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      • KCI등재후보
      • SCOPUSKCI등재

        식도 정맥류의 내시경적 분류에 관한 연구

        정정명(Jung Myung Chung),정해철(Hae Chul Chng),설상영(Sang Yeong Seol),정승진(Seung Jin Jeong),최석렬(Seok Reyol Choi),최하진(Ha Chin Choe) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

        N/A Although several classifications of esophageal varices are reported at present monent, none of them seems to be perfect in terms of clinical applicability. Some are too simple to cover the whole features of varices, or too much complicated to apply practically to clinical practices. Recent remarkable advances of endoscopy has let more precise serial observations and prognostic evaluation of varices be possible without great difficulties. Having observed 373 cases of esophageal varices from Jan. 1981 to June. 1984 at Paik Hospital, In-Je Medical College, we have tried a new classification of esophageal varices, according to not only their shape, size, numbers, colors and locations, but having particular consideration on their bleeding episodes. Endoscopic grades of esophageal varices are classified into following 4 grades, Grade I: One or two tiny tortuous, blue colored varices, less than 2 mm in diameter, being localized in lower esophagus. Grade II: Bead-like tortuosity, blue colored varices, mostly 2-4 mm in diameter being localized in lower esophagus. Grade III: Varices on the top of the varices, red colored, mostly more than 4 mm in diameter with spreading up to mid esophagus. Grade IV: Grade III varices with spreading through the entire esophagus and or down to the fundus of stomach. Bleeding tendency was most frequently observed in Grade IV varices.

      • KCI등재후보
      • KCI등재후보

        원폭 피폭자와 그 자녀들에 대한 임상적 및 염색체 이상에 관한 연구

        김동수,백용균,박상길,정정명,최하진,김상정,최원락 대한내과학회 1986 대한내과학회지 Vol.31 No.4

        Presented in this paper is the data from clinical labaratory examination of 50 Korean atomic-bomb survivors (in Hiroshima and Nagasaki, Japan in 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both $quot;stable$quot; and $quot;unstable$quot; types of chromosomal aberrations. Eight of their offspring could be tested for the chromosomal changes and SCE as well. The results were as follows: 1) All survivors were found to have suffered from various diseases, particularly from respiratory disease. Two had malignancies, viz., one case having squamous cell carcinoma of uterine cervix and another adenocarcinoma of stomach. 2) Serum total protein and serum albumin levels were found to be decreased in 18% and 27% of the survivors, respectively. Alkaline phosphatase, SGOT, IgG and IgM were increased in 22%, 6.3%, 36.7% and 13.6% of the survivors, respectively. IgA was within normal limit in all cases. 3) Stable type of chromosomal aberrations was discovered in none of the survivors and the offspring examined. However, approximately 50% of the survivors showed significantly higher incidence of chromatid breakage than normal controls. 4) None of the offspring showed the chromatid breakage, but 75% of them showed significantly higher rate of SCE when compared to controls.

      • SCOPUSKCI등재

        부산 경남지역 위암환자 226예에 관한 임상적 및 내시경적 고찰

        김경수,이홍식,정정명,김은균,박영근,최하진 대한소화기내시경학회 1983 Clinical Endoscopy Vol.3 No.1

        Among 7, 500 patients whom we have performed, gastrofiberoscopy from July 1979 to June 1982, 226 cases of stomach cancer were diagnosed. The frequency was 3.0. The ratio of male to female was 2 : 1, the peak incidence, 69 aases(30.5%) was in 5th decade. 1) The frequency of stomach cancer among the age were 0.5 in 1st decade, 0.4% in 2nd decade, 1.2 in 3rd decade, 2.5 in 4th decade, 5.9 in 5th decade, 12.6 in 6th decade, 16.8 in 7th decade. It seemed to show that the frequency was increased according to getting older. 2) The annual frenquency of stomach cancer was 2,4 in 1979, 2.2 in 1980, 3.4 in. 1981, 3. 9 in 1982. Increasing tendency of the frequent was seemed to be noticeable. 3) The most common symptom was epigastric discomfort, 153 casea(67.7 0). and epigastriG pain, weight loss, hematemiais, melena and dysphagia were presenting symptoms in order of their frequency. 4) The anatomical location of stomach cancer were found 138 cases(61.1 ) in antrum, 57 cases(25.2) in lesser curvature, 14 cases(6.2) in cardia and fundus, 6 cases(2.I) in greater curvature. 5) According to Borrmanns classification, following results were obtained. Borrmanns type IQ, 75 cases(34.4%). type IV, 71 casea(32.5%). type j[, 52 casea(23.9). type I, 20 cases( 9.20). 6) The evaluation of blood group on the 78 operated stomach cancer patients revealed that blood group A were 31 cases(39.7), blood group B were 23 cases(29.5%), blood group d were 15 cases(19.2) and blood group AB were 9cases(11.5%). Rather marked association of group A with stonnach cancer was noticeable. 7) Histological cisasification were as fallows, :ienoesarci;noma 15 (&9.5ib, aigae ag. cell type 4I caaes(18.16), undifgerentisted adaucarcinQrna 22 casea(g.7), mucinoros cell te se(2%). 8) 8 cases(3.5) among 228 caaea of atoaaca cancer were found, and 4 caae. of toae 8 caseea were type 1f c, 2 caaea were type 1I, 1 caass waa type I , and 1 case was mixed type. (type B b+type It c)

      • 만성 B형 간염에서 알파 인터페론의 치료 효과

        정정명,임대건,이원식,최봉기,장윤식,이연재,이상혁,설상명,최하진 인제대학교 1996 仁濟醫學 Vol.17 No.2

        1991년 1월부터 1993년 12월까지 인제의대 부산백병원에서 6개월 이상 HBsAg 및 HBeAg 양성이며 간조직 검사상 만성간염을 보인 환자들(활동성;26례, 지속성;3례)을 대상으로 알파 인터페론 치료시 혈청 전환 및 간기능 정상화율과 인터페론 투여에 따른 효과에 대해 분석하여 보았다. In order to evaluate the therapeutic efficacy and safety of recombinent alpha-interferon, we studied 29 patients proven to have chronic hepatitis B(CAH : 26 cases, CPH : 3 cases) through biopsy from January 1991 to December 1993. All patients were seropositive for HBeAg and HBsAg, and recieved alpha-interferon with tonal dosage up to 120 million units. The results were as follows ; 1) HBeAg sero-conversion rate was 51.7%(Total 15 cases including 3 cases in chronic per-sistant hepatitis group), and all these patients have showed normalized transaminase levels continously. 2) In response group, the serum transaminase level began to decrease at average 4.7th week after initiation of interferon. But in non-response group, the serum transaminase level began to decrease at 2nd to 4th week transiently after interferon, and then increased again. 3) Several adverse effects were noted during interferon treatment. General ache and myalgia were most common(65.5%), followed by fever and chillness(37.9%), headache(37.9%), leukopenia(17.2%) etc. But they were relatively tolerable. 4) Peripheral blood leukocyte counts showed slight reduction within 1 week after initiationof interferon treatment but rapidly recovered to normal level within 5 days after temporary withdrawal. And after completion of interferon treatment, no significant differences were remained compared with initial level. With these results, it suggests that α-interferon therapy may be effective and safe in chronic hepatitis B. However, further study will be required in non-responsive group thereafter.

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