라만 분광법을 이용한 Biphenylcarboxylic Acid 유도체들의 흡착 배향 연구

최혜란,최규석,정일기,송홍석,한건옥,최호섭,이상희,유수창,Heay Ran Choi,Kyu Seok Choi,Il Ki Jung,Hong Seok Song,Keun Ok Han,Ho Seob Choi,Sang Hee Lee,Soo-Chang Yu 대한화학회 2003 대한화학회지 Vol.47 No.5

Au와 Ag 콜로이드 단일막 표면위에 흡착된 4-biphenylcarboxylic acid(BPCA)의 유도체인 4''-cyano-BPCA(c-BPCA), 4''-mercapto-BPCA(m-BPCA), 그리고 4''-amino-BPCA(a-BPCA)가 어떠한 배향을 하는지 알아보기 위해 표면증강라만(SER)분광법을 이용하여 연구하였다. 체계적인 분석을 위해 benzoic acid, biphenyl, 그리고 BPCA의 분자 배향에 대한 정보를 기본으로 위 분자들에 대한 흡착정보를 유추해내었다. 배향에 대한 정보를 위해 벤젠고리 모드, C-H 신축진동모드, carboxylate 음이온의 신축진동모드, 그리고 각각의 주요 작용기에 해당되는 모드들의 거동변화를 살펴보았으며 이로부터 m-BPCA는 thiol 그룹이 금속에 흡착되고 biphenyl 그룹이 기울어 서 있는 형태를 취하고 있고 나머지 분자들은 금속표면에 편평한 형태로 흡착됨을 알아내었다. Surface-enhanced Raman(SER) spectroscopy was utilized to investigate the adorption orientation of the 4-biphenylcarboxylic acid(BPCA) derivatives, such as 4'-cyano-BPCA(c-BPCA), 4'-mercapto-BPCA(m-BPCA), and 4'-amino-BPCA(a-BPCA), which were adsorbed on Au and Ag colloid monolayers. For the systematic approach, information regarding the adsorption behavior of benzoic acid, biphenyl, and BPCA was applied to the target molecules. From the spectral behaviors of benzene ring, C-H stretching, carboxylate anion, and the other finger printing vibrational modes, it was concluded that only the m-BPCA was adsorbed tilt with thiol group being adsorbed on Au surface, whereas the other molecules were adsorbed flat on both Au and Ag surfaces.

Biphenyl-4-Carboxylic Acid Phenyl Amide의 금속표면에서의 흡착에 대한 표면증강라만 연구

최혜란,임정훈,한건옥,최호섭,김동희,유수창,Heay Ran Choi,Jung-Hoon Lim,Keunok Han,Ho Seop Choi,Dong Hee Kim,Soo-Chang Yu 대한화학회 2003 대한화학회지 Vol.47 No.5

에탄올로 발기부전을 유도한 흰쥐의 성기능 개선에 마카추출물이 미치는 영향

최혜란,이민정,이수정,박희전,송지영,김일수,신대근,Choi, Hye Ran,Lee, Min Jung,Lee, Su Jung,Park, Hee Jeon,Song, Ji-Young,Kim, Il Su,Shin, Daekeun 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.3

The purpose of this study was to examine the effects of Maca water and/or ethanol extract on the nitric oxide (NO) production in human umbilical vein endothelial cells HUVAC and on erectile dysfunction in rats. Maca was extracted due to both solutions, which are water and ethanol. Each Maca extract was applied to HUVAC, and NO production was checked. Additionally, three different dosages (250, 500 and 1,000 mg/kg) of Maca ethanol extract was administered to Sprague-Dawley rats for 4 weeks. All rats were sacrificed and each sample was collected for analysis. The control rats received only the saline vehicle. The NO production of HUVAC was significantly increased by domestic and homemade Maca water extracted at $60^{\circ}C$ group. Both NO generation and testosterone release were not influenced due to the oral administration of Maca. In the EtOH group rats, the number of sperm was reduced compared to that of the control group. All Maca groups had a high number of sperm and each sperm count had increased as a result of the Maca extract dose. The results of this research suggest that Maca has a positive effect on male erectile dysfunction, which need to be examined further in future studies.

어머니의 취업여부에 따른 양육태도, 모-자녀상호작용, 유아의 또래놀이 상호작용 및 문제행동 간의 관계

최혜란(Hea-Ran Choi),유지아(Ji-A Yoo),김선미(Seon-Mi Kim) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.3

연구는 육아정책연구소에서 제공하는 한국아동패널 6차년도(2013)데이터를 사용하여 유아기 자녀를 둔 1614명의 어머니를 대상으로 취업여부에 따른 양육태도, 모-자녀상호작용, 유아의 또래놀이 상호작용 및 문제행동에 미치는 영향을 살펴보고자 하였다. 수집된 자료는 SPSS 18.0 프로그램을 이용하여 위계적 회귀분석을 실시하였다. 본 연구의 주요결과는 다음과 같다. 첫째, 어머니의 취업여부에 관계없이 어머니의 온정적 양육태도가 높을수록, 유아의 또래놀이 상호작용이 높을수록 유아의 내재화, 외현화 문제행동이 모두 감소하는 것으로 나타났다. 둘째, 취업모의 경우 모-자녀상호작용이 유아의 내재화, 외현화 문제행동에 유의미한 영향을 미치지 않았지만, 비취업모의 경우에는 유의미한 영향을 미쳐 자녀와 상호작용이 많을수록 유아의 내재화, 외현화 문제행동이 증가하는 것으로 나타나 취업모와 비취업모의 차이가 있었다. 이러한 연구결과에 기초하여 유아의 다양한 문제행동을 예방하는 부모교육 프로그램이나 아동․가족 상담현장에 실제적으로 활용할 수 있는 기초자료를 제공했다는 데 본 연구의 의의가 있다. This study tried to look into influences to parenting style, mother-child interaction, child interactive peer play, and problem behaviors according to employment status by objecting 1,614 mothers having young child and also using Korea Child Panel 6th Year data (2013) having been provided from Korea Institute of Child Care and Education. Regarding collected data, hierarchical regression analysis was carried out by using SPSS 18.0 program. The results of this study were as follows. First, as much as warmth parenting style of mothers and child peer play interaction were high regardless of mothers’ employment status, child internalizing and externalizing problem behaviors appeared to be decreased. Second, there were differences between employed mothers and unemployed ones because mother-child interaction did not affect significant influences to child internalizing, externalizing problem behaviors in case of employed mothers, but child internalizing, externalizing problem behaviors were turned up to be increased as much as mother-child interaction was larger by affecting significant influences in case of unemployed mothers. Based on above finding, this study has a meaning in that it provides a basic data which could be actually utilized to parent education program in order to prevent various problem behaviors of children or child & family counseling field.

복분자 미숙과 물추출물의 콜레스테롤 개선 효과

최혜란(Hye Ran Choi),이수정(Su Jung Lee),이정현(Jung-Hyun Lee),권지웅(Ji Wung Kwon),이희권(Hee Kwon Lee),정종태(Jong Tae Jeong),이태범(Tae-Bum Lee) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.12

We investigated the effects of unripe black raspberry water extract (UBR-W) and oxidation-LDL treatment on cholesterol levels. Experiments using an established human hepatocellular carcinoma cell line (HepG2) showed a time-dependent increase in expression of LDL receptor after UBR-W treatment. Expression of LDL receptor-related genes, such as SREBP1 and 2, increased upon UBR-W treatment. However, expression of HDL-related genes was unaffected by UBR-W. HMG-CoA reductase activity was reduced by UBR-W treatment, whereas HMG-CoA mRNA expression significantly increased. In addition, the ApoB/ApoA1 mRNA level, which is a predictor of cardiovascular risk, was reduced in a time-dependent manner by UBR-W treatment. Macrophage-like cells (RAW 264.7) showed increased expression of ox-LDL-related genes, such as CD36, scavenger receptor-A, adipophilin, and PPAR-gamma, upon ox-LDL treatment compared to untreated control cells, and quantitative lipid analysis indicated a dramatic increase in lipid accumulation. However, UBR-W treatment significantly reduced expression of ox-LDL-related genes and largely prevented lipid accumulation. The results indicate that UBR-W mediates a cholesterol-lowering effect via inhibition of cholesterol synthesis and induction of LDL uptake through SREBP.

다양한 관련변수들에 따른 CT 조영제 부작용 원인 및 분석에 관한 연구

최혜란(Hye Ran Choi),김가연(Ga Yeon Kim),김문정(Mun Jeong Kim),신효정(Hyo Jeong Shin),배승환(Seung Hwan Bae),이종인(Jong In Lee),이영진(Youngjin Lee) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.11

중학생의 여가활동 참여와 사회성 발달에 관한 연구

최혜란(Hea Ran choi),심상신(Sang Shin Shim) 한국여가학회 2000 한국여가학회지 Vol.2 No.-

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자폐스펙트럼장애 아동의 의문사 ‘무엇’, ‘누구’, ‘어디’ 이해 특성

최혜란(Choi, Hye Ran) 한국통합치료학회 2009 통합치료연구 Vol.1 No.1

본 연구는 자폐스펙트럼장애 아동을 대상으로 의문사 ‘무엇’, ‘누구’, ‘어디’를 의미ㆍ화용적 분류에 따른 이해능력을 알아보았다. 연구대상은 언어연령 3;0-3;11세에 해당하며 동작성 지능이 -1.5SD이내인 학령전기 자폐스펙트럼장애 아동 15영으로 하였으며, 의문사 질문은 상황이 있는 그림카드를 제시한 후 그림 1장에 두 개의 의문사 질문을 한 후 답하게 하였다. 응답유형으로는 구어표현과 지적하기 반응을 모두 정반응으로 하였으며 연구 결과는 다음과 같다. 첫째, 의문사 종류에 따른 자폐스펙트럼장애 아동과 정상 아동의 이해 평균을 살펴본 결과 의문사 종류에 따라서는 통계적으로 유의한 차이를 보이지 않았으나 집단에 따라서는 유의한 차이를 나타냈다 (P<.05), 언어연령이 3;0-3;11세 수준의 자폐스펙트럼장애 아동은 동일한 언어연령의 정상발달 아동에 비해 의문사 ‘무엇’, ‘누구’, ‘어디’의 의문사 종류에 따른 이해 평균이 낮게 나타났다. 둘째, 자폐스펙트럼장애 아동과 정상 아동을 대상으로 의문사의 의미ㆍ화용적 분류에 따른 이해 평균을 살펴 본 결과 의문사 ‘무엇’은 의미ㆍ화용적 분류 중 ‘사물을 묻는 질문’이 ‘행위를 묻는 질문’에 비해 높은 이해 평균을 나타났으며, 의문사 ‘누구’의 의미ㆍ화용적인 분류 중 ‘그림에 나타나 있는 사람에 대한 질문’이 ‘그림에 나타나지 않은 사람에 대한 질문’보다 높은 이해 평균을 나타냈다. 또한 의문사 ‘어디’ 의 의미ㆍ화용적 분류 중 ‘장소를 묻는 질문’보다 ‘위치를 묻는 질문’에 대한 이해 평균이 더 높은 것으로 나타났다. 본 연구를 통해 자폐스펙트럼장애 아동은 정상 아동에 비해 의문사 ‘무엇’, 누구’, ‘어디’의 이해 평균이 더 낮은 것으로 나타났으며, 의문사의 의미ㆍ화용적 분류에 따라 낮은 이해 평균을 갖는 것으로 나타났다. This study investigated autistic spestrum disorder children’s understanding of interrogatives in an earlier stage of language development such as what, who, and where. The study used questions based on semantic and pragmatic usage: what-questions of an object and a behavior, who-questions of persons present and absent in the picture, and where-questions of a place and a position. All participants were autistic preschoolers at the language ages of 3;0 to 3;11 and with movements IQs of less than -1.5 SD. The participants were given picture cards and asked two questions for each card. The children was able to respond to the questions using their voice or hand gestures. First, autistic spestrum disorder children’s understanding levels of interrogatives were compared to those of normal children. Understanding levels of autistic spestrum disorder children at the speech ages of 3;0 to 3; 11 were low compared to those of normal children at the same speech ages. Secondly, understanding levels of interrogatives sorted by semantic and pragmatic usage were inspected. A what-question of an object showed a higher level of understanding compared to the one of a behavior. An understanding of a who-question of a person present in the picture was higher than the one of a person absent. A where-question of a place was easier to understand than the one of a position.

아동청소년 성지식과 성태도의 관계 분석

최혜란(Choi Hye-ran) 전주대학교 한국고전학연구소 2022 공존의 인간학 Vol.- No.7

교육 연극을 활용한 감성 중심 환경교육이 초등학생의 환경 소양에 미치는 영향

최혜란(Hye Ran Choi),이상원(Sang Won Lee) 한국환경교육학회 2009 環境 敎育 Vol.22 No.1

The purpose of this study was to investigate the influences of environmental education program through educational theatre on student’s environmental literacy of 5th graders in an elementary school in Seoul. The students were divided into an experimental group and a control group. Then, the experimental group had the emotion-centered environmental education program using educational theatre, and the control group had the regular education process, which is a general lecture about the environment. The SPSS 12.0 program was used to analyze the results. The major result of the study was as follows. First, the researcher was able to develop and apply professor-learning model for the environment education using the educational theatre by abstracting and recreating environment-related contents from the 5th grade curriculum. Second, the study has showed that applying the emotion-centered program using the education theatre for the environment education certainly contributes to the improvement of the environment knowledge of the elementary students. Third, the emotion-centered environment education program has influenced evenly on the elements of the environment knowledge divided by the four goal levels of the environment education. Finally, the higher the student’s emotional quotient is, the more improvement of the environment knowledge the student gets when using the emotion-centered environment education program using the education theatre. In conclusion, the emotion-centered environment education program using the education theatre is a usable method to the elementary schools, and has a positive effect on increasing the environment knowledge of 5th grade students. In the time of requiring the diverse environment education methods, this program is worth to try as a new education method. Therefore, it is necessary to research more on the professor-learning activities related to this study.