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이관순,김재주,송채석,오춘근,임규상,Lee, Gwan-Sun,Kim, Jae-Ju,Song, Chae-Seok,O, Chun-Geun,Im, Gyu-Sang 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.1
Recently many efforts were focused to understand the mechanical insights of melanogenesis to develop the agents for hyper-pigmentation and hypo-pigmentation. In the melanin biosynthetic pathway, tyrosinase is the rate limiting enzyme, and ${\alpha}$-melanocyte stimulating hormone(MSH) or cAMP-elevating agents stimulate melanogenesis and enhance the melanin synthesis and the tyrosinase activity. The author has analyzed the effects of Radix Trichosanthis on the basal melanogenic activities of B16/F10 mouse melanoma cells, and on the ${\alpha}$-MSH or forskolin-induced melanogenesis. Radix Trichosanthis alone markedly suppressed melanin content and tyrosinase activity in a dose-dependent manner. Pretreatment of the cells with Radix Trichosanthis also suppressed the increase of ${\alpha}$-MSH (10 nM) or forskolin (20${\mu}M$)-induced melanin content and tyrosinase activity. The decrease in the tyrosinase activity was paralled by a decrease in the abundance of tyrosinase protein and tyrosinase promoter activity. Pretreatment of the cells with Radix Trichosanthis also inhibited the increase of forskolin($20{\mu}M$) induced the amount of tyrosinase protein and tyrosinase promoter activity. The results of DOPA staining revealed that pretreatment of the cells with Radix Trichosanthis showed less intensity than B16 melanoma cells stimulated with ${\alpha}$- MSH or forskolin. These results suggest that Radix Trichosanthis inhibits melanogenesis and abrogates ${\alpha}-MSH and cAMP-induced melanogenesis in B16 melanoma cells.
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성교육 프로그램이 초등헉교 5학년 학생의 성 관련 지식 및 태도에 미치는 효과
이관순,이정숙 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.1
The purpose of this study is to examine the effect of the sex education program on the elementary school students' sex-related knowledge and attitude. The research method used in this study is an equivalent control group pre-test and post-test and post-test design in a quasi-experimental research format. The subjects of this study were the 5th-grade elementary school students(63 in the experimental group and 60 in the control group) in O and O elementary school in G city. The data was collected from April 4th to July 3th, 2003. The experimental group received a sex education program while the control group did not receive any treatment. The sex education program was implemented for 40 minutes every 2-3 days which total twelve sessions over 4 weeks. Using the SPSS 10.0 program, the data was analyzed by x²- test, Fisher exact test, t-test, and a repeated measures ANOVA., Results : The experimental group who received the sex education program showed a significantly higher sex-related knowledge score than the control group (F=140.52, p=.00l). The experimental group showed a significantly higher sex relatied attitudes score than the control group (F=40.80, p=.00l). This study concluded that the sex education program was effective in both sex-related knowledge and attitudes for elementary school students. Therefore, it appears to be effective for 5th-grade students to receive intensive sex education. It es recommended that the schools and government develop education media and a sex education program for parents, have a sex education teacher and a place where students can be counseled, and a professional consultant who can effectively counsel the students regarding sex-related issues.
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李寬順,金南權,林圭庠 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1
著者는 臨床에서 흔히 患者들로부터 구안와사의 豫候에 대해 "男左女右"와 關聯하여 질문을 받으므로 이에 대한 臨床的 妥當性을 알아보기 위해 1995年 9月 1日부터 1996年 8月 31日 까지 1年間 圓光大學校 附屬 全州韓方病院 外官科 外來에 來院하여 구안와사를 診斷받은 總 148명을 對象으로 發病動機 및 身體狀態, 年齡別 分布, 男女 左右別 發生率, 總 來院患者에 대한 治療率, 年齡別 發生率, 男女 左右에 따른 治療率을 각각 臨床 觀察하여 다음과 같은 결과를 얻었다. 1. 發病動機 및 身體狀態는 風寒과 연관되는 原因이 가장 많았으며, 肉體過勞, 精神過勞, 飮酒 등의 순으로 나타났고, 2가지 이상의 原因이 있는 경우는 精神過勞와 肉體過勞가 겸해오는 경우가 많았다. 2. 年齡別 分布는 50-59세가 가장 높았고, 40-49세, 30-39세, 20-29세, 60-69세, 70세 이상, 1-9세, 1세 이하의 순으로 각각 나타났다. 3. 男女 左右別 發病率은 右側 顔面神經이 痲痺된 男子 患者가 가장 많았으며, 右側 顔面神經이 痲痺된 女子 患者, 左側 顔面神經이 痲痺된 男子 患者, 左側 顔面神經이 痲痺된 女子 患者 순으로 나타났으나 發病率에 큰 차이는 없었다. 4. 總 來院患者 148명에 對한 治療率은 52.53%로 나타났다. 5. 年齡別 治療率은 1-9세가 가장 높았으며, 70세 이상, 50-59세, 40-49세, 60-69세, 20-29세, 30-39세, 10-19세의 순이었고, 주로 中·老年層이 治療率이 높게 나타났다. 6. 男女와 左右에 따른 治療率은 顔面神經痲痺의 女子 患者가 가장 높게 나타났고, 右側 顔面神經痲痺의 男子 患者, 左側 顔面神經痲痺의 女子 患者, 左側 顔面神經痲痺의 男子 患者의 순으로 나타났고, 男女 모두 右側에 發病한 患者의 治療率이 左側보다 높게 나타났으나, 특별한 有意性은 없었다. 以上의 結果로 보아 韓醫學的 生理 病理理論인 男左女右의 豫候와 治療率은 一致하지 않았으나 此後 좀더 많은 患者數와 오랜 期間의 臨床을 통한 硏究가 要求될 것으로 思料된다. The author analyzed 148cases of Facial Palsy, who were treated in the Jeon-ju Oriental Medical Hospital of Wonkwang University from September 1995 to August 1996. I've examined the 148 cases in the view of the etiologic distributions, the age, the relationship of the sex and paralytic side, and the ratio of recovery according to the age, the relations of sex and paralytic side. The following results are obtained. 1. The ratio of punghan(風寒) was 18.24%(27 cases), overwork was 14.86%(22 cases), stress was 12.84%(19 cases), excessive drinking was 2.70%(4 cases), teeth pain was 2.02%(3 cases), and idiopathy was 37.84(56) and etc. 2. The ratio of 5th decade were 20.95%(31 cases), 4th decade was 18.25%(27 cases), 3th decade was 17.57%(26 cases), 2th decade was 14.19%(21 cases), 6th decade was 12.16%(18 cases), over seventy was 10.81%(16 cases), teenagers was 4.05%(6 cases), under teenagers was 1.35%(2 cases), and infant was 0.67%(1 case). 3. The ratio of the male-right was 28.38%(42 cases), female-right was 25.68%(38 cases), male-left was 22.30%(33 cases), female-left was 21.62%(32 cases), female-both side was 1.35%(2 cases) and male-both side was 0.67%(1 case) in order. 4. When we examined the degree of recovery about the 148 patients, perfect cure was seen in 17.57%( 26 cases), excellent in 25.00%(37 cases), good in 22.30%(33 cases), fair in 20.27%(30 cases), poor in 14.86%(22 cases). The total remedial value of the 148 patients was revealed 52.53%. 5. When we examined the 148 patients the remedial value of the infant was 50.00%, under teenagers 62.50%, teenagers 41.67%, 2th decade 47.62%, 3th decade 44.23%, 4th decade 54.63%, 5th decade 58.87%, 6th decade 51.39%, over seventieth 60.94%. The remedial value of under teenagers, 4th decade, 5th decade, over seventieth were higher than the total remedial value(52.53%) 6. In the point of the relationship of the sex and the paralytic side, the remedial value of male-left was 51.47%, male-right 53.45%, male-both side 50.00%, femaled-left 47.62%, female-right 58.75% and female-both 37.50%. The remedial value of male-right(53.45%) and female-fight(58.75%) were higher than the total remedial value(52.53%). These results demonstrated that in the point of prognostic view, there was little concerned with the traditional rule of sex-paralytic relationship that man is awed left paralysis and woman right paralysis.
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