유두부선암에서 비정상 p53 유전자의 빈도 및 임상적 의의

박종재(Jong Jae park),현진해(Jin Hai Hyun),조현이(Hyun I Cho),김재선(Jae Sun Kim),최재현(Jae Hyun Choi),김한겸(Han Gyum Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu) 대한내과학회 1999 대한내과학회지 Vol.57 No.1

N/A Although abnormalities of p53 gene and their relation to clinicopathologic parameters have been identified in some human malignancies, there is little published data on their prevalence and clinical significance in ampullary adenocarcinoma (AAC). The aim of this study is to determine the prevalence of p53 abnormalities in AAC and to evaluate their relation to clinicopathologic features. Method : 35 formaline-fixed paraffin-embedded tissues of AAC were examined for detection of p53 abnormalities by both single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction- amplified DNA fragments corresponding to exons 5-8 and immunohistochemistry (IHC) using monoclonal antibody to p53 protein (Novocastra, DO7), and the association between the p53 abnormalities and clinicopathologic parameters was analyzed. Result : In 22.9% of AAC, p53 gene muation was demonstrated by SSCP analysis, mainly at PCR-amplified exon 8 and exon 7. The p53 protein overexpression by IHC was 48.6% of AAC. Six SSCP and IHC-positive (17.2%) cases and 16 normal (45.7%) cases showed concordant results between the methods, although 13 cases (37.1%) showed discordance, including 11 IHC-positive (31.4%) and 2 SSCP-positive (5.7%) cases. Overall, the prevalence of p53 abnormalities was 54.3%. No significant associations between the p53 abnormalities and clinicopathological parameters such as clinical manifestations, histologic differentiation, and tumor stage were observed. Conclusion : The p53 abnormalities detected in 55% of AAC are not associated with prognostic factor, suggesting that abnormal p53 gene may play a role in the development of AAC, but not in its invasiveness.

효율적인 의사결정을 위한 이벤트 기반의 프로세스 성과측정을 위한 모델

박제원,최재현,조풍연,이남용,Park, Jae-Won,Choi, Jae-Hyun,Cho, Poong-Youn,Lee, Nam-Yong 한국정보처리학회 2010 정보처리학회논문지D Vol.17 No.4

Information systems nowadays are heterogeneous and distributed which integrate the enterprise information by processes. They are also very complex, because they are linked together by processes. It aims to integrate the systems so that these systems work as one system. A process is a framework which contains all of the business activities in an enterprise, and has a lot of information which is needed for measuring performance. A process consists of activities, and an activity contains events which can be considered information sources. In most cases, it is very valuable to determine if a process is meaningful, but it is difficult because of the complexity in measuring performance, and also because finding relationships between business factors and events is not a simple problem. So it would reduce operation cost and allow efficient process execution if I could evaluate the process before it ends. In this paper we propose an event based process measurement model. First, we propose the concept of process performance measurement, and a model for selecting process and activity indexes from the events which are collected from information systems. Second, we propose at methodologies and data schema that can store and manage the selected process indexes, the mapping methods between indexes and events. Finally, we propose a process Performance measurement model using the collected events which gives users a valuable managerial information. 최근 정보시스템은 정보기술의 발달로 이기종의 환경으로 분산되어 프로세스를 중심으로 복잡하게 얽혀 있다. 프로세스는 어떠한 업무가 시작되어 끝날 때까지 의사결정의 선후관계를 갖는 인스턴스의 흐름을 가지고 여러 정보시스템을 넘나들며, 업무의 성과를 측정하는데 필요한 많은 정보를 담고 있다. 프로세스는 단위 업무활동인 작업으로 구성되며, 단위 작업은 정보 발생원인 이벤트로 구성된다. 그러나 대부분의 경우 직접 이벤트를 연계하여 프로세스의 진행이 경영적인 관점에서 얼마나 성과 있게 진행되고 있는지를 측정하는 것은 매우 어렵다. 따라서 프로세스가 완전히 끝나기 전에 작업의 진행에서 프로세스의 성과를 미리 측정한다면 운영비용 절감 및 효율적인 프로세스 실행이 가능하다. 이에 본 논문에서는 프로세스의 현재 성과를 사전에 평가할 수 있도록 이벤트 기반의 프로세스 성과측정 모델을 제안하였다. 첫째, 프로세스 성과측정개념을 제시하고, 단위 정보시스템의 이벤트로부터 수집된 정보를 통해 프로세스의 성과측정을 위한 성과지표 선정방법을 연구한다. 둘째, 프로세스 성과측정을 위한 이벤트 수집을 위해 선정된 성과지표와 기존 시스템의 이벤트 간 매핑방법과 수집된 이벤트를 프로세스 관점에서 효율적으로 저장관리 하는 데이터 스키마와 방법을 연구한다. 마지막으로 수집된 이벤트를 바탕으로 프로세스의 성과 측정 모델을 제시한다.

위 간질종양의 기원 및 분화에 관한 연구 - 면역조직화학적 방법을 중심으로 -

박동규(Dong Kyu Park),전훈재(Hoon Jai Chun),천황래(Hwang Rae Chun),박재홍(Jae Hong Park),오용열(Yong Leul Oh),박철희(Chul Hee Park),진윤태(Yoon Tae Jin),이홍식(Hong Sik Lee),이상우(Sang Woo Lee),엄순호(Soon Ho Um),최재현(Jai Hyun Cho 대한내과학회 2002 대한내과학회지 Vol.63 No.1

N/A Background: Gastrointestinal stromal tumors (GISTs) have the subject of debate and controversy regarding their histogenesis, criteria on malignancy, prognostic features, site-specificity and their nomenclature. These tumors have various phenotypical features and are generally divided into (1) tumors showing differentiation toward smooth muscle cells (2) tumors showing apparent differentiation toward neural elements (3) tumors showing dual differentiation toward smooth muscle and neural elements (4) tumors lacking differentiation toward either cell type (uncommitted type). This study was performed to identify the possible origin and differentiation of gastric stromal tumor. Methods: This study was performed on 38 patients who had gastric stromal tumors on endoscopy or endoscopic ultrasonography and confirmed by endoscopic or surgical resection between January 1994 and June 1999 at Department of Internal Medicine, Korea University College of Medicine. Formalin-fixed, paraffin-embedded tissues were studied by immunohistochemical method for detecting the presence of CD 34, CD 117, Vimentin, SMA, Desmin, S-100, PGP 9.5 and NSE. Results: The patients' age ranged from 26 to 81 years old, with an average age of 53.8 years. The male to female ratio was 1:1.2. Endoscopic resections were performed on 22 patients and surgical operations on 16 patients. The average tumor size was 25.3 mm in diameter. On immunohistochemical staining method, the uncommitted type was found in 18 patients (47.4%), of which 17 patients (94.4%) were CD117 (+), CD34 (+), Vimentin (+), 12 patients (31.6%) had muscular differentiation, 7 patients (18.4%) showed neural differentiation and 1 patient (2.6%) showed differentiation toward both neural and muscular immunohistochemical pattern. Conclusion: Gastric stromal tumors showed phenotypical diversity in immunohistochemical staining suggesting different histogenesis. Most uncommitted type had a phenotype of intersititial cells of Cajal (ICC) and this evidence supports the hypothesis that uncommitted type has the origin of ICC.(Korean J Med 63:14-22, 2002)

한국 성인에서 일과성 하부식도괄약근 이완의 특성

허병원(Byung Won Hur),송치욱(Chi Wook Song),김혜랑(Hye Rang Kim),김윤배(Yun Bae Kim),강창돈(Chang Don Kang),이정환(Jung Whan Lee),진윤태(Yoon Tae Jeen),전훈재(Hoon Jai Chun),엄순호(Soon Ho Um),이상우(Sang Woo Lee),최재현(Jae Hyun Cho 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2

N/A Background/Aims : Transient lower esophageal sphincter relaxation (tLESR) is the main cause of gastroesophageal reflux (GER) in both healthy subjects and patients with GER disease. Unfortunately, we have no data on tLESR and its relationship with GER in Korea. Therefore, this study was performed to evaluate the characteristics of tLESR in Korean subjects and the mechanisms of GER after Korean meals. Methods: Eight healthy volunteers (8 men, 23 to 25 yrs) received a Korean meal (laver-rolled rice, fried egg, sweet rice juice, 640 Kcal). A mylohyoid electromyogram, LES pressure using a Dent sleeve and esophageal pH were simultaneously recorded for 1 hour while fasting and 3 hours after the meal. We compared the manometric profile of swallow-induced LES relaxation (sLESR) with the manometric profile of tLESR and evaluated the frequency of tLESR and reflux episodes, and their relationship. Results : Compared with sLESR, tLESR showed longer time onset to completion, slower relaxation rate, longer duration of relaxation, and a lower nadir pressure. Incidence of tLESR increased after the meal, which was mostly accompanied by GER. Also, the frequency of GER increased after the meal, which mostly occurred during tLESR. Conclusions : Our results suggest that tLESR is a main cause of GER in healthy Korean adults, which is a similar result to studies of Westerners.

요소호기 검사로 평가한 치료 기간에 따른 Helicobacter pylori 제균율의 분석 : OAC 7, 10, 14 일간 병합요법의 비교

이상우,박동규,김성태,이성준,박재홍,이홍식,김창덕,진윤태,최재현,엄순호,류호상,현진해,박철희,조영직,전훈재,고동욱 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.4

Background/Aims: Efficacy of triple therapy with omeprazole, amoxicillin, and clarithromycin (OAC) for Helicobacter pylori (H. pylori) varies among different geographic regions and patient populations. And, there is no full consensus on how long this treatment should be maintained. We assessed the efficacy of the OAC regimen according to the treatment duration (7, 10 or 14 days) using (13)^C-urea breath test ((13)^C-UBT). Methods: Two hundred fifty five H. pylori positive patients with peptic ulcer were randomly assigned to a OAC (omeprazole 20㎎ b.d., amoxicilln 1.0 g b.d. and clarithromycin 500㎎ b.d.) 7, 10 or 14 days regimen. Eradication of H. pylori was assessed by (13)^C-UBT 4 weeks after the completion of the completion of therapy. Results: 140 male and 115 female (mean age, 51.3) patients were enrolled. The overall eradication rate of H. pylori in each group was significantly higher in OAC 14 days regimen than OAC 7 and 10 days regimen (91.9% in OAC 14 days, 74.4% in OAC 7 days, and 80.2% in OAC 10 days, respectively, p$lt;0.05). Conclusions: The overall eradication rate of H. pylori was highest in OAC 14 days regimen in our study. We have found significant differences in eradication rates with previous reports, using CLO and histology, in Korea. Thus, further studies focusing on the treatment period may be warranted.