재발성 호흡기 감염과 성장 부전을 보인 IgG 아형 결핍증 1례

최용성,홍정미,나영호,차성호,Choi, Yong-Sung,Hong, Jung-Mi,Rha, Young-Ho,Cha, Sung-Ho 대한소아감염학회 2006 Pediatric Infection and Vaccine Vol.13 No.2

원발성 면역 결핍증에는 항체형성에 영향을 주는 질환이 가장 흔하고 그중 선택적으로 분비성 IgA 결핍이 많으나 IgG 농도가 정상 혹은 증가되어 있는 어떤 환자에서는 4가지의 IgG 아형 중에서 한 두 개 이상의 결핍이 발견된다. 대부분의 환자, 특히 IgG4 결핍증 환자에서 폐구균, 포도구균, 헤모필루스균 등에 의한 부비동염, 중이염, 폐렴 등이 반복된다. 상기 10세 여아는 평소에 잦은 상기도 감염을 앓아 왔고, 결핵성 림프절염으로 약물요법을 시행한 병력이 있으며, 매년 2~3차례 폐렴으로 입원치료를 받아왔다. 키와 몸무게가 모두 3백분위수 미만으로 성장부전(growth failure)가 지속되었다. 2003년 9월 심한 폐렴으로 입원 치료 중에 면역결핍 검사를 시행하였다. IgG, IgM level은 정상이었으나 IgG subclass 2, 3, 4에서 모두 감소된 수치를 보여 IgG 아형 결핍을 보였다. 저자들은 반복적인 호흡기 질환을 앓는 환아에서 성장부전이 동반된 IgG 아형 결핍 1례를 보고하는 바이다. Immunodeficiency affected by antibody formation is most common among primary immuno-deficiencies. Selective IgA deficiency is more common but, one or more IgG subclass level is low or deficient in some patients. Patients with antibody production deficiency are vulnerable to pneumococci, staphylococci and H.influenzae leading to sinusitis, otitis media and pneumonia. A 10-year-old girl had suffered from frequent upper respiratory infections, a history of tuberculous lymphadenitis tuberculosis medication, and frequent pneumonia that requires hospital adimission. Her height and weight were below 3 percentile normal growth as a manifestation of failure to thrive. When she had another severe pneumonia, all the immunologic test was normal at first, and then we checked the IgG subclass levels. Her IgG1 was within normal, IgG2 was very low, IgG3 and IgG4 was not detected. We report a case of IgG subclass deficiency in frequent upper respiratory infection and failure to thrive.

자기력과 Random Fluidic Self-assembly에 의한 신규 바이오칩의 개발

최용성,권영수,박대희,Choi, Yong-Sung,Kwon, Young-Soo,Park, Dae-Hee 한국전기전자재료학회 2004 전기전자재료학회논문지 Vol.17 No.6

This paper describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and random fluidic self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

유기박막의 전기적 특성 연구

최용성,송진원,문종대,이경섭,Choi Yong-Sung,Song Jin-Won,Moon Jong-Dae,Lee Kyung-Sup 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.10

Langmuir-Blodgett(LB)layers of Arachidic acid deposited by LB method were deposited onto slide glass as Y-type film. The structure of manufactured device is Au/arachidic acid/Al, the number of accumulated layers are $9{\sim}21$. Also, we then examined of the Metal-Insulator-Metal(MIM) device by means of I-V. The I-V characteristics of the device are measured from -3 to +3 V. The insulation property of a thin film is better as the distance between electrodes is larger.

전기화학적 방법에 의한 유전자의 검출

최용성,이경섭,박대희,Choi, Yong-Sung,Lee, Kyung-Sup,Park, Dae-Hee 한국전기전자재료학회 2005 전기전자재료학회논문지 Vol.18 No.6

In this paper, a microelectrode away DNA chip was fabricated on glass slide using photolithography technology. Several probe DNAs consisting of mercaptohexyl moiety at their 5' end were immobilized on the gold electrodes by DNA arrayer utilizing the affinity between gold and sulfu. Then target DNAs were hybridized and reacted with Hoechst 33258, which is a DNA minor groove binder and electrochemically active dye. Cyclic voltammetry in 5mA ferricyanide/ferrocyanide solution at 100 mV/s confirmed the immobilization of probe DNA on the gold electrodes. Linear sweep voltammetry or cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. It was derived from Hoechst 33258 concentrated at the electrode surface through association with formed hybrid. It suggested that this DNA chip could recognize the sequence specific genes. It suggested that multichannel electrochemical DNA microarray is useful to develop a portable device for clinical gene diagnostic system.

초전도 벌크를 이용한 베어링기술

최용성,이상헌,Choi, Yong-Seong,Lee, Sang-Heon 한국전기전자재료학회 2006 전기전자재료 Vol.19 No.12

1,559례의 소아 신생검에 대한 고찰 : 단일기관 연구

최용성,김선경,김성도,조병수,Choi, Yong-Sung,Kim, Sun-Kyoung,Kim, Sung-Do,Cho, Byoung-Soo 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2

Purpose : To analyse the results of the renal biopsies and the clinical diagnoses of patients who had undergone percutaneous kidney biopsies in the department of pediatrics at Kyunghee University Hospital for 22 years from 1984 to 2005. Methods : We retrospectively reviewed the medical records of 1559 patients and analyzed the chief complaints that led to a renal biopsy, age, sex, histopathologic findings and diagnosis. Routine kidney biopsies were performed by automated gun biopsy guided by real time ultrasonography. The diagnoses were made based on the specimen's light microscopy, immunofluorescence microscopy and electron microscopy findings and clinical symptoms and signs. Results : The mean age of the patients was 10 years with the male to female ratio being 1.3:1. The chief complaints that led to a renal biopsy included hematuria only(753 cases, 48.3%), proteinuria only(125 cases, 8.0%) and hematuria combined with proteinuria(537 cases, 34.4%). The most frequent histopathological finding was primary glomerular disease(75.4%) which included IgA nephropathy(30.1%) and mesangial proliferative glomerulonephritis(27.6 %). Systemic disease comprised 11.4% which included Henoch-$Sch\ddot{o}nlein$ nephritis(10.5%) and lupus nephritis(0.8%). Alport syndrome was found in 1.1% of cases which was attributed to hereditary causes. 628 children(40.3%) visited the clinic due to abnormal school urine screening abnormalities and among these, 237 children had mesangial proliferative glomerulonephritis and 234 children who had IgA nephropathy were managed thereafter. Conclusion : IgA nephropathy and mesangial proliferative glomerulonephritis were the two major forms of primary glomerulonephritis found in Korean children who had kidney biopsies from 1984 to 2005.

경계인으로서 북한이탈주민의 윤리적 주체성 형성 연구: 한나 아렌트의『정신의 삶』을 중심으로

최병학(Choi, Byunghak),최용성Choi, Yongsung천명주(Chun, Myungju),강순규(Kang, Soongyu) 순천향대학교 인문학연구소 2021 순천향 인문과학논총 Vol.40 No.1

이 논문은 북한이탈주민이 남한 사회의 일원으로서 어떻게 윤리적 주체성을 형성해야 하는지에 관한 연구이다. 이를 위해 정치 철학자 한나 아렌트의 『정신의 삶』에 나타난 사유에 기초하여, 북한이탈주민이 남한 사회의 일원으로서 윤리적 주체성을 형성할 수 있도록 ‘법적 주체로 사유하기’, ‘도덕적 주체로 의지하기’, ‘인륜적 주체로 판단하기’를 제시하고, 결론으로 ‘서로-주체성’의 보편주의를 북한이탈주민은 물론 남쪽 국민의 윤리적 주체성으로 제안하고자 한다. ‘서로-주체성’을 통한 남과 북의 정체성 변화 및 강화는 마음의 통일로 이어져, 경제, 문화, 정치의 통일을 앞당기는 계기가 될 것이다. This paper is a study of how North Korean defectors should form ethical subjectivity as members of South Korean society. To this end, this paper was helped by the ideas that appeared in the political philosopher Hannah Arendt’s The Life of the Mind. Based on Arendt’s idea, I suggest ‘thinking as a Legal-Subject’, ‘relying as a Moral-Subject’, and ‘judging as a Human-Subject’. And as a conclusion, I would like to propose the universalism of ‘One Another-Subjectivity’ as an ethical subject of not only North Korean defectors but also the South Korean people. The change and strengthening of the identity of the South and the North through “subject to each other” will lead to unification of the mind, and will accelerate the unification of the economy, culture and politics.

복음주의와 에큐메니칼 선교의 통섭 및 분별의 선교

최용성 ( Yong Seong Choi ),강순규 ( Soon Gyu Kang ),최병학 ( Byung Hak Choi ) 기독교학문연구회 2022 신앙과 학문 Vol.27 No.1

한국교회는 18-19세기의 서양 교회사가 필연적으로 에큐메니칼 운동으로 이어지고 있다는 사실을 제대로 감지하지 못했으며, 지금까지도 그런 문제점을 가지고 있다. 그러므로 본 연구에서는 이러한 문제의식을 가지고 기존의 한국교회에서 주류라고 할 수 있는 복음주의적 선교에 에큐메니칼 선교가 어떤 점에서 통섭적인 공간을 마련할 수 있고, 서로 융합되면서 교역지대를 확보하면서도 각자의 강점의 발현할 수 있는 혼종화의 선교 방향성을 마련할 수 있는지를 모색해보고자 한다. 이를 위해서 한국교회의 역사적 현장성을 반추, 성찰함이 필요하고, 복음전도와 사회적 책임 속에서 공공신학적 매개와 다리놓기가 요청됨을 제시하였다. 또한 분열과 진영논리를 넘어서 혼종성과 통섭을 추구하되 교회의 하나됨을 추구하면서도 효과적인 선교를 위한 분별력이 필요함을 제시하였다. The Korean church did not properly perceive the fact that Western church history in the 18th and 19th centuries inevitably led to the ecumenical movement, and it can be said that it still has such a problem. Therefore, in this study, with this awareness of the problem, ecumenical missions can provide a consensual space for evangelical missions, which can be said to be the mainstream in the existing Korean church, in some respects, and by fusion with each other, they can secure a trading zone while maintaining their own strengths. We would like to explore whether it is possible to prepare a mission direction for hybridization that can be manifested. To this end, it is necessary to reflect on and reflect on the historical field of the Korean church, and it is suggested that public theological mediation and bridge-building are required in evangelism and social responsibility. I suggested the need for discernment for effective mission while pursuing the unity of the church.

소수성 Template를 이용한 DNA칩의 제작

최용성(Yong-Sung Choi),문종대(Jong-Dae Moon),이경섭(Kyung-Sup Lee) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarray was made by immobilizing many kinds of biomaterials on transducers (particles). DNA chip microarray was prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of m-scale sites. The particles occupied a different sites from site to site. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using a hydrophobic interaction for assembly.

스마트폰을 이용한 스마트 카트 시스템

최용성(Choi Yong Sung),장형민(Chang Hyung Min),주형종(Ju Hyoung Jong),엄성원(Eum Sung Won),이원철(Lee Won Cheol) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.6