Effects of epigallocatechin gallate on CoCl_(2)-induced apoptosis in PC12 cells

Yang, Kyu-Ho,Mo, Hyun-Chul,Choi, Nam-Ki,Kim, Seon-Mi,Kim,Won-Jae 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

Neuronal apoptotic events, consequently resulting in neuronal cell death, are occurred in hypoxic/ischemic condition. This cell death has been shown to be accompanied with the production of reactive oxygen species (ROS), which can attack cellular components such as nucleic acids, proteins and phospholipid. However, the underlying mechanisms of apoptosis induced in hypoxic/ischemic condition and its treatment methods are unsettled. Cobalt chloride (CoCl_(2)) has been known to mimic hypoxic condition including the production of ROS. Epigallocatechin gallate (EGCG). a green tea polyphenol, has diverse pharmacologial activities in cell growth and death. This study was aimed to investigate the apoptotic mechanism by CoCl_(2) and effects of EGCG on CoCl_(2)-induced apoptosis in PC12 cells. Administration of CoCl_(2) decreased cell survival in dose- and time-dependent manners and induced genomic DNA fragmentation. Treatment with 100 µM EGCG for 30 min before PC12 cells were exposed to 150 µM CoCl_(2), being resulted in the cell viability and DNA fragmentation being rescued. CoCl_(2) caused morphologic changes such as cell swelling and condensed nuclei, whereas EGCG attenuated morphologic changes by CoCl_(2). EGCG suppressed the apoptotic peak and a loss of Δψ_(m) induced by CoCl_(2). CoCl_(2) decreased Bcl-2 expression but Bax expression was not changed in CoCl_(2)-treated cells. EGCG attenuated the Bcl-2 underexpression by CoCl_(2). CoCl_(2) augumented the cytochrome c release from mitochondria into cytoplasm and increased caspase-8, -9 and caspase-3 activity, a marker of the apoptotic executing stage. EGCG ameliorated the incruement in caspase-8, -9 and -3 activity, and cytochrome c release by CoCl_(2). NAC (N-acetyl-cysteine), a scavenger of ROS, attenuated CoCl_(2)-induced apoptosis in consistent with those of EGCG. These results suggest, that CoCl_(2) induces apoptotic cell death through both mitochondria- and death receptor-dependent pathway and EGCG has neuroprotective effects against CoCl_(2)-induced apoptosis in PC12 cells. 신경세포자멸사는 저산소 및 허혈환경에서 일어나며 이러한 세포죽은 reactive oxidant species (ROS) 생성을 동반함이 알려져있다. 그러나, 저산소 및 허혈환경에서 일어나는 세포자멸사의 기전 및 그 치료방법은 아직 정립되어 있지 않다. CoCl_(2)는 ROS를 생성하는 등 저산소환경과 유사한 조건을 초래하는 것으로 알려져 있다. Epigallocatechin gallate (EGCG)는 녹차의 polyphenol 성분으로서 세포성장과 죽음에 다양한 약리학적 효과를 나타냄이 알려져 있다. 본 연구는 PC12 세포에서 CoCl_(2)에 의한 세포자멸사기전을 밝히고 이에 미치는 EGCG의 효과를 조사하는데 목적이 있다. Cell viability는 MTT 측정으로 조사되었고, DNA fragmentation은 DNA laddering으로 조사되었다. Bcl-2와 Bax발현 정도는 RT-PCR로, caspase-3와 -9의 활성은 spectrophotometer, caspase-8의 활성은 flow cytometry에 의해 측정되었다. 미토콘드리아에서 세포질로 분비된 cytochrome c는 western blot으로, 분해된 DNA 양과 미토콘드리아 세포막전위 (Δψ_(m))는 FACScan으로 조사되었다. CoCl_(2)투여로 PC12 세포수는 용량 및 시간 의존형태로 감소하였고, genomic DNA fragmentation이 발생하였다. CoCl_(2)투여로 야기된 cell viability의 감소와 DNA fragmentation은 EGCG 전처치에 의해 억제되었다. CoCl_(2)은 세포용적팽창과 condensed nuclei 같은 형태적 변화를 일으켰으며, apoptotic peak, Δψ_(m)감소 및 cytochrome c 유리를 야기하였다. EGCG는 CoCl_(2)에 의한 세포형태변화, apoptotic peak, Δψ_(m)소실 및 cytochrome c 유리를 억제시켰다. CoCl_(2)는 Bcl-2 발현을 감소시켰지만, Bax 발현에는 영향을 미치지 않았다. EGCG는 CoCl_(2)에 의해 야기된 Bcl-2 발현 감소를 억제시켰다. CoCl_(2)는 caspase-3, -8, 그리고 -9의 활성을 증가시켰으며, EGCG는 CoCl_(2)에 의한 세포자멸사를 억제시켰다. 본 실험결과는 PC12 세포에서 CoCl_(2)가 미토콘드리아 의존 및 death receptor의존 기전으로 세포자멸사를 일으키며, EGCG는 세포자멸사기전을 억세지킴으로 신경보호기능을 가짐을 시사하였다.

Profile^(Ⓡ), ProTaper™ 및 K^(3TM) Ni-Ti파일의 과기구 조작이 치근단공 변위에 미치는 영향

양현,양인석,황윤찬,황인남,윤숙자,김원재,오원만 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.2

본 연구는 ProFile, ProTaper 및 K^(3)를 이용하여 과잉 기구 조작에 의해 근관 성형 시 근관의 만곡형태와 Ni-Ti 파일의 종류에 따라 치근단공이 어떻게 변위 되는지를 비교 분석하고자 시행되었다. 본 실험에서는 레진모형근관으로 J자와 S자의 근관 형태가 재현된 ENDO-TRAINING BLOC을 사용하였다. 근관 성형 기구로는 ProFile^(®), ProTaper™, K^(3TM)를 사용하였다. 총 60개의 레진모형근관을 사용하였으며, 사용된 레진모형근관 및 Ni-Ti 파일의 종류에 따라 10개씩 6개의 군으로 나누어 근관성형을 시행하였다. 근관 성형 전·후 이미지를 Image-analyzing microscope 100X를 이용하여 얻고 Photoshop 7.0 프로그램을 이용하여 중첩하였다. 이미지 분석 프로그램을 이용하여 근관 성형 전·후 치근단공의 중심으로부터의 직경 변화량과 면적을 측정한 결과 만곡된 근관의 성형시 치근단공이 주로 만곡의 외측으로 변위됨을 나타내며 ProFile이 ProTaper나 K^(3) 보다 통계적으로 유의성이 있게 작은 변화량을 나타내어 근관성형시 바람직한 기구임을 시사한다. This study was done to evaluate transportation of the apical foramen after 0.5 mm overinstrumentation by ProFile, ProTaper and K^(3) in simulated resin root canal. Sixty simulated resin root canal with a curvature of J and S-shape were divided into two groups. Each group consisted of three subgroups with 10 blocks according to the instruments used: ProFile^(®), ProTaper™, and K^(3TM). Simulated resin root canal was prepared by ProFile, ProTaper and K^(3) with 300 rpm by the crown-down preparation technique. Pre- and post-instrumentation apical foramen images were overlapped and recorded with Image-analyzing microscope 100X (Camcope, Sometech Inc, Korea). The amounts of difference in width and dimension on overlapped images were measured after reference points were determined by Image Analysis program (Image-Pro^(®) Express, Media Cybernetic, USA). Data were analyzed using Kruskal-Wallis and Mann-Whitney U-test. The results suggest that ProFile showed significantly less canal transportation and maintained original apical foramen shape better than K^(3) and ProTaper.

Long-term Stability after Reduction of Mandible Fracture by Keyhole Plate: Evaluation at the Time of Plate Removal

Cheon, Kyeong-Jun,Cho, Seoung-Won,Jang, Won-Seok,Kim, Ju-Won,Yang, Byoung-Eun Korean Association of Maxillofacial Plastic and Re 2020 Maxillofacial Plastic Reconstructive Surgery Vol.42 No.-

Background: Various types of miniplates have been developed and used for the reduction of facial bone fractures. We introduced Yang's Keyhole (YK) plate, and reported on its short-term stability. The purpose of this study was to evaluate the long-term stability of the YK plate, as a follow-up study, by examining the patients who had used the YK plate among the patients with the reduction of mandible fractures and who visited for plate removal. Methods: We reviewed the medical records of 16 patients who underwent mandibular fracture fixation using a YK plate (group I) and 17 patients who underwent mandibular fracture fixation using a conventional plate (group II). Assessment was then made on malunion, occlusal stability, discomfort during the application, and clinical symptoms. Results: From January 2015 to December 2017, a total of 36 patients underwent mandibular fracture surgery using a YK plate. A total of 16 patients received plate removal. Among them, 15 were male and 1 female. The average age was 26 years. The applied surgical sites were the 12 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of YK plate was an average of 335 days. During the same period, 45 people underwent surgery on the conventional plate. A total of 17 patients received plate removal. Among them, 15 were male and 2 females. The average age was 36 years. The applied surgical sites were the 8 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of the conventional plate was an average of 349 days. No malocclusion occurred at the time of removal, and occlusion was stable. No patient complained of joint disease or discomfort. Conclusion: The YK plate system, in which the screw was first inserted and the plate was applied, for clinical convenience did not cause any particular problem and no significant difference from the conventional plate.

중국의 미니멀리즘 패션에 나타난 미의식 연구 -도가(道家)의 ‘도(道)’ 미학을 중심으로-

양정원(Yang, Jung Won),이미숙(Lee, Mi Suk) 한국디자인문화학회 2021 한국디자인문화학회지 Vol.27 No.2

본 연구 목적은 탈현대적 가치를 갖는 도가사상의 ‘도(道)’ 미학에 주목하여 중국의 미니멀리즘 패션에 내재되어 있는 미의식을 분석하고자 한다. 연구 방법은 선행 연구 및 관련 서적을 중심으로 문헌 고찰을 통해 서양 미니멀리즘과 이와 연관성을 갖는 ‘도’ 미학을 살펴보고 이를 토대로 도가적 미니멀리즘 미의식을 도출한 후 중국의 미니멀리즘 패션의 미의식을 분석하였다. 연구범위는 2008년 이후부터 2021년까지 중국문화에 노출되어 중국문화의 영향을 받은 중국계디자이너들이 전통적 미의식을 통해서 미니멀리즘으로 재해석한 작품을 대상으로 하였다. 서양 미니멀리즘과 상응하는 연관성을 갖는 ‘도’ 미학을 허(虛), 무위자연(無爲自然), 유(遊), 유무상생(有無相生) 등의 미적 개념으로 대별하여 조형적 특성 및 미적 가치를 살펴본 후 도출된 도가적 미니멀리즘의 미의식은 ‘비움의 허무미’, ‘미완의 약졸미’, ‘일기적 공간미’, ‘변증적 상생미’ 등으로 나타났으며 이를 토대로 중국의 미니멀리즘 패션에 내재된 미의식을 분석한 결과는 다음과 같다. 첫째, 서양의 미니멀리즘의 ‘단순성’은 자연의 ‘본질추구’라는 특성을 내포한 ‘허’의 미적 개념과 연관성이 발견되며, ‘허의 미니멀리즘적 단순성’에서 도출된 ‘비움의 허무미’는 무정형이며 일체의 꾸밈이 없는 직선형 실루엣의 간결한 형식으로 표출된다. 둘째, 미니멀리즘의 ‘환원성’은 ‘자연적 본질로의 회귀’라는 특성을 내포한 ‘무위자연’의 미적 개념과 연관성이 발견되며, ‘무위자연의 미니멀리즘적 환원성’에서 도출된 ‘미완의 약졸미’는 인위적 흔적을 덜어내고 자연의 본성 그대로를 전시하기 위해 천연재료의 본형을 살리려는 방법으로 표출된다. 셋째, 미니멀리즘의 ‘상황성’은 ‘절대 자유의 공간 추구’의 특성을 내포한 ‘유’의 미적 개념과 연관성이 발견되며, ‘유의 미니멀리즘적 상황성’에서 도출된 ‘일기적 공간미’는 비구조적 풍성한 실루엣, 천연의 질감을 갖는 소재 등을 통해 표출된다. 넷째, 미니멀리즘의 ‘전체성’은 ‘유무대립의 관계가 상생하여 강렬한 어울림’을 내포한 ‘유무상생’의 미적 개념과 연관성이 발견되며, ‘유무상생의 미니멀리즘적 전체성’에서 도출된 ‘변증적 상생미’는 비대칭, 비균제적 조화를 통해 표출된다. 이상으로 자연주의적 색채가 강한 도가적 미의식은 환경을 고려한 지속 가능한 패션 디자인의 기초자료로 활용되리라 기대된다. The purpose of this study is to analyze the aesthetic consciousness inherent in Chinese minimalism fashion by paying attention to the ‘Do’ aesthetics of the Taoism, which has post-modern values. As a research method, through literature review focusing on previous studies and related books, Western minimalism and its related ‘Do’ aesthetics were examined, and the aesthetic consciousness of Taoist minimalism was derived based on this, and then the aesthetic consciousness of Chinese minimalism fashion was analyzed. The scope of the study was targeted at works that were exposed to Chinese culture from 2008 to 2021 and reinterpreted as minimalism by Chinese designers who were influenced by Chinese culture with a traditional aesthetic consciousness. The aesthetic consciousness of Taoist minimalism, which was derived after examining formative characteristics and aesthetic values by dividing the aesthetics of ‘Do’, which has a corresponding connection with Western minimalism, into aesthetic concepts such as ‘Heo’, ‘Muwi-jayeon’, ‘Yu’, ‘Yumusangsaeng’, appeared as ‘Empty Heomu beauty’ and ‘Unfinished Yakzol beauty’, ‘Ilgijeok Space beauty’, ‘Dialectic Win-win beauty’. Based on this, the results of analyzing the aesthetic consciousness inherent in Chinese minimalism fashion are as follows. First, the ‘simplicity’ of Western minimalism is found to be related to the aesthetic concept of ‘Heo’ which implies the ‘pursuit of the essence’ of nature, the ‘Empty Heo-mu beauty’ derived from ‘Heo’s minimalistic simplicity’ is expressed in a concise form of a straight silhouette without any amorphous ornamentation. Second, the ‘reduction’ of minimalism is found to be related to the aesthetic concept of ‘Muwi-jayeon’, which contains the characteristics of ‘return to the essence of nature’ and ‘Unfinished Yakzol beauty’ derived from ‘minimalistic reducibility of Muwi-jayeon’ is expressed as a way to remove artificial traces and reveal nature. Third, the ‘situationality’ of minimalism is found to be related to the aesthetic concept of ‘Yu’, which contains the characteristics of ‘absolute freedom space pursuit’, and the ‘Ilgijeok Space beauty’ derived from ‘minimalistic situationality of Yu’, is expressed through unstructured silhouettes and natural textures. Fourth, the ‘wholeness’ of minimalism is found to be related to the aesthetic concept of ‘Yumusangsaeng’ that implies ‘intense harmony due to the coexistence of relationships’, and ‘Dialectic Win-win beauty’ derived from the ‘Yumusangsaeng’ of the aesthetics of the ‘existence-free coexistence’ is expressed through asymmetric and non-uniform harmony. As mentioned above, the Taoist aesthetic with strong naturalistic colors is expected to be used as a basic material for sustainable fashion design considering the environment.

자판기 시스템 운영문제의 휴리스틱 해법 개발과 평가

박양병(Yang Byung Park),장원준(Won Jun Jang),박해수(Hae Soo Park) 한국산업경영시스템학회 2011 한국산업경영시스템학회지 Vol.34 No.4

The operation of vending machine system presents a decision-making problem which consists of determining the product allocation to vending-machine storage compartments, replenishment intervals of vending machines, and vehicle routes, all of which have critical effects on system profit. Especially, it becomes more difficult to determine the operation variables optimally when demand for a product that is out-of-stock spills over to another product or is lost. In this paper, we propose a heuristic for solving the operation problem of the vending machine system and evaluate it by comparing with Yang’s algorithm on various test problems with respect to system profit via a computer simulation. The results of computational experiments show a substantial profit increase of the proposed heuristic over Yang’s algorithm. Sensitivity analysis indicates that some input variables impact the profit increase significantly.

국내 정형외과 의료소송 현황 파악

이원(Won Lee),이미진(Mi Jin Lee),김용민(Yong Min Kim),우찬명(Chan Myung Woo),김소윤(So Yoon Kim),김양수(Yang-Soo Kim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.3

목적: 국내 정형외과 관련 의료소송 판결문의 분석을 통하여 정형외과 의료소송의 현황과 원인이 된 과정을 파악하고자 함이다. 대상 및 방법: 소송시작이 2005년부터 2010년인 정형외과 의료소송 판결문 341건을 대상으로 하여 빈도분석을 실시하였다. 결과: 사건 발생 시점에서 소송 종결 시점까지의 평균 소요기간은 4.22년이었다. 의료소송의 원인이 된 과정은 수술이 46.3%였고, 수술의 종류는 척추 수술이 가장 많았다. 사고의 결과는 장애가 가장 많았고, 최종심 결과는 원고일부승이 40.5%, 원고패(기각)가 34.3%였다. 감염은 전체 중 26.1%에서 발생하였고, 손해배상 청구금액은 평균 181,998,036원이었으며 인용금액은 평균 58,897,161원이었다. 결론: 정형외과 의료소송으로 이어진 의료사고의 주요 원인 과정은 수술이 가장 많았고, 그 중에서도 척추 수술이 가장 많았다. 추후 의료사고의 근본 원인분석을 통해 의료사고를 줄이고 재발을 방지하기 위한 후속 연구가 이루어져야 할 것이다. Purpose: Through the analysis of orthopedics lawsuit rulings, the purpose of this study is to understand the current trends of medical lawsuits in orthopedics in Korea. Materials and Methods: An analysis of medical lawsuits in orthopedics was conducted. As the study method, a quantitative analysis was performed on 341 cases. Results: The average period of lawsuits, from the occurrence of the medical accident to end of the ruling, took an average of 4.22 years. The most frequent procedure that was the main cause of the medical accidents was surgery, at 46.3%. When surgery is the main procedure that caused the medical accidents, the result of examining the types of surgeries showed that spine surgery had the highest percentage. For the outcome of the accident, the highest number of cases resulted in disability and for the final court outcome, 40.5% ruled partially in favor of the plaintiff (the patient) with acknowledgement of only the damage incurred due to medical error of the total sum claimed, and dismissal of the claim made by the plaintiff (patient) accounted for 34.3%; 26.1% of cases develop infection. For the amount of claim for damage, the average amount of claim was 181,998,036 won; in the judgement amount, the average amount of judgement was 58,897,161 won. Conclusion: The most frequent procedure in orthopedics was surgery and spine surgery comprised a large proportion of these surgeries. Future studies to determine root causes of medical accidents should be conducted to reduce medical lawsuits and to plan against the repeating of medical accidents.

부울경 광역도시철도망 구축 필요성에 관한 연구 : 국도 7호선 중심으로

최양원(Choi Yang Won) 대한토목학회 2011 대한토목학회논문집 D Vol.31 No.6D

근래 양산시와 부산시간의 활발한 이동량에 따라 최근 도시철도 1호선 양산선(노포~북정)의 예비타당성조사가 완료되어 타당성이 있는 것으로 결론되어 짐에 따라 도시철도 서비스가 취약한 웅상지역의 교통문제를 개선하고 광역도시간의 균형발전을 도모할 수 있도록 부울경을 연계하는 광역도시철도망 구축 필요성이 요구되고 있다. 또한 광역도시철도망 구축의 필요성을 강조하기 위해 대상지역 수단별 통행량과 해당지역 도로통행배정을 조사하였고 노선대안별 수송수요를 예측하여 수단별 통행량과 통행배정 결과에 따라 개략적인 경제적 분석을 위해 설정된 노선대안별 건설비와 편익을 산정하였다. 본 과업의 3개의 대상 노선안 중 효율적인 노선으로 선정된 노선 1안의 건설에 필요한 총 사업비는 7,943.2억원으로 산출되었으며 사업비중 순 공사비가 가장 많은 비용을 차지하고 있으며 다음으로 예비비 차량구입비 부대비 순으로 나타났으며 단 용지보상비는 계상되지 않았다. 특히 노선 1안은 건설시 경제성 분석결과 편익/비용비가(B/C)가 0.584 순현재가치(NPV)가 -2,174.7억원 내부수익율(IRR)이 0.604%로 분석되어 현 단계에서는 경제성이 다소 없는 것으로 나타났으나 장기적으로 노선 3안인 월평~용당의 양산구간만을 건설시 편익/비용비가(B/C)가 0.737로 나타나고 있다. 따라서 도시철도 서비스가 취약한 웅상지역 주민의 편의를 도모하기 위해 부산 도시철도 기본계획 재정비시 기존 신정선을 연장하여 도시철도 관련 상위계획에 본 과업노선을 포함시켜 장래 노선 2안인 부산~양산~울산으로 이어지는 광역도시철도망 체계 구축이 반드시 필요할 것으로 판단되고 있다. Preliminary feasibility study on Busan metro line #1 in Yangsan line (Nopo-Bukjeong) depending on active volume of mass transportation between Yangsan city and Busan city was conducted. As the study concluded that it's valid the necessity to establish the metro railroad network connecting to Busan Ulsan and Gyeongnam Province is demanded to improve the transportation issues in Ungsang area vulnerable to metro service and to drive the balanced development between metropolitan cities. In addition the volume of transportation depending on methods in target areas and road traffic assignment are surveyed to put a stress on the necessity to establish the metro railroad network. As the demand of transportation for alternative lines is predicted the budget and benefits for construction for each alternative line set for the rough economic analysis depending on traffic volume for each method and traffic assignment results. The total project budget necessary for construction of proposal line #1 set as effective one among target three lines in this project is calculated in 794.32 billion won. Construction accounts for the most expensive in expenses for project and contingency allowances purchases for vehicles and collateral expense are followed in orders. However compensation for lands is not counted. In particular according to economic analysis in proposal #1 ratio of benefit/cost (B/C) is 0.584 net present value (NPV) is -217.47 billion won the internal rate of return (IRR) is analyzed in 0.604 %. At the current stage it is not economically feasible but the B/C is 0.737 in long-term upon construction of Yangsan line between Wolpheong and Yongdang which is proposal line #3. Therefore when Busan metro basic plan is reorganized to aim the benefit of residents in Ungsang area vulnerable to the metro service we think it must be necessary to establish the metro railroad network connecting to Busan-Yangsan-Ulsan which is proposal line #2 by extending the existing Sinjeong line and including this task line in high-ranked plan related to metro railroad.

홈쇼핑 기업과 소비재 중소기업의 해외 동반진출에 관한 사례연구

정소원(So Won Jeong),양희순(Heesoon Yang),정재은(Jae Eun Chung) 한국경영학회 2017 한국경영학회 통합학술발표논문집 Vol.2017 No.08

우리나라의 지속적인 경제발전과 경쟁력을 확보하기 위해서는 대기업과 중소기업의 간의 균형 잡힌 발전이 필요하다. 이에 대중소기업간 상생 및 해외 동반진출에 대한 관심이 높으며, 정부에서도 여러 가지 지원정책을 늘리고 있다. 이에 본 연구에서는 국내 홈쇼핑 기업과 소비재 중소기업의 해외 동반진출에 관한 인터뷰를 통해 홈쇼핑의 특수성을 고려한 효율적인 유통대기업과 중소기업의 해외 동반진출 확대 방안을 모색하고자 한다. 이를 위해 해외 동반진출을 하고 있는 3개의 홈쇼핑 기업을 대상을 인터뷰를 실시하였으며, 결과는 다음과 같다. 홈쇼핑 기업은 소비재 중소기업의 해외 판로 개척에 도움이 되며, 자원과 역량이 부족한 중소기업에게 경영 및 마케팅 역량을 활용할 수 있게 해준다. 홈쇼핑 기업이 소비재 중소기업을 지원하기 위해 영상을 제작하거나 언어를 번역해주기도 하며, 무역 통관과 관련된 서류를 지원해주기도 한다. 또한 시장개척단을 구성하여 해외시장 정보 제공 등의 지원을 한다. 그렇지만 아직까지는 홈쇼핑 기업에게 해외 동반진출이 주는 실질적인 혜택이 미미하기 때문에 장기적으로 서로 win-win할 수 있는 전략이 필요하다. 이를 위해 해외 동반진출을 독려할 수 있도록 실질적인 혜택을 제공해야 하며, 궁극적으로 CSV 개념을 실천할 수 있도록 해야 한다. There must be a balanced development of both conglomerates and small and mid-sized companies in order to secure constant economic growth and competitive edge of South Korea. Accordingly, high expectations are being placed on win-win growth and joint overseas expansion of conglomerates and small and mid-sized companies. This study seeks efficient ways to promote joint overseas expansion of major retailers and small and mid-sized companies considering the distinctiveness of home shopping by conducting interviews about joint overseas expansion of home shopping companies and small and mid-sized consumer goods companies in South Korea. Home shopping companies contribute to opening up overseas markets for small and mid-sized consumer goods companies, and allows them to make use of business and marketing competencies that they lack. Home shopping companies also produce visual materials or provide language translations, and help draw up documents for customs clearance in trading. They also form market development teams and provide information about the overseas markets. However, since the actual benefits from joint overseas expansion are minor for home shopping companies, there is a need for a strategy for win-win growth of both parties in the long run. To this end, it is necessary to provide substantial benefits to encourage joint overseas expansion and ultimately implement the concept of creating shared value (CSV).

Analysis of acne-related judicial precedents from 1997 to 2018 in South Korea

( Ji Hoon Yang ),( Soo Ick Cho ),( Su Hwan Shin ),( Won Lee ),( So Yoon Kim ),( Dae Hun Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Medicolegal disputes are increasing in practical medicine. Acne is a common problem but is usually related to cosmetic problems such as acne scars. Medications or procedures related to acne could lead to medical malpractice. Objectives: To analyze medical litigation associated with acne or acne scar in South Korea. Methods: Acne-related judgements were searched using the Supreme Court of Korea’s Written Judgment Management System based on the keywords “acne” or “acne scar.” Results: Eleven cases were selected as litigated cases of acne or acne scar. Eight cases (72.7%) were related to acne scar and three (27.3%) were related to acne. Treatment modalities such as peeling (n = 6), laser treatment (n = 3), photodynamic therapy (n = 1), and antibiotic (n = 1) resulted in lawsuit. Claimed sequelae of the treatment were hyperpigmentation (n = 5), scar worsening (n = 5), erythema (n = 3), skin bumps (n = 1), and liver transplant (n = 1). Eight cases (72.7%) were awarded to the plaintiff, and the others were dismissed. The average awarded amount was 16,801,324± 24,452,486 (mean±standard deviation) Korean Won. Conclusion: Various treatments for acne or acne scar can cause medical disputes. Unnecessary litigation could be prevented if simple measures such as history taking, choosing proper procedure, and adequate management after the procedure along with sufficient informed consent were performed.

農村 簡易給水 施設의 維持 管理에 關한 硏究

朱鍾裕,梁壽錫,吳元敎,金慶昊 國立保健硏究院 1973 국립보건연구원보 Vol.10 No.-