한국 여성에서 5-HTTLPR 유전자 다형성과 성격특성의 연관성

이승민,최종혁,함병주,이소희,Lee, Seung Min,Choi, Jong Hyuck,Ham, Byung Joo,Lee, So Hee 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Objectives : Findings from behavioral genetics which demonstrate the high heritability of personality traits have stimulated the search for the specific genes underlying personality. A large number of association studies have investigated a correlation between serotonin transporter-linked promoter region(5-HTTLPR) polymorphism and personality traits but the results have been inconsistent. So, the aim of this study is to investigate in a large sample with homogenous background about ethnicity, gender, occupation, and age. Methods : The participants included 247 healthy Korean female adults(mean age=23.12, SD=3.22)with no history of psychiatric disorders and other physical illnesses. Genomic DNA was extracted from peripheral blood, and genotyping was performed by PCR. Personality assessment was done with the Temperament and Character Inventory(TCI). Results : Genotype Frequencies are l/l 3.6%, l/s 32.8% and s/s 63.6%(l allele:20%, s allele:80%). This low frequency of the l allele and l/l genotype was different from Caucasian results. No significant association was observed between 5-HTTLPR polymorphism and personality traits in a Korean female population. Conclusions : This study investigated the association between 5-HTTLPR polymorphism and personality traits in Korean female subjects, a large sample with homogeneous background about ethnicity, gender, occupation, and age. No significant association was observed between 5-HTTLPR polymorphism and personality traits in a Korean female population.

화병과 주요우울증 환자의 신경인지기능

윤영환,이소희,최종혁,Yun, Young Hwan,Lee, So Hee,Choi, Jong Hyuck 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Objectives:Hwa-byung has been studied clinically for several years and introduced as Korean Culture- Bound Syndrome. However, the definition and the diagnostic method are not yet clarified, and there has not been any sufficient comparative study on this disease entity. This study was conducted to determine the clinical symptoms and the profile of the neurocognitive functions in Hwa-byung(HB) and Major Depressive Disorder(MDD), and We wish to identify any critical factors that differentiate the disorders. Methods:A total of 102 participants were examined, including 34 participants with MDD, 34 with HB, and 34 healthy controls. The MDD and HB patients were recruited from among inpatients and outpatients at the National Medical Center for the period from May to December of 2004. As a major diagnostic tool of MDD, diagnostic reference of DSM-IV-TR was used and as HB's diagnostic tool, We used computerized neurocognitive function test. Psychiatric symptomatology was evaluated by the Beck Depression Inventory(BDI), and Symptom Checkist-90-Revision(SCL-90-R). Oneway ANOVA, Scheffe post-hoc test and Chi-Squre Tests were used for statistical analysis. Results:The participants in three groups did not differ in terms of age, sex, and education. Assessment of BDI indicated that the MDD group had significantly higher total score than the HB group. MDD and HB groups showed significantly higher total scores on the SCL-90-R in comparison to the controls. The MDD group was found to have significantly more symptoms of depression than the HB group, based on the depression subscale of the SCL-90-R. The computerized neurocognitive function test suggest several results 1) Within the memory domain, it was found that one of the two memory tests in MDD and HB groups were significantly impaired in comparison to the control group. 2) Within the attention domain, it was found that only the MDD group was significantly impaired in comparison to the control group. 3) Within the higher cortical function domain, it was found that significant impairment exist in MDD group and HB group compared to the control group; the severity of impairment was found to be more profound in the MDD group than in the HB group. Conclusion:These results suggest that both HB group and MDD group have significantly decreased neurocognitive function than the control group, and neurocognitive function of the HB group is better than that of the MDD group.

송전철탑 도장용 도료 성능 개선

백승도(Seung-Do Baik),최종혁(Jong-Hyuck Choi),김태영(Tai-Young Kim),민병욱(Byeong-Wook Min),위화복(Hwa-Bok Wi),원봉주(Bong-Ju Weon) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

최근 대기환경 악화로 송전용 철탑 도장의 열화가 촉진되어 내후성이 강한 신도료를 송전철탑에 적용이 필요하게 되었다. 도료 제조업체의 신도료로 도장시편을 제작하여 옥외에 폭로후 전문기관에서 성능을 확인하였으며, 이를 토대로 도료의 재질을 실리콘 아크릴우레탄계로 변경하였으며, 철탑용 도료 성능시험 기준을 강화하여 철탑 재도장에 따른 유지보수 비용 절감이 될 수 있도록 개선하였다.

강원지역 소방관에서 외상후 스트레스 증상 및 동반증상에 미치는 리질리언스의 영향

이홍의,강석훈,예병석,최종혁,Lee, Hong-Eui,Kang, Suk-Hoon,Ye, Byoung Seok,Choi, Jong-Hyuck 대한불안의학회 2012 대한불안의학회지 Vol.8 No.2

Objective : This study investigated the relationship between the resilience and posttraumatic stress symptoms, as well as comorbid symptoms in firefighters. Methods : We collected 764 firefighters, who worked at six fire department stations in Gangwon-do. We investigated the impact of event scale-revised (IES-R), the life events checklists (LEC), Connor-Davidson resilience scale (CD-RISC), Beck depression inventory (BDI), state trait anxiety inventory (STAI) and alcohol use disorder identification test (AUDIT). Full PTSD groups, partial PTSD groups and non-PTSD groups, which were classified by IES-R scores, were compared in the LEC, CD-RISC, BDI, STAI and AUDIT, ; multiple linear regression analyses were done for independent predictors of variables. Results : Of the 764 firefighters, there were significant differences in LEC (p<0.001), CD-RISC (p<0.001), BDI (p<0.001), and AUDIT (p=0.001) among the full PTSD groups, partial PTSD groups and non-PTSD groups. However, STAI did not show significant difference among three groups. In multiple regression analysis, CD-RISC (${\beta}=-0.168$, p<0.001), LEC (${\beta}=0.211$, p<0.001) and AUDIT (${\beta}=0.115$, p=0.001) were significant predictors for IES-R. Conclusion : The results of the present study suggested that resilience might be a protective factor in PTSD and comorbid symptoms of PTSD.

무부하 충전케이블 개방시 잔류전압에 의한 과전압계전기 동작현상 연구

김영한(Yeong Han Kim),최종혁(Jong Hyuck Choi),윤기섭(Ki Seob Yoon) 대한전기학회 2000 대한전기학회 학술대회 논문집 Vol.2000 No.7

안정화된 만성 정신분열병 환자에서 강박장애 동반과 사회적 기능

강석훈,석정호,김찬형,김윤중,김형주,최종혁,Kang, Suk-Hoon,Seok, Jung-Ho,Kim, Chan-Hyung,Kim, Yoon-Joong,Kim, Hyoung-Ju,Choi, Jong-Hyuck 대한불안의학회 2011 대한불안의학회지 Vol.7 No.1

Objective : This study aimed to investigate the prevalence of obsessive-compulsive disorder (OCD) in schizophrenia, and the relationship among OCD, severity of psychopathology, and social function in stable patients with chronic schizophrenia. Methods : We interviewed 138 symptom-stable inpatients who had been on a constant dose of antipsychotics for at least 1 month prior and diagnosed as chronic schizophrenia. Subsequently, patients were classified according to the existence of OCD as investigated using the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I) and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Further, all clinical and demographic data was investigated. To investigate potential interrelationships, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Korea-Positive and Negative Symptom Scale (K-PANSS), and the Korean Personal and Social Performance (K-PSP) were used. An independent ttest and Chi-square test were used to compare groups and a Pearson's correlation coefficient was used to assess the relationship between the Y-BOCS and other clinical rating scales. Results : The prevalence of OCD in schizophrenia patients was 18.1%. Patients with schizophrenia and OCD exhibited significantly earlier onset of schizophrenia, more severe psychiatric symptoms, and lower personal and social performance ability as compared to those without OCD. There was no significant relationship among Y-BOCS, K-PANSS, and K-PSP. Conclusion : We found that comorbid OCD was relatively more frequent in patients with schizophrenia. An investigation involving larger samples of schizophrenia patients with OCD with respect to social function and thus, the effect on quality of life is required.

정신질환자에 대한 태도

윤광현(Kwang Hyun Youn),김병창(Byung Chang Kim),최종혁(Jong Hyuck Choi),이종국(Jong Gook Lee),황태연(Tae Yeon Hwang) 대한사회정신의학회 2006 사회정신의학 Vol.11 No.1

연구 목적: 본 연구는 일 종합병원에 근무하고 있는 의사들을 대상으로 정신질환자에 대한 태도를 파악하고, 정신보건문제의 심각도와 정신 보건서비스에 대한 필요도에 대한 인식을 조사하여 향후 정신보건사업의 수행에 있어서 기초 자료로 활용하고 정신질환자에 대한 올바른 태도를 갖도록 수련과정에 반영할 수 있는 대책들을 살펴보고자 한 것이다. 방 법: 2003년 9월 현재 일 종합병원에 근무하고 있는 67명의 의사들을 대상으로 하였으며 정신과 의사는 제외하였다. 조사도구는 직접 설문지를 작성하는 자기기재 방식을 원칙으로 하였으며 설문지에는 조사대상자의 일반적 특성, 정신보건문제의 심각도 11문항, 정신보건서비스에 대한 필요도 14문항, 40문항의 CAMI Scale이 포함되었다. 결 과: CAMI 4개 하위 척도 모두에서 비정신과 의사들은 일반지역 주민들에 비해 보다 온정적이고 긍정적인 태도를 보이고 있었다. 그러나 정신보건전문요원 수련생들보다는 보다 덜 긍정적인 태도를 보이고 있었다. 정신보건 문제의 유형에 있어서는 알코올 중독이 우리나라에서 가장 심각한 정신보건의 문제라고 응답하였고 다음으로는 성폭력과 청소년 비행, 우울증 순이었다. 정신보건 서비스 필요도에 있어서는 알코올 치료/교육 모임이 가장 많이 필요하다고 생각했고, 다음으로는 직업재활, 가족모임 혹은 상담, 교육 및정보의 제공 등이었다. 지역사회 정신보건사업에서 중요한 프로그램 중 하나인 가정방문에 대해서는 필요성은 있다고 생각하였으나 가장 낮은 순위를 보이고 있었다. 결 론: 정신질환자에 대한 태도에 있어서 비정신과 의사들의 인식도가 정신보건전문요원 수련생들에 비해 낮은 것은 일반 의사들에 대한 교육과정이나 수련과정에 정신질환 교육이 잘 되지 않고 있는 실정을 반영한다고 할 수 있으므로 이와 같은 문제점을 개선시킬 수 있는 교육과정이 필요하다. 또한 정신보건문제의 심각도에 있어서 알코올 중독, 성폭력은 일반인과 수련생 및 비정신과 의사 모두 심각하다고 인식하고 있어서 최근 우리 사회의 심각한 정신보건의 문제들임을 알 수 있으며 정신보건정책을 수립할 때 이에 대한 대책을 반드시 포함시 켜야 하겠다. Objectives:This study was performed to identify attitudes toward the mentally ill patients of the non-psychiatric physicians at National Medical Center in Seoul, Korea. We also intended to measure the severity of mental health problems and the priority of mental health services that perceived by the non-psychiatric physician. Methods:The Study tool was a self-report questionnaire including general characteristics, 11-item severity of mental health problems, 14-item priority of mental health services and 40-item CAMI scale. The study subject was composed of 67 non-psychiatric physicians. Results:1) The non-psychiatric physicians tended to take alcohol dependence, sexual abuse, adolescent delinquency and depression more seriously. however, psychosis such as schizophrenia was less significantly. 2) They believed that alcohol treatment meeting, vocational rehabilitation, family counselling, social campaign, education to be more important than either home visit or crisis intervention. 3) They showed more positive attitudes than general population, but less positive attitudes than mental health professional trainees, in all four sub-categories of CAMI scale. 4) There was no significant difference in demographic factors such as age, sex, marital status, religion and experience with the mentally ill patients in all four sub-categories of CAMI scale. Conclusion:We believe that further medical school education and residency training programs can change the attitudes toward the mentally ill of the non-psychiatric physicians.

병렬운전 변압기 전압제어 및 저압축 모선보호방식연구

윤기섭(Gi-Seob Yun),백승도(Seung-Do Baek),최종혁(Hyuck-Jong Choi) 대한전기학회 2001 대한전기학회 학술대회 논문집 Vol.2001 No.7

한국 여대생의 음주에서 충동성과 부정적 평가에 대한 두려움의 연관성

김현수(Hyun-Soo Kim),이태경(Tae-Kyung Lee),원성두(Seong-Du Won),최종혁(Jong-Hyuck Choi),이소희(So-Hee Lee) 한국중독정신의학회 2009 중독정신의학 Vol.13 No.1

Objective:Recently the prevalence of pathological drinking behavior in women is increasing, but the psychological characteristics of alcohol consumption in young women have rarely been investigated. In this study, the authors investigated the relationships between alcohol use severity, impulsivity, social dis-tress and fear of negative evaluation. Methods:The subjects, 157 college women, were assessed with the Korean Alcohol Use Dis-orders Identification Test (AUDIT-K), the Barratt Impulsiveness Scale (BIS), the Korean Social Avoidance & Distress (K-SAD) and Korean Fear Of Negative Evaluation (K-FNE) tests. We designated a cutoff score of twelve or above for the AUDIT-K as the criterion for the presence of problem drinking. The correlations between each psychological variable (BIS, K-SAD, K-FNE) and alcohol use severity were investigated. Results:The results of this study were as follows:1) The percentage of drinking within the preceding one-year period was 86.4% and the percentage of problem drinkers was 24.2% among the 157 subjects. 2) The problem drinkers showed statistically significant higher mean scores on the BIS than the non-problem drinkers. The problem drinkers showed statistically significant higher mean scores on the K-FNE than the non- problem drinkers, but there was no significant difference between these groups in the K-SAD. 3) The AUDIT-K was positively correlated with BIS and K-FNE, but there was no correlation with the K-SAD. 4) Impulsivity and fear of negative evaluation were positively correlated with problem drinking. Problem drinking was significantly increased when negative evaluation or impulsivity was increased. Conclusion: Women with drinking problems were more impulsive and more fearful of negative evaluation than women without drinking problems. Impulsivity and fear of negative evaluation were positively correlated with drinking. These results suggest that it is necessary to give more attention to psychiatric conditions of problem drinking college women and to evaluate psychosocial problems related with alcohol consumption.

여자 대학생들의 폭식 행동에 대한 애착, 충동성 및 강박성의 연관관계

박신영(Shin-Young Park):이소희(So-Hee Lee),이태경(Tae-Kyung Lee):윤해주(Hai-Joo Yoon),최종혁(Jong-Hyuck Choi) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.2

Objective:The aim of this study was to investigate the relationships among binge eating behavior and attachment, impulsivity and compulsivity of the female undergraduates in Korea. Methods:205 female undergraduates completed the Bulimia Test-Revised for binge eating behavior, Revised Adult Attachment Scale for quality of attachment, Self-report Attachment Style Scale for attachment pattern, BAS/BIS (Behavioral Activation System/Behavioral Inhibition System) Scale for impulsivity and Padua-ICMA Scale for compulsivity. Results:As to the attachment quality, high score in ‘fear of rejection’ and high ‘intimacy’ were related to the binge eating behavior. As to the impulsivity and compulsivity, high score in BAS-drive, BASfun seeking, BIS and ICMA were related to binge eating behavior. But ‘dependability’ of attachment and BAS-reward responsiveness of impulsivity were not significantly related to binge eating behavior. Conclusion:‘Fear of rejection’ and ‘intimacy’ were positively correlated with the binge eating behavior. Impulsivity and impaired control over mental activity were positively correlated with the binge eating behavior.