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( Ye-eun Kim ),( Seong-eun Ko ),( Da-eun Sa ),( Ji-eun Lee ),( Se-yoon Jeon ),( Do-seon Lim ) 한국치위생과학회 2020 치위생과학회지 Vol.20 No.4
Background: This study tries to compare and analyze the removal effect of dental plaque of general dentifrice and pregnant women’s dentifrice and quantify the results to provide basic data so that consumers can make reasonable choices when purchasing dentifrice, and also increase interest in the dental plaque. Methods: After forming a dental plaque (carbohydrate porridge) on the labial surface of the bovine teeth, a disclosing agent was applied. Then the same experimenter brushed the surface of the bovine teeth using an electric toothbrush and took photographs using a DSLR camera. Thereafter, the residual amount of dental plaque was analyzed using the ImageJ program, and SPSS 26.0 was used for statistical processing. Results: The average residual amount of dental plaque using the general dentifrice was 11.71% for Perio, 9.45% for Cliden, and 8.47% for 2080, and the average residual amount for the three types was approximately 9.88%. The average residual amount of dental plaque of pregnant women’s dentifrice was 13.95% for Jeninmothers, 12.53% for Tntnmoms, and 12.63% for Mommiracle, and the average residual amount of the three types was approximately 13.04%. On comparing the average residual amount of dental plaque between general and pregnant women’s dentifrices, it was observed to be 3.16% higher for the latter. However, the results were not statistically significant. Conclusion: According to the research results, there was no significant difference in removal effects of general dentifrice and pregnant women’s dentifrice. In addition, when a pregnant woman uses the right toothbrushing method with pregnant women’s dentifrice, it can prevent or inhibit the progression of the gestational periodontal disease. Therefore, we recommend pregnant women to use pregnant women’s dentifrices.
( Sa Ra Lee ),( Da Eun Lee ),( Hye Won Chung ),( Seung Cheol Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
We report a case of advanced stage pelvic organ prolapse (POP) as a result of pelvic floor muscle weakness after sacrococcygeal teratoma surgery. A 22-year-old woman who complaining of protruding mass was examed and POP-Q stage III was diagnosed. Pelvic muscle contraction was examined and it was normal. She had a history of sacral mass noted postnatally. She underwent sacral mass excision at her postnatal 5 days. 10 months later, she was very difficult in defecation and recurrence of sacral mass was noted. An explo-laparotomy was conducted and the pathologic diagnosis was sacrococcygeal teratoma with focal embryonal carcinoma. Six cycles of chemotherapy with CIS- VAB regimen was conducted. Left lower extremity hemiplegic gait and severe leg weakness with widen knee joint range of motion were noted immediate postoperation period. However she showed normal gait now and the EMG was conducted and there was no abnormality in pelvic floor muscle and pudendal nerve conduction. We inserted pessary number 4 and her POP related symptom was relieved and well tolerated.
IL-10 and TNF-α level changes in Oviduct and Endometrium at the Preimplantation Period in Sows
Da-Yeon Jeon(전다연),Soo-Jin Sa(사수진),Hyun-Ju Park(박현주),Hyun-Ju Jin(진현주),Jo-Eun Kim(김조은),Ye-Jin Min(민예진),Yo-Han Choi(최요한),Yong-Dae Jeong(정용대),Jo-Eun Kim(정학재) 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.11
수정란이 착상하는 동안 모체의 생식 기관에서 면역 세포 군집의 변화가 발생하며 이는 임신 과정의 핵심이다. 착상 전·후 기간동안 T 림프구를 포함한 면역 세포는 이식 초기에 생식 기관으로 불러들여지며, T 림프구 중 보조T세포인 Th1과 Th2 사이의 균형은 착상의 성공에 중요한 영향을 미친다. 본 연구에서는 돼지 수정란 착상 전 모체의 난관(OVI), 자궁내막 (ENDO), 자궁 점막층 (UML)에서 Th1, Th2의 균형을 확인하고자 종양괴사인자-알파 (TNF-α)와 인터루킨-10 (IL-10)의 농도를 효소결합 면역흡착 분석법 (ELISA)을 이용해 분석하였다. IL-10의 경우 7일차에 OVI, ENDO, UML에 유의한 차이가 있었으나 (p < 0.01), TNF-α의 경우 모두 유의한 차이가 없었다. IL-10:TNF-α 비율은 OVI에서만 7일째에 유의한 차이가 나타났다 (p < 0.05). 본 연구의 결과는 착상 전 생식 기관별 염증-항염증 기전의 변화를 통해 모체의 생식계가 배아를 수용하는 과정의 일부를 뒷받침할 수 있다. After implantation, dramatic shifts in immune cell populations occur in the maternal reproductive tract, and these changes are key to the implantation and pregnancy process in sows. Immune cells, including T lymphocytes, are recruited during the early implantation period, and an accurate balance between Th1 and Th2 is essential for successful implantation. In this study, the concentration of TNF-α (tumor necrosis factor-alpha) and IL-10 (interleukin-10) in early pregnancy were investigated using an enzyme-linked immunosorbent assay (ELISA) to determine Th1/Th2 ratios in oviduct (OVI), endometrium (ENDO), and the uterine mucosal layer (UML) before implantation. Significant differences in IL-10 levels were observed in OVI, ENDO, and UML tissues on day 7 post-implantation (p < 0.01), whereas TNF-α levels were no different. As regards IL-10 and TNF-α ratios, a significant difference was found on day 2 in OVI tissues (p < 0.05). The result of this study supports the notion that the maternal reproductive system accepts the embryo through changes in preimplantation reproductive system-specific pro-/anti-inflammatory mechanisms.
( Da Eun Lee ),( So Yun Park ),( Sa Ra Lee ),( Kyungah Jeong ),( Hye Won Chung ) 대한폐경학회 2015 대한폐경학회지 Vol.21 No.3
Objectives: To determine the diagnostic performance of transrectal ultrasound in virgin patients with polycystic ovary syndrome (PCOS) by receiver operating characteristic (ROC) curve analysis, compared with conventional transvaginal ultrasound assessment. Methods: Ultrasound examinations were performed in 963 Korean women, with transvaginal transducers in 677 women and transrectal transducers in 286 women at Ewha Womans University Mokdong Hospital. Transvaginal ultrasound examinations were performed in 494 normal control women and 183 PCOS patients according to National Institutes of Health (NIH) PCOS diagnostic criteria. In virgin patients, transrectal ultrasound examinations were performed in 141 normal control women and 145 PCOS patients. ROC curves were calculated for ovarian volume and follicle number. Results: By transvaginal ultrasound examination, the ovarian volume showed an area under the ROC curve (AURC) of 0.838. An ovarian volume decision threshold > 7 cm3 had a sensitivity of 73.0% and a specificity of 84.2% for the diagnosis of PCOS. The follicle number showed an AURC of 0.886. A follicle number decision threshold ≥ 9 had a sensitivity of 78.6% and a specificity of 87.2% for the diagnosis of PCOS. By transrectal ultrasound examination, the ovarian volume and the follicle number showed AURCs of 0.815 as same thresholds with a sensitivity of 67.2% and 66.4%, respectively and a specificity of 86.8% each. Ovarian volume and follicle number by transvaginal and transrectal ultrasound assessment had a high diagnostic power for PCOS screening. Conclusion: Transrectal ultrasound assessment is as effective as conventional transvaginal ultrasound for the detection of PCOS in virgin patients. (J Menopausal Med 2015;21:149-154)
( Da Eun Lee ),( Soo Yeon Park ),( So Yun Park ),( Sa Ra Lee ),( Hye Won Chung ),( Kyung Ah Jeong ) 대한폐경학회 2014 대한폐경학회지 Vol.20 No.3
Objectives: The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. Methods: In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormones, glucose metabolic and lipid profiles, and transvaginal or transrectal ultrasonogram were carried out. HOMA-IR was then calculated and compared with the clinical and biochemical profiles related to PCOS. The patients were divided into 4 groups by quartiles of HOMA-IR. Results: The mean level of HOMA-IR was 2.18 ± 1.73. Among the four groups separated according to HOMA-IR, body weight, body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, lipid accumulation product (LAP) index, high-sensitivity C-reactive protein (hs-CRP), Apoprotein B, free testosterone, and sex hormone binding globulin (SHBG) were found to be significantly different. TG, LAP index, glucose metabolic profiles, and hs-CRP were positively correlated with HOMA-IR after adjustment for BMI. Conclusion: Our results suggest that the clinical and biochemical profiles which are applicable as cardiovascular risk factors are highly correlated with HOMA-IR in Korean women with PCOS. (J Menopausal Med 2014;20:104-110)
Prolonged survival of islet allografts in mice treated withrosmarinic acid and anti-CD154 antibody
Da-Yeon Jung,주성연,Jae Berm Park,Eun-Young Kim,문철,Sa Hyun Kim,Eun-Young Sim,조재원,권준혁,권기영,김성주 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1
Pancreatic islet transplantation can corect the abnor-immunosuppressants greatly reduce the acute re-jection rate in transplant patients, the long-term side efects can be debilitating. Therefore, researchers are seeking to develop new immunosuppressive regi-mens that induce maximal levels of imunosuppres-sion with minor side effects. Rosmarinic acid (Ros A) is a secondary metabolite of certain herbs and has mul-tiple biological activities, including anti-inflamatory effects. Here, we have investigated whether treatment monoclonal antibody (MR1) improves islet allograft survival in a murine model. After transplantation, the mice were treated with either Ros A, MR1, or both (the "double" treatment). Alograft survival was prolonged in the double-treated animals compared to animals that received only Ros A or MR1. As is the case with the single-treated animals at 15 days after transplantation, the double-treated recipients did not display a sig-nificant decrease in the expression of cytokines or the ls. Infiltrating CD3+ T cells were reduced in the MR1- or double therapy relative to control or RosA group. However, at the same time point, double-treated graft showed fewer apoptotic cells and increased expression of insulin and gluca-gons, compared to the single-treatment groups. Fur-thermore, long-term (> 150 days) alografts that were received with double therapy exhibited larger islet clusters and contained more insulin- and gluca-conclusion, treatment with both Ros A and MR1 has a synergistic efect in murine islet allotransplantation.