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      • 림프절의 Langerhans세포 조직구증의 세침흡인 세포 소견 - 1예 보고 -

        김은경,주종은,Kim, Eun-Kyung,Joo, Jong-Eun 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

        Langerhans' cell histiocytosis is a relatively rare disorder of children, characterized by abnormal proliferation of Langerhans' cells. It usually presents as multiple osteolytic lesion with lymphadenopathy or cutaneous manifestations. We experienced a case of Langerhans' cell histiocytosis involving bone and lymph node, diagnosed by fine needle aspiration cytology of the lymph node. The patient was a 10-year old girl with left inguinal lymphadenopathy. Fine needle aspiration cytology from the lymph node disclosed very cellular smear consisted of Langerhans' cells, eosinophils and lymphocytes. The Langerhans' cells had eccentric oval to reniform shape nuclei with grooving and abundant pale cytoplasm. The diagnosis was confirmed later by histologic study of bone lesion.

      • SCOPUSKCI등재

        누두흉을 동반한 선천성 기관지낭종1 치험례

        손광현,주종은,이남수,Sohn, Kwang-Hyun,Joo, Jong-Eun,Lee, Nam-Soo 대한흉부심장혈관외과학회 1978 Journal of Chest Surgery (J Chest Surg) Vol.11 No.3

        A three year and seven month old girl with moderate depression deformity of the sternum associated with a huge well defined homogenous hazy mass density of the upper half of the right hemithorax on plain chest x-ray had developed, exertionaI dyspnea (Figs1, 2 and 3). Correction of the funnel chest was carried out with modified Ravitch procedure and resection of the intrathoracic cystic mass was performed through an anterolateral thoracotomy incision in one stage operation satisfactorily (Figs. 7 and 8). On exploration, the mass, $15{\times}12{\times}10$cm in size, was connected to the bronchus at 1cm a bove the carina by a stalk (Fig. 4). The outer surface showed abundant vasculature. The specimen was filled with mucoid material; the inner surface was much trabeculated. glistening and smooth (Fig. 5 and 6). yficroscopically, the cyst was lined with simple or pseudostratified ciliated columnar epithelium. The cystic wall was composed of loose fibrous connective tissue, muscle layers, cartilages with some lymphocytic infiltration (Fig. 9). Isolated cases of funnel chest deformity and congenital bronchogenic cystic disease are not uncommon; however, the assocbtion of the two conditions is yery rare. Therefore. report and review of the literature was done.

      • KCI등재

        인간 자궁내막에서 발견되는 극소형 추정줄기세포

        최종렬,주종,전은숙,고경래,이홍구,이규섭,김원규,Choi, Jong-Ryeol,Joo, Jong-Kil,Jun, Eun-Sook,Ko, Kyoung-Rae,Lee, Hong-Gu,Lee, Kyu-Sup,Kim, Won-Gyu 대한생식의학회 2010 Clinical and Experimental Reproductive Medicine Vol.37 No.2

        Objective: It has been recently reported that very small stem cells with pluripotency are detected in murine and human. The purposes of this study are to confirm whether very small putative stem cells (VSPSCs), which have the proper characteristics of stem cells as well as the expression of stem cell markers, are detected in human endometrium. Methods: The endometrial cells of 5 women, which were obtained by endometrial biopsy, were cultured for 2 weeks and were confirmed for the expressions of alkaline phosphatase, OCT-4 and CXCR4 by immunochemistry. Subsequently VSPSCs were separated by percoll density gradient method and were cultured. Also VSPSCs and their derived cells were confirmed for the expressions of OCT-4 and CXCR4. Results: The colonies, which is composed with VSPSCs less than 3 ${\mu}m$ and the 5~15 ${\mu}m$ sized hyperchromatic round cells, were detected in the endometrium of all of women and showed the strong expressions of alkaline phosphatase, OCT-4 and CXCR4. In culture after the separation of VSPSCs by percoll, these cells showed the morphological and functional characteristics of stem cells; self-renewal, colony formation, embryoid body-like formation and differential plasticity. VSPSCs formed gradually the 5~15 ${\mu}m$ sized hyperchromatic round cells and the 10~20 ${\mu}m$ sized sphere-shaped cells by cell-to-cell aggregation or cell fusion. Then these cells differentiated the various cells including fibroblast-like cells, nerve-like cells and endothelium-like cells. VSPSCs and their derived cells often showed the strong expressions of OCT-4 and CXCR4. Conclusion: VSPSCs less than 3 ${\mu}m$ and their derived cells are detected in human endometrium and these cells have the proper characteristics of stem cells and the expressions of stem cell markers as alkaline phosphatase, OCT-4 and CXCR4. 목 적: 최근 다능성을 가진 극소형 줄기세포가 생쥐와 인간에서 발견된다고 보고되었다. 이 연구의 목적은 극소형 추정줄기세포들이 인간 자궁내막에 존재하는지, 그리고 이 세포들이 줄기세포의 고유 특성들과 줄기세포 표지자들을 발현시키는지 확인하기 위함이다. 연구방법: 자궁내막조직검사로부터 채취한 여성 5명의 자궁내막세포를 2주 동안 배양하였으며, alkaline phosphatase, OCT-4, CXCR4 면역화학염색을 통해 줄기세포 표지자 발현 여부를 확인하였다. 이후 percoll density gradient method 방법으로 극소형 추정줄기세포들을 분리하여 배양하였으며, 또한 극소형 추정줄기세포들과 그 유래의 세포들이 OCT-4와 CXCR4를 발현시키는지 확인하였다. 결 과: $3{\mu}m$ 미만의 극소형 추정줄기세포들과 5~15 ${\mu}m$의 과다염색질 원형세포들로 구성된 군집들이 모든 여성의 자궁내막세포에서 발견되었으며, alkaline phosphatase, OCT-4 및 CXCR4를 강하게 발현시켰다. Percoll을 이용하여 극소형 추정줄기세포들을 분리 배양한 결과, 극소형 추정줄기세포들은 자가재생, 배아체양 형성, 군집 형성, 분화 가소성과 같은 줄기세포의 형태학적 및 기능적인 특성들을 나타내었다. 극소형 추정줄기세포들은 세포간 응집 혹은 세포융합을 통하여 약 5~15 ${\mu}m$ 과다염색질 원형세포들과 약 10~20 ${\mu}m$ 구형세포들을 점진적으로 형성시켰다. 이후이 세포들은 섬유아세포 유사세포, 신경유사세포, 혈관내피유사세포를 포함하는 다양한 세포로 분화하였다. 또한 극소형 추정줄기세포들과 극소형 추정줄기세포에서 유래한 세포들은 흔히 OCT-4와 CXCR4를 강하게 발현시켰다. 결 론: 3 ${\mu}m$ 미만의 극소형 추정줄기세포들과 극소형 추정줄기세포에서 유래한 세포들이 인간 자궁내막에서 발견되며, 이 세포들은 줄기세포의 고유 특성들과 줄기세포 표지자인 alkaline phosphatase, OCT-4, CXCR4를 발현시킨다.

      • KCI등재후보

        환자용 사상체질진단 설문지의 체질별 응답차이에 관한 연구

        이시우,주종,이수경,이혜정,장은수,Lee, Si-Woo,Joo, Jong-Cheon,Lee, Su-Kyung,Lee, Hae-Jung,Jang, Eun-Su 사상체질의학회 2007 사상체질의학회지 Vol.19 No.3

        1. Objectives This study aims to evaluate newly developing Sasang Constitution Diagnosis Questionnaire for accuracy and efficiency. 2. Methods Three hundred and twenty eight patients from 4 multi centers are involved in this study. Excluding 16 constitution-unidentified patients and 2 Taeyang-in patients, 310 patients' questionnaires are analyzed statistically by their constitutions. 3. Results Sixty one questions are statistically significant in whole 229 questions of Sasang Constitution Diagnosis Questionnaire. We have selected 30 questions from 61 questions by comparing total data from 4 multi centers with those of each center. Thirty questions are made up of 10 body shape questions, 10 appearance questions, 5 character questions and 5 symptom questions. 3. Conclusions There might be needs for revision of character and symptom questions. From results, we suggest to diagnose Sasang Constitution for screening by short-form questionnaire consisted of questions on body shapes and appearances.

      • KCI등재

        사상성격검사(SPQ)의 임상 타당화 연구

        장은수 ( Eun Su Jang ),이수진 ( Soo Jin Lee ),박수현 ( Soo Hyun Park ),이시우 ( Si Woo Lee ),주종천 ( Jong Cheon Joo ),이미숙 ( Mi Suk Lee ),김윤희 ( Yun Hee Kim ),채한 ( Han Chae ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.3

        Objectives : The purpose of this study was to validate the Sasang Personality Questionnaire (SPQ), based on the diagnosis of Sasang constitutional medicine clinical specialist. Methods : We performed Sasang type differentiation of 103 college students by certified specialist, and analyzed biopsychological traits of each groups with SPQ, Temperament and Character Inventory (TCI), Positive and Negative Affection Schedule (PANAS) and Body Mass Index (BMI). Results : The SPQ score of So-Yang (33.1±0.79), Tae-Eum (29.03±0.67) and So-Eum (25.76±0.98) Sasang groups showed significant differences from each other. The SPQ showed significant correlation with TCI Novelty-Seeking (r=.346), TCI Harm-Avoidance (r=-.348) and TCI Persistence (r=.346). But the BMI and PANAS did not show significant correlation with SPQ, although the PANAS Positive Affection (r=.332) has significant correlation with SPQ-Behavior. Conclusions : We confirmed the clinical validity of SPQ with clinical specialist and established biopsychosocial instruments. This study would contribute to a more objective diagnosis and studies on biopsychosocial mechanism of Sasang constitutional medicine.

      • 여성형 유방의 세침흡인 세포학적 소견 - 14예에 대한 고찰 -

        윤혜경,박설미,주종은,Yoon, Hye-Kyoung,Park, Seol-Mi,Joo, Jong-Eun 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

        Fine needle aspiration cytologic findings in 14 cases of gynecomastia are described. General cytomorphologic features resemble those of fibrocystic disease in women than those of fibroadenoma. Among the cytologic parameters, three-dimensional structure of epithelial cell clusters, presence of micronucleoli and irregularities of nuclear size and shape are suggestive of epithelial proliferative activity. In audition, 4 cases are proliferative breast disease without atypia and 10 cases are nonproliferative breast disease depending on cytologic criteria grading system.

      • KCI등재

        소아(小兒) 재발성(再發性) 삼출성(渗出性) 중이염(中耳炎)에서 가미형개연교탕(加味荊芥蓮翹湯)이 중이강(中耳腔) 삼출액(渗出液) 내(內) IL-8과 $TGF-{\beta}1$에 미치는 영향(影響)

        김현희,박은정,주종,Kim, Hyun-Hee,Park, Eun-Jeung,Joo, Jong-Cheon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.2

        The author measured IL-8 and $TGF-{\beta}1$ levels of 84 ears - 48 ears of them had treated by antibiotics, 36 of them by Kamihyunggyeyungyotang(KHY) - of pediatric recurrent otitis media with effusion using ELISA assay, and compared them. The results were obtained as follows. 1. The level of IL-8 in KHY group was significantly lower than that in antibiotics group(p<0.05). 2. The level of $TGF-{\beta}1$ in KHY group was lower than that in antibiotics group. According to above results, KHY is considered to be used for treating recurrent otitis media with effusion by controlling the production of interleukin-8 and transforming $growthfactor-{\beta}1$.

      • 유방 섬유낭성 질환의 세포학적 진단의 분류 - 세포학적 소견에 의한 등급점수표의 이용에 대한 제안 -

        윤혜경,김찬환,주종은,강신광,Yoon, Hye-Kyoung,Kim, Chan-Hwan,Joo, Jong-Eun,Khang, Shin-Kwang 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

        Fine needle aspiration biopsy has been proved as a safe, accurate and cost-effective diagnostic modality in palpable breast lesions. Cytologically, fibrocystic disease can be classified into 3 categories as nonproliferative breast disease, proliferative breast disease without atypia, and proliferative breast disease with atypia. This terminology for fine needle aspirates is compatible with that of diagnostic histopathology. Cytologic differentiation of nonproliferative disease from proliferative breast disease is important, since the risk of cancer development in cases of atypical hyperplasia is 4-5 times higher than that of general population. Twenty five fine needle aspirates of fibrocystic disease confirmed by subsequent histopathology were re-evaluated and classified into 3 categories depending on their architectural and nuclear features. In addition, these aspirates were scored according to the cytologic grading system, devised by Masood et al. and based on six cytologic criteria. Concordance rates between cytomorpholgic diagnosis and cytologic diagnosis using the cytologic criteria grading system and histologic diagnosis were 88% and 92%, respectively.

      • KCI등재

        20대와 60대에서 사상체질 완실무병 지표 소화 대변 땀 소변의 특징 비교

        김구,오승윤,주종,장은수,이시우,Kim, Koo,Oh, Seung-Yun,Joo, Jong-Cheon,Jang, Eun-Su,Lee, Si-Woo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2

        1. Objectives: The purpose of this study was verify the difference in digestion, feces, sweat and urination characteristics according to Sasang Constitution among subjects in the age range of their 20s and 60s. 2. Methods: Three hundred and thirty eight participants were recruited in the age range of their 20s and 264 participants in the age range of their 60s. All the participants' Sasang Constitutions were diagnosed by Sasang Constitutional medicine expert. Then their digestion, feces, sweat and urination characteristics were assessed through the questionnaire. 3. Results: 1)Regarding digestion, Soeumin in all age ranges had bad appetites and Soeumin in their 20s had low digestibility. 2)Regarding feces, the daily defecation frequency showed no difference according to constitution. Only Soeumin in their 20s showed diarrheal state of stool. 3)Regarding sweat, Taeeumin usually perspired more in their 20s and there was no difference in the feeling after sweating according to age and constitution. 4)Regarding urination, frequency and strength showed no difference according to age and constitution. 4. Conclusions: Some difference was observed in the digestion, feces and sweat characteristics according to Sasang Constitution but these characteristics were susceptible to change in different age ranges. There was no difference in urination according to constitution.

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