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민혜숙,허우준,이원석,최성윤,민혜정,이승호,최영빈,최태현 한국고분자학회 2016 Macromolecular Research Vol.24 No.5
To allow X-ray visibility, we coated a bioabsorbable bone plate in clinical use (PLT-1031, Inion, Finland) with a layer made of a composite of beta-tricalcium phosphate (β-TCP) and poly(lactic-co-glycolic acid) (PLGA) (i.e., β-TCP/PLGA plate) and assessed its in vivo acute biocompatibility for 4 months. For this, we fixed an intact Inion plate and β-TCP/PLGA plate on the left and right humeri of a New Zealand White rabbit, respectively. According to the X-ray imaging, the β-TCP/PLGA plate was observable for 2 weeks after the implantation while the intact plate was not visible during the whole tested period. To evaluate the biocompatibility of the plate, we performed a histological analysis with hematoxylin and eosin (H&E) staining on the tissues obtained at scheduled times. After being tested for 4 months, the overall biocompatibility of the β-TCP/PLGA plate was similar to that of the intact Inion plate and there was also no significant difference in bone repair process between the two plates. On the 5 day after the implantation, both plates exhibited a similar state of early reparative tissue reaction, showing tissue necrosis, abscess formation, and neutrophilic infiltration. In the 2 weeks, inflammation and granulation tissue formation around the plate extended to the skeletal muscle and fat tissue. This gradually decreased through the end of the experiment with only a few foreign body giant cells and macrophages remaining in the fibrotic tissue.
박인석,허준욱,임수연,설동원,허우준,박민욱,안혜석,김은미,한석정 한국유전학회 2008 Genes & Genomics Vol.30 No.2
Morphometric traits, percent shell weight, percent cavity volume and condition index of 4-year-old induced hybrid abalone from female Haliotis gigantea Gmelin and male Haliotis discus discus Reeve were compared to those of the parental species. Apex height/shell height of the induced hybrid abalone was in between the average height of the parental species. The induced hybrid abalone shared three traits with the paternal species and two with the maternal species. After 4 years of growth, the condition index of the induced hybrids weresignificantly higher than that of either parental species ( P< 0.05). Generally, induced hybrid abalone displayed an external morphology that was intermediate between the representative of both parental species. Haliotis gigantea and the induced hybrids had four respiratory pores, while H. discus discus had five. Morphometric traits, percent shell weight, percent cavity volume and condition index of 4-year-old induced hybrid abalone from female Haliotis gigantea Gmelin and male Haliotis discus discus Reeve were compared to those of the parental species. Apex height/shell height of the induced hybrid abalone was in between the average height of the parental species. The induced hybrid abalone shared three traits with the paternal species and two with the maternal species. After 4 years of growth, the condition index of the induced hybrids weresignificantly higher than that of either parental species ( P< 0.05). Generally, induced hybrid abalone displayed an external morphology that was intermediate between the representative of both parental species. Haliotis gigantea and the induced hybrids had four respiratory pores, while H. discus discus had five.