증례 : 내분비-대사 ; 다발·양측성 신세포암이 발병한 폰히펠린다우병 환자의 고주파 절제술

문상이 ( Sang Yi Moon ),김동현 ( Dong Hyun Kim ),정의한 ( Eui Han Jung ),박소영 ( So Young Park ),박미경 ( Mi Kyung Park ),김덕규 ( Duk Kyu Kim ),서성환 ( Sung Hwan Suh ) 대한내과학회 2014 대한내과학회지 Vol.87 No.5

폰히펠-린다우병의 신세포암의 표준치료는 콩팥 단위 보존 수술이지만 다발성, 양측성 및 재발을 잘한다는 특성으로 인해 여러 가지 한계가 존재하여, 최근에는 고주파 절제술을 통한 신세포암의 치료가 소개되고 있다. 저자들은 폰히펠-린 다우병 환자가 다발성, 양측성 신세포암을 진단 후 순차적인 고주파 절제술을 통한 성공적인 치료의 1예를 문헌고찰과 함께 보고하고자 한다. Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome that manifests as a variety of benign and malignant tumors in various organs. Notably, renal cell carcinoma (RCC) in patients with VHL disease tends to be multifocal and bilateral, and tends to recur or new tumors develop after removal. Radiofrequency ablation (RFA) has recently been introduced as a minimally invasive treatment for small hereditary RCCs with a low complication rate and a minimal decrease in renal function. We present a case of successful RFA of multiple bilateral RCCs in a 24-year-old female with VHL. Computed tomography (CT) of the abdomen revealed multiple bilateral RCCs. The patient received sequential RFA for the bilateral RCCs, resulting in a complete response. At the time of writing, there was no sign of recurrence or renal failure. In conclusion, percutaneous RFA is a promising treatment for VHL patients who cannot undergo surgery, with excellent treatment outcomes and minimal change in renal function. (Korean J Med 2014;87:603-608)

SOD(Spin On Doping)을 이용한 단결성 실리콘 태양전지에 관한 연구

문상일(San-il Moon),박성현(Sung-hyun Park),김경해(Kyung-hae Kim),우팔(U. Gangopadhyay),차크라바티(K. Chacrabarty),한창순(Changsoon Han),김대원(Dae-woon Kim),이준신(Jun-sin Yi) 한국태양에너지학회 2002 한국태양에너지학회 학술대회논문집 Vol.- No.-

HGM을 이용한 질날늪 기능평가 연구

김예화 ( Yi Hua Jin ),이란 ( Lan Li ),문상균 ( Sang Kyun Moon ),구본학 ( Bon Hak Koo ) 한국환경복원기술학회 2013 한국환경복원기술학회지 Vol.16 No.2

Wetlands occupy an important ecological position on the earth, carrying out very important functions and roles both ecologically and hydrologically. However, due to past industrialization, not only wetland areas but also the biodiversity of organisms has severely decreased due to several artificial interferences and damage as wetlands began to be perceived simply as targets for development and reclamation. However in recent times, with the importance of wetlands coming to the fore, the assessment of the function and value of wetlands is being made for their wise use and systematic maintenance. Accordingly, this study targeted the Jilnal Wetlands located in Haman, Gyeongnam, and conducted a functional appraisal of this wetland using the modified HGM Model which was modified & developed appropriately for the actual conditions of our country. The result of its appraisal by selecting the Upo Wetland as the reference wetland, which is a criterion of the index, showed a comparatively positive functional index with 0.89 of the Upo Wetland average. This means that the Jilnal Wetland carry out more than 89% of the functioning of the Upo Wetland. In this regard, it is thought that the Jilnal Wetland could carry out the wetland functioning equivalent to that of the Upo Wetland through a little more systematic management.

外傷性 膵臟損傷

白泰潤(Tae Yun Baik),文相殷(Sang Eun Moon),李昕雨(Heun Woo Yi),徐鎭根(Jin Keun Seu) 대한외과학회 1970 Annals of Surgical Treatment and Research Vol.12 No.12

연구논문 : 직업존중감이 조직몰입과 서비스지향성에 미치는 영향 -중국의 호텔종사원을 대상으로-

고동우 ( Dong Woo Ko ),서무일 ( Mao Yi Xu ),문상정 ( Sang Jeong Moon ) 대한관광경영학회 2015 觀光硏究 Vol.30 No.4

본 연구에서는 최근 들어 급성장하고 있는 중국의 호텔산업 종사원을 대상으로 하여 직업 존중감의 개념이 조직몰입과 서비스지향성을 예측하는 선행변수로서 타당한지를 확인하고자 하였다. 연구 목적을 위하여 중국 5성급과 4성급 호텔에 근무하는 종사원을 대상으로 설문조사(309부)를 실시하여 자료를 수집하였다. 수집한 자료에 대하여 SPSS 18.0을 이용하여 신뢰도 분석 및 탐색적 요인분석을 실행하였고, Amos 18.0을 이용하여 공분산구조분석 (structural equation model: SEM)실행하였다. 분석 결과는 다음과 같다. 첫째, 직업존중감 (자부심, 평판)은 조직몰입에 유의한 영향을 미치는 것으로 나타났다. 둘째, 직업존중감(일가치)는 서비스지향성에 유의한 영향을 미치는 것으로 나타났다. 셋째, 조직몰입은 서비스지향 성에 유의한 영향을 미치는 것으로 나타났다. 이와 같은 연구결과는 직업존중감 개념이 중국의 호텔 산업에서도 타당하게 적용 가능하다는 사실을 알려준다. 나아가 호텔종사원의 직업존중감을 향상시킬 수 있는 전략을 통해 종사원의 조직몰입과 서비스지향성이 개선될 수 있음을 보여준다. 따라서 중국의 호텔기업은 종사원에 대한 전문화 교육을 통하여 업무책임 감과 소속감을 크게 고양시키는 인적자원관리를 한다면 직업존중감은 향상될 것이다. 또한, 직업존중감의 향상은 호텔기업의 성과에 긍정적인 영향을 미칠 수 있는 중요한 선행요인으로 이해할 수 있다. Subjects of this research are employees in hotel industries of China, which are recently undergoing skyrocketing growth. Therefore, current research is to investigate the validity of the concept of job-esteem as an antecedent variable to predict organizational commitment and the service orientation. To achieve the research objective, this study collected data from a questionnaire survey of employees who worked at five-star hotels and four-star hotels in China (309 questionnaire copies). Reliability analysis and exploratory factor analysis were performed on data obtained from the returned questionnaires, using SPSS 18.0; and covariance structure analysis (structural equation model: SEM) was performed, using Amos 18.0. The result of the statistical analysis is as follows: first, it was found that job-esteem (pride, reputation) significantly influenced organizational commitment. Second, it was found that job-esteem (work value) significantly influenced the service orientation. Third, it was found that organizational commitment significantly influenced the service orientation. The above findings show that through the professionalization training of hotel employees to achieve a great enhancement of hotel employees`` sense of job responsibility and belongingness, job esteem of employees will improve, eventually influence the development of teamwork, and further imply the increase of their passion for an organization. Therefore, it is required to improve the level of hotel employees`` job-esteem and help them to deliver better services.

혈액종양 ; 불응성/재발성 다발골수종의 볼테조밉 구제 치료의 실제: 단일 기관의 경험

김동현 ( Dong Hyun Kim ),이지현 ( Ji Hyun Lee ),김성현 ( Sung Hyun Kim ),오성용 ( Sung Yong Oh ),이수이 ( Suee Lee ),문상이 ( Sang Yi Moon ),김효진 ( Hyo Jin Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.5

목적: 본 연구의 목적은 실제 진료실에서 볼 수 있는 환자군의 현실을 반영하여 볼테조밉의 효과 및 독성을 보기 위함이다. 방법: 다발골수종이 진행된 환자들과 전신수행 상태가 감소된 환자들을 대부분 포함한 37명의 환자를 대상으로 분석을 하였다. 결과: 이전에 많은 항암 요법에 실패한 환자에서 볼테조밉의 치료는 전체 반응률 64.9%로 실제 임상에서도 매우 효과적이었다. 독성으로 인하여 치료를 중단한 예는 59.5%였으나 4주기 이상 길게 치료하는 경우 추가적인 반응을 얻는 환자가 16.2%에서 있었다. 결론: 비록 본 연구에서는 독성으로 인하여 치료를 중단한 예가 많았으나 볼테조밉의 독성을 잘 조절하여 4주기 이상 길게 치료하는 경우 반응의 정도를 높이면서 다발골수종의 진행을 지연시킬 수 있을 것으로 생각된다. Background/Aims: Bortezomib-based chemotherapy has proven to be an effective salvage regimen for refractory/relapsed multiple myeloma patients in many clinical trials. However, few reports have shown the outcomes and adverse events of bortezomib-based salvage chemotherapy in clinical practice. Methods: From April 2006 to September 2011, 37 patients were retrospectively analyzed. A total of 19 patients received bortezomib therapy and 18 patients received bortezomib plus dexamethasone therapy. Results: The median follow-up duration was 18.13 months (range, 0.97-87.20 months). The median number of cycles administered was four (range, 1-13). The overall response rate by International Myeloma Working Group (IMWG) 2006 criteria was 64.9%, including six complete responses (16.2%). The median number of cycles to best response was three (95% confidence interval [CI], 1.36-4.64). Six patients achieved their best responses after four cycles of bortezomib therapy. The median time to progression and overall survival were 5.10 (95% CI 4.03-6.17), and 23.10 (95% CI, 9.24-36.96) months, respectively. The incidence of grade 3/4 neutropenia and thrombocytopenia was 29.7% and 64.9%, respectively. A total of 27.0% patients experienced grade 3 peripheral neuropathy. Herpes zoster developed in 11 patients (29.7%). Treatment was stopped in 22 patients (59.5%) due to adverse events after bortezomib-based therapy, and treatment-related mortality occurred in 4 of 25 deaths in total. Conclusions: Bortezomib-based therapy is a very effective salvage regimen in real clinical practice, although patients relapse after multiple chemotherapies. Despite intolerable in some patients, management of toxicities and extended cycles of therapy could benefit more patients, resulting in higher response rates. (Korean J Med 2015;88:537-546)

3차원 비선형 유한요소해석에 의한 콘크리트와 강재의 전단연결재 성능평가

조창근(Cho Chang-Geun),하기주(Ha Gee-Joo),서수연(Seo Soo-Yeon),이동렬(Yi Dong-Ryul),홍건호(Hong Kun-Ho),문상돈(Moon Sang-Don) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(구조계)

A nonlinear three-dimensional finite element analysis was applied to evaluate the load-carrying capacities and performances of shear connectors between concrete and H-shaped steel section. H-shaped steel sections and reinforcements were modeled as elastic and plastic materials and concrete was modeled as a three-dimensional elastic and plastic damage material. The interfacial characteristic of shear connector between concrete and steel section was modeled using a contact problem. By the three-dimensional nonlinear finite element method, several types of developed shear connectors were evaluated with experimental results.

PZT 강유전체 박막 캐패시터와 하부전극에 관한 연구

박영,정세민,문상일,정규원,김성훈,송준태,이준신 성균관대학교 2002 학술회의지원논문목록집 Vol.2002 No.-

This paper investigated experimental influencing factors in Pt and RuO₂ electrode preparations which were adopted to the subsequent fabrication of Pb(Zr_0.53 Ti_0.47)(PZT) thin film capacitors. Because a high substrate temperature may produce a built in stress, unwanted inter-diffusion, and rough surface morphology, we used two step processes for the bottom eletrode and PZT film growth, thin films were grown at a low temperature and then subjected to an RTA treatment. The as grown bottom electrodes at 300℃ for Pt and 200℃ for RuO₂ gave the film resistivity of 10^t Ω-cm, rms roughness about 55 Å, and the preferred crystal orientation of Pt(111) anf RuO₂(101). RTA treatment of Pt electrode at 600℃ for 30 seconds improved the resistivity to 5x10^6 Ω-cm and generated (111) preferred crystal orientation. PZT films exhibited multicrystalline structure with strong PZT(110)plane and weak (211) plane for an optimized Pt electrode and (111), (200), (112) planes for RuO₂. Well fabricated PZT capacitors showed a leakage current density in the order of 10^7 A/㎠, dielectric constant 365, a remanent polarization 75 μC/㎠, and coercive field 50.5kV/cm. Further details on the bottom electrode properties and recommended conditions in memory device applications of thin film PZT capacitors are presented.