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홍종원,김요한,최윤락,주동진,백우열,서영철,오원택,조재용,이상철,김상겸,류향주,전경옥,이원재 연세대학교의과대학 2024 Yonsei medical journal Vol.65 No.2
Purpose: With the revision of the Organ and Transplantation Act in 2018, the hand has become legal as an area of transplantable organs in Korea. In January 2021, the first hand allotransplantation since legalization was successfully performed, and we have per formed a total of three successful hand transplantation since then. By comparing and incorporating our experiences, this study aimed to provide a comprehensive reconstructive solution for hand amputation in Korea. Materials and Methods: Recipients were selected through a structured preoperative evaluation, and hand transplantations were performed at the distal forearm level. Postoperatively, patients were treated with three-drug immunosuppressive regimen, and func tional outcomes were monitored. Results: The hand transplantations were performed without intraoperative complications. All patients had partial skin necrosis and underwent additional surgical procedures in 2 months after transplantation. After additional operations, no further severe complications were observed. Also, patients developed acute rejection within 3 months of surgery, but all resolved within 2 weeks after steroid pulse therapy. Motor and sensory function improved dramatically, and patients were very satisfied with the appear ance and function of their transplanted hands. Conclusion: Hand transplantation is a viable reconstructive option, and patients have shown positive functional and psychologi cal outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should fo cus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea.
홍종원 국립특수교육원 1994 특수교육연구 Vol.1 No.-
The Purpose of this reasearch is to find out that how many graaphics have been converted into tactile ones in braille textbooks and how much the errors in tactile graphics have been happended. The results can be summarized as following : 1. 80%(134 graphics) of the graphics in arithmatic and 20%(24 graphics) in nature have been transcribed into tactile ones. In addition, it has been found that 36%(12 graphics) in arithmatics and 22%(22 graphics) in nature could be converted into tactile ones by givign some adaptation. 2. A number of tactile graphics visually different from original ones have been found, such as notch marks on watches, fractional divisions, lengths of squares, and so on. 3. Some graphics, though visually well-converted, are difficult to understand through finger-reading. The graphics with problems are knotty graphics, grapics of which visual information were damaged, and graphics in which show very small difference of dimension, size, angle. Accordingly, this research shows that tactile graphics should be developed in consideration of the psychological property of finger-reading, that not only braille transcribers but also teachers, subject-specialists and tactile-psychologists should take part in the process of transcribing for the better ones.
디지털 영상의 SNR을 고려한 템플리트 매칭 방법의 신뢰성 향상에 관한 연구
홍종원,오영석 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-
In the template matching, correlation coefficient has been frequently used to measure the similarity of gray-scale images. It is one of an important matching procedure to select a template of good quality which has influence on matching result. A template of good quality, which is generally distinguished by the naked eye, is not always successful in template matching experiment. To solve this problem, we introduce a SNR(signal-to-noise ratio) of template to compare templates each other and relates a SNR of template with correlation coefficient. From this compare templates each other and relates a SNR of tem plate with correlation coefficient. From this relation, we explain how to determine a threshold correlation coefficient that is to know whether a object exists or not and introduce method to measure a SNR of template. Subsequently, we show the fact that confidence of template matching method considering a SNR of template is improved.
홍종원,임정현,정주령,강태조,김태연,김영석,노태석,유대현 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.5
Purpose: Most studies on immune tolerance of mesenchymal stem cells (MSCs) have been performed using MSCs derived from bone marrow, cord blood, or adipose tissue. MSCs also exist in the craniofacial area, specifically in teeth. The purpose of this study was to evaluate the mechanisms of immune tolerance of dental pulp-derived MSC (DP-MSC) in vitro and in vivo. Materials and Methods: We isolated DP-MSCs from human dental pulp and co-cultured them with CD4+ T-cells. To evaluate the role of cytokines, we blocked TGF-β and IL-10, separately and together, in co-cultured DP-MSCs and CD4+ T-cells. We analyzed CD25 and FoxP3 to identify regulatory T-cells (Tregs) by fluorescence-activated cell sorting (FACS) and real-time PCR. We performedalloskin grafts with and without DP-MSC injection in mice. We performed mixed lymphocyte reactions (MLRs) to check immune tolerance. Results: Co-culture of CD4+ T-cells with DP-MSCs increased the number of CD4+CD25+FoxP3+ Tregs (p<0.01). TGF-β or/and IL-10 blocking suppressed Treg induction in co-cultured cells (p<0.05). TGF-β1 mRNA levels were higher in co-cultured DP-MSCs and in co-cultured CD4+ T-cells than in the respective monocultured cells. However, IL-10 mRNA levels were not different. There was no difference in alloskin graft survival rate and area between the DP-MSC injection group and the non-injection group. Nonetheless,MLR was reduced in the DP-MSC injected group (p<0.05). Conclusion: DP-MSCs can modulate immune tolerance by increasing CD4+CD25+FoxP3+ Tregs. TGF-β1 and IL-10 are factors in the immune-tolerance mechanism. Pure DP-MSC therapy may not be an effective treatment for rejection, although it may module immune tolerance in vivo.
홍종원 한국시각장애교육·재활학회 1987 시각장애연구 Vol.3 No.-
맹학생은 눈으로 수를 보지 못하고 손을 사용한 촉각으로 숫자 하나 하나를 만져서 계산하기 때문에 맹학교 교육 과정은 국민 학교 6학년에서 학습하는 수판셈을 2학년부터 가르치도록 하고 있다. 그런데, 맹학교에 공급되는 산수 교과서는 일반 교과서를 그래도 점역만 하여 공급하고 학년 수준에 맞게 지도할 수판셈 지도 자료는 없는 설정이도, 곱셈과 나눗셈의 지도 방법이 맹인 교사와 정안 교사는 달라서 학생들이 혼란을 일으키는 일도 있다.