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Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases
Jang, Bohyun,Han, Ji Won,Sung, Pil Soo,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Cho, Young I,Yoon, Seung Kew The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12
<P>Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (<I>P</I> < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: <I>r</I> = −0.25, diastolic: <I>r</I> = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.</P>
Lee, Jang Mee,Patil, Sharad B.,Kang, Bohyun,Lee, Seul,Kim, Min Gyu,Hwang, Seong-Ju The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.26
<P>The structure-property relationship in transition metal oxides is of crucial importance in designing and synthesizing economically feasible high-performance electrocatalysts. Since cation substitution allows to finely tailor the atomic arrangement, structural distortion, and electrocatalytic performance of transition metal oxides, a relationship between local structural order and electrocatalytic activity in crystalline manganese oxide can be systematically investigated by <I>in situ</I> X-ray absorption, electron paramagnetic resonance, and electrochemical impedance spectroscopic analyses for unsubstituted and Fe-substituted α-Mn1−xFexO2 during the oxygen evolution reaction (OER). The substitution of Mn with Fe is quite effective in improving the OER activity of α-MnO2 to reach a small overpotential of 0.40 V at 10 mA cm<SUP>−2</SUP>. Under OER conditions, the Fe substitution improves the local structural order of MnO6 octahedra in the α-MnO2 lattice, thus leading to a significant enhancement of charge transport kinetics. Since the Fe substitution induces only a limited alteration of the electronic structure and the substituted Fe ion itself shows only a negligible contribution to the OER activity, the excellent OER functionality of Fe-substituted α-Mn1−xFexO2 is attributable mainly to the improvement of local structural ordering upon Fe substitution. The present study underscores the crucial role of local structural order in optimizing the electrocatalytic functionality of crystalline transition metal oxides.</P>
김보현(Bohyun Kim),정소영(Soyoung Jung),최헌종(Honzong Choi),이성진(Sungjin Lee),장진영(Jinyoung Jang) (사)한국CDE학회 2011 한국CDE학회 논문집 Vol.16 No.6
The collaboration hub has been developed since 2004 as an online collaboration space, which supports the various collaborative works amongst small and medium enterprises using information sharing, collaboration project management, and project history management. Because of the change of manufacturing environment and rapid development of information technologies, it should be evolved from the existing version called Collaboration Hub 1.0. Recently, a lot of manufacturing enterprises know the importance of business process management(BPM) and start to introduce BPM systems. Our research group has developed the new version of Collaboration Hub 1.0 called Collaboration Hub 2.0 which contains the BPM concept, the consistent product data management, and the specialized functions overcoming the various variation of manufacturing. This study scrutinizes the meaning and role of the Collaboration Hub 2.0 and introduces an application study of it to the value chain of automobile module development consisted of a leading company and subcontractors. The case study covers the definition, execution and monitoring of collaboration process, the specialized functions overcoming the manufacturing variation and the key performance index of collaboration business.
( Hae Lim Lee ),( Si Hyun Bae ),( Bohyun Jang ),( Seawon Hwang ),( Hyun Yang ),( Hee Chul Nam ),( Pil Soo Sung ),( Sung Won Lee ),( Jeong Won Jang ),( Jong Young Choi ),( Nam Ik Han ),( Byung Joo Song 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: According to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus reactivation. The aim of this study was to evaluate the effect of pharmacological immunosuppression on HCV reactivation. Methods: The medical records of patients who underwent systemic chemotherapy, corticosteroid therapy, or other immunosuppressive therapies between January 2008 and March 2015 were reviewed. Subsequently, 202 patients who were seropositive for the anti-HCV antibody were enrolled. Exclusion criteria were: unavailability of data on HCV RNA levels, a history of treatment for chronic hepatitis C, and the presence of liver diseases other than a chronic HCV infection. Results: Among the 120 patients enrolled in this study, hepatitis was present in 46 patients (38%). None of the patients were diagnosed with severe hepatitis. Enhanced replication of HCV was noted in nine (27%) of the 33 patients who had data available on both basal and follow-up HCV RNA loads. Reappearance of the HCV RNA from an undetectable state did not occur after treatment. The cumulative rate of enhanced HCV replication was 23% at 1 year and 30% at 2 years. Conclusions: Although enhanced HCV replication is relatively common in HCV-infected patients treated with chemotherapy or immunosuppressive therapy, it does not lead to serious sequelae. (Gut Liver 2017;11:870-877)
풀리 제조공정의 셋업시간 단축을 위한 데이터 웨어하우스 시스템 설계
오봉훈(Bonghoon Oh),이규봉(Gyubong Lee),김보현(Bohyun Kim),장재덕(Jaeduk Jang) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_3
V-belt pulleys playa key role in transmitting the power from engine to cooling pump, oil pump, air-conditioner, etc. Prior to the mass production of pulleys, appropriate setup parameters of an equipment for manufacturing pulleys should be determined through making their prototypes. This operation called as the setup of pulley manufacturing process often requires a long time. To reduce the setup time, it is proposed to design and implement a data-warehouse system in this study. An example presented in this study shows the feasibility of applying the data-warehouse system to reduce costs in a manufacturing procedure.
Kim Hae Young,Cho Seung Hyun,Jang Jong Keon,Kim Bohyun,Lee Chul-min,Lim Joon Seok,Moon Sung Kyoung,Oh Soon Nam,Seo Nieun,Park Seong Ho 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.4
Objective: To measure inter-reader agreement and identify associated factors in interpreting complete response (CR) on magnetic resonance imaging (MRI) following chemoradiotherapy (CRT) for rectal cancer. Materials and Methods: This retrospective study involved 10 readers from seven hospitals with experience of 80–10210 cases, and 149 patients who underwent surgery after CRT for rectal cancer. Using MRI-based tumor regression grading (mrTRG) and methods employed in daily practice, the readers independently assessed mrTRG, CR on T2-weighted images (T2WI) denoted as mrCRT2W, and CR on all images including diffusion-weighted images (DWI) denoted as mrCRoverall. The readers described their interpretation patterns and how they utilized DWI. Inter-reader agreement was measured using multi-rater kappa, and associated factors were analyzed using multivariable regression. Correlation between sensitivity and specificity of each reader was analyzed using Spearman coefficient. Results: The mrCRT2W and mrCRoverall rates varied widely among the readers, ranging 18.8%–40.3% and 18.1%–34.9%, respectively. Nine readers used DWI as a supplement sequence, which modified interpretations on T2WI in 2.7% of cases (36/1341 [149 patients x 9 readers]) and mostly (33/36) changed mrCRT2W to non-mrCRoverall. The kappa values for mrTRG, mrCRT2W, and mrCRoverall were 0.56 (95% confidence interval: 0.49, 0.62), 0.55 (0.52, 0.57), and 0.54 (0.51, 0.57), respectively. No use of rectal gel, larger initial tumor size, and higher initial cT stage exhibited significant association with a higher interreader agreement for assessing mrCRoverall (P ≤ 0.042). Strong negative correlations were observed between the sensitivity and specificity of individual readers (coefficient, -0.718 to -0.963; P ≤ 0.019). Conclusion: Inter-reader agreement was moderate for assessing CR on post-CRT MRI. Readers’ varying standards on MRI interpretation (i.e., threshold effect), along with the use of rectal gel, initial tumor size, and initial cT stage, were significant factors associated with inter-reader agreement.
( Sun Hong Yoo ),( Jeong Won Jang ),( Jung Hyun Kwon ),( Seung Min Jung ),( Bohyun Jang ),( Jong Young Choi ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.4
Background/Aims: Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE. Methods: This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013. Acute hepatic deterioration following TACE was evaluated. Treatment-related hepatic decompensation was defined as newly developed encephalopathy, ascites, variceal bleeding, elevation of the bilirubin level, prolongation of prothrombin time, or elevation of the Child-Pugh score by ≥2 within 2 weeks following TACE. Univariate and multivariate analyses were conducted to identify factors influencing treatment-related decompensation. Preemptive antiviral therapy involves directing prophylaxis only toward high-risk chronic hepatitis B patients in an attempt to prevent the progression of liver disease. We regarded at least 6 months as a significant duration of preemptive antiviral treatment before diagnosis of HCC. Results: Of the 108 patients, 30 (27.8%) patients received preemptive antiviral therapy. Treatment-related decompensation was observed in 25 (23.1%) patients during the follow-up period. Treatment-related decompensation following TACE was observed more frequently in the nonpreemptive group than in the preemptive group (29.5% vs. 6.7%, P=0.008). In the multivariate analysis, higher serum total bilirubin (Hazard ratio [HR] =3.425, P=0.013), hypoalbuminemia (HR=3.990, P=0.015), and absence of antiviral therapy (HR=7.597, P=0.006) were significantly associated with treatment-related hepatic decompensation. Conclusions: Our findings suggest that preemptive antiviral therapy significantly reduces the risk of acute hepatic deterioration. Preventing hepatic deterioration during TACE by applying such a preemptive approach may facilitate the continuation of anticancer therapy and thus improve long-term outcomes. (Clin Mol Hepatol 2016;22:458-465)