대동맥중막의 화학적 손상이 Cholesterol 식이성 가토동맥경화증에 미치는 영향에 관한 실험적 연구

오성용 ( Sung Yong Oh ) 대한내과학회 1965 대한내과학회지 Vol.8 No.2

3차 병원에 입원한 한국 지역사회획득 폐렴 환자에서 미국흉부학회 추천 항생제의 유용성

오성용 ( Sung Yong Oh ),박상준 ( Sang Joon Park ),강경우 ( Kyeong Woo Kang ),고영민 ( Young Min Koh ),서지영 ( Gee Young Suh ),정만표 ( Man Pyo Chung ),김호중 ( Ho Joong Kim ),최동철 ( Dong Chull Choi ),권오정 ( O Jung Kwon ),이 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.4

일반강연 : 간경변증에 있어서의 신사구체변화

이유복 ( Yoo Bock Lee ),오성용 ( Sung Yong Oh ),김동식 ( Dong Sik Kim ) 대한내과학회 1964 대한내과학회지 Vol.7 No.11

혈액종양 ; 불응성/재발성 다발골수종의 볼테조밉 구제 치료의 실제: 단일 기관의 경험

김동현 ( Dong Hyun Kim ),이지현 ( Ji Hyun Lee ),김성현 ( Sung Hyun Kim ),오성용 ( Sung Yong Oh ),이수이 ( Suee Lee ),문상이 ( Sang Yi Moon ),김효진 ( Hyo Jin Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.5

목적: 본 연구의 목적은 실제 진료실에서 볼 수 있는 환자군의 현실을 반영하여 볼테조밉의 효과 및 독성을 보기 위함이다. 방법: 다발골수종이 진행된 환자들과 전신수행 상태가 감소된 환자들을 대부분 포함한 37명의 환자를 대상으로 분석을 하였다. 결과: 이전에 많은 항암 요법에 실패한 환자에서 볼테조밉의 치료는 전체 반응률 64.9%로 실제 임상에서도 매우 효과적이었다. 독성으로 인하여 치료를 중단한 예는 59.5%였으나 4주기 이상 길게 치료하는 경우 추가적인 반응을 얻는 환자가 16.2%에서 있었다. 결론: 비록 본 연구에서는 독성으로 인하여 치료를 중단한 예가 많았으나 볼테조밉의 독성을 잘 조절하여 4주기 이상 길게 치료하는 경우 반응의 정도를 높이면서 다발골수종의 진행을 지연시킬 수 있을 것으로 생각된다. Background/Aims: Bortezomib-based chemotherapy has proven to be an effective salvage regimen for refractory/relapsed multiple myeloma patients in many clinical trials. However, few reports have shown the outcomes and adverse events of bortezomib-based salvage chemotherapy in clinical practice. Methods: From April 2006 to September 2011, 37 patients were retrospectively analyzed. A total of 19 patients received bortezomib therapy and 18 patients received bortezomib plus dexamethasone therapy. Results: The median follow-up duration was 18.13 months (range, 0.97-87.20 months). The median number of cycles administered was four (range, 1-13). The overall response rate by International Myeloma Working Group (IMWG) 2006 criteria was 64.9%, including six complete responses (16.2%). The median number of cycles to best response was three (95% confidence interval [CI], 1.36-4.64). Six patients achieved their best responses after four cycles of bortezomib therapy. The median time to progression and overall survival were 5.10 (95% CI 4.03-6.17), and 23.10 (95% CI, 9.24-36.96) months, respectively. The incidence of grade 3/4 neutropenia and thrombocytopenia was 29.7% and 64.9%, respectively. A total of 27.0% patients experienced grade 3 peripheral neuropathy. Herpes zoster developed in 11 patients (29.7%). Treatment was stopped in 22 patients (59.5%) due to adverse events after bortezomib-based therapy, and treatment-related mortality occurred in 4 of 25 deaths in total. Conclusions: Bortezomib-based therapy is a very effective salvage regimen in real clinical practice, although patients relapse after multiple chemotherapies. Despite intolerable in some patients, management of toxicities and extended cycles of therapy could benefit more patients, resulting in higher response rates. (Korean J Med 2015;88:537-546)

위 MALT 림프종의 임상적 고찰

김지향 ( Ji-Hyang Kim ),김원석 ( Won Seog Kim ),고영혜 ( Young-Hyeh Ko ),송서영 ( Seo Young Song ),오성용 ( Sung Yong Oh ),김기현 ( Ki Hyun Kim ),남은미 ( Eun Mi Nam ),정현식 ( Hyun Sik Jeong ),윤성수 ( Sung-Soo Yoon ),이홍기 ( Ho 대한내과학회 2001 대한내과학회지 Vol.61 No.4

Background: Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach has recently been defined as a distinct clinicopathologic entity, often associated with Helicobacter pylori (H. pylori) infection. Characteristics and treatment outcomes of 57 patients with gastric MALT lymphoma were analyzed. Methods: Retrospective analysis of 57 cases of gastric MALT lymphoma who underwent treatment with various modalities at Samsung Medical Center from Mar. 1995 to Jul. 2000 was performed. Results: The median age of the patients was 47 years (ranged from 22 to 75 years) and the ratio of males to females was 1.1:1. The presenting symptoms were abdominal pain, indigestion and GI bleeding. By Modified Ann Arbor system, stage 1E accounted for 70.2%, stage 21E 14.0%, stage 22E 14.0%, and stage 4 1.8%, respectively. H. pylori had been evaluated histologically in 49 cases of which 81.6% was positive. Low grade histology accounted for 71.9% and high grade histology 28.1%. Treatment modalities included H. pylori eradication, surgery, chemotherapy, radiotherapy and their combination therapy. In one case, the patient was observed without treatment. Complete remission rate was 98.2%. H. pylori eradication alone resulted in lymphoma regression successfully in 20 out of 23 patients . With median follow-up of 33 months (3-61 months), median survival was not reached. Over all 3-year survival rate was 94.7%. Conclusion: Regardless of treatment modality, high survival rate (3-year survival rate 94.7%) was obtained. H. pylori eradication was feasible and safe in the cases of low grade, stage 1, and H. pylori-positive lymphoma, and allowed stomach preservation. Longer follow-up evaluation is required to determine the long-term efficacy and side effects of H. pylori eradication. (Korean J Med 61:417-423, 2001)

다발성골수종에서 염색체 이상의 임상적 중요성

김경태 ( Kyoung Tae Kim ),백정환 ( Jeung Hoan Paik ),이창재 ( Chang Jae Lee ),김진호 ( Jin Ho Kim ),배이지 ( Yee Zee Bae ),서봉근 ( Bong Gun Seo ),권혁찬 ( Hyuk Chan Kwon ),오성용 ( Sung Yong Oh ),김성현 ( Sung Hyun Kim ),김재석 ( 대한내과학회 2005 대한내과학회지 Vol.69 No.3

목적: 다발성골수종은 단일 클론에서 유래하는 B 림프구의 악성종양으로 형질세포의 악성증식을 특징으로 하는 질환이다. 다발성 골수종은 임상 양상이 매우 다양하게 나타나며 생존율은 수개월에서 10년 이상으로 다양하다. 이 연구의 목적은 다발성골수종에서 특정한 세포유전학적 염색체 결함이 예후인자로서 가치가 있는지 알아보고자 하였다. 방법: 1995년 4월부터 2004년 8월까지 다발성골수종으로 진단 받은 환자 40예를 대상으로 하였다. 세포유전학적 검사는 세포중기 핵형분석을 하여 염색체 검사를 시행하였다. 정상염색체를 보인 군(A군)과 13번 염색체 결손 또는 부분 결손이나 저두배수체를 보이는 군(B군), 그리고 그 외의 염색체 이상을 보이는 군(C군)으로 분류하였다. 결과: 관찰기간의 중앙값은 13.1개월이었다(범위 1.5~92.1개월). 항암화학요법에 대한 총 반응율은 58.8%였고, A군, B군, C군 간의 치료에 대한 반응율은 각각 56.3%, 33.3%, 75%였다(p=0.229). 생존기간에 영향을 미치는 예후인자로는 임상적 병기, 활동도, 혈청 크레아티닌 수치, 성별 그리고 염색체 이상 여부 등이었다. A군, B군, C군 사이에 중앙생존기간이 유의하게 차이가 있었으며(각각 34.9개월, 8.5개월, 19.8개월, p=0.0125), 염색체 이상 중 13번 염색체 결손 또는 부분 결손과 염색체 저두배수체성이 다발성골수종에서 생존기간에 불리하게 작용하였다. 결론: 다발성 골수종에서 진단시 염색체 이상은 임상적 예후에 중요한 인자로 작용한다. Background: Multiple myeloma is a clonal B-cell malignancy manifested by the accumulation of terminally differentiated plasma cells. The disease is characterized by clinical heterogeneity, with survival ranging from a few months to more than 10 years. The purpose of this study is to evaluate the prognostic value of specific chromosomal abnormality in multiple myeloma. Methods: We analyzed the clinical records of 40 patients who were diagnosed as multiple myeloma, between April, 1995 and August, 2004. Cytogenetic analysis was conducted by metaphase karyotype analysis. Patients were grouped into normal cytogenetic group (arm A), complete or partial deletion of chromosome 13 and hypodiploidy group (arm B) and other cytogenetic abnormality group (arm C). Results: Median follow up duration was 13.1 months (range 1.5-92.1). Overall response rate to chemotherapy was 58.8% and response rate among arm A, B and C were 56.3%, 33.3% and 75%, respectively (p=0.229). The prognostic factors affecting survival were clinical stage, performance status, serum creatinine level, sex and chromosomal abnormality. The median overall survival was significantly different among arm A, B and C (34.9 months, 8.5 months and 19.8 months, respectively, p=0.0125). Conclusion: chromosomal abnormality, especially, complete or partial deletion of chromosome 13 and hypodiploidy at initial diagnosis is significantly associated with survival duration. (Korean J Med 69:303-311, 2005)

원발부위 불명의 선암

송서영(Seo Young Song),김원석(Won Seog Kim),이혜란(Hye Ran Lee),정현식(Hyun Sik Hyun),이남수(Nam Su Lee),오성용(Sung Yong Oh),김지향(Ji Hyang Kim),김기현(Ki Hyun Kim),남은미(Eun Mi Nam),오영륜(Young Ryun Oh),정철원(Chul Won Jung),윤성수 대한내과학회 2001 대한내과학회지 Vol.61 No.3

N/A Background : To study clinical characteristics and treatment outcomes of adenocarcinoma of unknown primary site (ACUPS). Methods : A retrospective analysis of 81 patients who were diagnosed as ACUPS, seen at Samsung Medical Center from May, 1995 to July, 1999, was performed. Results : The median age of the patients was 58 years. The common sites of metastases were the lymph node, liver, lung, bone. In 49 of 81 patients (60.5%), the dominant tumor location was below the diaphragm. The majority of patiens (76 of 81) were initially treated with systemic chemotherapy including cisplatin. Responses were evaluable in 70 of 76. Eighteen of 70 patients (25.7%) responded to chemotherapy and complete remission was observed in 6 patients. The overall median survival of 81 patients was 5.6 months. The median survival of the responding patients was 18.3 months but the median survial of the nonresponding patients was 4.6 months (p<0.01). In univariate and multivariate analysis, age, performance status and response to initial chemotherapy were significant prognostic factors for overall survial. Conclusion : Poor survival rate and treatment response were observed in ACUPS but complete response and long-term survival were observed in several patients.(Korean J Med 61:234-239, 2001)

건조 혈액 여과지에서의 β-Globin DNA와 RNA의 추출 및 그 안정성에 관한 검토

한진영,김정만,오성용,김덕인,최용천,김인후,한진영,최용천,김인후 大韓血液學會 1995 大韓血液學會誌 Vol.30 No.2

건조 혈액 여과지에서의 β-Globin DNA와 RNA의 추출 및 그 안전성에 관한 검토

김덕인,김인후,김정만,한진영,오성용,최용천 東亞大學校附設遺傳工學硏究所 1996 遺傳工學硏究 Vol.- No.3

연구배경: Guthrie spot는 1963년부터 신생아 유전 질환의 선별검사에 사용되기 시작한 이후로 최근에는 DNA와 RNA를 이용한 분석에도 응용이 시도되고 있다. 저자들은 일반 여과지에 채취된 건조 혈액으로부터 β-globin 유전자의 DNA와 RNA를 추출하는 데에 있어서 여과지의 전처리 조건이 미치는 영향과 특히 장기 보관에 따른 RNA의 안정성을 살펴보고자 하였다. 방법: 전처리를 하지 않은 경우, 5% HCI로 전처리를 한 경우, 고압 멸균을 한 경우, 그리고 5% HCI 전처리 후 고압 멸균을 한 경우의 네가지로 나누어서 정상인의 혈액을 떨어뜨린 후 상온에서 2주 동안 보관하였다가 각각 DNA와 RNA를 추출하여 PCR과 RT-PCR을 실시하였다. 그리고 2년간 보관하였던 전처리를 하지 않은 건조 혈액 여과지에서 RNA를 추출하여 RT-PCR을 시행하고 염기서열 분석을 하여 β-globin 유전자인지를 확인하였다. 결과: 여과지의 전처리 여부에 관계없이 DNA와 RNA는 PCR에 의해 기대된 크기의 증폭 산물을 나타내었고, 2년간 장기 보관하였던 여과지에서도 RNA가 안정하게 보존되어 있어서 RT-PCR 생성물을 염기서열 분석한 결과, β-globin 유전자의 일부임을 확인할 수 있었다. 결론: 건조 혈액 여과지를 이용한 β-globin 유전자의 DNA와 RNA 분석은 검체의 채취와 보관이 용이하고 안정성이 높아서 혈색소 이상증을 포함한 유전 질환의 대규모 연구나 선별 검사에 매우 유용할 것으로 사료된다. Background: Since newborn screening efforts were facilitated by the use of Guthrie spots in 1963, the development of a routine procedure for microextraction of DNA and recently even RNA from these specimens would allow direct screening at the molecular level. The purpose of the current investigation was to optimize pretreatment condition of filter paper for improvement of microextraction and stability of β-globin DNA and RNA from dried blood specimens on Whatman filter papers. Methods: Normal whole blood was spotted on filter papers pretreated by four different ways, respectively ; untreated, 5% HCI treated, autoclaved, and 5% HCI treated and autoclaved. The samples were then stored at room temperature for two weeks until processed. DNA and RNA were extracted from each filter paper and amplified by PCR(polymerase chain reaction) and RT(reverse transcriptase)-PCR. We also extracted RNA from untreated dried blood spot stored at room temperature for two years for cDNA synthesis and did nucleotide sequencing to identify that the PCR products were part of β-globin gene. Results: DNA and RNA were stable in filter papers, and could be microextracted for PCR and RT-PCR regardless of pretreatment conditions. It also has been demonstrated that RNA could be obtained from dried blood spots stored for two years in sufficient quality and quantity for amplification and sequencing. Conclusion: The prolonged stability of β-globin DNA and RNA in these specimens will be very helpful for conducting a mass screening and research in genetic diseases including hemoglobinopathies principally because of the ease of sample collection, storage, handling, and shipment.