연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

한국 선거제도 변천과정 연구: 국회의원 선거를 중심으로

안철현 경성대학교 2000 論文集 Vol.21 No.2

This study aims to review the history of electoral system, particularly parliamentary electoral system, in Korea. The history of electoral system has four stages, introduction of modern electoral system(the periods of United States Amy Military Government and !st Republic), change by the characteristics of political power(the periods of 2nd and 3rd Republic), distortion by the dictatorship for development(the periods of 4th and 5th Republic), exertion for democratization and rationalization(after 6th Republic). From the period of introduction to now, the systems of the suffrage and eligibility, the representative system and constituency, the methods of election canvassing, the election administration have been changed gradually toward the direction of modernization and democratization, lrut it isn't enough yet. Now we have to take more interest in the political institutions including electoral system, and try to reform each part of the electoral system, partienlarly, to introduce the system of two votes(a candidate and a party) a person.

智異山國立公園의 登山路 毁損

安鉉哲,趙顯瑞,秋甲喆 진주산업대학교 농업기술연구소 1998 農業技術硏究所報 Vol.11 No.-

지리산국립공원의 주요 등산로에 대해 이용강도에 따른 등산로 훼손상태를 조사하였다. 총 37.15km, 111개 지점에서 등산로 상태를 조사한 바, 등산로폭과 나지노출폭 및 최대침식깊이는 다른 국립공원의 등산로보다 크게 나타났다. 훼손유형의 출현빈도는 뿌리노출, 노폭확대, 암석노출, 분기 등의 순으로 나타났으며, 이들 지점의 등산로상태는 건전한 지점과 뚜렸한 차이를 보였다. Major trails of Chirisan National Park were selected to investigate the use impacts on trail according to the different amount of use. The entire width, bare width and maximum depth of trail as the trail condition surveyed at the total of 111 points were greater on the other National Parks. Major deterioration types of trail were rock-exposure, deeping, root-exposure, widening, in order of frequency. And trail conditions of deteriorated points were significantly different from those of non-deteriorated points.

직장암에서 수술 전 방사선-화학요법 후 발생한 후기 합병증

이승현,이철민,안병권,백승언 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

OBJECTIVES: To compare the late complications after operations for rectal cancers with and without preoperative chemoradiation. METHODS: From January 2003 to December 2005, 55 patients underwent operation after preoperative chemoradiation for adenocarcinoma of the rectum. All of them received the full scheduled dose of radiation with concurrent chemotherapy. The interval between preoperative chemoradiation and surgery was 4-6 weeks. 47 patients who had tumors below 8 cm from the anal verge were enrolled into the study group (CRT group). During same period, we selected 153 patients who had adenocarcinoma of the rectum below 8cm from the anal verge, underwent surgery alone without postoperative radiotherapy non-CRT group). We compared the early and the late postoperative complications between the CRT group and the non-CRT group. RESULTS: Of the late complications, the incidence of anastomotic stricture was significantly higher in the CRT group (P = 0.018). The incidence of anal stricture was higher in the CRT group (P = 0.164). In the CRT group, 3 cases (17.6%) had failed to preserve the anal function due to moderate or severe anal stricture. Of the 3 cases, protective ileostomy was persistent in 2 cases, colostomy was performed in one case. Otherwise, the late complications of the CRT group were intestinal obstruction in 2 cases (4.3%), lymph edema in 2 cases (4.3%). CONCLUSION: In CRT group, failure of anal function preservation due to anastomotic stricture or anal stricture was more common and serious than non-CRT group. We emphasize the need for careful management for postoperative anal stricture after preoperative chemoradiation.

Al 7075 合金의 時效硬化處理가 疲勞龜裂傳播에 미치는 影響

안창남,김현철,임병수 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2

An experimental investigation has been carried out to determine the effect of age hard-ening on the fatigue crack propagation behavior and mechanical properties using Al 7075 alloy hot extruded. Fatigue and mechanical property tests have been performed with the specimens prepared in various age hardening heat treatment conditions. Analysis of the experimental results was made to determine the relationship between Δ K_th, yield strength, % elongation and ageing temperature and time.

연화산 도립공원의 산림군집구조와 동태에 관한 연구

안현철,조현서 진주산업대학교 농업기술연구소 2000 農業技術硏究所報 Vol.13 No.-

본 연구는 연화산도립공원 소나무림의 식생구조와 동태를 분석하여 소나무림의 지속적인 유지와 경영에 대한 정보를 제공하기 위하여 수행되었다. 그 결과 연화산 도립공원의 산림군집 구조는 교목층(12종류), 아교목층(35종류), 관목층(50종류)으로 구성되어 있다. 각 층위별 중요치는 교목층에서 소나무(160.32)가 가장 높고 굴참나무(54.07%), 서어나무(36.41) 등이었다. 아교목층에서 서어나무(114.53), 굴참나무(27.66), 때죽나무(15.13), 졸참나무(12.48%) 등이 높은 우점율을 나타내었고, 관목층에서는 진달래(13.76), 당단풍(9.27), 덜꿩나무(9.57), 가막살나무(8.93) 등으로 나타났다. 조사방형구를 대상으로 출현-비출현에 의한 χ^2검정결과 느티나무-비목, 비목-서어나무, 자귀나무-산벚나무, 개서어나무-말채나무간에는 1% 수준에서 양의 상관이 인정되었고, 또 쪽동백-당단풍, 개옻나무-졸참나무 등 9개 수종간에는 5% 수준에서 양의 상관이 있어 동일한 생태적 지위를 가지고 있었다. 그리고 서어나무-당단풍, 굴참나무-느티나무, 소나무-산벚나무간에는 5% 수준에서 음의 상관이 발생하여 생태적 지위가 이질적이었다. 연화산 소나무림은 활엽수림과의 천이경쟁이 진행되고 있어 지속적인 소나무림 보존을 위한 관리가 요구된다. This study was focused on the dynamics and structure of Pinus densiflora forest to provide the information for management and sustainable maintenance in Mt. Yeonhwa Kyungnam Provincial park. The layer structure of Pinus densiflora forest were consist of tree layer (12 species), subtree layer (35 species), shrub layer (50 species). According to the importance value of stratification of layers, In tree layer, Pinus densiflora was dominante the highest value of 160.32%, Quercus variabilis 54.67, Carpinus laxiflora 36.41%, in middle layer were Carpinus laxifora 114.53%, Quercus variabilis 27.66%., Stylax japonica 15.13%, Quercus serrata 12.48%, Lindera erythrocarpa 24.52% and shrub layer were Rhododendron mucronulatum 13.76%, Acer pseudo-sieboldianum 9.27%, Viburnum erosum 9.57%, Viburnum dilatatum, 8.93% etc, respectively. Results of chi-square test statistics based on presence-absence parameters, the positively associated species pair were Zelkoba serrata - Lindera erythrocarpa, Lindera erythrocarpa-Carpinus laxiflora, Albizzia julibrissin-Prunus sargentii. And covariation was calculated based on quantitative measure of density. The results showed that the association and covariation values among species not agreed with each other. Pinus densiflora was competition status with Quercus variabilis and Carpinus laxiflora of tree layer, and Carpinus laxiflora was dominance species with Quercus variabilis of subtree layer. Therefore for the sake of sound management and sustainable maintenance of Pinus densiflora forests was requires to conserve for the natural resources and gene pool.

第1共和國의 反共政策에 관한 硏究

安哲鉉 慶星大學校 1994 論文集 Vol.15 No.1

응급환자에 대한 맥박산소측정기의 임상적 평가

안철민,이한식,조광현,황태식,김성규 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Pulse oximetry is a noninvasive method of measuring blood oxygen saturation even before changes to the cardiopulmonary functions become apparent clinically. Therefore it has been widely excepted in many disciplines as a standard patient monitoring equipment. But its accuracy has been argued at low oxygen saturation levels. To determine the accuracy of the pulse oximetry in the emergency department where the patients presenting with respiratory difficulty are expected to have low oxygen saturation levels. Prospective, cross-sectional, paired measurements of oxygen saturation by two different pulse oxineters(SpO2) against oxygen saturation of arterial blood gas analysis(SaO2) was performed from May 1994 to September 1995 at two different university hospitals. Two pulse oxineters each with its digital probe were applied to the patient for the measurement of SpO2 simultaneously and arterial blood gas was drawn for analysis(ABGA) at the same time to measure SaO2. 98 patients who met the criteria mostly consisted of cardiopulmonary patients. There were no significant differences between mean SpO2(88.1±11.4, 88.2±10.0) of the two pulse oximeters and mean SaO2(88.7±11.4) from the arterial blood gas analysis(p=NS). Strong correlations were found(r=.80). But the regression declined as SaO2 decreased especially SaO2 < 90%. The pulse oximetry is potentially useful in patients with clinical signs of acute hypoxemia and patients receiving interventions that may produce acute hypoxemia, because of their ability to continuously monitor the oxygen saturation. But pulse oximetry along cannot identify the degree of hypoxemia or severity of distress. Therefore patients complaining of respiratory difficulty in an emergengy department, history and physical examination must be performed with pulse oximeter as a guide while backing it up with ABGA.