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치수절단술에 사용되는 약제가 백서 치배 및 치배주위조직세포에 미치는 영향에 관한 ^3H-thymidine을 이용한 자기방사법적인 연구
박경주,이종헌,임창윤 단국대학교 치의학연구소 1992 논문집 Vol.4 No.-
Formocresol(FC) had been widely used as medicament for pulpotomy, but because FC have strong toxicity, carcinogenic potential, and strong diffusible properties in tissues, Glutaraldehyde, another medicament for pulpotomy was greatly presented by many investigators and practitioners. Although many investigators had studied difference of two medicament's effects on periodontal tissues and tooth germ, there were no manuscripts of cellular activity about these medicaments applied to teeth, but there were almost clinical, histopathological studies. Especially in the investigative effects on tooth germ, the results were controversal. Thus to investigate about effects on cellular actiity of perigerminal tissue and tooth germ of rat, author presented the cellular activity and the pathologic change through calculating Thymidine labelling index(TLI) from autoradiographic technique using 3H-thymidine after these medicaments were applied to tooth. The obtained results were as follows. 1. Inflammation was initiated after one week of FC and two weeks of GA. It was thought that diffusible property of GA was lesser than that of FC. 2. In group treated with FC, inflammation, vasodilation and bone destruction continuously increased for all periods of experiment and the feature of 8 weeks was very severe. But in group treated with GA, inflammation, vasodilation and bone destruction slightly incresed for all period of experment. 3. TLI was increased after two weeks of FC, but decreased after four weeks because of different accumulative concentration between 2 and 4 weeks. 4. GA treated group which did not show the change of the cellular activity of perigerminal tissue and tooth germ presented the slight effects on these cells. 5. Changes of cellular activities in FC treated group did not result from inflammation, but formocresole's property itself. And bone destruction was derived from secondary effects of inflammation. 6. The fact that FC arose severe inflammation and change of cellular activity reflected that FC might affected
김인아,박영주,서문경애,임지영 대한간호학회 간호행정학회 2006 간호행정학회지 Vol.12 No.2
Purpose: The objective of this literature review study was to identify patterns and trends of studies on leadership among nurse managers in nursing organization and suggest the direction of future researches. Methods: Research Studies on the leadership were selected from thesis and related journals, which had been conducted from 1975 to 2006.5. Search Terminologies were used "leadership". The Total number of the collected studies were 69. Results: The number of studies on leadership has been increased rapidly since 1990's. In research design, Quantitative studies were 68 except for a Qualitative study. Correlation research were 45(65.2%) among quantitative studies. Conceptual frameworks, research questions and hypotheses were involved 31.9%, 98.6%, 31.9%. In subject, General nurse is 46.4%, Head nurse and General nurse was 23.2% and Head nurse is 2.9%. All the studies used questionnaire in data collection method. Measurement tools were used 50% for Bass' MLQ(MLQ-5X). For the statistical analysis, Correlation, ANOVA, t-test were used for 20.3%, 17.4%, 10.5% respectively. The number of leadership related variables were work-related, organization-related, personal recognition or attitude, empowerment, personality. The sub-variables were used for 31 Job satisfaction. Further studies were suggested the develop of leadership program, measurement for the effect of leadership, repeated studies on leadership, the development of measurement about leadership. Conclusion: These results will be used to provide the basic data for developing leadership theory on nursing organization.
Lim, Sun Min,Park, Byeong Bae,Park, Keun‐,Chil,Kim, Hoon‐,Kyo,Lee, Jong Seok,Bae, Sung Hwa,Lee, Seung‐,Sei,Kang, Jin‐,Hyoung,Park, Se‐,Hoon,Lee, Gyeong‐,Won,Lee, Hy John Wiley and Sons Inc. 2016 Thoracic cancer Vol.7 No.2
<P><B>Abstract</B></P><P><B>Background</B></P><P>To investigate the efficacy, safety, and tolerability of weekly docetaxel treatment in advanced non‐small cell lung cancer (NSCLC) patients in Korea.</P><P><B>Methods</B></P><P>This prospective observational study included Korean advanced NSCLC patients with Eastern Cooperative Oncology Group performance status <2 who received weekly monotherapy of docetaxel at a dose determined by the physician. Efficacy measurements included tumor response rate, overall survival (OS), progression‐free survival, and one‐year survival rate. Safety was analyzed through recorded incidences of adverse events (AEs), serious adverse events (SAEs), deaths, and other related safety parameters, along with their toxicity grades.</P><P><B>Results: </B></P><P>Of 274 patients analyzed, one patient achieved a complete response and 42 partial responses; thus, the overall response rate was 15.7%. The OS rate at baseline and at one‐year follow‐up was 38.3% and 33.8%, respectively. AEs were reported in 229 (83.6%) patients. The most frequently reported hematologic AE of grade ≥3 was a decrease in neutrophils, with 6.6% of the patients developing neutropenia. In non‐hematologic AEs of grade ≥3, the most common were infection with unknown absolute neutrophil count and death not associated with Common Terminology Criteria for Adverse Events (CTCAE) (4.7% each). The most common SAE reported was death, not associated with CTCAE (7.3%).</P><P><B>Conclusions</B></P><P>In Korean patients, the weekly regimen of docetaxel monotherapy was safe and efficacious against advanced NSCLC.</P>
임경묵(Lim, Gyeong-Muk),임병철(Lim, Byung-Chul),박상흡(Park, Sang-Heup) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.2
그레이팅은 건축, 토목에서 배수의 주목적으로 하는 구조물이다. 본 연구 에서는 가로형 그레이팅보다 유속에 대한 저항성을 감소시킨 구조인 세로형 그레이팅의 3가지 모델(35.3형, 40형, 43형)을 시뮬레이션하여, 응력 분포 및 변형에 대해 연구하고 최적의 격자 간격의 그레이팅을 설계함이 목적이다. 세로형과 가로형 그레이팅에 하중에 대한 최대 응력 및 변형을 비교 분석하여 보다 나은 제품을 확인하였다. The grating is the main purpose of drainage in civil engineering, architecture. This study examined the change and stress distribution by simulating three models of Vertical type grating structures that reduced the resistibility in respect of velocity rather than horizontal type grating and to design a grating with the optimal grating gap. The vertical type and horizontal type grating were compared in terms of the maximum stress and strain to identify the better product.
Park, Oee-Sook,Lim, Jae-Gyeong The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.6
A new formal total synthesis of (+)-6-oxo-3, 4, 4a, 5-tetrahydro-3-hydroxy-2, 2-dimenthylnaphtho-1, 2-pyran (1) which has been known to have bactericidal, bacteriostatic, fungicidal, fungistatic activities against Staphylococcus aureus and other microorganism, is described. The key reaction involves enantioselective prenylation of .alpha.-tetralone via chiral lithioenamine.