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화피(樺皮) 에탄올 추출물의 Ultraviolet B로 자극한 피부 각질 세포 보호 작용
최학순,김현주,이학송,백승원,김지은,송용선,Hag Soon Choi,Hyun Joo Kim,Hark Song Lee,Seung Won Paik,Ji Eun Kim,Yung Sun Song 대한한의학회 2023 대한한의학회지 Vol.44 No.2
Objectives: Betula Platyphylla(BP) has been used as a analgesic, anti-microbial, anti-oxidant drug in Eastern Asia. However, it is still unknown whether BP ethanol extract could exhibit the inhibitory activities against ultraviolet B(UVB)-induced skin injury on human keratinocytes, HaCaT cells. This study was aimed to investigate the protective activity of BP ethanol extract on UVB-irradiated skin injury in HaCaT cells. Methods: The skin injury model of HaCaT cells was established under UVB stimulation. HaCaT keratinocyte cells were pre-treated with BP ethanol extract for 1 h, and then stimulated with UVB. Then, the cells were harvested to measure the cell viability, production of reactive oxygen species(ROS), pro-inflammatory cytokines such as interleukin(IL) 1-beta, IL-6, and tumor necrosis factor(TNF)-𝛼, hyaluronidase, type 1 collagen, matrix metalloproteinase(MMP)s. In addition, we examined the mitogen activated protein kinases(MAPKs) and inhibitory kappa B alpha(I𝜅;-B𝛼) as inhibitory mechanisms of BP ethanol extract. Results: The treatment of BP ethanol extract inhibited the UVBinduced cell death and ROS production in HaCaT cells. BP ethanol extract treatment inhibited the UVB-induced increase of IL-1beta, IL-6, and TNF-𝛼. BP ethanol extract treatment inhibited the increase of hyaluronidase, MMP and decrease of collagen. BP ethanol extract treatment inhibited the activation of MAPKs and the degradation of I𝜅-B𝛼. Conclusions: Our result suggest that treatment of BP ethanol extract could inhibit the UVB-induced skin injury via deactivation of MAPKs and nuclear factor kappa B(NF-𝜅B) in HaCaT cells. This study could suggest that BP ethanol extract could be a beneficial agent to prevent skin damage or inflammation.
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남상식(Sang Sik Nam),최인후(In Hu Choi),최학순(Hag Soon Choi),김천환(Cheon Whan Kim),배상경(Sang Kyung Bae),방진기(Jin Ki Bang) 한국원예학회 2005 원예과학기술지 Vol.23 No.4
‘생올’은 1998년 중국 산동지방에서 통구마늘을 도입하여 특성검정, 선발 및 종구를 증식하여 ‘목포 1호’로 계통명을 부여하고 무안, 남해, 제주 등 3개 지역에서 2003년부터 2004년까지 지역적응 재배시험을 거쳐 육성하였다. ‘생올’은 초형이 직립형, 엽색은 진한 녹색으로 ‘남도’ 마늘과 같다. 주아크기는 극소립으로 균일하며 총포 당 주아수가 73개 이상으로 많다. 화경출현기 및 수확기가 ‘남도’ 마늘에 비해 각각 14일, 7일 정도 빠른 조숙성 품종이다. ‘생올’ 마늘의 피르브산 함량은 19.4μ㏖/g 수준으로 ‘남도’ 마늘에 비해 낮아 생마늘 맛이 순하여 생식용으로 적합하다. 수량은 ‘남도’ 마늘 대비 92% 수준이나 조숙성이기 때문에 조기출하가 가능하고 수확 후 벼 이앙, 콩, 땅콩, 참깨 등의 재배가 가능하므로 작부체계상 유리하여 난지형 마늘 재배지에서 재배가 용이하다고 판단된다. A new garlic ‘Saengol’ (Allium sativum L.) was developed at Mokpo Experiment Station in 2004. The variety was introduced as a genetic resource from China in 1998. The leaves of this variety are erect and dark green. Size and number of bulbils were small (0.05 g) and numerous (73 ± 16). Clove differentiation, scape emergence, and harvesting dates were 11, 14, and 7 days respectively, earlier than those of ‘Namdo’ garlic. The yield of ‘Saengol’ was 8% lower than ‘Namdo’ garlic with 1,282 ㎏/10a, but the pyruvic acid content of this variety was low with 19.4 μ㏖ g⁻¹ compared to 35.4 μ㏖ g⁻¹ of ‘Namdo’ garlic. This variety can be adapted all over the southern type garlic cultivation area in Korea.
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황재문(Jae Moon Hwang),하현태(Hyun Tae Ha),최학순(Hag Soon Choi) 한국원예학회 2009 원예과학기술지 Vol.27 No.4
남해와 의성지역에서 4가지 생태형 품종을 각각 공시하고 2004년부터 2006년까지 3년간 동일한 장소에서 그 지역의 관행 방식대로 재배하여 마늘의 구중과 생장량의 변화를 추정하고 지역별 선발효율을 검정하였다. 남해에서 수집 당시(2004년)에 구중이 높았던 ‘육백’종과 ‘남도’종이 다른 품종에 비하여 3년간 지속적으로 구중이 높았으나, 의성에서는 ‘남도’종의 구중이 초기보다 감소되었고 ‘의성’종과 ‘육백’종의 구중은 증가하였다. 남해와 의성에서 마늘의 생장은 ‘남도’종과 ‘의성’종이 각각 타 품종에 비하여 안정적이며 우수한 결과를 보였다. 따라서 남해에서는 한지형 마늘인 ‘단양’종이, 의성에서는 난지형인 ‘남도’종이 각각 선발효율도 가장 낮아 지역적응성이 낮았다. The field performance of cultivars collected from different growing regions were tested and evaluated for the selection efficiency of seed garlic in Euiseong (128.53'/36.21') and Namhae (128.02'/34.35') in Korea. For this experiment we used 4 cultivars such as ‘Euiseong’ and ‘Danyang’ local cultivars collected from Euiseong and Danyang area, and ‘Namdo’ and ‘Yukbaek’ from Namhae and Yongin areas in 2004, respectively. Seed cloves selected from the healthy and normal type bulb of each cultivar were sown on November, and the garlic was harvested on June for three years from 2004 to 2006. In Namhae, mean bulb weight of all cultivars in 2005 was enhanced as compared with cv. ‘Namdo’, but in 2006 bulb weight of cv. ‘Yukbaek’ and ‘Namdo’ were increased. The highest selection efficiency on bulb and clove weight was shown in cv. ‘Uiseong’. In Uiseong, the increase of bulb and clove weight in 2005 and 2006 was substantial in cv. ‘Uiseong’ and ‘Yukbaek’, but decreased in warm ecotype cv. ‘Namdo’. No. of cloves increased in all cultivars except cv. ‘Namdo’ in both regions from 2004 to 2005. Growth of garlic plant was significantly vigorous as its own cultivar, that is, cv. ‘Namdo’ was the best in Namhae and cv. ‘Uiseong’ in Uiseong region. The secondary growth rate showed much difference in regions and generations, but it showed same tendency as plant growth patterns. We should conclude that cv. ‘Namdo’ is not adaptable but cv. ‘Uiseong’ and ‘Yukbaek’ would be eligible to grow in Uiseong area. However, the regional adaptability of garlic cultivars will be continuously evaluated through the selection efficiency test at the same and/or different regions.
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소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과
조주현 ( Joo-hyun Jo ),임지성 ( Ji-sung Im ),김종규 ( Jong-gyu Kim ),박중현 ( Jung-hyun Park ),최학순 ( Hag-soon Choi ),황규원 ( Geu-won Hwang ),송용선 ( Yung-sun Song ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.1
Objectives The aim of this study is to evaluate anti-inflammatory and anti-arthritic effects of Sogyunghwalhyel-tang-gamibang (SGHHTGB) in cell and animal models and also to suggest one of putative mechanisms underlying its anti-arthritic effects. Methods Enzyme-linked immunosorbent assay was applied to measure the concentrations of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in culture medium and blood serum and nitric oxide (NO) was assayed by Griess reagent. The expressions of inducible NO synthase (iNOS) and cyclooxygenase- 2 (COX-2) were analyzed by Western blot method. Results In a cell model using RAW264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS), the drug, at its non-cytotoxic concentrations, inhibited the production of the pro-inflammatory cytokine TNF-α, IL-1β and IL-6. In addition, it suppressed the expression of the inflammatory enzyme iNOS and COX-2, and reduced the synthesis of the enzyme product NO (as stable nitrite) and PGE2 in activated macrophages. Meanwhile, in an animal model using rheumatic arthritis (RA) mice induced with injection of type II collagen antibody (CAb) and LPS, the drug improved clinical symptom of arthritis and reduced paw thickness and inflammatory cell infiltration. In blood of RA mice, the drug reduced serum levels of TNF-α, IL-1β, IL-6, nitrite, and PGE2, all inflammatory mediators produced by activated macrophages. Conclusions SGHHTGB may ameliorate CAb and LPS-induced RA in mice, presumably by inactivating macrophages that are capable of initiating joint inflammation by producing pro-inflammatory cytokines and expressing inflammatory enzymes. (J Korean Med Rehabil 2021;31(1):33-46)
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