신생아 폐고혈압

황종희 ( Jong Hee Hwang ) 대한주산의학회 2013 Perinatology Vol.24 No.1

Neonatal pulmonary hypertension is associated with meconium aspiration syndrome, sepsis, asphyxia, respiratory distress syndrome, congenital diaphragmatic hernia, congenital heart disease, or bronchopulmonary dysplasia. Newborns with pulmonary hypertension are at risk of death, chronic lung disease, neurodevelopmental disability, and other complications. Because of the diverse pathophysiology of the underlying disease, the diagnostic evaluation and therapeutic approach are important. This article will review the pathophysiologic background and the current therapeutic options for neonatal pulmonary hypertension.

초극소 저출생 체중아에서 유로키나제로 치료한 심동맥혈전증 1례

황종희 ( Jong Hee Hwang ),신창균 ( Chang Guyn Shin ),박지원 ( Ji Won Park ) 대한주산의학회 2010 Perinatology Vol.21 No.4

Newborns are at the highest risk for thromboembolism, although significant thromboembolic diseases are relatively rare in children and newborn. The use of central catheters seems to be the most important risk factor for vein and artery thrombosis. Additional risk factors include the properties of developing hemostatic system, hereditary, and acquired risk factors. Treatment for neonatal thromboembolism has not been established. We report a case of deep vein thrombosis that was completely treated with urokinse in extremely low birth weight infant.

디지털 통신시스템에서 효율적인 구조를 갖는 오류정정부호화기 설계

황종희(Jong-Hee Hwang),김동순(Dong-Sun Kim),정덕진(Duck-Jin Chung) 한국통신학회 2004 한국통신학회 학술대회논문집 Vol.2004 No.11

빌리루빈의 신경독성에 대한 MK-801의 신경학적 방어효과에 관한 연구

황종희 ( Jong Hee Hwang ),최창원 ( Chang Won Choi ),장윤실 ( Yun Sil Chang ),박원순 ( Won Soon Park ) 대한주산의학회 2004 Perinatology Vol.15 No.1

목적 : 일차배양을 통해 얻어진 마우스 태아의 대뇌피질세포를 이용하여 빌리루빈 세포독성에 대한 N-methyl-D-aspartate (NMDA) 수용체 길항제인 MK-801의 신경학적 방어효과에 대해 lactate dehydro genase (LDH) 활성도를 측정하여 정량적으로 평가하고자 하였다. 방법 : 14일 된 마우스 태아로부터 대뇌피질을 적출하여 일차배양을 통해 대뇌피질세포들을 얻었다. 100 μM 빌리루빈과 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohept-5,10-imine (MK-801, dizocilpine), 1,2,3,4-tetrahydroxy-6-nitro-2,3-dioxo-benzo [f] quinoxaline-7-sulfonamide disodium (NBQX), NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)을 각각 혼합한 배지들을 만들어 여기에 대뇌피질세포들을 4시간 동안 노출시켰다. 그 후 각 배양액의 상층부를 얻어 대뇌피질세포로부터 배양액 내로 유리된 LDH의 활성도를 측정하여 빌리루빈에 의한 세포독성을 평가하였으며 형광염색 후 공초점 현미경으로 죽은 세포들을 관찰하였다. 결과 : 빌리루빈에만 노출된 세포와 MK-801, NBQX, L-NAME 등을 혼합한 세포에서 LDH 활성도로 평가한 세포독성은 각각 55±7%, 32±9%, 52±8%, 53±9%였으며 MK-801로 처리한 대뇌피질세포에서 세포독성이 가장 유의하게 감소하였다( p<0.05). 또한 공초점 현미경 상에서도 MK-801로 처리한 대뇌피질세포에서 죽은 세포가 가장 적게 관찰되었다. 결론 : 일차배양한 마우스 태아의 대뇌피질세포에서 빌리루빈의 흥분독성은 NMDA 수용체에 의해서 일어나며 비경쟁적 길항제인 MK-801은 신경세포의 손상을 감소시킬 수 있었다. Objective : To evaluate whether MK-801, N-methyl-D-aspartate (NMDA) receptor antagonist, could protect against bilirubin neurotoxicity in mouse neuronal cells. Methods : Mouse cerebral cortical cells were obtained from 14 day-old mouse fetal cerebral cortex primary culture. Cerebral cortical cells were exposed to medium containing concentrations of bilirubin 100 μM and additionally treated with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohept-5,10-imine (MK-801, dizocilpine), 1,2,3,4-tetrahydroxy-6-nitro-2,3-dioxo-benzo [f] quinoxaline-7-sulfonamide disodium (NBQX), NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) for 4 hours. Then, the bilirubin cytotoxicity for cerebral cortical cells was quantitated by the activity of LDH released from cerebral cortical cells into the culture media. Cortical cells were stained with propidium iodide and visualized by confocal laser scanning microscopy for detection of apoptotic cells. Results : After exposure for 4 hours, the cytotoxicity for cortical cells was the least in bilirubin treated with MK-801 compared to bilirubin alone, bilirubin treated with NBQX, and L-NAME (32±9%, 55±7%, 52±8%, 53±9%, respectively, p<0.05). Cells treated with MK-801 had fewer apoptotic nuclei evident on confocal microscopy. Conclusion : Our study suggests bilirubin neurotoxicity is mediated NMDA receptors and MK-801 is capable to prevent bilirubin-induced neuronal damage.

TFT-LCD에서 새로운 접근을 통한 FRC Noise의 발생 원인 분석 및 저감 방법에 대한 연구

황종희(Jong-Hee Hwang),김혜진(Hye-Jin Kim),최윤식(Yoon-Sik Choe) 대한전기학회 2010 전기학회논문지 Vol.59 No.7

FRC(Frame Rate Control) has been applied to the monitor and TV product as part of cost-saving in many flat panel display manufacturers. As FRC can represent the same number of gray scale level with bits of a smaller amount than bits of the input image data, it is widely used. However, FRC causes visual artifacts by using repeatedly pre-designed the FRC unit size of block pattern in display devices. Therefore, this paper analyzes the cause of the visual artifacts. And in order to improve them, it proposed the pattern arrangement of FRC unit blocks through frame rolling method as analytic solution for the first time. So, we could embody causes of FRC noise. Using the proposed structure, more robust pattern to FRC noise will be designed.

근적외선 필터용 인산계 유리의 광학적 특성 및 구조적 특성에 미치는 CuO 의 영향

김성일,황종희,임태영,김진호,김영호,이종화,최덕균,Kim, Seong-Il,Hwang, Jong-Hee,Lim, Tae-Young,Kim, Jin-Ho,Kim, Young-Ho,Lee, Jong-Hwa,Choi, Deuk-Kyun 한국재료학회 2009 한국재료학회지 Vol.19 No.12

Optical characteristics and structural changes depending on CuO content in phosphate glasses that are used in near-infrared (near-IR) filters were investigated. With phosphate glasses that contain 1-9 mol% CuO, changes in optical transmittance, optical absorption, and color coordinate were measured with a UV-VIS spectrophotometer. An XPS (X-ray photoelectron spectroscopy) analysis was performed to determine valence of copper ion that influences optical characteristics in near-IR filter glasses. Structural changes in glasses depending on CuO content were also analyzed by FT-IR (Fourier transform infrared) and Raman spectrophotometers. From the UV-VIS spectrophotometer results, strong absorption peaks at 220 & 900 nm were found and transmittance was decreased. The color coordinates of the glasses were shifted to the green color direction with CuO addition for increasing absorption of long wavelength range spectra, in spite of the amount of $Cu^{2+}$, which gives a blue color to glasses, and which was increased in XPS results. Also, structural de-polymerization of glasses with CuO addition were found by FT-IR and Raman results.

저온실링용 ZnO-V₂O₅-P₂O₅계 봉착재의 물성에 미치는 TiO₂ 의 영향

이헌석,황종희,임태영,김진호,이석화,김일원,김남석,김형순,Lee, Heon-Seok,Hwang, Jong-Hee,Lim, Tae-Young,Kim, Jin-Ho,Lee, Suk-Hwa,Kim, Il-Won,Kim, Nam-Suk,Kim, Hyung-Sun 한국재료학회 2009 한국재료학회지 Vol.19 No.11

We designed new compositions for lead free and low temperature sealing glass frit of $ZnO-V_2O_5-P_2O_5$ system, which can be used for PDP (Plasma Display Panel) or other electronic devices. The $ZnO-V_2O_5-P_2O_5$ system can be used as a sealing material at temperatures even lower than 430$^{\circ}C$. This system, however, showed lower bonding strength with glass substrate compared to commercialized Pb based sealing materials. So, we added $TiO_2$ as a promoter for bonding strength. We examined the effect of $TiO_2$ addition on sealing behaviors of $ZnO-V_2O_5-P_2O_5$ glasses with the data for flow button, wetting angle, temporary & permanent residual stress of glass substrate, EPMA analysis of interface between sealing materials and glass substrate, and bonding strength. As a result, sealing characteristics of $ZnO-V_2O_5-P_2O_5$ system glasses were improved with $TiO_2$ addition, but showed a maximum value at 5 mol% $TiO_2$ addition. The reason for improved bonding characteristics was considered to be the chemical interaction between glass substrate and sealing glass, and structural densification of sealing glass itself.

LBL 법을 이용한 기능성 나노 입자 제조

김진호,황종희,임태영,김세훈,Kim, Jin-Ho,Hwang, Jong-Hee,Lim, Tae-Young,Kim, Sae-Hoon 한국결정성장학회 2009 한국결정성장학회지 Vol.19 No.6

PMMA 입자의 표면에 양전하를 갖는 전해질 폴리머 PDDA와 음전하를 갖는TALH를 사용하여 $TiO_2$ 박막을 LBL 법에 의해 성공적으로 제조하였다. 수정진동자의 측정을 통해 TALH의 용액의 pH가 감소됨에 따라 TALH의 적층량이 늘어나고 PMMA의 입자 표면에 코팅된 (PDDA/TALH) 박막의 두께가 증가됨을 확인하였다. (PDDA/TALH)n의 순서에 의해 코팅된 PMMA 입자들은 bilayer 수의 변화에 따라 다양한 색 변화를 보여주었다. (PDDA/TALH) 박막의 bilayer 수(n)가 10과 20 일 경우에 $a^*$와 $b^*$의 값은 막이 코팅되지 않은 PMMA의 값보다 감소하였고 색 변화는 $a^*$, $b^*$ 색도도에서 각각 green과 blue 방향으로 이동하였다. 이후 n의 수가 30, 40으로 증가됨에 따라 $a^*$와 $b^*$의 값은 증가하였고 색의 변화는 red와 yellow 방향으로 각각 이동하였다. 최종적으로 $(PDDA/TALH)_{50}$ 박막이 코팅된 PMMA 입자들은 박막이 코팅되지 않은 PMMA 입자들과 거의 비슷한 $a^*$와 $b^*$의 값을 보여주었다. $TiO_2$ thin films consisting of positively charged poly (diallyldimethylammonium chloride) (PDDA) and negatively charged titanium (IV) bis (ammonium lactato) dihydroxide (TALH) were successfully fabricated on a poly (methyl methacrylate) (PMMA) by layer-by-layer (LBL) self-assembly method. By the measurement of quartz crystal microbalance (QCM), it was found that as the solution pH of TALH decreased, the deposition volume of TALH increased and the thickness of (PDDA/TALH) thin film coated on the surface of PMMA particles increased. The PMMA particles coated with the coating sequence of (PDDA/TALH)n showed the variation of color changes as a function of the number of bilayer. The number of bilayer (n) of (PDDA/TALH) thin films was 10 and 20, the values of $a^*$ and $b^*$ decreased from those of PMMA particles without coating films and the color changes was shifted to green and blue direction in the $a^*$, $b^*$ chromaticity diagram. And then, the number of n increased to 30 and 40, the values of $a^*$ and $b^*$ increased and the color changes was shifted to red and yellow direction, respectively. Finally the PMMA particles coated with $(PDDA/TALH)_{50}$ thin film showed a little same value of $a^*$ and $b^*$ with the PMMA particles without (PDDA/TALH) thin film.

교호흡착법에 의해 제조된 초친수 박막 특성

김진호,황종희,임태영,장장훈,김세훈,Kim, Jin-Ho,Hwang, Jong-Hee,Lim, Tae-Young,Jang, Jang-Hoon,Kim, Sae-Hoon 한국결정성장학회 2010 한국결정성장학회지 Vol.20 No.4

양전하를 갖는 poly(allylamine hydrochloride)(PAH)와 음전하를 갖는 poly(acrylic acid)(PAA) 전해질 폴리머를 사용하여 layer-by-layer(LBL) self-assembly 방법에 의해 초친수 특성을 갖는 박막을 제조하였다. PAH/PAA 박막의 밀착강도를 증가시키기 위하여 glutaraldehyde(GA) 수용액을 이용하여 amine-aldehyde의 화학반응에 따른 박막의 표면구조 변화, 막두께, 투과율, 접촉각, 밀착강도 특성을 측정하였다. PAH와 PAA 용액 침적 사이에 기판을 GA 수용액에 침적함으로써 박막의 두께는 감소하였지만 밀착강도는 2배 이상 증가하였다. 밀착강도의 증가는 PAH 와 GA의 amine-aldehyde의 화학반응에 의한 결과라는 것을 fourier transform infrared(FT-IR) spectroscopy를 사용하여 확인하였다. 제조된 PAH/PAA and PAH/GA/PAA 박막은 물 접촉각 $5^{\circ}$이하의 초친수 박막 특성을 보여주었고, 550 nm 파장에서 91.3% 이상의 높은 투과율을 나타내었다. Superhydrophilic thin film consisted of positively charged poly (allylamine hydrochloride) (PAH) and negatively charged poly (acrylic acid) (PAA) was fabricated by a layer-by-layer (LBL) self-assembly. Glutaraldehyde (GA) was used in order to increase an adhesion hardness by amine-aldehyde reaction. The surface morphology, thickness, transmittance, water contact angle and adhesion hardness of PAH/PAA thin film with or without GA were measured. The adhesion hardness of PAH/PAA thin film with GA deposition increased over 2 times although the film thickness of PAH/GA/PAA decreased than that of PAH/PAA thin film. The increase of adhesion hardness by amine-aldehyde reaction between PAH and GA was measured by fourier transform infrared (FT-IR) spectroscopy. Fabricated PAH/PAA and PAH/GA/PAA thin films showed water contact angel under $5^{\circ}$ and high transmittance over 91.3% at 550 nm.

메칠멜캅탄 가스센서용 TiO₂/전해질폴리머 박막 제조

김진호,황종희,이미재,김세기,임태영,Kim, Jin-Ho,Hwang, Jong-Hee,Lee, Mi-Jai,Kim, Sei-Ki,Lim, Tae-Young 한국결정성장학회 2010 韓國結晶成長學會誌 Vol.20 No.5

메칠멜캅탄($CH_3SH$) 가스를 검출하는 수정진동자(QCM) 가스센서를 QCM의 전극에 $TiO_2$ 나노입자와 전해질 폴리머를 증착하여 제조하였다. LBL-SA법에 의해 제조된 $TiO_2$/PSS 박막은 높은 비표면적을 나타내었고, 가스센서의 감도를 증가시켰다. 1.0 ppm의 농도를 갖는 메칠멜캅탄에 노출된 TEA 혹은 $TiO_2$/PSS 막이 증착된 QCM의 주파수 변이는 각각 약 9 Hz, 2 Hz 였다. ($TiO_2$/PSS) 박막의 증착수가 늘어남에 따라 제조된 박막의 비표면적이 증가하게 되어 QCM 센서의 주파수 변이도 점차적으로 증가하였다. 추가적으로 메칠멜캅탄 가스의 농도가 0.5 ppm에서 2.0 ppm으로 높아짐에 따라 QCM 센서의 주파수 변화도 증가되었다. 본 연구에서는, ($TiO_2$/PSS) 박막이 증착된 QCM 센서의 표면구조의 변화와 센서 특성을 측정하였다. Quartz crystal microbalance (QCM) gas sensor to detect methyl mercaptan ($CH_3SH$) gas was fabricated by depositing $TiO_2$ nanoparticles and polyelectrolyte on the electrode of QCM. The $TiO_2$/poly(sodium 4-styrenesulfonate) (PSS) thin film fabricated by a layer-by-layer self-assembly (LBL-SA) method showed a high surface area and increased the sensitivity of gas sensor. When the QCM sensors coated with triethanolamine (TEA) or ($TiO_2$/PSS) were exposed to methyl mercaptan gas (1.0 ppm), the frequency shifts of QCM with TEA casting film and $TiO_2$/PSS thin film were ca. 9 Hz and ca. 24 Hz, respectively. As the bilayer number of ($TiO_2$/PSS) increased, the frequency shift of QCM sensor with ($TiO_2$/PSS) thin film was gradually increased. In addition, the frequency shift of QCM sensor was gradually increased as the concentration of methyl mercaptan gas increased from 0.5 ppm to 2.0 ppm. In this study, the surface morphology and sensor property of QCM sensor coated with ($TiO_2$/PSS) thin film were measured.