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술후 방사성 요오드 사멸요법을 받은 갑상선암 환자들의 재발 관련인자에 관한 연구
고양석(Yang Seok Koh),윤정한(Jung Han Yoon),제갈영종(Yong Jong Jaegal) 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.2
Background and Objective: Factors that are associated with the recurrence after radioactive iodine ablation therapy have not been identified yet. The aim of this study is to elucidate the factors that are related to the recurrence after thyroid surgery of the thyroid papillary cancer followed by radioactive iodine ablation therapy. Patients and Methods: Fifty four cases who had underwent thyroid cancer surgery and postoperative radioactive iodine ablation therapy were included in this study. Mean followup duration was 7 years. There were 41 women and 13 men. Data analysis was done retrospectively with medical record review. Chi-square test and Fisher's exact test was used for the statistical analysis. Results: Age over 40, capsular invasion, and loca invasion were the factors that were associated with the high rate of recurrence. But sex, size of the tumor, multiplicity and extent of the surgery were not related to the recurrence. Conclusion: Without the curative resection of the tumor, radioactive iodine ablation therapy cannot lower the recurrence rate. So aggressive resection of the thyroid papillary cancer is important.The more data accumulated and the longer the followup, the easier we can reveal the recurrence-related factors of postoperative radioactive ablation therapy.
위암에서 CK20과 CEA의 RT-PCR을 이용한 수술조작 전후 유출 정맥과 복막에서의 미세전이의 검출
주재균,이지희,고양석,김정철,류성엽,김동의,김영진,Joo Jai Kyun,Lee Ji Hee,Koh Yang Seok,Kim Jung Chul,Ryu Seong Yeob,Kim Dong Yi,Kim Young Jin 대한위암학회 2003 대한위암학회지 Vol.3 No.3
Purpose: The benefits of the 'no-touch' isolation techniquethat is usually performed to prevent the circulation of tumor cells are not evident. The aim of this study was to determine whether the no-touch isolation technique for treating gastrointestinal cancers could prevent the circulation of tumor cells detected by reverse transcriptase polymerase chain reaction (RT-PCR). Matrials and Methods: By using RT-PCR to amplify mRNAs for two specific epithelial markers, carcinoembryonic antigen (CEA) and cytokeratin 20 (CK-20), we examined 34 gastric cancer patients who had been histologically diagnosed and 22 patients had undergone serosal and peritoneal brushing. Results: In 10 ($29.4\%$) of the 34 gastric cancer patients, we detected CK20 mRNA before manipulation, and in 17 ($51.5\%$) of those patients, after we detected it. The density of the CK20 mRNA band was increased in 11 cases ($33.3\%$) and the density was decreased in 2 cases ($6.1\%$). In 16 ($48.5\%$) of the 34 gastric cancer patients, we detected CEA mRNA before manipulation, and in 17 ($51.5\%$) patients after we detected it. The density of the CEA mRNA band was increased in 8 cases ($24.2\%$) and decreased in 3 cases ($9.1\%$). Conclusion: These result suggest that the ' no-touch isolation technique ' might be useful when operating on advanced gastric cancer patients and that serosal or Douglas pouch brushing can be used to determine the status of micrometastasis.
김호현(Ho Hyun Kim),허영회(Young Hoe Hur),박찬용(Chan Yong Park),고양석(Yang Seok Koh),김정철(Jung Chul Kim),조철균(Chol Kyoon Cho),김현종(Hyun Jong Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.6
Lymphangioma of the spleen is a rare benign neoplasm with clinical manifestations ranging from insignificant incidental findings to large, symptomatic cystic masses requiring surgical intervention. We report a case of splenic cavernous lymphangioma mimicking splenic hemangioma. A 59-year-old woman presented with left upper quadrant pain and epigastric discomfort. Computed tomography showed a 9.5×8 ㎝ high attenuated mass with relatively homogenous enhancement in the spleen. The initial impression was a splenic hemangioma. The patient underwent splenectomy. Gross pathologic examination revealed a 9.5×6.8×9 ㎝-sized fairly well circumscribed soft mass. Histologically, the tumor was composed of dilated lymphatic vessels, which contained homogenous eosinophilic material. The Final diagnosis was cavernous lymphangioma of the spleen. Herein, we report a case of splenic cavernous lymphangioma mimicking splenic hemangioma and also review the existing literature.
김호현(Ho Hyun Kim),성진식(Jin Sik Sung),허영회(Young Hoe Hur),고양석(Yang Seok Koh),김정철(Jong Chul Kim),조철균(Chol Kyoon Cho),김현종(Hyun Jong Kim) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.3
Background : An increasing number of small prospective studies have been published, since the first report of laparoscopic liver resection by Gagner et al. in 1992. They have shown encouraging results for the feasibility and safety of the procedure. This paper provides a retrospective analysis of a single center"s experience with elective laparoscopic liver resections. Methods : We did a retrospective study on laparoscopic liver resections performed from July 2005 to April 2009, undertaken in 34 patients with preoperative diagnosis of a benign lesion(7 cases, 20.6%), hepatocellular carcinoma in absence of complicated cirrhosis (18 cases, 52.9%), or liver metastasis (9 cases, 26.4%). The mean tumor size was 2.63±1.57 cm(range 0.55-7.5) Results : We carried out 15 wedge resections(44.1%), 3 right hemi-hepatectomies(8/8%), 4 left hemi-hepatectomies(11.8%), 5 liver segmentectomies(14.7%), 7 left lateral sectionectomies(20.6%). The average duration of an operation was 175.00±129.12 minutes. There were 6 patients (15%) in which a conversion to laparotomy was required none of the conversions occurred under emergency situations. Intraoperative transfusion was required for 5 patients(14.7%). Postoperative complications developed in 2 patients (5.8%)(1 intraabdominal abscess, 1 bile leakage). There were no deaths and no reoperations for complications. The mean postoperative hospital stay was 9.9 days. Conclusion : Our experience shows that laparoscopic liver resections, including major hepatectomies, are feasible and safe. Nonetheless, a prospective randomization study with a greater number of cases and longer follow-up is needed before laparoscopic liver resection can be regarded as the gold-standard approach for hepatic lesions.