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東醫壽世保元-辛丑本 소양인 형방도적산에 관한 문헌적 연구
하진호,이정환,구덕모,서은희 사상체질의학회 2007 사상체질의학회지 Vol.19 No.1
A Literature Study on Soyangin Hyungbangdojok-san on the Dongyisusebowon․Shinchukbon Ha Jin-Ho, Seo Eun-Hee, Lee Jung-Hwan, Goo Deok-Mo Dept. Sasang Constitutional Medicine, College of Oriental Medicine, Daegu Haany Univ. 1. Objectives This study is purposed to distinct of Soyangin Hyungbangdojok-san on the Dongyisusebowon․Shinchukbon through compare with early medical books prescription and early dongmu's books prescription 2. Methods This study is research to use of dujok-san in early medical books and Dongmu's books. so the process of Hyungbangdojok-san formation is knowed 3. Result and conclusions 1) Early dojok-san is mostly used in oligouria 2) The use of dojok-san is changed by Dongmu' books 3) Hyungbangdojok-san is used in the superficial disease's pathology
5/6 NTX로 유발된 만성 신부전 랫트에 대한 형방지황탕(荊防地黃湯)의 효과
하진호,최애련,Ha, Jin-Ho,Choi, Ae-Ryun 사상체질의학회 2013 사상체질의학회지 Vol.25 No.4
Objectives The object of this study was to observe the effects of Hyeongbangjihwhang-tang (HB; Soyangin prescription) on the 5/6 NTX induced CRF rats. Methods Each of Hyeongbangjihwhang-tang aqueous extracts 200mg/kg were orally administered once a day for 35 days from 4 weeks after 5/6 NTX surgery. Four groups, each of 8 rats per group were used in this study, were sham group, CRF group, ${\alpha}$-Tocoperol group and HB group. Changes on the left remnant kidney weights, serum BUN, creatinine levels, caspase-3, PARP immunoreactivities were observed to nephroprotective effects, and relative immunomodulatory effects were monitored based on the changes of lymphatic organ weights and splenic cytokine contents. In addition, the changes on the kidney MDA, GSH contents and SOD, CAT activities were also calculated for antioxidant effects, and the effects on the CRF related cachexia were demonstrated based on the changes of body and epididymal fat pad weights, serum TG, TC, LDL and HDL levels. Results and Conclusions 1) HB was significantly decreased the left remnant kidney weights, serum BUN, creatinine levels and caspase-3, PARP immunoreactivities. 2) HB was significantly increased lymphatic organ weights and splenic cytokine contents. 3) HB was significantly increased body and epididymal fat pad weights, and was significantly decreased serum TG, TC, LDL and HDL levels. 4) HB was significantly decreased MDA contents, and was significantly increased GSH contents and SOD, CAT activities. The results obtained in this study suggest that HB significantly retarded immunosuppressions and cachexia related to the 5/6 NTX induced CRF through modulations of oxidative defense systems. Especially HB showed the highest favorable effects more than those of ${\alpha}$-tocoperol.