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황종현,김승만,황귀서,전찬용,강기성,Hwang, Jong-hyun,Kim, Seung-man,Hwang, Gwi-seo,Jeon, Chan-yong,Kang, Ki-sung 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4
Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.
고효율 LED 방열효과 증대를 위한 융합형 Heat Sink 장치 방열 해석
강창수(Chang Soo Kang),강기성(Ki Sung Kang) 대한전자공학회 2011 電子工學會論文誌 IE (Industry electronics) Vol.48 No.2
본 논문은 조명용 LED 모듈과 히트싱크 장치의 방열 특성을 확인하기 위한 수치 시뮬레이션을 하였다. 해석 케이스는 200 W급의 가로등 또는 보안등용 조명장치이며 용도에 따라 장치의 자세가 달라짐을 고려하여 발광면이 정상부를 향하는 경우와 정하부를 향하는 경우로 나누어서 해석이 진행되었고, 또한 발열소자의 체적이 큰 경우와 작은 경우로 나누어 해석하였다. 해석 결과 현재의 히트싱크 형상으로 충분히 LED의 발열량을 외부로 배출시킬 수 있음을 확인하였고, 장치의 자세와 발열소자의 크기에 따라 방열 성능의 차이가 나타남을 조사하였다. In this paper, did numerical simulation to confirm LED module for lighting and protection against heat special quality of heat sink device. Analysis was gone dividing on case that emitting light side turns normalcy department considering that eat of device according to usage and case that turn down looking being street lamp of 200 W or security appointment lighting device analysis case, and also, volume of thermal element divides on big case and small case and analyzed.Confirmed that can do so that may discharge LED's thermal value to outside enough in analysis wave and current heat sink shape, and investigated that difference of protection against heat performance according to position of device and size of thermal element appears.
LPS로 유도된 RAW 264.7 대식세포에서 닭발, 오가피, 두충 혼합 추출물의 항염증 활성
백지윤(Ji Yun Baek),강기성(Ki Sung Kang),이아영(Ah Young Lee),김현영(Hyun Young Kim) 한국생물공학회 2020 KSBB Journal Vol.35 No.4
This study was to investigate the anti-inflammatory effect of chicken-feet, Acathopanax, and Eucommia ulmoides Oliver mixture (CAEM) extract against lipopolysaccharide (LPS) in RAW 264.7 macrophage cells. We examined cytotoxicity of CAEM extract on RAW 264.7 cells, and their anti-inflammatory properties by measuring nitric oxide (NO) and pro-inflammatory cytokine production. In addition, inflammation-related gene expression was analyzed by real time-PCR in LPS-stimulated RAW 264.7 macrophage cells. Treatment of CAEM extract at concentrations of 0.31-2.5 mg/mL did not have any cytotoxic effect in RAW 264.7 cells. Treatment of LPS significantly increased the NO production, whereas CAEM extract (1.25, 2.5mg/mL) significantly decreased the levels of NO, compared to only LPS-treated cells. Furthermore, treatment with CAEM extract significantly suppressed the LPS-induced interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) production. In order to confirm whether CAEM extract regulates inflammation-related gene expression, we analyzed the mRNA levels of IL-6, TNF-α, IL-1β, and inducible NO synthase (iNOS) by real time-PCR. Exposure of RAW 264.7 cells on LPS upregulated the mRNA levels of IL-6, TNF-α, IL-1β, and iNOS, compared to control group. However, those of expression were downregulated by treatment with CAEM extract. These findings suggest that CAEM extract may contribute to the prevention and treatment of inflammatory-related diseases.
표준한방처방 EBM 구축을 위한 이진탕 문헌 연구 분석
이준경 ( Jun Kyoung Lee ),서창섭 ( Chang Seob Seo ),정다영 ( Da Young Jung ),강기성 ( Ki Sung Kang ),신현규 ( Hyeun Kyoo Shin ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.3
Objectives: The purpose of this report was to provide the information activity and safety of Yijin-tang by analyzing domestic/international papers and theses about Yijin-tang. Methods: Domestic/international papers and theses related to Yijin-tang were reviewed and analyzed. These papers were then classified by year, experimental method and subject. Results: 1. Administration of Yijin-tang showed therapeutic effects on diseases of the circulatory system such as thrombosis and hyperlipisemia in in vivo experiments. 2. Administration of Yijin-tang reduced hemorrhagic erosion and ulcer by inhibition of gastric juice secretion and protection effect of gastric mucosa in in vivo experiments. 3. Both clinical and basic science researches, Administration of Yijin-tang showed improvement of digestive function by up-regulated of digestive enzyme and gut-regulated protein in plasma levels. Conclutions: Administration of Yijin-tang showed therapeutic effects on diseases of the circulatory system and protection effect of gastric mucosa in in vivo experiments. Furthermore, both clinical and basic science researches, administration of Yijin-tang showed improvement of digestive function.