용과(Hylocereus Undatus) 껍질 추출물의 생리활성 연구

허지원(Hur, Ji-Won),이인철(Lee, In-chul) K교육연구학회 2021 사회과학리뷰 Vol.6 No.1

본 연구에서는 버려지고 있는 용과(Hylocereus Undatus)의 껍질을 활용하기 위해 물과 70% 에 탄올로 추출하여 항산화 및 세포 독성 확인을 통해 천연 소재로서의 이용가치를 확인하고자 하였다. 용과 껍질의 항산화 활성을 확인하기 위해 총 폴리페놀 함량, 전자공여능, ABTS 라디칼 소거능을 측정하였다. 총 폴리페놀 함량 측정 결과, 70% 에탄올 추출물에서 103.43 ± 0.42 mg/100 g을 나타내어 열수 추출물 보다 높은 폴리페놀 함량을 확인하였다. 전자공여능 및 ABTS 라디칼을 측정한 결과, 열수 및 70% 에탄올 추출물은 농도 의존적으로 활성이 높아지는 것을 확인하였으며 70% 에탄올 추출물이 열수 추출물보다 높은 활성을 나타내었다. 대식세포인 RAW 264.7을 이용하여 MTT assay를 통해 세포 생존율을 확인한 결과, 열수 및 에탄올 추출물은 100 ㎍/㎖ 농도에서 85%의 세포 생존율을 확인하였다. 용과 껍질의 열수 및 70% 에탄올 추출물의 항산화 및 세포 생존율이 우수함을 나타내었으며, 이에 용과 껍질 추출물은 천연 소재로서의 개발 가능성을 가진 것으로 사료되어진다. In this study, hot water and 70% ethanol were extracted to utilize the abandoned Hylocreus Undatus peel. After that, it was intended to verify the value of its use as a natural material by verifying antioxidant and cytotoxicity. The total polyphenol content of Hylocreus Undatus peel was measured, and the electron donating ability and ABTS Radical scavenging effect were measured to check the antioxidant activity. As a result of measuring the total polyphenol content, 103.43 ± 0.42mg/100 g of the ethanol extract was found to have a higher polyphenol content than the hot water extract. Measurements of electron donating ability and ABTS Radical scavenging effect confirmed that both extracts were concentration-dependent active. 70% ethanol extract was more active than hot water extract. Cell survival was measured using MTT assay using RAW 264.7. As a result, hot water and ethanol extracts were found to have a cell survival rate of 85% at 100㎍/㎖ concentration. The antioxidant and cell survival rates of the hot water and 70% ethanol extract of Hylocreus Undatus peel have been shown to be excellent, and Hylocreus Undatus peel extracts is considered to have the potential to be developed as a natural material.

화이트 리튬 그리스의 동적 마찰 특성과 소산 에너지 변화 연구

허지원(Ji Won Hur),김경목(Kyungmok Kim) 항공우주시스템공학회 2015 항공우주시스템공학회 학술대회 발표집 Vol.2015 No.11

비닐하우스 내부 유해가스 제거 및 온습도조절을 위한 자동환기시스템 구현

허지원(Ji-Won Hur),장준호(Jun-Ho Jang),김진하(Jin-Ha Kim),이수민(Su-Min Lee),박수경(Su-Gyeong Park),이인수(In-Soo Lee) 한국정보기술학회 2018 Proceedings of KIIT Conference Vol.2018 No.6

비닐하우스와 같은 시설재배의 밀폐환경에서 발생할 수 있는 유해가스는 농작물에게 피해를 줄 뿐만 아니라 하우스 내부에서 작업하는 농민의 건강에도 치명적 영향을 준다. 본 논문에서는 암모니아 가스, 일산화탄소, 온도, 습도를 실시간으로 모니터링하고 자동으로 환기하는 시스템을 제안한다. 센서값은 사용자가 직접 설정할 수 있으며 센서값 이상의 유해가스와 온습도가 감지되면 비닐하우스 내부를 환기한다. 시스템을 실험하기 위해 실제 비닐하우스와 비슷한 모형 비닐하우스를 제작하여 실험하였으며, 설정한 센서값에 맞춰 환기부가 동작하였고 실험 결과 비닐하우스 내부의 대기상태가 환기되었음을 확인하였다. Noxious gases that can occur in the enclosed environment of planting facilities such as greenhouse do not only damage crops, but they also have a fatal impact on the health of farmers working inside the greenhouse. In this paper, we propose an automatic ventilation system for monitoring ammonia gas, carbon monoxide, temperature and humidity in real time. The sensor value can be set by the user and ventilate greenhouse when the noxious gases and the temperature and humidity above the sensor value are detected. In order to test the system, a model greenhouse similar to the actual greenhouse was constructed and tested. And the ventilation part was operated according to the set sensor value and it was confirmed that the atmosphere inside the greenhouse was ventilated.

ICT 기반 비대면 정신건강 개입 서비스의 실제

허지원(Ji-Won Hur) 한국정신건강사회복지학회 2021 한국정신건강사회복지학회 학술발표논문집 Vol.2021 No.10

초발 주요우울장애 환자의 우울 삽화 및 관해 상태에서 신경인지기능 결함 비교

허지원,김용구,Hur, Ji-Won,Kim, Yong-Ku 대한생물정신의학회 2008 생물정신의학 Vol.15 No.2

Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) in depressed state and 2) the changes of neuropsychological dysfunctions during depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who were diagnosed and classified by DSM-IV and SCID-IV interview participated in this study. The psychopathology was measured using the Hamilton rating scale for depression(HAM-D) and Brief Psychiatric Rating Scale(BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist using the Korean version of Memory Assessment Scale(K-MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions in remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of the K-MAS, total errors of the WCST, response time of Vigilance and response time at "Yes" response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in the patient group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved except for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.

머신러닝을 이용한 열화상 카메라의 고장 예지

정선우(Sun-Woo Jeong),신지원(Ji-Won Shin),민순재(Sun-Jae Min),허장욱(Jang-Wook Hur) 한국기계가공학회 2022 한국기계가공학회 춘추계학술대회 논문집 Vol.2022 No.4

적외선 센서를 이용한 자동소화시스템 구현

장준호(Jun-Ho Jang),김진하(Jin-Ha Kim),허지원(Ji-Won Hur),김현진(Hyeon-Jin Kim),안쯔쉬(ZiXu An),이인수(In-Soo Lee) 한국정보기술학회 2018 Proceedings of KIIT Conference Vol.2018 No.6

본 논문에서는 적외선 센서와 Logger Pro를 이용하여 자동으로 화재를 진압할 수 있는 시스템을 개발하였다. 매년 화재로 인한 피해가 발생하기 때문에 초기에 화재를 진압할 수 있는 시스템이 필요하다. 시스템을 구현하기 위해 화재 위치 추적 알고리즘을 개발하였고, 구현된 시스템은 사람의 조작 없이 화재를 진압한다. 이를 10번의 실험을 통해서 확인하였다. In this paper, we developed a system that can automatically extinguish fire using infrared sensor and Logger Pro. A system that can suppress the fire in the early stage is needed because the damage is caused by the fire every year. We have developed a fire location tracking algorithm to implement the system, and the implemented system extinguish the fire without human manipulation. This was confirmed through 10 experiments.

성인여성의 심폐체력 수준과 우울증상(Depressive Symptom)과의 관련성

박세정 ( Saejong Park ),고병구 ( Byung Goo Ko ),정진욱 ( Jin Wook Jung ),권준수 ( Jun Soo Kwon ),김성년 ( Sung Nyun Kim ),허지원 ( Ji Won Hur ),신예슬 ( Ye Seul Shin ),박수현 ( Soo Hyun Park ) 한국운동생리학회 2015 운동과학 Vol.24 No.4

PURPOSE: The purpose of this study was to evaluate the relationship between cardiorespiratory fitness and depressive symptom in Korean women. METHODS: The participants of the study was women aged 20-64 yr (n=639) who participated in the 2014 Korea Institute of Sports Science Fitness (KISS Fit) study. Maximal oxygen uptake was measured using a maximal graded exercise testing. Depressive symptom was assessed using Beck Depression Inventory (BDI). The participants were classified as low, intermediate and high fitness levels. Logistic regression models were used to test the association between fitness and depressive symptom. RESULTS: The prevalence of the depressive symptom defined by BDI score in this study was 13.4%. Fitness levels were significantly reduced in the participants with the depressive symptom (p=.002) compared to the ones without the depressive symptom. After controlling for age, body mass index, and house income, participants with low fitness level showed higher level of depressive symptom than the ones with medium and high fitness level (p<.001). Women with intermediate and high fitness level had 60% and 62% lower odds for depressive symptom, respectively, than the ones with low fitness level after adjustment for age, hypertension, dyslipidemia, heart disease, alcohol intake, smoking, body mass index, percent body fat, physical activity level and income. CONCLUSIONS: These results demonstrate that fitness is independently associated with the depressive symptom in women. Cardiorespiratory fitness might be utilized as an important component to prevent depressive symptom in women.

양극성 장애 환자에서 급성 조증기 및 관해기 사이의 인지기능 변화와 조증 증상과의 상관성

허지원,김용구 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : The purpose of this study was to investigate 1) whether the change of manic symptoms in bipolar patients would be correlated with cognitive functions and 2) whether there would be significant changes in the cognitive function between acute manic and euthymic states. Methods : The thirty-five patients who were diagnosed as manic episode by DSM-IV and SCID-IV interview participated in this study. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale(MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in the Vienna Test System respectively. The psychopathology was measured using Young Mania Rating Scale (YMRS) and Brief Psychiatric Rating Scale(BPRS) by a trained psychologist. After 6 weeks of drug treatment, the cognitive tests and psychopathology were retested by the same psychologist. Results : The normal control group (N=76) and bipolar disorder patients group (N=35) showed different neurocognitive performance which were performed at baseline. After 6 weeks of medication, the YMRS and BPRS scores in the patient group decreased significantly. Although the psychiatric symptoms were attenuated, most of the neurocognitive functions including attention, Psychomotor speed, memory (N=34), and frontal/executive function (N=35) were still impaired after treatment. Furthermore, the correlations between the variation of psychiatric symptoms and the differences in neurocognitive functions were statistically insignificant. Conclusion : This study provides an evidence for distinct neuropsychological dysfunctions in acute manic state in bipolar disorder patients. Besides, the impairments of neuropsychological functioning remain after medication and remission. These neuropsychological dysfunctions might be one of the trait markers of the disorder, and we suggest that the dysfunctions make the bipolar disorder patients with medication still experience difficult to adjust daily life.

자살 시도에 영향을 미치는 정신사회적 요인

허지원,최광연,이분희,심세훈,양종철,김용구 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objectives : A lots of studies have investigated the psychosocial characteristics of suicidal attempters in order to find eff-cient coping strategy and treatment intervention. The purpose of this study was to examine the psychosocial factors affecting the suicide attempt in psychiatric patients. Methods : Two hundred eighty patients who attempted suicide and admitted in the emergency room in 3 university hospitals from December 2003 to May 2006 were recruited in this study. The patients were interviewed using Structured Clinical Inter-view for DSM-IV Axis I disorder (SCID-RV), Lethality of Suicide Attempt Ratings Scale (LSARS) and Risk-Rescue Rating system (RRR). Results : The suicide attempters have psychosocial characteristics of female preponderance, age 20-39, high school in educational level, married in marriage condition, inoccupation, house makers in occupation. Most of attempters used the non-severe methods such as drug ingestion or wrist cutting, and selected home as the place of attempt. The delay until discovery was less than 4 hours for most suicide attempters, and the rate of asking for help directly or dropping clues were high. Major depressive disorder was the most common psychiatric illness among attempters. Conclusions : The present study would be the early stage to explore the risk factor and protect factor of suicidal attempt. This study suggests that the closed observation to potential-suicidal attempter in daily life is critical to protect against the fatal results due to suicidal attempts.