少腹逐瘀湯의 效能에 關한 實驗的 硏究

金恩基,張峻福,李京燮,宋炳基 慶熙大學校 1995 論文集 Vol.24 No.-

This experiment was performed on analgesic, anti-pyretic, sedative, anti-swelling, anti-thrombotic, anti-tumor effect and response of isolated uterus by administrating high and low concentration of Sopokchukeotang's hot-water-extract to experimental animals. This administration purpose to investigate the efficacy of the Sopokchukeotang which is known as having effects on treating female genital diseases on basis of oriental medicine literature and its clinical use. The results obtained were as follows: 1. The writhing syndrome induced by acetic acid was decreased by administration of the Sopokchukeotang's hot-water-extract. However, there was no statistical significance between sample and control group. 2. The administration of the Sopokchukeotang's hot-water-extract elevated the pain threshold significantly by on hindpaw edema induced by 1% carrageenin in rat. 3. Abnormally elevated body temperature induced by thyphoid vaccine was decreased by the administration of the Sopokchukeotang's hot-water-extract. But, there was no statistical significance. 4. Sleeping time induced by Pentobarbital-sodium was prolonged by the administration of the Sopokchukeotang's hot-water-extract. However significant effect was recognized only in the treated by low concentration group(p<0.05). 5. The significant decrease of swelling induced by carrageenin was noted in the group treated by high concentration(p<0.05, p<0.01). 6. The group treated by low concentration showed significant anti-swelling effect on the swellings induced by yeast, but not in the group treated by high concentration didn't show it(p<0.05). 7. The serum FDP was decreased significantly by administrating the Sopokchukeotang's hot-water-extract to the experimental thrombosis(p<0.05, p<0.01). 8. The serum fibrinogen was increased significant by the administration of the Sopokchukeotang's hot-water-extract on the experimental thrombosis(p<0.01, p<0.001). 9. The prothrombin time was not influenced by the adminstration of the Sopokchukeotang's hot-water-extract on the experimental thrombosis. 10. The administration of the Sopokchukeotang's hot-water-extract did riot make a prolongation the survival in Saroma 180 ascitic tumor implanted Rats. 11. The administration of the Sopokchukeotang's hot-water-extract had no effect on the normal movement of the isolated uterus. However, it showed the relaxation effect on the oxytocin induced muscle contraction of the isolated uterus. According to the above results, it might be recognized that the Sopokchukeotang's hot-water-extract has the effect of analgesia, anti-pyrexia, sedation, anti-swelling, anti-thrombosis and relaxation effect on the oxytocin induced contraction of uterus muscle. However, anti-tumor effect of Sopokchukeotang's hot-water-extract was not appeared in the experiments. According to the above results. Sopokchukeotang's not-water-extract can be applied on the various inflammatory diseases in female genital organs.

운동신경원성 질환을 동반한 전두측두엽치매의 임상양상과 신경심리소견

박기정,정용,김은주,진주희,강수진,나덕렬 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1

Backgrounds:Frontotemporal dementia (FTD) is rarely associated with motor neuron disease (MND). This comorbidity (FTD-MND), a subtype of FTD, results in progressive dementia and muscle weakness. Among the few available reports of series of patients, however, there have been controversies about the clinical course of FTD-MND. This study, the first report of a series of FTD-MND patients in Korea, investigated demographic and clinical features, clinical course, and neuropsychological findings of nine patients with FTD-MND. Methods:Nine FTD-MND patients (2 men and 7 women with mean age 55.6±7.2 years) were selected among 45 FTD patients who met the FTD criteria proposed by the Lund and Manchester Groups. Their clinical and neuropsychological findings were analyzed retrospectively. Results:Mean age of onset was 54.3±8.0 years. The time interval from onset to death was 27±11.3 months. Presenting symptoms were personality change, hyperphagia, nonfluent speech or motor weakness. In most cases (8/9), dementia preceded the muscle weakness;in only one patient the muscle weakness preceded the cognitive decline. Regarding the muscle weakness, bulbar symptoms occurred earlier than limb weakness in four patients;bulbar and limb weakness occurred simultaneously in another four patients;in the remaining one patient limb weakness preceded bulbar weakness. Neuropsychologic tests showed no specific patterns but diffuse dysfunction in all cognitive domains. Conclusions:Our study suggests that FTD-MND predominantly affects the bulbar muscles rather than the limb muscles in early stage and symptoms related to MND occurs later than those related to FTD. The time from diagnosis to death was 10.6±6.5 months, suggesting that FTD-MND is a rapidly progressive disease. This rapid clinical course may account for our neuropsychological findings that showed general cognitive deficits father than predominant frontal dysfunctions.

혐기·호기공정을 이용한 생물막법에서 유기물, 질소 및 인제거에 관한 연구

이성기,송영일,김현중,진성기,김은영 조선대학교 환경연구소 2001 環境硏究 Vol.17 No.1

Anoxic and Oxic process with contact media is used to remove an organic matter, nitrogen and phosphorus in sewage which derives from domestic wastewater. Experiments have been done with various conditions that concentration of oxygen can be 3mg/ℓ, 4∼5mg/ℓ and 5∼6mg/ℓ by controlling an retention time can be 10hr, 12hr and 14hr, return rate can be 0%, 100% and 200%. As the concentration of oxygen is 2∼3mg/ℓ. The rate of removal of BOD. COD. SS. T-N and T-P is 87%, 76%, 82%, 34% and 24%. As the concentration of oxygen is 5∼6mg/ℓ. The rate of removal of BOD, COD, SS, T-N and T-P is 92%, 84%, 88%, 45% and 33%. In the rate of removal of an organism, nitrogen and phosphorus thus It well be known that the rate of removal an organic matter, nitrogen and phosphorus will be increased as the concentration of oxygen becomes higher. As th retention time is increased, the rate of removal of BOD, COD, SS, T-N and T-P is gradually higher in the rate of removal of an organic matter, nitrogen and phosphorus. Because contact time and contact area will be increased, which generates active substrate transfer and metabolic react according to increment of retention time. As the return rate is increased. The rate of removal of BOD, COD and SS is likely to be increased. In the case of T-N. It is also increased by 28% at 0% of the return rate and by 60% at 200% of the return rate. In the case of T-P, however, It is deceased, as the return rate is increased by 42% at 0% of the return rate and by 30% at 00% of the return. As the return rate is increased the retention time is decreased, which causes less activity of bacterial which affects that the rate of removal of Phosphorus is decreased.

혐기·호기공정을 이용한 생물막법에서 유기물, 질소 및 인제거에 관한 연구

이성기,송영일,김현중,진성기,김은영 조선대학교 환경공해연구소 2001 環境公害硏究 Vol.17 No.1

Anoxic and Oxic process with contact media is used to remove an organic matter, nitrogen and phosphorus in sewage which derives from domestic wastewater. Experiments have been done with various conditions that concentration of oxygen can be 3㎎/ℓ, 4~5㎎/ℓ and 5~6㎎/ℓ by controlling an retention time can be 10hr, 12hr and 14hr, return rate can be 0%, 100% and 200%. As the concentration of oxygen is 2~3㎎/ℓ, The rate of removal of BOD. COD, SS, T-N and T-P is 87%, 76%, 82%, 34% and 24%. As the concentration of oxygen is 5~6㎎/ℓ, The rate of removal of BOD, COD, SS, T-N and T-P is 92%, 84%, 88%, 45% and 33%. In the rate of removal of an organism, nitrogen and phosphorus thus It well be known that the rate of removal an organic matter, nitrogen and phosphorus will be increased as the concentration of oxygen becomes higher. As th retention time is increased, the rate of removal of BOD, COD, SS, T-N and T-P is gradually higher in the rate of removal of an organic matter, nitrogen and phosphorus. Because contact time and contact area will be increased, which generates active substrate transfer and metabolic react according to increment of retention time. As the return rate is increased, The rate of removal of BOD, COD and SS is likely to be increased, In the case of T-N, It is also increased by 28% at 0% of the return rate and by 60% at 200% of the return rate. In the case of T-P, however, It is deceased , as the return rate is increased by 42% at 0% of the return rate and by 30% at 200% of the return. As the return rate is increased the retention time is decreased, which causes less activity of bacteria which affects that the rate of removal of Phosphorus is decreased.

전두측두엽 치매의 행동 및 심리적 증상

강수진,이병화,김은주,박기정,나덕렬 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2

Background: Frontotemporal dementia (FTD) usually presents with behavioral and psycho-logical symptoms of dementia (BPSD) rather than cognitive deficits. Thus, understanding of BPSD associated with FTD is important not only from the management perspective but also from the diagnostic viewpoint. However, few studies have investigated BPSD in patients with FTD in Korea. The aim of the current study is to describe in detail BPSD associated with FTD. Methods: Firstly, a BPSD list was designed based on the symptoms reported in previous studies of FTD, items from the Neuropsychiatric Inventory (NPI), and the review of medical records of FTD patients from our clinic including FTD patients not selected in this study. Then an interviewer asked caregivers whether the BPSDs listed had been present from onset of disease to the time of interview. Subjects who participated in the interview consisted of 23 patients (9 men and 14 women) with a mean age of 65.6 (range, 41-75) years who met the FTD criteria proposed by the Lund and Manchester group. The BPSD list was completed by face-to-face interviews or by telephone interviews with the caregivers. Results: BPSDs as classified by subscales of the NPI in the order of frequency were aberrant motor behavior (95.6%), apathy (95.6%), disinhibition (91.3%), appetite/eating change (91.3%), agitation/aggression (87%), euphoria (65.2%), anxiety (60.9%), irritability/lability (52.1%), delusions (43.5%), night-time behavior (39.1%), depression/dysphoria (34.8%), hallucinations (0%). Other symptoms not listed in the NPI were stereo-typical behaviors as stereotypy of ordering, hoarding, reading signboards, wandering a fixed route, washing, and counting, utilization behaviors, and sundowning. Conclusion: Our detailed description of BPSD associated with Korean FTD patients would help understand symptoms of FTD and develop a Korean version of BPSD questionnaire for FTD in the future studies.

Suppression of Lipopolysaccharide-Induced Microglial Activation by a Benzothiazole Derivative

Kim, Eun-A,Kim, Han-Wook,Ahn, Jee-Yin,Hahn, Hoh-Gyu,Kim, Key-Sun,Kim, Tae-Ue,Cho, Sung-Woo Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.1

We previously reported that KHG21834, a benzothiazole derivative, attenuates the beta-amyloid (A${\beta}$)-induced degeneration of both cortical and mesencephalic neurons in vitro. Central nervous system inflammation mediated by activated microglia is a key event in the development of neurodegenerative disease. In this study, we show that KHG21834 suppresses inflammation-mediated cytokine upregulation. Specifically, KHG21834 induces significant reductions in the lipopolysaccharide-induced activation of microglia and production of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interlukin-1${\beta}$, nitric oxide, and inducible nitric oxide synthase. In addition, KHG21834 blocks the expression of mitogen-activated protein kinases, including ERK, p38 MAPK, JNK, and Akt. In vivo intracerebroventricular infusion of KHG21834 also leads to decreases the level of interleukin-1${\beta}$ and tumor necrosis factor-${\alpha}$ in brain. These results, in combination with our previous findings on A${\beta}$-induced degeneration, support the potential therapeutic efficacy of KHG21834 for the treatment of neurodegenerative disorders via the targeting of key glial activation pathways.

Improved Cloning Efficiency and Developmental Potential in Bovine Somatic Cell Nuclear Transfer with the Oosight Imaging System

Kim, Eun Young,Park, Min Jee,Park, Hyo Young,Noh, Eun Ji,Noh, Eun Hyung,Park, Kyoung Sik,Lee, Jun Beom,Jeong, Chang Jin,Riu, Key Zung,Park, Se Pill Mary Ann Liebert 2012 Cellular reprogramming Vol.14 No.4

Proline-Rich Transcript in Brain Protein Induces Stress Granule Formation

Kim, Jung-Eun,Ryu, Incheol,Kim, Woo Jae,Song, Ok-Kyu,Ryu, Jeongeun,Kwon, Mi Yi,Kim, Joon Hyun,Jang, Sung Key American Society for Microbiology 2008 Molecular and cellular biology Vol.28 No.2

<B>ABSTRACT</B><P>The repression of translation in environmentally stressed eukaryotic cells causes the sequestration of translation initiation factors and the 40S ribosomal subunit into discrete cytoplasmic foci called stress granules (SGs). Most components of the preinitiation complex, such as eIF3, eIF4A, eIF4E, eIF4G, and poly(A)-binding protein, congregate into SGs under stress conditions. However, the molecular basis of translation factor sequestration into SGs has not been clearly elucidated. Here, we report that proline-rich transcript in brain (PRTB) protein interacts with eIF4G and participates in SG formation. PRTB was recruited to SG under sodium arsenite and heat stress conditions. When overexpressed, PRTB inhibited global translation and formed SGs containing TIA-1, eIF4G, and eIF3. Knockdown of PRTB reduced the SG formation induced by sodium arsenite. These results suggest that PRTB not only is a component of SG formed by cellular stresses but also plays an important role in SG formation via an interaction with the scaffold protein eIF4G, which is associated with many translation factors and mRNAs.</P>

Post-Death Cloning of Endangered Jeju Black Cattle (Korean Native Cattle): Fertility and Serum Chemistry in a Cloned Bull and Cow and Their Offspring

KIM, Eun Young,SONG, Dong Hwan,PARK, Min Jee,PARK, Hyo Young,LEE, Seung Eun,CHOI, Hyun Yong,MOON, Jeremiah Jiman,KIM, Young Hoon,MUN, Seong Ho,OH, Chang Eon,KO, Moon Suck,LEE, Dong Sun,RIU, Key Zung,P The Society for Reproduction and Development 2013 The Journal of reproduction and development Vol.59 No.6

<P><B>Abstract</B></P><P> To preserve Jeju black cattle (JBC; endangered native Korean cattle), a pair of cattle, namely a post-death cloned JBC bull and cow, were produced by somatic cell nuclear transfer (SCNT) in a previous study. In the present study, we examined the <I>in vitro</I> fertilization and reproductive potentials of these post-death cloned animals. Sperm motility, <I>in vitro</I> fertilization and developmental capacity were examined in a post-death cloned bull (Heuk Oll Dolee) and an extinct nuclear donor bull (BK94-13). We assessed reproductive ability in another post-death cloned cow (Heuk Woo Sunee) using cloned sperm for artificial insemination (AI). There were no differences in sperm motility or developmental potential of <I>in vitro</I> fertilized embryos between the post-death cloned bull and its extinct nuclear donor bull; however, the embryo development ratio was slightly higher in the cloned sperm group than in the nuclear donor sperm group. After one attempt at AI, the post-death cloned JBC cow became pregnant, and gestation proceeded normally until day 287. From this post-death cloned sire and dam, a JBC male calf (Heuk Woo Dolee) was delivered naturally (weight, 25 kg). The genetic paternity/maternity of the cloned JBC bull and cow with regard to their offspring was confirmed using International Society for Animal Genetics standard microsatellite markers. Presently, Heuk Woo Dolee is 5 months of age and growing normally. In addition, there were no significant differences in blood chemistry among the post-death cloned JBC bull, the cow, their offspring and cattle bred by AI. This is the first report showing that a pair of cattle, namely, a post-death cloned JBC bull and cow, had normal fertility. Therefore, SCNT can be used effectively to increase the population of endangered JBC.</P>

Entity Summarization Based on Entity Grouping in Multilingual Projected Entity Space

KIM, Eun-kyung,CHOI, Key-Sun 'Institute of Electronics, Information and Communi 2017 IEICE transactions on information and systems Vol.100e.d No.9

<P>Entity descriptions have been exponentially growing in community-generated knowledge databases, such as DBpedia. However, many of those descriptions are not useful for identifying the underlying characteristics of their corresponding entities because semantically redundant facts or triples are included in the descriptions that represent the connections between entities without any semantic properties. Entity summarization is applied to filter out such non-informative triples and meaning-redundant triples and rank the remaining informative facts within the size of the triples for summarization. This study proposes an entity summarization approach based on pre-grouping the entities that share a set of attributes that can be used to characterize the entities we want to summarize. Entities are first grouped according to projected multilingual categories that provide the multi-angled semantics of each entity into a single entity space. Key facts about the entity are then determined through in-group-based rankings. As a result, our proposed approach produced summary information of significantly better quality (p-value = 1.52 x 10(-3) and 2.01 x 10(-3) for the top-10 and -5 summaries, respectively) than the state-of-the-art method that requires additional external resources.</P>