한국인에서 면역글로불린-저항성 가와사키병 환자의 예측

최명현,박청수,김동수,김기환,Choi, Myung Hyun,Park, Chung Soo,Kim, Dong Soo,Kim, Ki Hwan 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

Purpose: The objective of this study was to find the predictors and generate a prediction scoring model of nonresponse to intravenous immunoglobulin in patients with Kawasaki disease. Methods: We examined 573 children diagnosed with KD at the Severance Children's Hospital between January 2009 and december 2012. We retrospectively reviewed their medical records. These patients were divided into 2 groups; the experimental group (N=433) and the validation group (N=140). Each group were divided into 2 groups the intravenous immunoglobulin nonresponders and the responders. Multivariate logistic regression analysis identified predictive factors of intravenous immunoglobulin nonresponders which make predictive scoring model. We practice internal validation and external validation. Results: Multivariate logistic regression analysis identified male, cervical lymphadenopathy, changes of the extremities, platelet, total bilirubin, alkaline phophatase, lactate dehydrogenase, C-reactive protein as significant predictors for nonresponse to intravenous immunoglobulin. We generated prediction score assigning 1 point for (1) male, (2) cervical lymphadenopathy, (3) changes of the extremities, (4) platelet (${\leq}368,000/mm^3$), (5) total bilirubin (${\geq}0.4mg/dL$), (6) alkaline phophatase (${\geq}227IU/L$), (7) lactate dehydrogenase (${\geq}268IU/L$), (8) C-reactive protein (>77.1 mg/dL). Using a cut-off point of 4 and more with this prediction score, we could identify the intravenous immunoglobulin nonresponder group. Sensitivity and specificity were 52.5% and 82.4% in experimental group and 37.8% and 81.8% in validation group, respectively. Conclusion: Our predictive scoring models had high specificity and low sensitivity in Korean patients. Therefore it is useful in predicting nonresponse to intravenous immunoglobulin with Kawasaki disease. 목적: 이 연구의 목적은 면역글로불린-저항성 가와사키병의 예측 인자를 찾고 점수화된 예측 모델을 만들고자 하는 것이다. 방법: 2009년 1월부터 2012년 12월까지 세브란스 어린이 병원에서 가와사키병으로 진단된 573명의 환자를 대상으로 하였다. 실험군과 검증군으로 나누었고, 각 군들은 면역글로불린-반응성과 저항성으로 나누었다. 실험군에서 면역글로불린의 예측 인자를 찾았고, 점수화된 예측모델을 만들었다. 그리고 외적, 내적 타당성 검증을 시행하였다. 결과: 남성, 경부림프절종대, 손과 발의 변화, 혈소판, 총빌리루빈, 젖산탈수효소, CRP가 면역글로불린-저항성 가와사키병의 예측 인자로 나타났다. 점수화된 예측 모델을 만들었고, 민감도와 특이도가 실험군에서는 52.5%와 82.4%, 검증군에서는 37.8%와 81.8%로 나타났다. 결론: 우리의 점수화된 예측 모델은 한국 환자에 적용하였을 때 높은 특이도와 낮은 민감도를 갖는다.

개인 특성 및 지역사회특성에 대한 인식이 범죄의 두려움에 미치는 영향

최명현(Myung Hyun Choi),염보아(Bo A Yeom) 한국셉테드학회 2014 한국셉테드학회지 Vol.5 No.1

The purpose of study is to examine the effectiveness of CPTED on fear of crime, especially CCTV. Individual characteristics(sex, age, income, education, crime victimization experience) and perception of community characteristics(social disorder, physical disorder, neighborhood cohesion, collective efficacy) could have impact on fear of crime, and the perception of CCTV installation could have an moderate effect on fear of crime. This study used the secondary data 「A Survey of Crime Prevention through CPTED around School, 2010」, which consists of 1,620 residents’ responses. With SPSS 18.0, OLS multiple regression analysis was used. As the result of the study, as the perception of CCTV installation increases, fear of crime is more likely to decrease. In other words, there was a moderate effect of CCTV installation on fear of crime. 본 연구는 일반인들이 가장 쉽게 인식할 수 있는 셉테드(CPTED) 요인인 CCTV 설치 인식의 정도에 따라 범죄의 두려움에 미치는 영향력의 변화를 통해 셉테드의 효과성을 살펴보고자 하였다. 범죄의 두려움을 결정짓는 요인으로 수많은 검증을 거친 범죄피해모델, 무질서모델, 지역사회통제모델의 변인과 CCTV 인식의 정도와의 상호작용 변인으로 범죄의 두려움에 대한 CCTV 설치 인식의 조절효과 살펴보았다. 연구의 대상은 성 및 연령별 할당 표집을 통해 선정된 1,620명으로,「학교주변 환경설계를 통한 범죄예방에 관한 주민인식 조사」자료를 이차데이터로 활용하였다. 연구목적 달성을 위해 모형을 구분한 OLS 다중회귀분석(OLS multiple regression analysis)을 이용하였으며, SPSS. 18.0 프로그램을 사용하여 분석을 실시하였다. 연구결과 지역사회 특성에 대한 인식이 범죄의 두려움에 미치는 영향에서 CCTV의 인식이 높을수록, 범죄의 두려움을 낮게 나타내는 조절효과가 있는 것으로 나타났다.

청소년들의 신체, 정신 건강 취약성과 위험지각

이민식 ( Min Sik Lee ),최명현 ( Myung Hyun Choi ) 대한범죄학회 2014 한국범죄학 Vol.8 No.2

This study examines how physical and mental health related factors such as self-evaluated physique and health, exercise, medical history, injuries, stress, discrimination experiences, suicide intention, happiness, etc. affect S. Korean youths`` perceptions of crime victimization risk around their schools and residential areas. The topic was examined using the cross-sectional data of the 2009 Survey of Youths’ Rights executed by National Youth Policy Institute. The data are composed of 6,601 middle and high school male and female students nationwide. The findings show the youths who have thin physique and are healthy, happy, older, and wealthy are less likely to perceive risk of crime victimization, whereas the juveniles who have medical history, injuries, stress, suicide intention and are female and residents in urban areas are more likely to perceive risk of victimization.

가와사키병 환아에서 아스피린 치료 후 나타난 호산구증가증 1예

설인숙 ( N Suk Sol ),최명현 ( Myung Hyun Choi ),김민정 ( Min Jung Kim ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),김기환 ( Ki Hwan Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Kyu 대한천식알레르기학회(구 대한알레르기학회) 2014 Allergy Asthma & Respiratory Disease Vol.2 No.2

Drug hypersensitivity is one of drug adverse reactions that develop in susceptible patients following exposure to certain drugs and cannot be predicted from the known pharmacology of a drug. Severe hypersensitivity is associated with high morbidity and mortality. Although the issue of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has been largely investigated in adults, data related to NSAIDs hypersensitivity is insufficient in childhood. And in spite of the recommendation to avoid use of aspirin due to Reye syndrome in children, aspirin is one of major treatment along with intravenous immunoglobulin in Kawasaki disease. We report a case of a 10-month-old boy who underwent intravenous immunoglobulin and aspirin treatment for Kawasaki disease, and subsequently revealed severe leukocytosis and eosinophilia. To our knowledge, there have been no previous reportsof aspirin-induced eosinophilia in Korea. (Allergy Asthma Respir Dis 2014;2:142-145)

자기적 평형과 동손최소화조건을 이용한 단상 LSPM 전동기의 설계방법

백수황(Soo-Whang Baek),최명현(Myung-hyun Choi),권병일(Byung-il Kwon),김병택(Byung-taek Kim) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.4

본 논문에서는 단상 Line Start Permanent Magnet(LSPM) 전동기의 정상상태 운전 시 불평형 자계에 의한 회전자의 손실을 제거하기 위해 평형운전조건을 도출하였다. 대칭자계법을 적용한 등가회로를 이용하여 정격운전점에서의 평형운전 및 고정자 동손 최소화 조건을 찾았으며, 유한요소해석을 통하여 단상 LSPM 전동기의 효율개선 여부를 확인함으로써 자기적 평형과 동손최소화조건을 적용한 설계 방법의 타당성을 검증하였다.

고속운전 조건에 따른 EPS용 3상 유도전동기 특성분석

김보미(Bo-Mi Kim),최명현(Myung-Hyun Choi),김병택(Byung-Taek Kim) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.7

가변속을 고려한 3상 유도전동기 설계방안

김보미(Bo-mi Kim),최명현(Myung-hyun Choi),김병택(Byung-taek Kim) 대한전기학회 2012 대한전기학회 학술대회 논문집 Vol.2012 No.11

상엽의 혈당강하 활성

이주선(Ju Seon Lee),최명현(Myung Hyun Choi),정성현(Sung Hyun Chung) 대한약학회 1995 약학회지 Vol.39 No.4

Mori Folium(MF) methanol extract and its water soluble fraction showed significant blood glucose lowering effects alloxan-induced hyperglycemic mice. Their hypoglycemic activities seemed to have nothing to do with the stimulation of insulin release or insulin-like action, according to our experiments. On the other hand, MF prevents the hyperglycemic responses from an oral load of starch and glucose in vivo. Since complex carbohydrates present in a diet must be degraded to monosaccharides by alpha-glucohydrolase before being absorbed in the gastrointestinal tract, it is thought that blood glucose lowering effects of MF may be related to the inhibition of alpha-glucohydrolase catalyzed enzymatic reaction. In addition, experiments that examined an effect of MF water soluble fraction on gasintrointestinal movement showed no significant GI movement inhibitory effect. In conclusion, MF water soluble fraction may possess active component which is a potential candidate as an orally active agent for the treatment of diabetes mellitus.

안테나에서 페라이트 위치 변화에 따른 전자계 시뮬레이션과 전기적ㆍ광학적 특성

李主?(Joo-Ho Lee),梁種璟(Jong-Kyung Yang),李鐘燦(Jong-Chan Lee),崔明鉉(Myung-Hyun Choi),金炳澤(Byung-Tack Kim),朴大熙(Dae-Hee Park) 대한전기학회 2008 전기학회논문지 Vol.57 No.5

The RF inductive discharge of inductively couples plasma (ICP) continues to attract growing attention as an effective plasma source in many industrial applications, the best known of which are plasma processing and lighting technology. Although most practical ICPs operate at 13.56 [MHz] and 2.65 [MHz], the trend to reduce the operating frequency is clearly recognizable from recent ICP developments. In an electrodeless fluorescent lamp, the use of a lower operating frequency simplifies and reduces cost of RF matching systems and RF generators and can eliminate capacitive coupling between the inductor coil and plasma, which could be a strong factor in wall erosion and plasma contamination. In this study, We discussed simulation and experimental results when changing ferrite position in antenna.

상엽수층의 흰쥐 소장 α-Glycosidase 억제활성

정성현,최명현,류정화 경희대학교 유전공학연구소 1996 遺傳工學論文集 Vol.8 No.-

Among the four subfractions obtained from methanol extract of mulberry leaves (Folium Mon), water soluble fraction showed the most potent blood glucose lowering activity in mice loaded a maltose. SLH-2 active fraction, which was collected by utilizing Sephadex LH20 and Dowex 50W column chromatography, seemed to have at least two α-glucohydrolase inhibitors (MF-2 MF-3) and myoinositol which is known to delay and treat diabetic complications. In the experiments to examine the effects of SLH-2 and acarbose on blood glucose from an oral load of maltose in mice, SLH-2 exhibited a similar or little but lower extent of blood glucose lowering activity than acarbose.