통계학적 분석

김병무,이상한,KIM, Byeong-Moo 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.2

This study was made on persons applying for treatment at Korea veterans Hospital Dental Clinic at Seoul, Pusan. 1,758 dental patients were screened from January 1985 to October 1985. The presence or abscence, of tori, largely detected by visual examination were recorded for each patents and the following results were obtained. 1. The prevalence of tori showed that plate and mandibular tori occurred in 25.09%, 10.13%, of each total group. The ratio of tori in palate and mandible was about 2.5:1 and coexisting tori of the palate and mandible occured in 1.31%, of total group 2. palatine tori occured more frequently in female(27.47%) than in male(23.31%) 3. After the 2nd decade of life group, palatine tori revealed significant difference in percentage of occurrence (the 1st decade 11.38%, the 2nd decade 26.4%), with subsequent decade showing no significant difference 4. Slight type palatine tori(73.92%) collectively occurred most frequently compared to moderate(20.86%) and marked(55.22%) type. 5. Mandibular tori occured more frequently in male(11.60%) than in female(8.13%) 6. After the 3rd decade of life group, mandibular tori revealed significant difference in percentage of occurrence(the 2nd decade 4.15%, the 3rd decade 12.6%), with subsequent decade showing no significant difference. 7. Simple bilateral mandibular tori(6.43%) occurred most frequently, and bilateral mandibular tori(87%) collectively occurred more frequently than unilateral tori(13%) 8. Mandibular tori including canine and premolar teeth area(42.93%) collectively occurred most frequently compared to premolar teeth area(32.07%) and canine tooth area(13.04).

한국판 해리경험척도의 표준화 연구 (1)

박제민(Je Min Park),최병무(Byeong Moo Choe),김명정(Myung Jung Kim),한홍무(Hong Moo Hahn),유승윤(Seung Yoon Yoo),김성환(Seong Hwan Kim),주영희(Young Hee Joo) 한국정신병리진단분류학회 1995 精神病理學 Vol.4 No.1

N/A N/A

Loganin Inhibits α-MSH and IBMX-induced Melanogenesis by Suppressing the Expression of Tyrosinase in B16F10 Melanoma Cells

Hee Jin Jung(정희진),EunJin Bang(방은진),Byeong Moo Kim(김병무),Seong Ho Jeong(정성호),Gil Han Lee(이길한),Hae Young Chung(정해영) 한국생명과학회 2019 생명과학회지 Vol.29 No.11

Loganin은 Corni fructus의 주요 iridoid glycoside이며 항염증, 항당뇨 그리고 뇌신경보호 효과 등이 보고되었다. 본 연구에서는 α-MSH와 IBMX처리된 B16F10세포에서 loganin의 melanogenesis억제효과의 신호전달 경로를 조사하였다. Loganin의 미백 활성을 확인하기 위해 B16F10세포에서 1 μM에서 20 μM사이의 농도를 처리하여 세포독성 실험을 수행한 결과 최대 20 μM농도에서 독성을 나타내지 않았다. 또한 loganin은 α-MSH와 IBMX처리된 B16F10세포에서 농도-의존적으로 멜라닌 생성을 감소시키는 것을 확인하였다. 또한 loganin의 멜라닌 생성을 억제하는 신호전달 경로를 Western blotting을 실시하여 조사하였다. Western blot결과에 따르면 loganin은 α-MSH와 IBMX 처리된 B16F10세포에서 증가된 CREB인산화(Ser133)와 MITF 발현 및 tyrosinase의 유전자 발현을 감소시켰고 ERK의 인산화를 증가시켜 melanin 생성을 억제하였다. 결론적으로 loganin은 α-MSH와 IBMX에 의해 유도된 과도한 멜라닌 합성을 CREB인산화와 MITF 및 tyrosinase의 유전자 발현을 억제하고 ERK의 활성화를 통해 멜라닌 합성을 감소됨을 확인하였다. 따라서 loganin은 과색소 침착과 관련된 피부질환의 보호제로서 활용될 가능성을 가지는 것으로 사료된다. Ultraviolet radiation exposure is a major cause of extrinsic skin aging, which leads to skin hyperpigmentation. Loganin, a major iridoid glycoside obtained from Corni fructus, has anti-inflammatory, anti-diabetic, and neuroprotective effects. In this study, we investigated the mechanisms underlying the anti-melanogenic effects of loganin in B16F10 melanocytes treated with α-melanocyte stimulating hormone (α-MSH) and 3-isobutyl-1-methylxanthine (IBMX). Anti-melanogenic activity was measured by treating cells with loganin at concentrations between 1 and 20 μM. Cell viability assays confirmed that doses of loganin up to 20 μM were not cytotoxic. Loganin significantly and dose-dependently decreased intracellular melanin production. We also investigated potential molecular signaling pathways for the anti-melanogenesis effects of loganin. Western blotting showed that treatment with α-MSH and IBMX increased the phosphorylation of cAMP response element-binding protein (CREB) and the gene expressions of microphthalmia-associated transcription factor (MITF) and tyrosinase. Addition of loganin suppressed these increases, while promoting the phosphorylation of extracellular signal regulated kinase (ERK) and the anti-melanogenesis response. Our data therefore indicated that loganin could attenuate the increased melanin synthesis induced by α-MSH and IBMX treatment of B16F10 melanocytes. This attenuation appears to occur by downregulation of CREB phosphorylation and MITF and tyrosinase gene expression and upregulation of ERK phosphorylation. These finding suggests that loganin could be a valuable candidate for treatment of skin diseases related to hyperpigmentation.

Effects of Piperine on Insulin Resistance and Lipid Accumulation in Palmitatetreated HepG2 Cells

Hee Jin Jung(정희진),EunJin Bang(방은진),Seong Ho Jeong(정성호),Byeong Moo Kim(김병무),Hae Young Chung(정해영) 한국생명과학회 2019 생명과학회지 Vol.29 No.9

간의 지질 축적과 인슐린 저항성은 비알콜성 지방간 환자에게서 증가한다. Piperine은 후추(Piper nigrum)와 필발(인도산 후추, P. longum)의 주요 성분으로 항암, 항비만, 항 당뇨병, 항염증 및 항산화 등의 생리활성이 보고되었다. 그러나 piperine의 인간 간세포 HepG2 세포에서 지질 축적과 인슐린 저항성의 억제제로서의 연구는 보고된 바가 없다. 본 연구의 목적은 지질 축적 및 인슐린 저항성에 대한 piperine의 효과를 palmitate처리된 HepG2 세포에서 잠재적인 분자 기전을 밝히는 것이다. 그 결과 piperine처리군은 지질 함량을 감소시켰고, 지방 형성 표적 유전자인 SREBP-1c와 FAS의 발현을 억제함으로써 palmitate처리된 세포내 지질 축적을 감소시켰다. 게다가 piperine처리군은 지방산 산화에 관련된 CPT-1과 인산화된 ACC 및 인산화된 IRS-1 (Tyr632)와 Akt의 레벨을 증가시켰다. 또한, piperine처리군은 인산화된 IRS-1 (Ser307)의 레벨을 감소시켰다. 결론적으로 palmitate처리된 HepG2 세포에서 piperine은 SREBP-1와 FAS발현의 감소 및 CPT-1과 ACC 인산화의 증가 및 인산화된 IRS-1 (Try632)와 Akt 신호전달 경로를 조절함으로써 지질 축적 및 인슐린 저항성을 개선함을 확인하였다. 따라서 piperine의 지질 축적 및 인슐린 저항성을 예방하는 약물로써 가능성이 제시되었다. Hepatic lipid accumulation and insulin resistance increases in patients with non-alcoholic fatty liver disease. Piperine is a major compound found in black pepper (Piper nigrum) and long pepper (P. longum). Piperine has been used in fine chemical for its anti-cancer, anti-obesity, anti-diabetic, anti-inflammatory and anti-oxidant properties. However, the signaling-based mechanism of piperine and its role as an inhibitor of lipogenesis and insulin resistance in human hepatocyte cells remains ill-defined. In the present study, we explored the effects of piperine on lipid accumulation and insulin resistance, and explored the potential underlying molecular mechanisms in palmitate-treated HepG2 cells. Piperine treatment resulted in a significant reduction of triglyceride content. Furthermore, piperine treatment decreased palmitate-treated intracellular lipid deposition by inhibiting the lipogenic target genes, sterol-regulatory-element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS); whereas the expression of carnitine palmitoyl transferase (CPT-1) and phosphorylation of acetyl coenzyme A carboxylase (ACC) gene involved in fatty acid oxidation was increased. Moreover, piperine also inhibited the phosphorylation of insulin receptor substrate (IRS)-1 (Ser307). Piperine treatment modulated palmitate-treated lipid accumulation and insulin resistance in HepG2 cells with concomitant reduction of lipogenic target genes, such as SREBP-1 and FAS, and induction of CPT-1-ACC and phosphorylation of IRS-1 (Tyr632)-Akt pathways. Therefore, piperine represents a promising treatment for the prevention of lipid accumulation and insulin resistance.

당뇨병을 유발시킨 흰쥐 소화기관으로 이자 Langerhans Islet 이식에 관한 연구

김병무,박인선,민본홍 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.6

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

NO(Nitric Oxide)에 의한 이자의 외분비 조절작용

한유미,김병무,민본홍,박인선 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.5

성전환증 환자에 대한 임상적 연구

정영인,한홍무,최병무,김명정 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.1

A clinical study was made on the transsexuals who sought sex reassignment surgery. The subjects were given the diagnosis of true primary transsexualism according to DSM-Ⅲ-R. Fifteen male patients and seven female patients visited the psychiatric out-patient unit of Dong-A University Hospital from July. 1990 through April, 1992 The results were as follow: 1) The transsexuals were characterized by greater number of siblings. The female subjects had conspicuously greater number of sisters. 2) 45.5% of the patients showed depression at the time of visit and the nature of the depressions was generally thought to be reactive. The severity of depression at the time of visit appeared to be much less in comparison to previous periods of depression characterized by suicidal ideas or attempts among most of them. 3) No patient underwent any psychiatric treatment before visiting our unit. 4) Some patients gave us the impression that certain biological factors contributed as causative determinants, since they showed late and retarded development of the secondary sex characteristics.