자궁내막 증식증과 선암종의 Estrogen 및 Progesterone 수용체 발현 양상과 PCNA를 이용한 세포증식능의 관련성에 대한 면역조직화학적 연구

박설미,윤혜경,주종은 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.1

놀이 중심의 이야기치료 프로그램이 한부모 가정 아동의 자아존중감에 미치는 효과

박설미,여인숙 한국아동심리재활학회 2009 놀이치료연구 Vol.13 No.2

본 연구는 놀이 중심의 이야기치료 프로그램이 한부모 가정 아동의 자아존중감 향상에 미치는 효과를 알아보는데 목적을 두고 실시하였다. 연구대상은 대구광역시 00모자원에 거주하는 초등학교 고학년 아동이다. 선정방법은 사회복지사로부터 적응에 어려움이 있다고 의뢰된 아동 중에서 자아존중감 검사를 실시하여 하위 33%에 속하는 아동 6명을 선정하여 통제집단과 실험집단에 각각 3명씩 배정하였다. 연구문제는 놀이 중심의 이야기치료 프로그램이 한부모 가정 아동의 자아존중감(자아존중감 척도, 언어표현, 행동, 삶에 대해 긍정적으로 서술하는 이야기 내용)에 미치는 효과이다. 이야기치료의 프로그램은, 자신의 문제 분리, 대안적 문제 해결, 능동적인 문제 해결 및 유능감 경험의 요소를 중재전략으로 하고 저항을 감소하는 놀이의 치료적 요인을 활용하였다. 아동의 자아존중감 향상을 알아보기 위해서는 실험집단과 통제집단의 사전·사후 자아존중감 척도 점수를 비교하였고, 실험집단은 매회기 자기와 타인에 대한 긍정, 부정 언어표현과 자아존중감 관련 행동, 삶에 대해 긍정적으로 서술하는 이야기 내용을 분석하였다. 연구의 결과는 다음과 같다. 놀이 중심의 이야기치료 프로그램은 자아존중감 척도에서 점수가 향상되었으며, 긍정언어표현은 증가하였고, 부정언어표현은 감소하였으며 행동 및 이야기의 내용도 긍정적으로 변화하였다. 따라서 놀이 중심의 이야기치료 프로그램은 한부모 가정 아동의 자아존중감을 향상시킨 측면에서 연구의 의의를 찾을 수 있다. The aim of the study was to examine effects of a play-based narrative therapy program on self-esteem of the child in a single parent family. The subjects of the study were higher grade elementary school children living in X single mothers' home in Daegu Metropolitan City. The selection process of the subjects was as follows. A social worker recommended several children whose had difficulties in socializing. Among the suggested, six children with lower 33% self-esteem were finally subjected to the study after a self-esteem test. They were grouped into a control and a test group with three children for each. The research task was to examine changes in self-esteem by applying a play-based narrative therapy for the children of a single parent family. The details of the self-esteem to be measured involved the self-esteem scale, verbal expression, behavior, and narrative positively describing their own life. The narrative therapy program was devised with a moderating strategy such as self-understanding, distinction of one's problems, alternative problem solving, active problem solving, and competence experience. It was also designed to utilize a therapeutic element of the play which reduces resistance. The self-esteem scales before and after the program were compared to examine an increase of the self-esteem of the children. Analyzed were positive and negative verbal expressions of self and others, behavior related with the self-esteem, narrative positively describing one own's life in each session. The results of the study are as follows. The play-based narrative therapy enhanced the self-esteem of the child in a single parent family. More specifically self-esteem scale improved, positive verbal expressions increased, negative verbal expressions decreased, and contents of behavior and stories became more positive. In conclusion, it proved that a play-based narrative therapy enhanced the self-esteem of the child in a single parent family.

유방 염증성 질환의 세침흡인소견

윤혜경,박설미,강미선,양영일,김찬환,Yoon, Hye-Kyoung,Park, Seol-Mi,Kang, Mi-Sun,Yang, Young-Il,Kim, Chan-Hwan 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

Fine needle aspiration of the breast is an important diagnostic tool in malignant lesions, but is also useful in differentiation of inflammatory breast diseases mimicking carcinoma clinically and radiologically. Recently, the authors have experienced eight biopsy-proven cases of chronic inflammatory diseases of the breast, which consisted of 4 cases of duct ectasia, 2 cases of fat necrosis, and a case of tuberculous mastitis and granulomatous mastitis respectively. Their cytologic features mainly based on the components and the relative frequency of inflammatory cells were evaluated for differential diagnosis of chronic inflammatory breast diseases. The results are as follows; 1. In cases of duct ectasia, varying amount of neutrophils, mononuclear leukocytes, histiocytes and multinucleated giant cells were intermixed with benign epithelial cell clusters. 2 Abundant fat tissue fragments were diagnostic for fat necrosis. Histiocytes and mononuclear cells were main components but not rich, and neutrophils and giant cells were infrequently observed. 3. Characteristic granulomas composed of epithelioid cells, mononuclear leukocytes and Langhans' type giant cells and lymphocytic infiltrates were conspicuous in tuberculous mastitis, and occasionally neutrophils, necrotic materials and epithelial cell clusters were found 4. In granulomatous mastitis, epithelioid cell granulomas were also noted but numerous neutrophils and histiocytes were intermingled within or outside the granulomas.

여성형 유방의 세침흡인 세포학적 소견 - 14예에 대한 고찰 -

윤혜경,박설미,주종은,Yoon, Hye-Kyoung,Park, Seol-Mi,Joo, Jong-Eun 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

Fine needle aspiration cytologic findings in 14 cases of gynecomastia are described. General cytomorphologic features resemble those of fibrocystic disease in women than those of fibroadenoma. Among the cytologic parameters, three-dimensional structure of epithelial cell clusters, presence of micronucleoli and irregularities of nuclear size and shape are suggestive of epithelial proliferative activity. In audition, 4 cases are proliferative breast disease without atypia and 10 cases are nonproliferative breast disease depending on cytologic criteria grading system.

모발상 세포 백혈병 1례

윤혜경,박설미,이정녀,손창학 大韓血液學會 1993 大韓血液學會誌 Vol.28 No.2

중추신경계 병변의 압착도말 세포학적 소견

양영일,박설미,김영주,강신광,Yang, Young-Il,Park, Sul-Mi,Kim, Young-Joo,Khang, Shin-Kwang 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

This study was performed in order to evaluate the accuracy and the usefulness of the cytology of crush preparation in central nervous system (CNS) lesions. Forty four intraoperative biopsies were performed at the time of craniotomy including 34 benign and 10 malignant lesions. Crush preparations were prepared from tiny tissue fragments of craniotomy products. All cases were stained with toluidine blue. Intraoperative diagnoses made on cytologic examination were compared with the final paraffin section diagnoses. Comparison between the results of the cytologic and histologic findings revealed an overall diagnostic accuracy of 88.6%. This study attests to the diagnostic accuracy of cytologic examination in CNS lesions. The detailed cytologic features are described and important criteria for the cytodiagnosis of CNS lesions are discussed. This review leads us to think that cytologic examination by crush preparation in CNS lesions is considered as a simple, safe and highly diagnostically accurate method.

유방암종의 MMP-2와 MMP-9 발현과 예후 인자와의 연관성

윤혜경,박설미 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.2

Background : MMP-2 and MMP-9 are involved in the degradation of extracellular matrix, and MMP-2 and MMP-9 expressions in breast carcinomas have been reported as a poor prognostic factor. The aim of this study is to evaluate the prognostic value and the regulatory factors of MMP-2 and MMP-9 expressions in 73 cases of infiltrating ductal carcinomas, NOS type. Methods : Immunohistochemistry for MMP-1, -2, -3, -9 and TIMP-1, -2 were performed and evaluation for patient’s age, size, histologic grade, lymph node metastasis and tumor markers such as ER, PR, p53, c-erbB-2, cathepsin D, MIB-1, and microvessel density was done. Results : The expression rates of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1 and TIMP-2 were 74.0%, 76.7%, 1.4%, 87.7%, 24.7% and 75.3%, respectively. MMP-2 expression rate was higher in the tumors of low and intermediate grade and PR positive tumors (p<0.05), and MMP-9 expression showed an increasing tendency in ER positive tumor (p=0.0676). Positive relationships between MMP-2 and MMP-1 expressions, and MMP-9 and TIMP-2 expressions were recognized (p<0.05). Conclusion : The prognostic significance of MMP-2 and MMP-9 expressions is still unclear, and MMP-2 and MMP-9 expressions seemed to be positively related with MMP-1 and TIMP-2 expression, respectively.