난소 절제 백서에서 17β-Estradiol 투여가 골조직에 미치는 영향

장원석,김종렬,박봉수,성일용 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

This study was focused on the changes of mineral density and histopathologic features of osseous tissue when ovariectomized rats were administered with 17β-Estradiol. Forty-eight rats, 11 weeks of age, were divided into four groups, which are a normal control group, an ovariectomized control group, an experimental group 1 which was given 17β-estradiol immediately after the ovariectomy and an experimental group 2 which was given 17β-Estradiol 3 weeks after the ovariectomy. They were sacrificed at different time intervals (1, 3, 4 and 8 weeks) for histopathologic observation, histo-morphometric analysis and immunohistochemistry with fibronectin and CD34 antibody. Most rats showed the increase in bone density, which was the least in the ovariectomized control group. In histopathologic features of both the mandible and the tibia, the osteoclasts in bone marrow increased in the ovariectomized control group of more than 3 weeks. In histomorphometric analysis, the osteoclasts increased in both the mandible and the tibia in length of time. In comparison of the increase of osteoclast between four groups, it decreased as following order: the ovariectomized control group, the expermiental group 2 the experimental group 1, the normal control group. Especially the experimental group 1 and experimental group 2 at 4 weeks showed remarkable changes both in the mandible and in the tibia in comparison with the ovariectomized control group. In immunohistochemical anaylsis with fibronectin, the more week-ovariectomized control groups of both the mandible and the tibia showed weaker fibronectin expression in osteoblast and bone marrow. Among the experimental group 1 and 2, 4-week group showed the strongest expression. In immunohistochemical analysis with CD34, the mandible showed generally weak expression but 8-week experimental group 1 and 2 showed relatively moderate expression in osteoblast and bone marrow. In case of the same groups of tibia, 4-week group show the strongest expression. With all these results, it is assumed that 17β-Estradiol has more effect on the development and differentiation of osteoclasts than those of osteoblasts and contributes to the initial bone formation most efficiently by inhibiting osteoclastic action and stimulating osteoblasts.

상용 소프트웨어 GENESIS를 이용한 강도 설계 민감도해석에 관한 연구

이선봉,장득열,조석수 三陟大學校 2001 論文集 Vol.34 No.1

Mechanical component under fatique loading has striation with constant width, and SEM can estimate fracture type and loading condition. SEM has benefit to fatigue fracture analysis but striation can be observed according to the kind of material and range of crack growth rate, and can't. In this case, it needs AFM that can measure 3-dimensional surface profile with resolution of atomic size. In this study, to find fracture reason of torsion-mounted blade in nuclear plant, we estimate the relation between stress intensity factor range and surface roughness in 12% Cr steel by AFM and predict in-service load condition. Finite element analysis is performed on torsion-mounted blade

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

중환자실에서 기계적 환기를 시행받는 환자들의 기관내삽관 튜브의 기낭내압

이영주,윤장운,문봉기,이규완,박미미,이영석 아주대학교 1997 아주의학 Vol.2 No.2

Background and Objectives : High volume, low pressure (HVLP) cuffed tubes have been substituted for low volume, high pressure (LVHP) cuffed tubes in order to reduce complications created by the cuffed endotracheal tubes contact with the tracheal wall. Several physidans, however, prefer to use the LVHP cuff for habitual or economic reasons. Even so, careless cuff Inflation of the HVLP cuff could also induce complications. The purposes of this study were to see whether there are any differences between the usual intracuff pressure (UICP) and the Optimum intracuff pressure (OICP), to compare the OICP of three groups, and to study the correlation between the OICP and the peak inspiratory pressure (PIP) of three kinds of endotracheal tubes under mechanical Ventilation. Methods : 82 adult patients, upon admission of the ICU, were divided into 3 groups with different cuffed tube types according to the following: Portex Profile group (n=66), HVLP cuffed tube; Portex Regular group (n=11), LVHP cuffed tube; Rusch Red group (n=5), LVHP cuffed tube. We used the Portex cuff pressure manometer for Portex Profile group, the Hewlett-Packard pressure transducer for Portex Regular, and Rusch Red group to measure the intracuff pressure (ICP). The OICP was measured with the minimal leak technique (MLT). Intracuff pressure difference (ICPD) was calculated by subtracting OICP from UICP. Results : UICP and OICP of Portex Profile group were 33.12±22.25 ㎝H₂O, 22.02±12.5㎝H₂O, Portex Regular group, 70.09±30.88 ㎝H₂O, 69.45±30.41 ㎝H₂O and Rusch Red group, 378.40±38.60 ㎝H₂O, 337.60±74.45 ㎝H₂O. Significant difference was shown among the groups (p < 0.05). The significant difference of the PIP was not seen among the groups. Significant correlation between OICP and PIP (regression = 0.463, p < 0.01) was demonstrated only in Portex Profile group. ICPD of three groups were as high as 84 ㎝H₂O to as low as -56 ㎝H₂O. About 40% of the patients showed the allowable range. Conclusions : This study suggests that routine check-ups of ICP are needed when the patients are admitted to the ICU. The OICP of the HVLP cuffed tube is 1/3 -1/15 of the LVHP cuffed tube. Therefore, the routine use of the HVLP tube is highiy recommended. The OICP shows positive correlation with the PIP. This suggests to make every effort to reduce the PIP.

외부 프리스트레스 도입에 의한 노후된 콘크리트 거더교의 보강성능평가

박승범,홍석주,이봉춘,장석호,권혁준 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

One of the promising methods to enhance the flexural strength of a externally prestressed girder is to place the tendons with large eccentricities. The analysis and design of composite girders prestressed by external tendons involve difficulties related mainly to the position of anchorages and the construction sequences. This study was conducted on the concrete bridges reinforced by the continuous girders and the external prestressing. The test results in this study showed that the external prestressing of a composite girder increased the range of the elastic behavior, reduced deflections, increased ultimate strength, and added to the redundancy by providing the multiple stress paths.

새로운 방법에 의한 1,1-R,R'-2,3,4,5-테트라페닐-1-실라사이크로펜타디엔의 합성

주완철,흥장환,최석봉 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1

A new synthesis of 1,1-R, R',-2, 3, 4, 5-tetraphenyl-1-silacyclopentadiene was described. It was synthesized from one-pot reaction of 1,4-dilithio-1, 2, 3, 4-tetraphenylbutadiene with R_nSiCl_4-n (n=0, 1, 2), where 1, 4-dilithio-1, 2, 3, 4-tetraphenyl butadiene was prepared from the reaction of diphenyl acetylene and lithium metal in ether solution with good yield (80∼85%).

Endovenous Laser Treatment of the Leg Varicose Veins: Long-Term Results

( Bong Seok Jang ),( Chang Keun Oh ),( Moon Bum Kim ),( Kyung Sool Kwon ) 대한피부과학회 2006 초록집 Vol.44 No.10

[PA-0079] Detection of multiple SNPs in ginseng genome based on encoded hydrogel microparticles

Seok Joon Mun(Seok Joon Mun),Yong Jun Lim(Yong Jun Lim),Woo Kyung Jang(Woo Kyung Jang),Ki Wan Bong(Ki Wan Bong) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Small diameter vascular graft with fibroblast cells and electrospun poly (L-lactide-<i>co</i>-ε-caprolactone) scaffolds: Cell Matrix Engineering

Jang, Bong Seok,Cheon, Ja Young,Kim, Soo Hyun,Park, Won Ho Informa UK (TaylorFrancis) 2018 Journal of biomaterials science, Polymer edition Vol.29 No.7

Multiple scrotal epidermolytic acanthomas successfully treated with topical imiquimod

JANG, Bong-Seok,JANG, Ho-Sun,PARK, Hyun-Je,KIM, Moon-Bum,OH, Chang-Keun,KWON, Kyung-Sool Wiley (Blackwell Publishing) 2007 The Journal of Dermatology Vol.34 No.4