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항공안전 보고 데이터 텍스트 분석 기반 조성을 위한 비식별 처리 기술 적용 연구
황도빈,김영곤,심영민 한국항공운항학회 2021 한국항공운항학회지 Vol.29 No.4
In order to identify and analyze potential aviation safety hazards, analysis of aviation safety report data must be preceded. Therefore, in consideration of the provisions of the Aviation Safety Act and the recommendations of ICAO Doc 9859 SMM Edition 4th, personal information in the reporting data and sensitive information of the reporter, etc. It identifies the scope of de-identification targets and suggests a method for applying de-identification processing technology to personal and sensitive information including unstructured text data.
면역체계 이상 활성화를 유도할 수 있는 보체계 유전자 다형성 고찰
김효리,황도빈,한정원,이화경,양원준,진준영,김기현,김상일,유덕균,김수현,정준호 대한이식학회 2016 Korean Journal of Transplantation Vol.30 No.2
The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.
한정원,이종혁,윤수민,Aerin Yoon,황도빈,Hwa K Lee,Min S Kim,이유진,Won J Yang,박선영,윤홍덕,김효리,정준호 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-
The C-terminal domain of RNA polymerase II is an unusual series of repeated residues appended to the C-terminus of the largest subunit and serves as a flexible binding scaffold for numerous nuclear factors. The binding of these factors is determined by the phosphorylation patterns on the repeats in the domain. In this study, we generated a synthetic antibody library by replacing the third heavy chain complementarity-determining region of an anti-HER2 (human epidermal growth factor receptor 2) antibody (trastuzumab) with artificial sequences of 7–18 amino-acid residues. From this library, antibodies were selected that were specific to serine phosphopeptides that represent typical phosphorylation patterns on the functional unit (YSPTSPS)2 of the RNA polymerase II C-terminal domain (CTD). Antibody clones pCTD-1stS2 and pCTD-2ndS2 showed specificity for peptides with phosphoserine at the second residues of the first or second heptamer repeat, respectively. Additional clones specifically reacted to peptides with phosphoserine at the fifth serine of the first repeat (pCTD-1stS5), the seventh residue of the first repeat and fifth residue of the second repeat (pCTD-S7S5) or the seventh residue of either the first or second repeat (pCTD-S7). All of these antibody clones successfully reacted to RNA polymerase II in immunoblot analysis. Interestingly, pCTD-2ndS2 precipitated predominately RNA polymerase II from the exonic regions of genes in genome-wide chromatin immunoprecipitation sequencing analysis, which suggests that the phosphoserine at the second residue of the second repeat of the functional unit (YSPTSPS)2 is a mediator of exon definition.