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      • KCI등재후보

        고혈압으로 인한 좌심실비대에 미치는 항고혈압제의 효과

        김성근(Sung Keun Kim),이종영(Jong Young Lee),정덕자(Duk Ja Jeong),정동균(Dong Gyun Jeong),최조영(Cho Young Choi),최일균(Il Gyun Choi),이상용(Sang Young Lee) 대한내과학회 1990 대한내과학회지 Vol.39 No.3

        N/A In has been recently suggested that left ventricular hypertrophy (LVH) in patients with hypertension is a very useful predictor of increased cardiovascular morbidity and mortality. So the therapeutic goals of antihypertensive therapy in hypertensive patients with LVH are in the reduction of LVH. In these days angiotensin converting enzyme (ACE) inhibitor has been chosen as a first line drugs of anti-hypertensive therapy. In order to evaluate the efficacy of antihypertensive drugs in reduction of LVH (as a result of administrated captopril and / or diuretics or prazosin and / or diuretics treatment), we examined 75 cases who had antihypertensive drugs with follow-up periods of over 6 months. They were groups into two, group 1 and 11, The group 1 (37 cases: 14 males, 21 females, mean 57.0±8.7 years) had been administrated prazosin and / or diuretics and group II (38 cases: 17 males, 23 females, mean 54.8±10.5 years) had been administrated captopril and/or diuretics. We observed the effect of BP control, reduction in cardiothoracic ratio with chest roentgenogram, symptoms and laboratory abnormalities between pretreatment and 6 months after treatment in two groups. And echocardiographic measurements were observed between pretreatment and after treatment in 13 cases of group II. The results were as followings: 1) Age, sex, duration of hypertension and class of hypertension were not different significantly in two groups. 2) The blood pressure was reduced significantly from 2 weeks after treatment in two groups. But the difference of BP reduction in two groups was not stastically significant. 3) The cardiothoracic ratio in chest roentgenogram was reduced after 6 months therapy than pretreatment in two groups and the difference of cardiothoracic ratio reduction was significant in group II than the group 1. 4) Severity of symptoms were reduced after treatment than pretreatment in both groups but the difference of reduction degree was not significant in two groups. 5) The abnormal laboratory findings were reduced after treatment than pretreatment. But no significance was found in the laboratory parameters except cardiothoracic ratio. 6) Interventricular septal wall thickness, posterior wall thickness and left ventricular mass were measured by echocardiogram. They were more reduced significantly after 6 months treatment than pretreatment in 13 cases of group II.

      • 균혈증시 쇽크의 발생빈도 및 사망률에 영향을 미치는 요인

        이상용,김걸,박찬근,방규태,김형길,정동균,오광제,최조영 대한감염학회 1990 감염 Vol.22 No.4

        A retospective clinical review on 130 patients with bacteremia was done in order to evaluate factors affecting the incidence of shock and mortality. The result were as follows: 1) The incidence of bacteremia was 0.3%. 2) The incidence of septic shock in bacteremia was 37.7%. 3) The mortality of the total bacteremia was 28.5%, that of bacteremia without shock was 13.6% and that of septic shock was 53.1%. 4) The incidence of septic shock appeared to be unrelated to sex, age or antecedent therapy with antibiotics. There was, however, significantly increased incidence of septic shock in more severe underlying disease, gram-negative bacteremia (esp. pseudomonas and proteus), antecedent therapy with immunosuppressive agents and hypothermia or failure to mount a febrile response greater than 38℃. 5) The mortality of bacteremia appeared to be unrelated to sex, age and etiologic agent (except, pseudomonas) of bacteremia. The mortality was associated with septic shock, more severe underlying disease, psudomonas bacteremia, antecedent therapy with antibiotics or immunosuppressive agents and hypothermia or failure to mount a febrile response greater than 38℃. 6) There were significant differences between the admission value for serum albumin, total serum proteins, total serum calcium and serum phosphate and those levels observed during septic shock. The corrected hypocalcemia occurred in 58.8% and the mortality was higher (though not attaining a statistical significance) among hypocalcemic patients compared with normocalcemic ones.

      • 무증상 T파 역위의 수술과 관련된 심전도 변화

        최일균,변동일,이종영,이상용,정덕자,최조영,이정균 한양대학교 의과대학 1989 한양의대 학술지 Vol.9 No.2

        Cardiac arrhythmias during operation have been increased because the number of patients with cardiovascular disease, especially symptomatic or asymptomatic ischemic heart disease, has increased and cardiac arrhythmias can be a warning that the patient is under physiologic or anesthetic distress and that rapid correlation is necessary. To reduce the operation risk is major concern and preliminary screen is important as one of cardiac origin risk, the role of silent myocardial ischemia must be evaluated. But there has been rare studies for the ECG abnormalities during operation related to T wave inversion on preoperative ECG. In order to investigate the frequency, duration, relation to the site of inverted T wave and characteristics of arrhythmia or ST-T change, we started this study. Preoperative ECG had been performed to 1,872 patients who were prepared general anesthesia, there were 48 patients (2.56%) of only T wave inversion without accompanying symptoms of ischemic heart disease. We observed the 48 patients with ECG monitoring in operation room from anesthetic induction to recovery, but could not observe any electrocardiological abnormalities especially ST-T changes or arrhythmias compared with preoperative ECG except one case (2.1%) of sinus bradycardia. And the amplitude of inverted T wave was not shown statistically significant changes between preoperative ECG and intraoperative or postoperative ECG. It is concluded that there will be no problems in the anesthetic procedure for the operation in the patients with asymptomatic T wave inversion and will be no need to postpone the operation for performing the other studies to confirm ischemic heart disease. So ECG monitoring may be more important in the patients with asymptomatic T wave inversion during general anesthesia for operation.

      • KCI등재후보

        항 내인자 및 항 벽측 세포 항체 양성을 보인 악성 빈혈 1 예

        박영석,이정애,정지영,강승식,이재명,조성태,한태호,박수종,이록윤,선덕재,박찬정,최조영 대한내과학회 1997 대한내과학회지 Vol.52 No.4

        We present a case of pernicious anemia without history of operation in 52 year old female. She suffered from oral ulcer, gum bleeding, nausea, vomiting, and beefy tongue. She had dysesthesia on the both arm and foot, and hypesthesia of global and stocking type by neurologic examination. Laboratory findings were as follows: serum cobalamin 9.1 pg/mL (normal range: 180-710pg/mL), anti intrinsic factor antibody (strong positive), antiparietal cell Antibody 1:10 (positive), first stage of Schilling test (1.4%). The findings of peripheral blood and bone marrow were compatible with megaloblastic anemia. We report a case of pemicious anemia with positive anti intrinsic factor antibody and antiparietal cell antibody.

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