강건 설계를 이용한 전자제품 신뢰성 향상방법

김경모,이지수,신호균 金烏工科大學校 1997 論文集 Vol.18 No.-

Reliability is one of the important quality factor in electronic products. As it is time-consuming to estimate mean time to failure, it has not been integrated in the process of product design. In this study, we propose a method which can optimize the product with respect to robustness design and can estimate mean time to failure of electronic products by only one experimentation. This proposed method can quarantee quality improvement by making the life time of the designed products robust to customer's environment. We explaine the detailed steps of this proposed method through a case study.

불산 제조업체 근로자의 골밀도 변화에 관한 조사

김지용,임현술,정회경,이현경,강흥식 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Hydrofluoric acid is one of strongest irritating, corrosive and poisonous inorganic chemicals. The most significant chronic consequence of excessive fluoride exposure is the disorder of skeletal system and connective tissue. The first stage of osteofluorosis consists of an increase in the density of flatbone such as pelvic bone and vertebral bones, with coarseness and blurring of bone trabecular. Therefore we wanted to observe the change of the bone density among workers exposed to hydrofluoric acid. Questionnairs and radiological investigations were performed for 39 hydrofluoric acid manufacturing factory worker sexposed to hydrofluoric acid. And then authors checked urinary fluoride level by fluoride ion method. The radiographs were doubly read by two radiologists for reliability. The results were as follows; 1. There was a significant difference in urinary fluoride level(p<0.01), but not in age, in tenure(p>0.05) among workers by the job title. 2. By the two radiologists, eight cases were read as bone fluorosis. The prevalence rate of bone fluorosis was 20.5%. 3. There was not a significant difference in general characteristic such as age, tenure and in muculoskeletal signs and symptoms between the fluorosis group and the normal group. 4. However, a close relationship between the occurence of the change of bone density and the degree of fluoride exposure such as burn was found. The difficulties in diagnosing fluorosis result from the questionable sensitivity of x-ray techniques and from the non-specific associated signs and symptoms. A quantitative method such as densitometry to assessosteosclerosis and bone structure alteration and a follow-up study are needed.

Thirteen-week Repeated Dose Toxicity and Genotoxicity Studies of Sophorae radix

Ji-Ran You,Jeong-Hwan Che,Seung-Hyun Kim,Euna Kwon,Eun-Young Cho,Jung-Hee Yoon,Yun-Soon Kim,Chang-Gil Kang,Hye-Jeong Jeong,Jung Ki Kim,Ja-June Jang,Hee-Chan Kim,Young-Tae Kim,Hyeon-Hoe Kim,Byeong-Cheo 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

A Computerized In-Hospital Alert System for Thrombolysis in Acute Stroke

Heo, Ji Hoe,Kim, Young Dae,Nam, Hyo Suk,Hong, Keun-sik,Ahn, Seong Hwan,Cho, Hyun Ji,Choi, Hye-Yeon,Han, Sang Won,Cha, Myoung-Jin,Hong, Ji Man,Kim, Gyeong-Moon,Kim, Gyu Sik,Kim, Hye Jin,Kim, Seo Hyun,K Ovid Technologies Wolters Kluwer -American Heart A 2010 Stroke Vol.41 No.9

<P>Background and Purpose-An effective stroke code system that can expedite rapid thrombolytic treatment requires effective notification/communication and an organized team approach. We developed a stroke code program based on the computerized physician order entry (CPOE) system and investigated whether implementation of this CPOE-based program is useful for reducing the time from arrival at emergency departments (ED) to evaluation steps and the initiation of thrombolytic treatment in various hospital settings. Methods-The CPOE-based program was implemented by 10 hospitals. Time intervals from arrival at the ED to blood tests, computed tomography scanning, and thrombolytic treatment during the 1-year period before and the 1-year period after the program implementation were compared. Results-Time intervals from ED arrival to evaluation steps were significantly reduced after implementation of the CPOE-based program. Times from ED arrival to CT scan, complete blood counts, and prothrombin time testing were reduced by 7.7 minutes, 5.6 minutes, and 26.8 minutes, respectively (P<0.001). The time from ED arrival to intravenous thrombolysis was reduced from 71.7 +/- 33.6 minutes to 56.6 +/- 26.9 minutes (P<0.001). The number of patients who were treated with thrombolysis increased from 3.4% (199/5798 patients) before the CPOE-based program to 5.8% (312/5405 patients) afterward (P<0.001). The CPOE implementation also improved the inverse relationship between onset-to-door time and door-to-needle time. Conclusions-The CPOE-based stroke code could be successfully implemented to reduce in-hospital time delay in thrombolytic therapy in various hospital settings. CPOE may be used as an efficient tool to facilitate in-hospital notification/communication and an organized team approach. (Stroke. 2010; 41:1978-1983.)</P>

Feasibility Study of Different Biochars as Adsorbent for Cadmium and Lead

Kim, In Ja,Kim, Rog-Young,Kim, Ji In,Kim, Hyoung Seop,Noh, Hoe-Jung,Kim, Tae Seung,Yoon, Jeong-Ki,Park, Gyoung-Hun,Ok, Yong Sik,Jung, Hyun-Sung 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5

The objective of this study was to evaluate the effectiveness of different biochars on the removal of heavy metals from aqueous media. The experiment was carried out in aqueous solutions containing $200mg\;CdL^{-1}$ or $200mg\;PbL^{-1}$ using two different biochars derived from soybean stover and orange peel (20 mg Cd or $Pbg^{-1}$ biochar). After shaking for 24 hours, biochars were filtered out, and Cd and Pb in the filtrate were analyzed by flame atomic absorption spectrophotometer (FAAS). In order to provide information regarding metal binding strength on biochars, sequential extraction was performed by modified SM&T (formerly BCR). The results showed that 70~100% of initially added Cd and Pb was adsorbed on biochars and removed from aqueous solution. The removal rate of Pb (95%, 100%) was higher than that of Cd (70%, 91%). In the case of Cd, orange peel derived biochar (91%) showed higher adsorption rate than soybean stover derived biochar (70%). Cd was adsorbed on the biochar mainly in exchangeable and carbonates fraction (1st phase). In contrast, Pb was adsorbed on it mainly in the form of Fe-Mn oxides and residual fraction (2nd and 4th phase). The existence of Cd and Pb as a form of surface-precipitated complex was also observed on the surfaces of biochars detected by field emission scanning electron microscope (FESEM) and energy dispersive X-ray spectrometer (EDAX).

Clinical Implications and Determinants of Left Atrial Mechanical Dysfunction in Patients With Stroke

Kim, Darae,Shim, Chi Young,Hong, Geu-Ru,Kim, Mi-Hyun,Seo, Jiwon,Cho, In Jeong,Kim, Young Dae,Chang, Hyuk-Jae,Ha, Jong-Won,Heo, Ji Hoe,Chung, Namsik American Heart Association, Inc. 2016 Stroke Vol.47 No.6

<P>Background and Purpose-The evaluation of sources of cardioembolism with transesophageal echocardiography (TEE) in patients with stroke is crucial but semi-invasive. We hypothesized that the size and mechanical function of the left atrium (LA) assessed by transthoracic echocardiography (TTE) could provide useful information on high risk of cardioembolism on TEE in patients with stroke. Furthermore, we sought to define the determinants of LA mechanical dysfunction in these patients. Methods-A total of 248 patients with acute ischemic stroke (147 men; 64 +/- 13 years) who underwent 2-dimensional and speckle tracking TTE followed by TEE were analyzed. Results-LA appendage emptying velocity, prevalence of LA or LA appendage thrombus, prevalence of aortic plaques, and incidence of embolic stroke showed significant differences among the 4 groups classified according to the median values of the LA volume index and global LA longitudinal strain (LALS). Patients at high risk of cardioembolism evidenced by TEE revealed significantly larger LA volume index and lower global LALS than those without. Global LALS (cutoff, 11.5%; area under the curve, 0.947; sensitivity, 100%; specificity, 91%; P<0.001) revealed a significantly better diagnostic power (P=0.04) for LA or LA appendage thrombus than LA volume index (cutoff, 36.2 mL/m(2); area under the curve, 0.823; sensitivity, 88%; specificity, 75%; P=0.002). Age, left ventricular systolic function, LA volume index, and pulse wave velocity were independent determinants for global LALS. Conclusions-LA mechanical dysfunction is closely associated with high risks of cardioembolism. Global LALS assessed by speckle tracking TTE well discriminates the presence of LA or LA appendage thrombus on TEE in patients with acute ischemic stroke.</P>

Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke

Ji Hoe Heo,Hyo Suk Nam,Young Dae Kim,Jin Kyo Choi,Byung Moon Kim,Dong Joon Kim,Il Kwon 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1

Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.

Original Articles : The Widespread Distribution of the Venomous and Poisonous Blue-Lined Octopus Hapalochlaena spp., in the East/Japan Sea: Possible Effects of Sea Warming

( Ji Hoe Kim ),( Toshiyuki Suzuki ),( Kil Bo Shim ),( Eun Gyoung Oh ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.1

The geographical distribution of the toxic blue-lined octopus (commonly known as the blue-ringed octopus), Hapalochlaena spp., around the East/Japan Sea was investigated. Observation records of the octopus were gathered using commercial search engines on the Internet. A questionnaire to complement and enhance the base data was conducted that targeted fishermen from areas where the octopus was most likely to occur, i.e., the southeast coast and islands of Korea in the East/Japan Sea. Overall, 32 observational records of the blue-lined octopus were found from Korea and Japan. In Korea, only one record, from 2003, was found on a website; none of the 240 fishermen who participated in the questionnaire reported seeing blue-lined octopus. However, a total of 31 observations of the blue-lined octopus from 2004 to July 2010 were found from 17 different regions in the East/Japan Sea and neighboring waters in Japan. Twenty-two cases were from coastal Honshu Island, and nine were from the west coast of Kyushu Island, Japan. The northern distributional boundary of the blue-lined octopus on the Japanese coast was off Fukui Prefecture around latitude 36º10` N. Our results indicate that the blue-lined octopus is distributed extensively along the Japanese coast, at a low frequency, in the East/Japan Sea.

Increased Risk of Cardiovascular Events in Stroke Patients Who had Not Undergone Evaluation for Coronary Artery Disease

Kim, Young Dae,Song, Dongbeom,Nam, Hyo Suk,Choi, Donghoon,Kim, Jung-Sun,Kim, Byeong-Keuk,Chang, Hyuk-Jae,Choi, Hye-Yeon,Lee, Kijeong,Yoo, Joonsang,Lee, Hye Sun,Nam, Chung Mo,Heo, Ji Hoe Yonsei University, College of Medicine 2017 Yonsei medical journal Vol.58 No.1

<P><B>Purpose</B></P><P>Although asymptomatic coronary artery occlusive disease is common in stroke patients, the long-term advantages of undergoing evaluation for coronary arterial disease using multi-detector coronary computed tomography (MDCT) have not been well established in stroke patients. We compared long-term cardio-cerebrovascular outcomes between patients who underwent MDCT and those who did not.</P><P><B>Materials and Methods</B></P><P>This was a retrospective study in a prospective cohort of consecutive ischemic stroke patients. Of the 3117 patients who were registered between July 2006 and December 2012, MDCT was performed in 1842 patients [MDCT (+) group] and not in 1275 patients [MDCT (−) group]. Occurrences of death, cardiovascular events, and recurrent stroke were compared between the groups using Cox proportional hazards models and propensity score analyses.</P><P><B>Results</B></P><P>During the mean follow-up of 38.0±24.8 months, 486 (15.6%) patients died, recurrent stroke occurred in 297 (9.5%), and cardiovascular events occurred in 60 patients (1.9%). Mean annual risks of death (9.34% vs. 2.47%), cardiovascular events (1.2% vs. 0.29%), and recurrent stroke (4.7% vs. 2.56%) were higher in the MDCT (−) group than in the MDCT (+) group. The Cox proportional hazards model and the five propensity score-adjusted models consistently demonstrated that the MDCT (−) group was at a high risk of cardiovascular events (hazard ratios 3.200, 95% confidence interval 1.172–8.735 in 1:1 propensity matching analysis) as well as death. The MDCT (−) group seemed to also have a higher risk of recurrent stroke.</P><P><B>Conclusion</B></P><P>Acute stroke patients who underwent MDCT experienced fewer deaths, cardiovascular events, and recurrent strokes during follow-up.</P>

Histopathological Findings of Intracranial Thrombi in Nonbacterial Thrombotic Endocarditis

Kim, Kyoungsub,Kim, Jayoung,Ahn, Seong Hwan,Ha, Woo Seok,Koo, Yu Jin,Kim, Dong Joon,Nam, Hyo Suk,Heo, Ji Hoe Korean Stroke Society 2017 Journal of stroke Vol.19 No.3