濟州道 住民 蟯蟲感染의 疫學的 硏究

李根泰,李範珪,盧英俊,任世旭,李在興 醫藥係社 1955 綜合 醫學 Vol.12 No.12

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

급성 및 만성 호흡기질환의 치료에 있어서 경구용 LETOZOL^(�)(Letosteine)의 효과와 내약성에 대한 임상 연구

이이형,김세규,김성규,이원영 최신의학사 1993 最新醫學 Vol.36 No.2

구강병 예방진료 일부항목의 건강보험급여를 위한 재정추계 연구

이영수,정세환,이규식 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

Objectives: This study aims (1) to determine the actuarial budget of national insurance payment for some items of preventive dental service and (2) to obtain basic data to develop dental policy which is for including preventive dental service within insurance payment. Methods: Pit and Fissure Sealing (PFS), Self-plaque Control Instruction (S-PCI), and Fluoride Topical Application (FTA) were selected for some items of preventive dental service. The actuarial budget of insurance payment was calculated through multiplying followings; 1) Applicable population or number of teeth (based on population data and Korean National Oral Health Survey 2000) 2) The usual and customary fee of 2001 from three dental colleges which have preventive dental clinic or RBRVS (Resource-based relative value scale) fee which was multiplied the RBRVS developed through the research of Yonsei University and conversion factor Korean Ministry of Health and Welfare had announced at 2001 as 55.4 won 3) 70% of insurer share rate 4) The utilization rate of the items of preventive dental service presumed to be at least 5% and at the most 36% Results: Actuarial budgets of 1) PFS are 18.8 billion (usual and customary fee) and 5.7 billion (RBRVS fee) for 5% utilization rate and 135.1 billion (usual and customary fee) and 41 billion (RBRVS fee) for 36% utilization rate when limited to first molar and second molar which are firstly facing teeth of 6-14 age group; 2) FTA are 2.5 billion (usual and customary fee) and 1.5 billion (RBRVS fee) for 5% utilization rate and 18.3 billion (usual and customary fee) and 10.6 billion (RBRVS fee) for 36% utilization rate when applied only to 6-14 age group annually once; 3) S-PCI are 9.1 billion usual and customary fee) and 5.5 billion (RBRVS fee) for 5% utilization rate and 65.7 billion (usual and customary fee) and 39.8 billion (RBRVS fee) for 36% utilization rate when limited over 12 age group who could have periodontal pocket. Conclusions: The actuarial budgets of PFS, FTA, and S-PCI if they were included within insurance payment system are minimum 13 billion and maximum 219 billion. It is presumed, however, that over 1,000 billion for dental treatment and the pain and time consuming from oral &ease could be decreased when dental caries and periodontal disease were prevented effectively. As a conclusion, preventive dental service should be included to the insurance payment system to decrease budget.

防波堤의 任意 配置에 對한 波浪 廻折

李한배,李庸揆,吳世汎,片宗根 명지대학교 공학기술연구소 1988 공학기술연구소 논문집 Vol.3 No.-

In harbor design, it is a necessary condition to retain calmness inside a harbor. For this purpose, breakwaters are disposed as exterior structures against incident waves. There are cases that necessitate main and auxiliary breakwaters according to frequent directions of incident waves. In these cases, harbor entrances have various geometric shapes in horizontal plane. In the program developed here, harbor entrances are classified into six different cases by the disposition of breakwaters and the attack angle of incident waves. For each case, the diffraction phenomena inside and around harbor entrance are analysed by superposing the solutions of Sommerfeld's. The method gives fairly good results compared with those reported before, and also is proved to be computationally very efficient. Therefore, the method may be applicable to the preliminary design of breakwater dispositions, and also the program can be used as the basic subroutine in the calculation of wave height distributions inside a harbor with reflected waves.

Effect of Long -term Treatment with the Adventious Root Cultured Mountain Ginseng (CBN-3) on Functions of Central Nervous System in Healthy Human Volunteers

LEE SE0UL,YU KEE WON,KEUM KYUNG SOO,KIM NARI,PAEK KEE-YEUP,JUNG KYUY0NG,CHOI BONG KYU,OH GYUNG JAE4 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.1

분광 엘립소메트리의 응용을 위한 0차 Retardation Plate의 Alignment

이용달,박명규,김세덕,방경윤,안일신 한양대학교 이학기술연구소 2000 이학기술연구지 Vol.2 No.

A zero-order retarder was fabricated using two pieces of magnesium fluoride plates. In order to achieve desired zero-order retardation for specific wavelength, both the thickness of plates and the alignment of two fast axes were very important. We found that the alignment should be checked using broad band detection system for spectroscopic application, We devised alignment method by which the two fast axes lie perpendicularly to each other. The periodic oscillation feature in retardation angle versus wavelength disappeared with good alignment. We also developed calibration method to deduce the retardation angle over a wider spectral range using rotating compensator ellipsometer. 두 조각의 마그네슘 플로라이드 판을 이용한 0차 retarder를 제작하였다. 특정한 파장에 대하여 원하는 0차 retardation을 얻기 위해서는 판의 두께와 alignment가 매우 중요하였다. 분광학적인 응용을 위해서는 넓은 파장 영역을 측정할 수 있는 detection system의 사용이 필요하였다. 이를 이용하여 두 판의 fast axes가 서로 수직으로 놓이게 할 수 있는 alignment 방법을 개발하였다. 파장에 대한 retardation 각도에서의 주기적인 진동의 모양은 alignment를 잘하게 되면 사라지게 된다. 또한 rotating compensator ellipsometer를 사용 할 때 넓은 분광영역에 걸친 retardation angle을 측정해 낼 수 있는 calibration 방법을 개발하였다.

항파킨슨 제제가 추체외로 증상의 발생에 미치는 영향

이귀행,엄세연 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5

This study investigated 161 patients receiving antipsychotic medication and benztropine mesylate as an antiparkinson agent in order to evaluate the development of extrapyramidal symptoms that could be occurred when an antiparkinson drug was stopped. The authors observed the development of extrapyramidal symptoms after the withdrawal of benztropine mesylate for 6 weeks. Brief Psychiatric Rating Scale and Rating Scale for Extrapyramidal Symptoms was used for the assessment of psychotic symptoms and extrapyramidal symptoms respectively. The results were as follows : 1) Of the 161 subjects, 105 patients(65.2%) developed extrapyramidal symptoms necessitating the antiparkinson agent. 2) Daily mean dose of benztropine in symptomatic group was much more than in asymptomatic group(t=2.52, df=159, p<0.05). 3) In the development of EPS, perphenazine(χ²=4.5, df=1, p<0.05) and haloperidol(χ²=24.5, df=1, p<0.001) was used more frequently in symptomatic group than in asymptomatic group, but chlorpromazine was not significantly different between two groups(χ²=2.6, df=1, p<0.05). 4) Mean Scores of BPRS at the manifestation of extrapyramidal symptoms were higher in symptomatic group than in asymptomatic group(t=6.39, df=159, p<0.001). 5) IN symptomatic group, 81.9% of subjects developed extrapyramidal symptoms within the third week and those developments commonly occured from 9 o'clock a.m. to 3 o'clock p.m. and from 6 o'oclock p.m. to 9 o'oclock p.m. in a 24 hour period. Our data suggest that we should prescribe the antipsychotic medication with antiparkinson agent carefully. Also we can anticipate more frequent extrapyramidal symptoms in relatively high potency antipsychotic medication. Our data recommends that it is better to prescribe the antiparkinson agent at a low dose, single morning dose due to frequent developments of extrapyramidal symptoms during the day.

허혈성 장질환의 조기진단을 위한 혈청 락테이트(lactate)의 유용성

이미진,오동렬,박규남,김세경,양진홍,박상현 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Intestinal ischemia remains a devastating event despite improvements in clinical recognition and in diagnostic and therapeutic modalities. The ischemic bowel diseases encompass a wide clinical spectrum from mild, reversible disease to severe, irreversible injury. The clinical picture is characterized initially by poorly localized visceral pain. Thus, it is difficult to diagnose this ischemia at an early stage. This study investigated whether an increased serum lactate level is a recognized danger signal marker for intestinal ischemia in patients who present at the emergency department because of abdominal complaints. Methods: Patients who came to our emergency department with abdominal pain and the risk factors of intestinal ischemia between Apr. 1999 and Nov. 1999 were included in this study. The data analysis included age, sex, final diagnosis, pathogenesis of bowel ischemia, and serum lactate level. Results: The serum lactate level in the intestinal ischemia group was 28.54±22.51 mg/dl; in non-ischemia group, it was 15.49±22.52 mg/dl. This difference between the two groups was significant(p<0.05). An increased serum lactate level had a sensitivity of 88.2% and specificity of 59.2%, a positive likelihood ratio of 4.92, and a negative likelihood ratio of 0.47 as a marker of bowel ischemia. These results do not represent a very meaningful revision of bowel ischemlc provability, but may make a small contribution to management of the disease, depending upon their magnitude and the clinical context in which they are applied. Conclusion: In patients with abdominal complaints, an increased serum lactate level is usually a useful aid as a diagnostic marker of bowel ischemia.

이중컨버터방식 직류전원공급장치의 순환전류제어에 의한 입력 역율개선

이규종,이기홍,성세진 忠南大學校 産業技術硏究所 1989 산업기술연구논문집 Vol.4 No.2

이중컨버터방식의 직류전원공급장치는 4상한 운전이 필요한 직류모터, 직류쵸파, PWM인버터등의 대용량 전력변환장치의 직류전원으로 주로 사용된다. 그러나 순환전류를 제어하는 이중컨터방식의 직류전원공급장치에서는 위상제어와 P와 N 두 컨버터 사이에 흐르는 순환전류에 의하여 교류입력측에 무효전력을 발생시키는 단점이 있다. 최근 이중컨버터방식의 순환전류제어에 관한 논문이 몇편 발표된 일이 있다. 본 논문에서는 이 순환전류제어방식을 이용하여 교류입력측 역율을 1로 보상할 수 있는 방안을 제시하였으며 이방안의 가능성을 컴퓨터 시뮤레이션과 실험을 통하여 확인하다.