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Lee, Moon Hee,Cha, Hee-Jae,Choi, Eun Ok,Han, Min Ho,Kim, Sung Ok,Kim, Gi-Young,Hong, Su Hyun,Park, Cheol,Moon, Sung-Kwon,Jeong, Soon-Jeong,Jeong, Moon-Jin,Kim, Wun-Jae,Choi, Yung Hyun Spandidos Publications 2017 International journal of molecular medicine Vol.39 No.3
<P>Natural phytochemicals of plant origin, including flavonoids, have been found to be potent antioxidants providing beneficial effects against oxidative stress-related diseases. The present study was carried out to investigate the antioxidant properties of morin, a flavonoid originally isolated from the flowering plants of the Moraceae family. Superoxide dismutase (SOD)-like activity and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging activity were determined. We also investigated the cytoprotective effects of morin against hydrogen peroxide (H2O2)-induced DNA damage and apoptosis in V79-4 Chinese hamster lung fibroblasts. Our results demonstrated that morin had strong scavenging effects against ABTS' radicals with enhanced SOD activity, which varied in a dose-dependent manner. Morin was found to reduce H2O2-induced intracellular reactive oxygen species generation and nuclear DNA damage, and it recovered cell viability damaged by H2O2 via inhibition of mitochondrial dysfunction-mediated apoptosis. Notably, the treatment of V79-4 cells with morin markedly enhanced the expression of heme oxygenase-1 (HO-1) but not quinone oxidoreductase-1, which was associated with the increased expression and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the downregulation of Kelch-like ECH-associated protein 1 expression. Based on our findings, we conclude that morin effectively ameliorated oxidative stress-induced DNA damage through intrinsic free radical scavenging activity and activation of the Nrf2/HO-1 pathway.</P>
Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2
<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>
만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구
차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.
Glutaraldehyde와 Formaldehyde가 齒髓組織 損傷後 治癒에 미치는 影響에 對한 實驗的 硏究
車文豪,崔在弘 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1
The purpose of this study was to evaluate the pulpal response against formocresol and various concentrations of glutaraldehyde (2%, 5%, 10%, 20%). The experiment was performed on dog's teeth (64 teeth from 4 dogs) and the teeth were rountinely treated in laboratory procedures. Histologic examinations of pulp tissue reaction were observed at various time intervals (1, 2, 5, 10 weeks). Followings are the results obtained through microscopical examination. 1. The reactions and changes of pulp tissue were similar in formocresol group, and in 2%, 5%, 10% glutaraldehyde groups within 1 week. 2. According to the time increase after experiment, there was seen the progression of degenerative changes toward the apical third in formocresol group, and in 2%, 5%, 10% glutaraldehyde group degenerative changes was seen in the coronal third, but normal pulp tissue in the apical third. 3. In formocresol group and 20% glutaraldehyde group, the odentoblastic layer was damaged and destructed, but there was good odontoblastic layer in 2%, 5%, 10% glutaraldehyde group at the apical third of 10 weeks. 4. In formocresol group and glutaraldehyde group, the formation of dentin bridge was not seen, but the resorption of dentin was seen in the formocresol group and in the glutaraldehyde groups of 10 weeks. 5. In glutaraldehyde groups there was no differences in inflammatory reactions and degenerative changes, but 20% glutaraldehyde group showed the thickest fixed pulp tissue.
차재호 서울大學校 社會科學大學 心理科學硏究所 1995 心理科學 Vol.4 No.1
파노라마적 사회심리학(차재호, 1991,1994)에서 사용되는 형태분석의 서설로서 재난에 대한 미국에서의 심리학적 재난연구를 중심으로 재난연구역사와 연구에서 밝혀진 결과들을 개관했다. 재난연구의 연혁, 재난의 구분, 재난과 사고의 관계, 그리고 재난 후의 심리사회적 영향, 재난전의 대응반응에 대해서 다루었다. 부분적으로 필자의 분석을 첨가했다. As a prelude to a planned paper on the configurational analysis of disasters within the framework of a panoramic social psychology proposed by the writer(Cha, 1991, 1994), social scientific studies dealing with disaters done in the United States were reviewed with special attention to topics of interest to psychologists. History of disaster studies, types of disasters, the relation between accident and disaster, psychological impact of disaster, psychological responses of survivors to disaster during and after the disaster, and psychological processes involved immediately prior to disaster impact including perception of danger and decision making in the face of impending danger were discussed. The writer's own analyses were added at appropriate places.