비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

Jacobi 반복법을 이용한 합성 근사 구조재해석

황진하,김경일 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.1

A design-oriented structural reanalysis method is presented in this paper. The new combined approximation method is based on combining the computed terms of Jacobi iteration and coefficients of a reduced basis method. Some examples are demonstrated to show the validity and efficiency of the present study. Satisfactory results compared to the exact method show that the proposed method is worth being incorporated into the design procedures of the large structural systems. This method can improves the total efficiency when they are appropriately used according to the design informations for the redesign process of large scale structures. The numerical results for some trusses show the validity and usability of the method.

배 농가의 경영효율성 분석 : 비모수적 접근방법에 의한 사례연구 A case study using non-parametric method

우수곤,유진채,강경하,신용광 한국농촌지도학회 2002 농촌지도와 개발 Vol.9 No.2

The objective of this study was to compare the farm efficiency of members of cooperative firms with that of non-members in Korea. Data were collected from 27 farms members of three cooperatives and 13 non-member farms, based on the managerial achievements of 1999. For the analysis, the data were divided into three different farming types: type I and Ⅱ of member farms and non-member farms. Economic analysis were implemented using DEA(Data Envelopment Analysis). Major findings was as follows. Total average technology efficiency was 0.782, which implies that there still remains 21.8% of improvement possibility. Among the time types, type I showed the highest technology efficiency of 0.9055, while " 11 and non-member farms showed 0.7670 and 0.7171, respectively. This means that these farms have relatively high potential improved. Also, comparing technology efficiency by dividing into pure technology and scale efficiency, all type of the farms exhibit a higher pure technology efficiency compared to scale efficiency. Therefore, to improve current technology efficiency, farms need to focus more on pure technology efficiency improvement. Meanwhile, profit analysis based on farm size indicate that most of the farms demonstrated the increasing-return-to-scale, which means it is necessary to extend the farm size to improve technical efficiency. Type I member farms achieve higher profit and efficiency than other two types and relatively higher producer prices through introducing cooperative sorting, grading and packing. Also, these labor saving technologies increased farm size.

장수군 주민의 핵심역량 수준 분석

조영숙,김병진,황대용,강경하 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.3

이 연구는 농촌사회 속에서 살아가는 성인들의 삶의 현장 속에서 직업을 갖고 살아가는데 주어진 과제를 성공적으로 수행하기 위해 펼요한 핵심역량 수준을 진단하고 개인 특성에 따른 핵심역량 보유수준의 차이를 분석함으로써 핵심역량 향상을 위한 시사점을 탐색하고 제언하는 데 목적이 있다. 이를 위해 선행연구를 바탕으로 개발한 농촌주민의 핵심역량 설문지를 가지고 층화무작위추출(One-Staged Stratified Random Sampling)과 체계적 표집방법을 사용하여 선정된 600명의 장수군 농촌주민을 대상으로 핵심역량을 측정하였다. 이 연구의 주요 결과는 다음과 같다. 첫째, 장수군 농촌주민의 핵심역량은 전반적으로 직업기초능력이 가장 높았고, 그 다음으로 시민의식 능력, 기초문해능력, 직업전환능력, 전문직업능력, 여가문화능력 순으로서 전문직업능력과 여가문화능력이 낮게 나타났다. 따라서 농업기술센터 등 교육기관에서는 전문직업능력과 여가문화능력에 대한 교육 기회 확대나 강화가 펼요하다. 둘째, 6개 핵심역량 보유수준은 직업교육 경험이 없는 층보다 경험있는 층이, 비농가보다 농가가, 여자보다 남자가, 40대 이하와 60대 이상보다 50대에서, 저학력층보다 고학력층, 주부, 무직보다는 농업과 직장인 층에서, 소농보다는 대농과 중농에서 더 높은 것으로 나타났다. 따라서 농촌지역 성인의 현재 직업기초능력 수준을 정확히 진단하고 대상층의 특성과 요구를 명확히 파악하여, 그 결과를 토대로 교육프로그램을 개발하고 제공하는 노력이 필요하다. 이상의 연구결과를 바탕으로 몇 가지 제언을 하였다. 국어 및 컴퓨터 활용 교육 등 기초문해능력 향상을 위한 교육프로그램 개발 및 운영 강화, 자기주도적 학습능력, 문제해결능력 등 핵심역량 향상을 위한 교육프로그램의 개발·운영 등이 필요하다. The purpose of this study was to find core competencies necessary for successful performance of tasks given to rural resident in the age of human resource development and to determine whether the level of core competencies were different according to individual background. For these purpose, we analyzed domestic and foreign literature, and derived core competencies required to rural adult. We surveyed rural resident's perception about their level of vocational competencies. We conducted a questionnaire survey of 600 rural residents living in Jangsu gun sampled by One-Staged Stratified Random Sampling and systematic sampling. The result of this study was summarized as follows. First, rural residents' level of core competencies were generally low. Out of core competencies, basic vocational competency is high, professional competency and leisure culture competency is low. Second the level of core competencies was perceived highly by experienced vocational education, farm house, male, 50's, high educated, farmer and worker, large and middle size farm house. Thus the opportunity for developing the core competencies for these the vulnerable have to be enlarged. Based on the results of this study, we proposed several tasks to be promoted as a part of regional human resources development in Jangsu Gun: 'develop and strengthen education program for basic literacy competency such as literacy and computer', 'expand the opportunity to develop professional competency and leisure culture competency'.

Does ovarian reserve affect the pregnancy outcomes in women with unexplained repeat pregnancy loss ?

( Jin Kyeong Ha ),( Joon Cheol Park ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Repeat pregnancy loss (RPL) must be a painful and frustrated situation to couple. Advanced maternal age is related with miscarriages, which is predisposed to a greater risk of fetal aneuploidy. It has been proposed biological ovarian age is more important than chronologic age. The aim of this study was to evaluate whether antimullerian hormone was associated with pregnancy loss in unexplained RPL women. Methods: RPL patients were consecutively registered in this study for 3 years. Unexplained RPL was defined after excluding the genetic, anatomic, endocrinological cause and antiphospholipid antibody syndrome. Finally, 152 women were enrolled as unexplained RPL. Serum AMH levels were defined as low (< 1.0ng/ml), normal (1.0-3.5ng/ml) and high ( >3.5ng/ml). To compare other etiological causes, NK cell proportion, protein C activity, protein S activity, antithrombin III, homocystein and PAI-1 were evaluated. Pregnancy rate and miscarriage rate were compared depends on the AMH levels. Results: Mean age of enrolled women was 34.11±4.51 years-old, mean parity was 0.18±0.40, and mean number of miscarriage was 2.51±1.01. AMH level was significantly correlated with age (r=-0.51, p<0.01) However, AMH or maternal age was not correlated with ongoing pregnancy or miscarriage of subsequent pregnancy. Depending on AMH levels, mean value of NK cell proportion, protein C activity, protein S activity, antithrombin III, homocystein and PAI-1 were not different. Pregnancy rate in normal AMH group was 34/54 (63.0%), higher than 44/74 (48.7%) of high AMH group, 11/24 (45.8%) of low AMH group, statistically insignificant. Miscarriage rates of each group were not statistically different (36.4% in low AMH group, 23.5% in normal AMH group, 25.0% in high AMH group). For subgroup analysis with patients under 35 years-old, pregnancy rate or miscarriage rated was not different either. Conclusion: AMH values were not associated with subsequent pregnancy loss in women with unexplained RPL. Further larger studies are required.

Impedance Characterization of Tantalum Oxide Deposited through Pulsed-Laser Deposition

Kyeong-Woo Kwon,Jin-Kwan Jung,Chan-Rok Park,Jin-Sang Kim,Seung-Hyub Baek,Jin-Ha Hwang 한국진공학회 2013 한국진공학회 학술발표회초록집 Vol.2013 No.8

Inhibitory Effects of Panaxatriol from Panax ginseng C. A. Meyer on Phosphoinositide Breakdown Induced by Thrombin in Platelets

Kyeong-Mee Park,Man-Hee Rhee,Han-Jae Shin,Yong-Bum Song,Hak-Chul Hyun,Ki-Hyun Park,Hyun-Jeong Cho,Sun-A Choi,Hyo-Chan Kang,Kyoung Jin Kim,Hyeong-Soo Kim,Hee-Jin Kang,Woo-Jeong Ok,Dong-Ha Lee,Hwa-Jin P 고려인삼학회 2008 Journal of Ginseng Research Vol.32 No.2

In this study, we have investigated the effect of panaxatriol (PT) on phosphoinositides (PIS) breakdown and Ca<SUP>2+</SUP>-elevation in thrombin-induced platelet aggregation. Thrombin (5U/ml), a potent platelet agonist which activates phospholipase Cβ via protease activated receptor (PAR), hydrolyzed PIS in platelet membrane. The phosphatidylinositol 4, 5-bisphosphate (PIP₂) was hydrolyzed after 10 sec of the thrombin-stimulation, and both the phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol (PI) were brokendown after 30 sec of the thrombin-stimulation. However, PT inhibited the thrombin-stimulated hydrolysis of PIP₂, PIP, and PI. On the other hand, thrombin increased the level of phosphatidic acid (PA) which is phosphorylated from diacylglycerol (DG) generated by PIS-hydrolysis. However, PT inhibited the thrombin-increased PA level non-significantly. Thrombin increased cytosolic free Ca<SUP>2+</SUP>[Ca<SUP>2+</SUP>]i) up to 72% as compared with control (30.8±0.9 nM) in intact platelet. However, PT (100 ㎍/ml) inhibited the thrombin-elevated [Ca<SUP>2+</SUP>]i to 100%. These results suggest that PT may have a beneficial effect on platelet aggregation-mediated thrombotic disease by inhibiting thrombin-induced platelet aggregation via suppression of the [Ca<SUP>2+</SUP>]i level and PIS breakdown.

빈발 패턴 네트워크에서 아이템 클러스터링을 통한 연관규칙 발견

오경진(Kyeong-Jin Oh),정진국(Jin-Guk, Jung),하인애(Inay Ha),조근식(Geun-Sik Jo) 한국지능정보시스템학회 2008 지능정보연구 Vol.14 No.1

데이터 마이닝은 대용량의 데이터에 숨겨진 의미있고 유용한 패턴과 상관관계를 추출하여 의사결정에 활용하는 작업이다. 그 중에서도 고객 트랜잭션의 데이터베이스에서 아이템(item) 사이에 존재하는 연관규칙을 찾는 것은 중요한 일이 되었다. Apriori 알고리즘 이후 연관규칙을 찾기 위해 대용량의 데이터베이스로부터 압축된 의미있는 정보를 저장하기 위한 데이터 구조와 알고리즘들이 많이 제안되어 왔다. 연관규칙을 발견하기 위한 기존의 연구들은 모든 규칙을 찾아내지만, 사람이 분석하기에 너무 많은 규칙이 생성되기 때문에 규칙을 분석하기 위한 일 또한 많은 과정을 거쳐야 한다. 본 논문에서는 빈발 패턴 네트워크(Frequent Pattern Network)라 부르는 자료 구조를 제안하고 이를 활용하였다. 네트워크는 정점과 간선으로 구성되며 정점은 아이템을 표현하고, 간선은 두 아이템 집합을 표현한다. 아이템의 빈도수를 이용하여 빈발 패턴 네트워크를 구성하고, 아이템 사이의 유사도를 측정한다. 그리고 클러스터 내의 아이템과는 유사도가 높고, 다른 클러스터의 아이템과는 유사도가 낮도록 클러스터를 생성한다. 클러스터를 이용해 연관규칙을 생성하고 실험을 통해 Apriori와 FP Growth 알고리즘과의 성능을 비교를 하였다. 그 결과 빈발 패턴 네트워크에서 신뢰도 유사도를 이용하는 것이 클러스터의 정확성을 높여줌을 볼 수 있었다. 그리고 전통적인 방법과 비교를 통해 빈발 패턴 네트워크를 이용하는 것이 최소지지도에 유연성을 가짐을 알 수 있었다. Data mining is defined as the process of discovering meaningful and useful pattern in large volumes of data. In particular, finding associations rules between items in a database of customer transactions has become an important thing. Some data structures and algorithms had been proposed for storing meaningful information compressed from an original database to find frequent itemsets since Apriori algorithm. Though existing method find all association rules, we must have a lot of process to analyze association rules because there are too many rules. In this paper, we propose a new data structure, called a Frequent Pattern Network (FPN), which represents items as vertices and 2-itemsets as edges of the network. In order to utilize FPN, We constitute FPN using item's frequency. And then we use a clustering method to group the vertices on the network into clusters so that the intracluster similarity is maximized and the intercluster similarity is minimized. We generate association rules based on clusters. Our experiments showed accuracy of clustering items on the network using confidence, correlation and edge weight similarity methods. And We generated association rules using clusters and compare traditional and our method. From the results, the confidence similarity had a strong influence than others on the frequent pattern network. And FPN had a flexibility to minimum support value.

菊花 插木時 플러그 셀크기, 用土 및 遮光期間이 發根과 苗生育에 미치는 影響

우진하(Jin Ha Woo),심용구(Yong Gu Sim),한윤열(Youn Yol Han),서영진(Yong Jin Seo),김창배(Chang Bae Kim),최경배(Kyeong Bae Choi),김규원(Kiu Weon Kim) 한국원예학회 2000 Horticulture, Environment, and Biotechnology Vol.41 No.3