유리 산소 기 청소제가 자외선 B에 의한 생쥐 표피 Langerhans 세포의 ATPase 표현에 미치는 영향

전성진,서기석,김상태 ( Seong Jin Jeon,Kee Suck Suh,Sang Tae Kim ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

N/A The Effect of Free Oxygen Radical Scavengers on the Expression of ATPase of Mouse Epidermal Langerhans Cells After UVB Irradiation Seong Jin Jeon, M.D., Keo Suck Suh, M.D., Sang Tae Kim, M.D. Department of Dermatology, Kosin Medical College, Pusan, Korea Langerhans cells are dendritic cells with specific granules in their cytoplasm, and Ia antigen and receptors for Fc portion of IgG and C3 on their cell surface. They are known to perform immunological functions such as processing and presentation of antigen to T cells in delayed type contact hypersensitivity, and surveillance of virus and cancer. It is known that Langerhans cells are damaged functionally and morphologically by UVB irradiation, but the mechanisms are still not known or are largely speculative, though keratinocytes are known to be damaged by reactive oxygen species generated by UV irradiation. It was the investigator`s idea that reactive oxygens generated by UVB exposure on skin could also play a role in Langerhans cell damage and that free oxygen radical scavengers would prevent the damage of Langerhans cells from UVB. Free radical scavengers used in this experiments were superoxide dismutase(SOD), α-tocopherol acetate(α-TCA) and sodium azide(SA), and these chemicals were known to inactivate O_2^-, OH and 1^O_2 respectively. Groups of BALB/c mice were injected intraperitoneally wth 0.2㎖ of SOD(0.1 or 1.0mg/㎖), α-TCA(10^4 or 10^2mole) or SA(10^4 or 10^2mole) just before or immediately after UVB irradiation(40mJ/㎠). Control mice given saline, saline plus UVB irradiation or free oxygen radical scavengers without UVB. Seventy two hours after the irradiation of UVB, biopsy specimens were taken from the ears of mice. Number, area and perimeter of Langerhans cells were evaluated using ATPase-stained epidermal sheets. The results were as follows : 1. The number of Langerhans cells was significantly decreased by UVB irradiation(p<0.01). 2. The area and perimeter of Langerhans cells were significantly increased by UVB irradiation(p<0.01). 3. SOD could prevent Langerhans cell damage significantly from UVB(p<0.05). 4. For α-TCA, only high dose(10^2mole) and treatment immediately before UVB irradiation showed protective effect from Langerhans cell damage(p<0.05). 5. SA had no protective effect regardless of the doses or time of administration(p>0.05).

사물탕의 용량별 투여가 임신 랫드와 태자에 미치는 독성학적 연구

전성진,신헌태,김경태,박해모,이선동,Jeon, Sung-Jin,Shin, Heon-Tae,Kim, Kyung-Tae,Park, Hae-Mo,Lee, Sun-Dong 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.3

Objective : Samulatang (herbal description) is much used for women's disease in Korean Traditional Medicine. The aim of this study is to evaluate reproductive toxic effect by Samultang in pregnant rats and fetuses, and ascertain a dose-response relationship Method : Pregnant Sprague-Dawley rats were administered with the Samultang at single, double and quadruple dose for 20 days, orally. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Live fetuses of gestation were randomly selected and fixed in 95% ethanol. Fetuses were stained with alcian blue and alizarin red S. We observe maternal body weight,, index associated pregnancy, and skeletal malformations in fetus Result : Maternal body weight of Samultang treated group has increased, side effect was not found in maternal body compared to that of control group. There were no significant difference in internal and reproductive organs. Double concentration administered group had lowest value in number of implantation, live fetuses, implantation rate and delivery rate, Also double concentration administered group showed higher early and late resorption rate than the other group. But, these are not significant. In the sex ratio, number of females, bigger than number of males in all Samultang administered groups. The fetuses of dams treated with Samultang didn't showed external and skeletal malformation. Vertebral and sternal variations were observed in single, double and quadruple concentration administered group but, compared to the control, those variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumber, sacral and caudal vertebrae Conclusion : Samultang is not expected to affect on pregnant rats and fetus about maternal body weight and number of live fetuses. There were no significant changes in organ weight, reproductive organs. Although skeletal variations were showed in vertebrae and sternum, treated groups were shown insignificant changes in skeletal variation

Mycobacterium fortuitum에 의한 피부감염증

전성진,서기석,김상태,유경식,박인달,장명웅 ( Seong Jin Jeon,Kee Suck Suh,Sang Tae Kim,Gyung Sig Yoo,In Dal Park,Myung Woong Chang ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

We report a case of cutaneous Mycobacterium fortuitum infection occurring in a 53-year-old man with multiple subcutaneous nodules on his right thigh and right lower leg. He has been treated with long-term systemic corticosteroids for his nephrotic syndrome. He had no constitutional symptoms and no lymphadenopathy. Laboratory findigs were within normal limits except for abnormal values for nephrotic syndrome. The skin biospy specimen showed a mixed pattern of epithelioid granuloma with micropseudocyst containing acid-fast bacilli. Methenamine silver stain was negative. The cultures from the skin biopsy specimens on Ogawa media(3% KH_2PO_4) at 24℃, 32℃, 37℃, yielded colonies of M. fortuitum after 4 days. Culture on Sabouraud media revealed no growth. DOPA reaction was negative. Nitrate reduction test was positive and Tween 80 hydrolysis test was negative. Urine and sputum cultures for atypical mycobacteria were negative. This M. fortuitum was sensitive to amikacin or tetracycline. Four months later, the skin lesions regressed without therapy.

증례 : Methimazole 복용 후 발생한 간부전으로 간이식을 시행 받은 1예

전성진 ( Sung Jin Jeon ),김태용 ( Tae Yong Kim ),이승훈 ( Seung Hoon Lee ),강종식 ( Jong Sik Kang ),최광현 ( Gwang Hyeon Choi ),이승규 ( Seung Gyu Lee ),황희상 ( Hee Sang Hwang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.3

최근 가이드라인을 보면 PTU의 간독성 부작용과 관련하여 갑상선기능항진 증 치료로 메티마졸을 사용하도록 권장하고 있다. 그러나 매우 드물지만 메티마졸에 의해서 간독성이 발생할 수 있고, 본 증례처럼 간이식이 필요할 정도로 심각한간부전을 일으킬 수도 있다. 저자들은 60세 남자 환자가 메티마졸을 복용한 후 간부전이 발생하여 간이식을 시행한 증례를 경험하였기에 문헌고찰과 함께 보고하였다. Antithyroid drugs inhibit the synthesis and excretion of thyroid hormone from the thyroid gland. Propylthiouracil (PTU) and methimazole are well known as antithyroid drugs. In 2011, the American Thyroid Association and American Association of Clinical Endocrinologists published management guidelines for hyperthyroidism and other causes of thyrotoxicosis, and recommended methimazole as the first-choice antithyroid drug for the treatment of hyperthyroidism. Lower hepatotoxicity is an advantage of methimazole. Fulminant hepatitis rarely occurs in methimazole users, and spontaneous recovery is expected even if it does occur. We describe a rare case of acute liver failure after methimazole intake in a 60-year-old man who underwent liver transplantation.

나노스크래치 시험과 편마찰 실험을 이용한 합금화 온도별 GA 강판의 코팅층 마찰특성에 관한 연구

전성진(Sung Jin Jeon),이정민(Jung Min Lee),고대철(Dae cheol Ko),김병민(Byung Min Kim) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

The frictional and lubrication characteristics of coating layers are a significant factor in stamping process. The studies on the frictional characteristics are not thoroughgoing enough even though GA sheet steel has been widely used. The frictional characteristics of coating layers in galvannealed sheet steels were verified though one flat friction and nanoscratch test in this study. The coefficient of friction of coating layers on the surface was obtained from the nanoscratch test and it was certified by one flat friction test. The variation of frictional coefficient versus velocity and pressure was taken into consideration in this paper.

턴키 프로젝트의 주요 성공요인 분석에 관한 연구

전성진(Jeon Sung-Jin),김예상(Kim Yea-Sang) 대한건축학회 2003 大韓建築學會論文集 : 構造系 Vol.19 No.6

The volume of Turn-key projects in Korea is tremendously increasing and is expected to keep growing. In most of cases, large construction companies would be the primary contractors to handle both design and construction. However since these companies traditionally have worked as construction contractors, they need to improve management skills over whole phases of the projects as well as construction phase. This improvement requires a lot of resources and efforts. Critical Success Factors(CSFs) can offer the areas where they should focus their efforts to improve their abilities, to complete projects successfully and finally to be a successful turn-key contractor. There have been many studies on CSFs but no studies for turn-key projects. In this study, the CSFs to the turn-key projects were identified from the construction companies' point of view and analyzed in terms of importance to the project success. The results shall show potential areas for the construction companies to put their efforts to improve turn-key project management skills. Data analysis was done by Analytic Hierarchy Process(AHP) method and MS-Excel and Expert Choice were used as analysis tools.

아질산염의 화학적 산화 및 질산염의 생물학적 환원을 촉매하는 전극의 개발

전성진 ( Sung Jin Jeon ),신인호 ( In Ho Shin ),상병인,박대원 ( Dae Won Park ),박두현 ( Doo Hyun Park ) 한국환경분석학회 2003 환경분석과 독성보건 Vol.6 No.4

특발성 치은 섬유종증 및 다모증

전성진(Seong Jin Jeon),김광(Kwang Kim),채영수(Young Soo Chae),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.1

Idiopathic gingival fibromatosis is associated with other abnorma ities of which the most striking is hypertrichosis of variable degree. Gorlin and Pindborg described this condition as a distinct syndrome termed idiopathic gingival fibromatosis and hypertrichosis. We report a case of idiopathic gingival fibromatosis and hypertrichosis occuring in 34-year-old woman with enlarged gingival tissue, hypertrichosis, and enlargenment of the breasts, ears and nose. Laboratory tests including hormonal and chromosomal studies were all within normal limits. Histologically, the gingival hyperplastic tissue showed thick bundle of collagen fibers with few fibroblasts or capillaries and little or no inflammatory infiltrate. (Kor J Dermetol 1993; 31(1): 118-122)

Annular Elastolytic Giant Cell Granuloma

전성진(Seong Jin Jeon),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1

Annular elastolytic giant cell granuloma(AEGC(3) has been called as atypical necrcibiosis lipoidica, Mieschers granuloma of the face and scalp, and actinic granu- Joma and needs differen(iation from granuloma annulare, elastosis perforans serpiginosa and nerrobiosis lipoidica. We report a case of AECCG occurring in a 53-year-old male. The patient. had an annular erythematous plaque measuring 4 cm in diameter with serpiginous raised edges and slightly atrophic centers on the right forearm for 5 years. The histopathologic finding showed patchy dermal infiltration of lymphocytes, histiocytes, and multinucleated giant cells engulfing elastic fibers. The. skin lesion cleared after intrader mal injection cf cortieosteroids. (Kor J Dermatol 29(1): 86--90, 1991)

십전대보탕과 육미지황탕이 실험동물의 태자에 미치는 독성학적 연구

한상백,전성진,신헌태,박해모,이선동,박철수,Han, Sang-Baek,Jeon, Seong-Jin,Shin, Heon-Tae,Park, Hae-Mo,Lee, Sun-Dong,Park, Chul-Soo 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3

Purpose : To evaluate safety of Sibjeondaebotang and Yugmijihwangtang in rats' fetus Methods : Female Sprague-Dawley rats were orally administered with the Sibjeondaebotang and Yugmijihwangtang at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. To observe skeletal malformations, fetuses were stained with alcian blue and alizarin red S. Results : Neonatal body weight and number of fetus of Sibjeondaebotang, Yugmijihwangtang group were increased to those of control group. The fetuses treated with Sibjeondaebotang, Yugmijihwangtang didn't showed external malformation. Vertebral and sternal skeletal variations were observed in Sibjeondaebotang, Yugmijihwangtang administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumbar, sacral and caudal vertebrae Conclusion : From these results, it can be concluded that Sibjeondaebotang, Yugmijihwangtang shows no toxicity effects on fetus body weight and number of live fetuses. Although skeletal variations were shown in vertebrate and sternum, Sibjeondaebotang, Yugmijihwangtang did not show significant changes in bone malformation.