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( Yoon Seok Koh ),( Hae Ok Jung ),( Byeong Wook Song ),( Sang Hong Baek ),( Pum Joon Kim ),( Ki Bae Seung ),( Jae Hyung Kim ),( Kyu Bo Choi ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Matrix metalloproteinase-2(MMP-2) is closely associated with ventricular remodeling after myocardial infarction(MI). Angiotensin II receptor antagonist and aldosterone receptor antagonist prevent ventricular remodeling after MI. However, the effect of the combination of these two antagonists on MMP-2 expression and activity has not been precisely established. Hence, we investigated how the combination influences MMP-2 expression. We used Western blot and immunohistochemistry for observing MMP-2 and the tissue inhibitor of metalloproteinase-2 expression, and zymography for detecting MMP-2 activity. In the no treatment group, MMP-2 expression and activity decreased according to the time course from 1 week to 3 weeks. In irbesartan group, the trend of the increase in MMP-2 expression and activity was observed and compared with the no treatment group at 3 weeks however, there were no statistical differences. In the combination group, there was a statistically significant increase in the MMP- 2 expression and activity, when compared with the no treatment and irbesartan group at 3 weeks. However, these phenomena were not observed at 1 week. Thus, it can be concluded that the combination treatment does not simply inhibit or promote the MMP-2 expression and activity, but modulate it more strongly than irbesartan monotherapy.
Koh, Yoon-Seok,Jung, Hae-Ok,Park, Mahn-Won,Baek, Joo-Yeoul,Yoon, Sung-Gyu,Kim, Pum-Joon,Ihm, Sang-Hyun,Chang, Kiyuk,Oh, Yong-Seog,Youn, Ho-Joong,Baek, Sang Hong,Chung, Wook-Sung,Seung, Ki-Bae,Kim, Jae Korean Society of Echocardiography 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4
<P>Left ventricular hypertrophy (LVH) has been known as an important predictor of prognosis of cardiovascular disease. Carboxy-terminal propeptide of procollagen type I (PIP) is related with myocardial fibrosis. We sought to analyze the differences in the characteristics of LVH, myocardial fibrosis, and LV functions among hypertension (HBP), diabetes mellitus (DM) and chronic renal failure (CRF).</P>
Hwang, Hyeon Seok,Park, Mahn-Won,Yoon, Hye Eun,Chang, Yoon Kyung,Yang, Chul Woo,Kim, Suk Young,Cho, Jung Sun,Kim, Chan Joon,Park, Gyung-Min,Park, Chul-Soo,Choi, Yun-Seok,Koh, Yoon-Seok,Lee, Jong Min,S S. Karger AG 2014 American journal of nephrology Vol.40 No.4
<P>Abstract</P><P><B><I>Background/Aims:</I></B> Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. <B><I>Methods:</I></B> Between January 2004 and December 2009, a total of 4,738 AMI patients were enrolled prospectively. Patients were divided into four groups according to the combined status of CKD and AF. The primary endpoint was a combination of 5-year major adverse cardiac and cerebrovascular events (MACCE). <B><I>Results:</I></B> The prevalence of AF was significantly higher in CKD patients than in non-CKD patients (6.76 vs. 3.31%, p < 0.001). The highest cumulative event rate of MACCE and death was observed in patients with both CKD and AF (68.5 and 64.0%), respectively. In multivariable analyses, compared with patients with neither AF nor CKD, hazard ratios (HR) for composite of MACCE were 1.66 (95% CI, 1.14-2.41), 1.24 (95% CI, 1.06-1.46), and 2.10 (95% CI, 1.42-3.13) for patients with AF only, those with CKD only, and those with both CKD and AF, respectively (p for interaction = 0.935). Patients with both CKD and AF had a greatest risk for all-cause mortality (HR 2.54; 95% CI, 1.60-4.53), and the significant synergistic interaction was observed between CKD and AF (p for interaction = 0.015). <B><I>Conclusion:</I></B> The combined effect of AF and CKD on the risk of MACCE after an AMI is stronger than any separate condition, and it confers a synergistic effect on the all-cause mortality risk.</P><P>© 2014 S. Karger AG, Basel</P>
Mesoporous Carbon Additives for Long Cycle Life Sulfur Cathodes of Li-S Batteries
Koh, Jeong Yoon,Kim, Tae Jeong,Park, Min-Sik,Kim, Eun Hee,Kim, Seok,Kim, Ki Jae,Yu, Ji-Sang,Kim, Young-Jun,Jung, Yongju Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
We examine the potential use of disordered mesoporous carbon as a functional additive for confining dissolved Li-polysulfides and improving the cycling performance of Li-S batteries. To promote a better understanding of the correlation between the total pore volume of disordered mesoporous carbon and the cycling performance of Li-S batteries, a series of disordered mesoporous carbons with different total pore volumes are successfully synthesized using a commercial silica template. Based on the electrochemical and structural analyses, we suggest that the total pore volume of disordered mesoporous carbon is a predominant factor in determining its capability for either the absorption or adsorption of Li-polysulfides, which is primarily responsible for enhancing the cycling performance. The addition of disordered mesoporous carbon is also effective in enhancing the homogeneous distribution of active sulfur in the cathode, thereby affecting the cycling performance.
Seok Hoon Yoon,Young Jin Joe,Chang Seong Koh,Ju Hwan Woo,Hyun Suk Lee 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.1
The Horn River Basin in the northeastern British Columbia, Canada, is one of the largest unconventional gas-bearing basins in North America. The main reservoir of this gas accumulation is the Devonian Horn River Formation that is stratigraphically divided into three members, the Evie, Otterpark and Muskwa in ascending order. This study focuses on sedimentary processes and depositional environments of the Horn River Formation based on sedimentary facies analysis by the aid of well-log mineralogy (ECS) and total organic carbon (TOC) data from the Kiwigana well. The shales of the formation consist dominantly of silicate minerals (quartz, feldspar and mica) and subordinate clay mineral and carbonate materials, with TOC ranging from 0.3 to 7.6%. Three sedimentary facies were identified on the basis of centimeter-scale description of sedimentary structures and texture in borehole cores: homogeneous mudstone (HM), indistinctly laminated mudstone (ILM), and planar laminated mudstone (PLM). Integration of sedimentary facies, lithology and TOC suggests that the Horn River shale was primarily deposited in overall distal marine setting deeper than shelf or marginal slope, possibly base-of-slope to deeper basin plain off the carbonate reef (or shelf). Facies HM is siliceous and organic-rich, and dominant in the Evie and the overlying lowermost Otterpark members. It is interpreted as a pelagic to hemipelagic deposit formed mainly by suspension fall-out in an anoxic setting below maximum storm wave base. Likewise, facies ILM shows relatively high proportion of silicate minerals and TOC. This facies is identified frequently in the Muskwa and rarely in the Otterpark; it reflects a deposition from hemipelagic settling with an influence of persistent and weak bottom currents or nepheloid flows. Facies PLM, dominant in the large part of the Otterpark, is relatively depleted in silicate minerals and TOC. This facies indicates more frequent inflow of episodic turbidity currents punctuating the hemipelagic settling of the background sedimentation process. During the deposition of the Horn River Formation, the depositional site has experienced an earlier relative sea-level fall changing from a deep basin (Evie) to shallower marginal slope (middle Otterpark), and subsequent relative sea-level rise turning back to a deeper marine environment (Muskwa).
Koh, Jin-Sin,Park, Yongwhi,Ahn, Jong-Hwa,Kang, Min Gyu,Kim, Kye-Hwan,Bae, Jae Seok,Park, Hyun Woong,Jang, Jeong Yoon,Park, Jeong Rang,Hwang, Seok-Jae,Kwak, Choong Hwan,Hwang, Jin-Yong,Tantry, Udaya,Gu Georg Thieme Verlag KG 2019 Thrombosis and Haemostasis Vol.119 No.2
<B>Abstract</B><P>Amlodipine has a potential to reduce clopidogrel bioactivation through the cytochrome P450 3A4 enzyme in vivo, but the clinical impact of this interaction remains controversial. This randomized, open-label, two-period, crossover study was performed to evaluate the influence of amlodipine on the haemostatic profiles of high-risk patients during clopidogrel treatment. We recruited 40 Asian patients (Male/Female: n = 36/4) receiving clopidogrel (75 mg/day), aspirin (100 mg/day) and rosuvastatin for at least 6 months following percutaneous coronary intervention. Patients were randomly assigned to receive either 5 mg daily amlodipine or not for 2 weeks, and then were crossed over to the other treatment for 2 weeks. Haemostatic measurements were conducted with the VerifyNow assay and thromboelastography (TEG). Primary endpoint was P2Y12 Reaction Units (PRU) during on- versus off-amlodipine treatment. The on-amlodipine strategy showed higher level of PRU compared with the off-amlodipine strategy (176.8 ± 75.4 vs. 150.7 ± 65.5 PRU; ∆mean: 26.1 PRU; ∆95% confidence interval [CI]: 4.5-47.7 PRU; p = 0.019). Platelet-fibrin clot strength measured by TEG was lower during on- versus off-amlodipine treatment (7,712 ± 1,889 vs. 8,559 ± 2,174 dyne/cm2; ∆mean: -847 dyne/cm2; ∆95% CI: -1,632 to -62 dyne/cm2; p = 0.035). After amlodipine discontinuation, 27 patients (67.5%) showed a decrease in PRU, which was associated with ‘PRU ≥ 160 on-amlodipine’ in multivariate analysis (odds ratio: 62.014; 95% CI: 2.302-1670.328; p = 0.014). In conclusion, amlodipine increases platelet reactivity and decreases platelet-fibrin clot strength during clopidogrel treatment. In addition, the effect of amlodipine discontinuation on clopidogrel responsiveness is associated with on-amlodipine platelet reactivity.</P>
Yoon Haesung,Ihn Kyong,Kim Jisoo,Lim Hyun Ji,Park Sowon,Han Seok Joo,Han Kyunghwa,Koh Hong,Lee Mi-Jung 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.5
Objective: To evaluate the feasibility of ultrasound shear wave elastography (SWE) for predicting hepatic fibrosis and native liver outcomes in patients with biliary atresia. Materials and Methods: This prospective study included 33 consecutive patients with biliary atresia (median age, 8 weeks [interquartile range, 6–10 weeks]; male:female ratio, 15:18) from Severance Children’s Hospital between May 2019 and February 2022. Preoperative (within 1 week from surgery) and immediate postoperative (on postoperative days [PODs] 3, 5, and 7) ultrasonographic findings were obtained and analyzed, including the SWE of the liver and spleen. Hepatic fibrosis, according to the METAVIR score at the time of Kasai portoenterostomy and native liver outcomes during postsurgical follow-up, were compared and correlated with imaging and laboratory findings. Poor outcomes were defined as intractable cholangitis or liver transplantation. The diagnostic performance of SWE in predicting METAVIR F3–F4 and poor hepatic outcomes was analyzed using receiver operating characteristic (ROC) analyses. Results: All patients were analyzed without exclusion. Perioperative advanced hepatic fibrosis (F3–F4) was associated with older age and higher preoperative direct bilirubin and SWE values in the liver and spleen. Preoperative liver SWE showed a ROC area of 0.806 and 63.6% (7/11) sensitivity and 86.4% (19/22) specificity at a cutoff of 17.5 kPa for diagnosing F3–F4. The poor outcome group included five patients with intractable cholangitis and three undergoing liver transplantation who showed high postoperative liver SWE values. Liver SWE on PODs 3–7 showed ROC areas of 0.783–0.891 for predicting poor outcomes, and a cutoff value of 10.3 kPa for SWE on POD 3 had 100% (8/8) sensitivity and 73.9% (17/23) specificity. Conclusion: Preoperative liver SWE can predict advanced hepatic fibrosis, and immediate postoperative liver SWE can predict poor native liver outcomes in patients with biliary atresia.