Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

경도 및 중등도 본태성 고혈압환자에서 Amlodipine단독요법

안기완,서영환,김상도,박윤환,김철,조경상,김완중,홍순표 최신의학사 1992 最新醫學 Vol.35 No.9

제6차 교육과정에 따라 편찬된 초등학교 자연 교과서의 분석(Ⅱ)

김광명,장병기,이대형,신순임,강태완 춘천교육대학교 과학교육연구소 1997 과학교육연구 Vol.20 No.-

결핵치료제인 시판 리팜피신제제의 생체내 이용율

김종두,안기완,서영환,조경상,김철,김상도,홍순표 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

This study was attempted to investigate the dissolution rate and the bioavailability of commercially available rifampicin preparations after oral administration in nine normal volunteers. Cross-over design was used for the analysis. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using basket method with four rifampicin preparations (A, B, C, and D) which were pharmaceutically equivalent. The results were as follows; The dissolution rate was higher in the order of A>C>B>D in artificial gastric juice, and A>B>C>D in artificial intestinal juice. Area under the blood concentration time curve (AUC) was larger in order of A>C>B>D. Relative bioavailability(%) of rifampicin preparations were 93.6% for B, 97% for C, 84.4% for D preparation compared with standard A preparation. Peak blood concentration (Cmax) was higer in order of A>B>C>D. Peak time (Tmax) was larger in order of D>C>A>B. Absorption rate constant (Ka) was larger in order of B>A>D>C. there was little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate in artificial gastric juice and area under the blood concentration time curve as well as correlation of the dissolution rate in artifical intestinal juice and peak time showed significant linear relationship. From the result of the this experiments, it can be concluded that for the choice of preparations, bioavailability must be performed in man because the bioavailability of rifampicin preparations showed big differences among commercial preparations which were abvertised as pharmaceutically equivalent, and that the bioavailability of rifampicin preparations in man partially could be predicted from the results of dissolution rate.

중량운동의 운동유형이 운동에 따른 면역반응에 미치는 영향

김병완,김원식,임순길 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.1

이 연구의 목적은 일시적인 서키트 웨이트트레이닝과 일반적인 웨이트트레이닝에 따른 면역 반응의 변화를 분석하여 지질대사를 촉진하면서도 안전한 중량운동의 유형을 규명하는 것이었다. 건강한 20대 남자 대학생 9명을 대상(22.8 ± 2.6세)으로 72시간 이상 공복상태에서 set 사이에 거의 휴식 없이 수행하는 서키트 웨이트트레이닝과 set 사이에 1분의 휴식과 운동기구사이에 3분의 휴식을 취하는 일반적인 웨이트트레이닝을 일시를 달리하여 각각 수행하게 하고 운동전과 운동 직후, 회복기 30분에 각각 10㎖의 혈액을 채취하여 T₃cell, NK cell에 대하여 분석했다. 연구의 결과 서키트 웨이트트레이닝과 일반적인 웨이트트레이닝은 운동 중과 회복기 30분의 면역반응(T₃cell, NK cell)에서 유의한 차이를 보이지 않았다. 하지만 서키트 웨이트트레이닝이 일반적인 웨이트트레이닝보다 면역계에 대한 운동반응에 더 큰 것으로 나타났지만 회복기 30분에는 모두 안정시 수준으로 회복했다. 결론적으로 운동 중과 회복기의 지질대사를 촉진하여 체지방 감소를 촉진하고 골격근의 대사율을 높여서 궁극적으로 비만을 해소하기 위하여 기존의 낮은 강도의 유산소성 운동과 함께 웨이트트레이닝을 실시해야 하는데 서키트 웨이트트레이닝과 일반적인 웨이트트레이닝 모두 안전한 것으로 나타났다. The purpose of this study was to investigate the impact of acute weight training pattern on immune responses. Nine healthy male college students(22.8 ± 2.6yrs) performed circuit weight training without rest and regular weight training with 1 min rest between sets and 2 min rest between exercise machines in different occasion with 12 hr fasting. Blood samples of 10㎖ were drawn at resting, immediately after exercise, and 30 min recovery and analyzed The results of this study was as following. There was no significant differences between circuit weight training and regular weight training in immune responses to exercise. Although the circuit weight training showed somewhat higher immune responses to exercise, the levels of T₃ cell and NK cell in both training methods returned to resting value after 30 min rest. As conclusion, both circuit weight training and regular weight training seemed safe to combine with low intensity aerobic exercise for managing obesity.

치수생활력 검사를 위한 Laser Doppler flowmeter의 이용

김영진,남순현,김현정,서완종 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

저자는 본 병원에 내원한 환자중 미완성치구근단을 가지고 있으며 외상받은 치아 및 자가이식치아를 대상으로 기존의 치수생활력 검사방법과 더불어 LDF를 이용한 검사방법을 통해 다음과 같이 요약할 수 있다. 1. 치수 생활력 유무를 판단함에 있어 현재까지 널리 사용된 전기치수검사, 냉검사등의 방법은 치수 내 신경발달 정도 및 피검자의 주관에 의해 반응이 다르게 나타나는 경우가 많다. 2. 이에 반해 LDF를 이용한 치수생활력 검사방법은 위음성 및 위양성 반응의 빈도가 낮아 신뢰도가 높으며 비교적 조기에 치수생활력을 특정할 수 있는 우수한 방법이다. Various diagnostic methods, such as electric pulp test, cold test, cavity etc, have been used to determine the pulp vitality. At least two or more methods should be used with supplemental information to diagnose each case because using one method doesn't provide sufficient accuracy. These conventional methods have depended on nervous responses, but laser Doppler Flowmeter determines the pulp vitality by measuring pulpal blood flow. In this case, we tested the vitality of the traumatized teeth with incomplete root apices and autotransplanted teeth with conventional methods and Laser Doppler Flowmeter . Conventional methods. such as electric pulp test and cold test can produce various responses according to the development state of the pulpal nerve and the sensory threshold of the patient. but ,laser doppler Flowmeter has a lower false response rate than other pulp vitality test methods and it can determine the vitality somewhat earlier than the other method.

CORBA 클라이언트/서버 구조의 자바 통합 개발 환경의 설계 및 구현

김완수,김흥준,박순규 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

Today, most of the well-known software development tools and methods faced with problems of scalability, modularity, granularity, and maintenance. These problems result in the fact that these tools and methods are standalone. In this paper, we propose a design and implementation of software development environment for Java application based upon CORBA-based Client/Server model. Proposed model has facilities to overcome a problem caused by updates and its distribution and is possible to overcome problems of scalability, modularity and granularity because it based upon Client/Server model.

共同住宅 中央 集中 煖房設備의 信賴度에 관한 硏究

김동완,정순성,조용수 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.1

The purpose of this study is to obtain reliability of heating equipments in apartment building. Field data concerning the failure of heating equipments recorded at the apartments constructed 14 years ago are used. As a result of the field data analysis, failure time distribution and cumulative hazard function of boiler, heat exchanger, steam header and various pumps are expressed in Weibull probability graph. The scale and shape parameters, MTBF of each equipments are presented by regression line of Weibull probability graph. Presented parameter wi31 be come into use a reference data to evaluate the reliability, to plan the maintenance scheme, and to evaluate economic renewal of equipments.

자연 교과 지도에 대한 초등 교사의 인식

김광명,신순임,강태완,이대형,장병기 춘천교육대학교 과학교육연구소 1995 과학교육연구 Vol.18 No.-

共同住宅 中央 集中 煖房設備의 信賴度에 관한 硏究

김동완,정순성,조용수 東亞大學校 建設技術硏究所 1997 硏究論文集 Vol.21 No.1

The purpose of this study is to obtain reliability of heating equipment’s in apartment building. Field data concerning the failure of heating equipment’s recorded at the apartments constructed 14 years ago are used. As a result of the field data analysis, failure time distribution and cumulative hazard function of boiler, heat exchanger, steam header and various pumps are expressed in Weibull probability graph. The scale and shape parameters, MTBF of each equipment’s are presented by regression line of Weibull probability graph. Presented parameter will be come into use a reference data to evaluate the reliability, to plan the maintenance scheme, and to evaluate economic renewal of equipment’s.