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RISS 인기검색어
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- 저자 : 문규 ( Gyoo Moon ) (검색결과 5 건)
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위장관 ; 경도 및 중등도 활동성 궤양성 대장염 환자에서의 VSL#3의 효능
이지현 ( Ji Hyun Lee ),문규 ( Gyoo Moon ),권혁진 ( Hyeok Jin Kwon ),정우진 ( Woo Jin Jung ),서평주 ( Pyoung Ju Seo ),백태윤 ( Tai Yoon Baec ),이주형 ( Ju Hyeong Lee ),김현식 ( Hyun Shig Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2
Background/Aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC. Methods: Twenty-four eligible patients with mild to moderate UC received open-label VSL#3 4 sachets daily in 2 divided doses for 8 weeks. The disease activity pre- and post-VSL#3 therapy was assessed by ulcerative colitis disease activity score and colonic tissue cytokine profiling done at baseline and at week 8. Results: Twenty-four patients (mean age, 43.7 years; range, 20-70 years; male/female, 15/9) were enrolled and 2 patients did not have the final endoscopic assessment. A total of 22 patients were analyzed. Intent to treat analysis demonstrated remission in 45.8% of subjects (n=11); partial response in 20.8% (n=5); no change or worse in 25.0% (n=6) of subjects. The mean ulcerative colitis disease activity index (UCDAI) scores decreased from 7.09±1.81 to 1.45±1.29 in patients with a remission (p<0.001). The mean endoscopic scores had also significantly decreased from 1.91±0.54 to 0.63±0.50 in patients with a remission (p<0.001). The concentrations of colonic cytokines did not change significantly during treatment in patients with a remission. Conclusions: Our study demonstrated that VSL#3 is effective in achieving clinical responses and remissions in patients with mild-to moderately active UC, further supporting the potential role in UC therapy. (Korean J Gastroenterol 2012;60:94-101)
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문규,김동민,김현리,이기주,이봉규,이만재,김태원,이영미,정춘해 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Primary conjunctival Non-Hodgkin's lymphoma is a very rare lymphoma. A 36-yera-old woman presented with an indolent salmon-colored tumor of the left lower eyelid conjunctiva. Histologically, we found a small lymphocytic infiltrate in the subepithelium consist of uniform component. An immunohistological study demonstrated B cell lineage. A comprehensive investigation, in particulary an orbital CT scan did not demonstrate any other localization of this lymphoma. She was treated with chemotherapy (CHOP) and Radiotherapy. Here in we report a case of primary Non-Hodgkin's lymphoma on the conjuctinva with literature review.
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김현리,문규,김동민,정중화,이지현,김태원,이만재,정회상,정종훈,정춘해 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
A 34-year-old man was admitted with 3 month history of nausea, vomiting and general weakness. On admission, laboratory studies revealed Hb 8.8g/dL, Hct26.2%, WBC 9040/mm3, Platelet 243,000/mm3, serum calcium 18mg/dL, serum phosphate4. Img/dL and serum PTH 7.0pg/dL. Bone marrow study showed abnormal lymphoid cell as much as 23%. Simple X-ray showed osteolytic bone lesions on left mandibular area. The patients was treated with cyclophosphamide, adriamycin, vincnstin, prednisone as remission chemotherapy and achieved normal range of serum calcium and renal function with complete remission hematologically and received 2 times of chemotherapy thereafter. The patient was re-admitted with nausea, vomiting and general weakness, during follow-up. He was improved symptomatically and hypercalcemia was disappeared, but lymphoma was metastasis to lung. The patient with his family refused further therapy, and discharged. He died after discharge.
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진영기,이기주,문규,김현리,김태원,이만재,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Objective: Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow and frequently invades the adjacent bone. producing extensive skeletal destruction that results in bone pain and fractures. Anemia. hypercalcemia, and renal insufficiency are important features. We analyses clinical manifestation of multiple myeloma. Method: A clinical observation on 20 cases of myeloma which were diagnosed by criteria of the SW0G(Southwest Oncology Group) between March 1993 and December 1996 at Chosun University Hospital was done. Result: 1. The peak incidence was in 6th decade and male to female ratio was 0.8:1 2. The presenting symptoms at first diagnosis were bone pain(45%). and anemia(20%), but non specific symptoms were also noted. 3. Initial clinical stages were classified as stage in 20%, stage Ⅰ in 25%. and stage 11 in 55%. 40% of stage Ⅱ and 64% of stage Ⅲ patients showed renal impairment. 4. The distribution of immunoglobulin classes were IgG 61%, IgA 22% and light chain 5% 5. Complications of multiple myeloma, such as renal impairment, infections, compression fractures of spine and spinal cord compression were observed, Pneumonia was predominant in infections.
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곽재정,김현리,이기주,문규,이지현,김동민,정중화,이봉규,김창욱,박치영,배학연 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Kallmann's syndrome is a rare condition, defined as an isolated GnRH deficiency with anosmia and may be associated with cleft lip, cleft palate, color blindness, craniofacial abnormalities, renal agenesis, sensory neural hearing loss, cryptorchidism. obesity and osteoporosis. The mode of inheritance in Kallmann's syndrome is still uncertain, it has been described as possible autosomal dominant, autosomal recessive. X-linked dominant, and an X-linked recessive trait. We experienced a case of the Kallmann's syndrome associated with anosmia, renal agenesis. cryptochidism. gynecomastia and severe osteoporosis.
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