65종 한약처방이 3T3-L1 지방전구세포의 지방 분화에 미치는 효능 비교 연구

최혜민,유병우,김민주,김정옥,Choi, Hye-Min,Yu, Byung-Woo,Kim, Min-Ju,Kim, Jung-Ok 한방비만학회 2020 한방비만학회지 Vol.20 No.2

Objectives: To expand and provide information on the efficacy of herbal medicines, anti-obesity effects were evaluated. In many studies, plant-derived components with anti-obesity efficacies have been investigated for their potential inhibitory effects on 3T3-L1 preadipocyte cells. The purpose of this study was to investigate the anti-obesity effects of 65 herbal medicine in 3T3-L1 preadipocyte cells. Methods: Preferentially, 3T3-L1 cells were treated with 65 herbal medicines (500 ㎍/mL) during differentiation for 8 days. Next, 3T3-L1 cells were treated with selected herbal medicines at concentrations ranging from 50 to 200 ㎍/mL during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining. The expressions of genes related to adipogenesis were measured by reverse transcription polymerase chain reaction and Western blot analyses. Results: Among the 65 kinds of herbal medicines, 13 herbal medicines that been shown to be effective against the accumulation of lipid droplets were selected. Finally, selected Banhasasim-tang and Samhwangsasim-tang showed inhibitory activity on adipocyte differentiation at 3T3-L1 preadipocytes without affecting cell toxicity. In addition, Banhasasim-tang and Samhwangsasim-tang significantly reduced the expression levels of several adipocyte marker genes including peroxisome proliferator activated receptor-γ and CCAAT/enhancer binding protein-α. Conclusions : These results suggest that the ability of Banhasasim-tang and Samhwangsasimtang has inhibited overall adipogenesis and lipid accumulation in the 3T3-L1 cells. Banhasasim-tang and Samhwangsasim-tang may be a promising medicine for the treatment of obesity and related metabolic disorders.

정삼투막에 의한 붕산함유 방사성 폐액 처리를 위한 pH 및 이온강도 영향

최혜민,황두성,이근우,문제권,Choi, Hye-Min,Hwang, Doo-Seong,Lee, Kune-Woo,Moon, Jei-Kwon 한국방사성폐기물학회 2013 방사성폐기물학회지 Vol.11 No.3

일반적으로 역삼투압 공정에 의해 중성 pH 조건에서 40~90%의 붕소를 회수할 수 있다.정삼투공정은 새로운 선진 기술로 폐수처리 및 담수화 분야에서 관심이 높아지고 있다. 본 연구의 목적은 정삼투공정으로 방사성 액체 폐기물의 붕소제거 가능성을 고찰하고자 하는데 있다. 액체폐기물에서의 붕소 제거를 위한 정삼투공정의 성능을 평가하기 위해 pH, 삼투압, 용액의 이온강도 등을 고려하였다. 폐액의 붕산분리능을 좌우하는 주 조업변수인 pH 조건은 pH 7 이하에서 80% 이상의 붕소분리를 달성할 수 있었다. 약 1,000 mg/L 정도의 염농도에서는 막의 물의 플럭스는 거의 영향이 없었으나 붕소 투과율은 약간 감소하는 경향을 나타내었다. 공급액 내 붕소 농도 증가에 따라 붕소플럭스는 선형적으로 증가하였으며, 붕소의 투과율은 약 80% 정도로 일정하였다.

고지방 식이 비만 모델 마우스의 체중 및 혈장 지질 대사에 미치는 한방보조식품의 영향

최혜민,석장미,양재하,김상찬,김미려,Choi, Hye-Min,Suk, Jang-Mi,Yang, Chae-Ha,Kim, Sang-Chan,Kim, Mi-Ryeo 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2

Objective : Recently, obesity has increased at an alarming rate and is now a worldwide health problem. Natural dietary supplement, $CharmSlim^{(R)}$(C), is mixed pills, which consists of beans, black sesames, kelps, onions, adlay seeds, anchovies, pyogo mushrooms, green tea. Our study was performed to determine the weight-loss effects of natural dietary supplement, based on natural ingredients, in mice fed high-fat diet with an abundance of carbohydrates. Methods : Four groups of male ICR mice were fed different diets during 6 weeks: normal diet(NOR), high-fat (15%, w/w) diet(HF), high-fat supplemented with natural dietary supplement powdered 5%(C5) and 10%(C10) groups. We measured the changes of food intake, body weight and adipose tissues weights. Also we examined levels of lipid profiles in serum. Results : Body weight, liver weight and food efficiency ratio were significantly higher in the HF group than in NOR group. After 6 weeks of treatment, body weight, liver weight and adipose tissues weights (epididymal, perinephric, visceral and BAT) were significantly decreased in the C10 group when compared to the control HF group. The C10 group had markedly lower serum levels of total cholesterol and triglyceride when compared with HF group. Conclusion : These results demonstrate that this dietary supplement can suppress the increased lipid profiles, body weight and fat gains, thus could be considered as an effective adjunct in the treatment of obesity.

무행동 관성 효과가 패션 상품의 구매 의도에 미치는 영향 -상품 가격대 조절효과를 중심으로-

최혜민 ( Hyemin Choi ),이은정 ( Eun-jung Lee ) 한국의류학회 2019 한국의류학회지 Vol.43 No.1

Consumers believe it is more profitable to buy products at a discount price than at a fixed price. However, consumers who miss an opportunity for a discount would experience regret; consequently, they may also forgo a purchase despite experiencing regret if a subsequent opportunity was no more attractive than the initial one. This phenomenon has been conceptualized as inaction inertia. In this study we investigate if consumers showed behavior of inaction inertia under the situation of fashion products purchase as well as if price and involvement had a moderating effect on product purchase. The following are the results of the research based on an empirical investigation. First, according to the results of influence of inaction inertia on purchase intention, respondents exposed to scenario of experiencing similar price discount in the past, both under high-price situations and low-price situations, made statistically fewer responses than those exposed to situations without such experience; therefore, effect of inaction inertia could be confirmed. Second, the moderating effect of product price on relationships between inaction inertia and purchase intention was not statistically significant.

한반도 근해 고수온 예측을 위한 딥러닝 모델

최혜민(Hey-Min Choi),김민규(MinKyu Kim),양현(Hyun Yang) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.12

논문 : 국어학 ; 한국어능력시험 대화문에 나타난 거절 화행 분석

최혜민 ( Hye Min Choi ) 숙명여자대학교 한국어문화연구소 2013 한국어와 문화 Vol.14 No.-

본고에서는 한국어 능력시험에 나타난 대화문 중에서 거절의 의사를 표시하는 대화문을 추출하여 분석하였다. 토픽에 제시된 거절 대화문을 추출한 후, 거절을 이끌어내기 위해 제시된 상황, 거절 화행 전략, 대화자 간의 사회적 변인의 세 가지의 분석 기준을 통하여 대화문을 분석하였다. 대화문을 분석한 결과, 거절을 이끌어내는 유도 화행은 요청, 제공, 제안, 초대 상황으로 분석할 수 있었는데, 요청, 제안 상황은 매우 높은 빈도로 나타난 반면 제공, 초대 상황은 매우 낮은 빈도로 나타나 있어 거절 발화 장면이 요청과 제안 상황으로 치우쳐져 있는 것을 알 수 있었다. 또한 본고에서 거절 화행의 분석의 틀로 삼은 이해영(2003)에서 거절 화행 분석 기준으로 제시한 화행 전략 중 다수의 전략이 전혀사용되고 있지 않은 점을 보아 한국어 능력시험 대화문에서는 다양한 거절 전략이 제시되지 않는다는 것을 알 수 있다. 한편 문제를 풀기 위해 제시되는 대화문의 특성상 대화를 통해 대화자 간의 관계가 정확하게 제시되지 않은 경우가 더 많아 정확한 사회적 변인을 분석할 수는 없었으나, 관계가 제시된 경우를 살펴볼 때 판매원과 손님 관계가 가장 많이 나타난 것을 알 수 있었다. 분석을 통해 한국어 능력시험 거절 대화문에는 다양한 대화 상황과 대화자의 관계, 거절 전략이 제시되어 있지 않다고 볼 수 있겠다. 한국어 능력시험은 한국어 학습자들이 가장 접하기 쉬운 자료 중의 하나로, 한국어 능력시험에 나타난 거절 대화문을 통하여 학습자들이 한국어 거절 전략을 간접적으로 학습할 가능성이 있으므로 다양한 거절의 상황과 전략, 대화자의 관계가 제시되어야 하겠다고 본다. This study analyzed dialogues that express the intention to refuse among dialogues in the Test of Proficiency In Korean(TOPIK). After extracting dialogues that contain refusals in the TOPIK, the study analyzed dialogues based on three standards of refusal situations, strategies for the speech act of refusals, and social factors between speakers. The analysis results showed that the acts that induce refusals were largely classified into the request, provision, suggestion, and invitation. While the situations of request and suggestion exhibited high frequencies, the situations of provision and invitation were at visibly low frequencies. In other words, the scenes that prompted refusals in the TOPIK were inclined toward situations of request and suggestion. Moreover, given that many of the strategies for the act of speech proposed by Hae-Yeong Lee(2003) were not used at all, this study confirmed that dialogues in the TOPIK did not suggest various refusal strategies. In terms of the relationship between speakers, salesmen and customers accounted for the largest share of the dialogues. This analysis revealed that refusal-based dialogues in the TOPIK did not offer a variety of conversational situations, relationships between speakers, and refusal strategies. The TOPIK is one of the most accessible materials for Korean learners. Therefore, a number of Korean learners are likely to learn refusal strategies in Korean through dialogues exhibited in the TOPIK. Therefore, the TOPIK should be modified to suggest various refusal situations, strategies, and relationships between speakers.

리포익산 나노 입자의 식욕 억제에 대한 고분자의 영향

최혜민 ( Hye Min Choi ),박철호 ( Chul Ho Park ),이기업 ( Ki Up Lee ),박중열 ( Joong YeoI Park ),고은희 ( Eun Hee Koh ),김현식 ( Hyoun Sik Kim ),이종휘 ( Jong Hwi Lee ) 韓國藥劑學會 2007 Journal of Pharmaceutical Investigation Vol.37 No.6

Cryosurgery로 호전된 피부 리슈마니아증

최혜민(Hai Min Choi),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.2

Cutaneous leishmaniasis (oriental sore) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. The disease is endemic to the Mediterranean, Asia, Africa, and the Middle East. It has been seen in this country among many Korean technical experts and labourers working in the endemic areas of the disease. Our patient had acquired cutaneous leishmaniasis in Saudi Arabia and it had remained active for six months. He had been treated with antimony and metronidazole but failed because of severe side effects. And then we treated the patient witb cryosurgery and the skin lesions were followed by resolution with cosmetically acceptable scar in 4 months. The brief review of literature on the treatment of cutaneous leishmaniasis was undertaken.

혈액투석에서 복막투석으로 전환한 환자에서 발생한 특발성 적혈구 증가증

최혜민 ( Hye Min Choi ),현영율 ( Young Yul Hyun ),부창수 ( Chang Su Boo ),성수아 ( Su Ah Sung ),조상경 ( Sang Kyung Jo ),조원용 ( Won Yong Jo ),김형규 ( Hyung Kyu Kim ),이지혜 ( Ji Hye Lee ) 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.3

선천성 피부 형성부전증 2예

최혜민(Hai Min Choi),명기범(Ki Bum Myung),국홍일(Hong Il Kook) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.1

Aplasia cutis congenita is an anomaly characterized by absence of localized areas of the integument. The most common type of aplasia cutis congenita is a circular or oval, sharply outlined ulcer 1 to 3cm in diameter on the vertex of the scalp at the level of the posterior fontanel. Two cases of aplasia cutis congenita are presented. The first case was in a male newborn infant with a localized defect on his scalp. The second case was also in a male newborn infant who had extensive symmetrical involvement of his heels. No similar conditions and associating other congenital anomalies were found in the family members of reported cases.