High-sensitivity C-reactive Protein Can Predict Major Adverse Cardiovascular Events in Korean Patients with Type 2 Diabetes

이상흔,김인태,박형복,현유경,김윤지,송선옥,김형진,성주헌 대한의학회 2011 Journal of Korean medical science Vol.26 No.10

Inflammation is thought to play a role in the pathogenesis of major adverse cardiovascular events (MACE). It has been suggested that the measurement of markers of inflammation may aid in predicting the risk of such events. Here, the relationship between highsensitivity C-reactive protein (hs-CRP) levels and MACE in Korean patients with type 2diabetes is assessed. A retrospective cohort study was conducted as a follow-up among 1,558 patients with type 2 diabetes and without cardiovascular diseases over a mean period of 55.5 months. A Cox proportional-hazards model was used to determine whether increased hs-CRP levels are useful as a predictor for future MACE. The hazard ratio of MACE was 1.77 (95% CI; 1.16-2.71) in subjects who had the highest hs-CRP levels ( > 0.21 mg/dL) compared to subjects who had the lowest hs-CRP levels ( < 0.08 mg/dL),after adjusting for age, regular physical activity, current smoking, and duration of diabetes. The present results indicate that high hs-CRP levels can act as a predictor for the MACE occurrence in Korean patients with type 2 diabetes.

누가 현상과 청각 피로검사

이상흔 釜算慶南耳鼻咽喉科學會 1996 임상이비인후과 Vol.7 No.2

Y-Junction을 이용한 H-평면 8-Way 구형 도파관 전력 분배기

이상흔(Sang Heun Lee),윤지환(Ji Hwan Yoon),윤영중(Young Joong Yoon),김준연(Junyeon Kim),이우상(Woo Sang Lee),박슬기(Seulgi Park) 한국전자파학회 2012 한국전자파학회논문지 Vol.23 No.2

본 논문에서는 Y-junction을 이용한 H-평면 8-way 구형 도파관 전력 분배기를 제안한다. 일반적인 N-way 전력 분배기의 경우 T-junction을 이용하여 다단 형태로 구성이 되는데, 출력 포트 간의 간격이 가까운 경우 T-junction만으로는 공간상의 제약으로 인하여 매칭 특성을 개선할 수 없다. 따라서 이 같은 경우에는 T-junction과 함께 다른 형태의 3포트 junction이 최종 출력단에 사용되어야 하는데, 본 논문에서는 Y-junction이 사용되었다. 제안된 Y-junction은 임피던스 매칭 특성을 향상시키기 위해 테이퍼드-라인 임피던스 변환기와 유도성 iris가 적용되었다. Y-junction을 이용한 8-way 전력 분배기를 제작하여 측정한 결과, 동작 주파수에서 반사 손실 값은 ―30.8 dB, 삽입 손실은 약 ―9.5 dB로 측정되었다. 또한, 출력 포트 간의 최대 위상차는 약 1°로 측정되었다. 따라서 제안된 전력 분배기는 배열 안테나의 급전 구조와 같이 입력 전력을 동일한 크기와 위상으로 분기하는데 필요한 다양한 마이크로파 시스템에 적용하는데 있어서 매우 유용할 것으로 판단된다. This paper proposes a H-plane 8-way rectangular waveguide power divider using Y-junction. A general N-way power divider can be composed of multi-stage T-junctions. However, if the distances of output ports are close, the matching characteristic is not improved by using only T-junctions because of space limitation. In this case, since other types of 3-port junctions should be used to final output stage, Y-junctions are used with T-junctions in this paper. The proposed Y-junction uses the tapered-line impedance transformer and inductive irises to improve impedance matching characteristic. The 8-way power divider using Y-junction is fabricated and measured. The measured return loss and insertion loss from input port to output port are ―30.8 dB and ―9.3 dB at operating frequency, respectively. The measured maximum phase difference is about 1°. Therefore, the proposed power divider will be useful to apply to various microwave systems, which need to divide the input power equally, such as feed networks for array antennas.

조혈모세포 이식으로 치료한 Late infantile-onset globoid cell leukodystrophy 환자 1예

이상흔(Sang Heun Lee),고아라(Ara Ko),유철주(Chuhl Joo Lyu),이진성(Jin Sung Lee),이준수(Joon Soo Lee) 대한소아신경학회 2018 대한소아신경학회지 Vol.26 No.1

GLD는 지질 침착 질환 중 하나로 라이소좀 효소인 GALC의 결핍에 의해 나타난다. GLD 환자에서 적절한 치료가 빠르게 이뤄지지 않으면, 증상 시작 후 2-3년 안에 사망할 수 있어 빠른 진단과 치료가 중요한 질환이다. GLD 환자는 뇌 자기공명영상에서 뇌실 주변 백질의 탈수초, 말초 신경에서 운동 신경 전도 속도 감소, 뇌척수액 검사에서 단백 양의 증가 등의 소견을 보이며, 확진은 GALC level의 감소를 통해서 한다. 치료로서는 조혈모세포이식이 질병의 진행을 막을 수 있는 것으로 알려져 있다. 이 증례는 보챔과 사지 강직, 정신 운동 발육 지연을 주소로 내원한 1세 여아에 대한 보고이다. 환아의 신경학적 진찰상 근긴장도가 저하된 소견을 보이고, 건반사는 증가되어 있었다. 환아의 초기 뇌 자기공명영상 및 운동 신경 전도 속도는 정상 소견을 보였었다. 4개월 후 시행한 뇌 자기공명영상에서는 뇌실 주변 백질의 demyelination이 확인되어 GALC level을 검사하여 GLD을 진단하였다. 환아는 조혈모세포이식을 통해 치료 후 증상이 호전되었으며, 지속적인 인지 및 운동발달을 보이고 있다. 또한 시행한 추적관찰 뇌 자기공명영상에서 백질의 demyelination의 범위가 감소하는 소견을 보였다. 이 증례를 통해 본 보고에서는 환아와 같이 GLD를 의심할 수 있는 증상이 진행된 환자임에도 뇌 자기공명영상, 운동 신경 전도 속도는 정상 소견을 보일 수 있기에, 초기에 GALC level을 같이 확인하여GLD를 진단하는 것이 중요함을 강조하였다. 또한 저자들은 Late infantile-onset GLD 환자에서는 조혈모세포이식을 빠르게 시행하여 성공적으로 치료된 증례를 보고하고자 한다. Globoid cell leukodystrophy is a rare autosomal recessive disorder of the brain white-matter caused by galactosylceramidase deficiency; the disorder is classified into four types based on the age of onset. Approximately 80-85% of patients have an early infantile form, while 10-15% has a late infantile form. Globoid cell leukodystrophy leads to a progressive neurological deterioration, and affected patients rarely survive more than 2-3 years. Although many different treatments have been investigated over several decades, further research is still needed. Hematopoietic stem cell transplantation is the standard treatment for globoid cell leukodystrophy. Here, we report a case of symptomatic late-infantile globoid cell leukodystrophy treated with stem cell transplantation. After transplantation, disease progression ceased and cognitive and motor function improved. And a 6 months follow-up study using brain magnetic resonance imaging showed white matter involvement was increased. After that, annual follow-up brain magnetic resonance imaging showed a stable status of disease.

청성안정유발반응

이상흔 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.8

환자안전과 QA활동

이상흔 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

HVS 기반 워터마킹에서 외부 공격에 강인한 방법에 관한 연구

심상흔(Sang-Heun Shim),정용주(Yong-Ju Jung),강호경(Ho-Koung Kang),노용만(Yong Man Ro) 대한전자공학회 2001 대한전자공학회 학술대회 Vol.2001 No.6

간헐외사시 환자에서 사시의 자연 퇴행

이상흔,유혜린,윤영수 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: To compare the characteristics of the intermittent exotropia patients with spontaneous regression to the surgically corrected group. Methods: Twenty-five patients who had exodeviation of around 25 prism diopters (PD). Visual acuity and best corrected visual acuity were measured. The latter was obtained by using cycloplegic refraction. Far and near deviation angles were measured through alternating prism cover test. Stereo acuity was measured using a Titmus stereo acuity test chart and occlusion was performed for those who had more than 2 lines of difference between the best corrected visual acuity of the left and right eyes on the Snellen E chart. We divided the patients into two groups. The first group is the spontaneous regression group (SRG), who showed declining deviation angles and maintained less than 10 PD for more than 3 months. The second group is the surgically corrected group (SCG), showed the same or increasing deviation angle and underwent operation. Results: There was no difference in the age or observation period between the two groups. The prevalence period was significantly higher in the SRG than in the SCG. The deviation angle from a distance at the first visit was not different for the SCG from that of the SRG. However, the deviation angle at near was significantly larger for the SCG than that of the SRG and increased at the last examination. Stereo acuity of the SRG was better than that of the SCG at the first visit. Conclusions: Deviation angle could be reduced in the mild intermittent exotropia patients with relatively small deviation angle at near or with good stereo acuity.

갑상샘눈병증 환자에서 보툴리눔독소를 이용한 위눈꺼풀뒤당김 치료의 결과

이상흔,유혜린,윤영수,Sang Hun Lee,Helen Lew,Young Soo Yun 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: This study is to determine the effects of botulinum toxin injection on patients who suffer from upper eyelid retraction caused by thyroid ophthalmopathy. Methods: We injected 10-15 units botulinum toxin (Botox?, Allergan, USA) on the upper tarsus of 12 eyes of 12 thyroid ophthalmopathy patients and compared duration of disease, clinical activity scores (CAS), intraocular pressures (mmHg), exophthalmometry (mm), upper eyelid retraction (mm), marginal reflex distance1 (MRD1, mm), levator function test (mm), lid lag (mm), limitation of ocular movement (mm), lid tension test results, phenylephrine test results, and orbital computed tomography results before and after the injection. Results: The patient group with smaller-sized cross section of superior rectus/levator complex before the injection showed a greater decrease of upper eyelid retraction after the injection (p=0.04). Other clinical parameters showed no significant relations on the effect of the toxin injection. Conclusions: Botulinum toxin injection can have variable effects on the upper eyelid retraction of thyroid ophthalmopathy patients. The patients who had smaller volume of superior rectus/levator complex measured in orbital cross sections on CT, could expect good results after botulinum toxin injection.

TASK 개념을 기초로 한 듣기 말하기 수업 연계 방안 - INTERMEDIATE LEVEL 을 대상으로 -

곽상흔 국제한국어교육학회 1994 한국어 교육 Vol.5 No.-