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카르니틴이 비알코올성 지방간 질환에서 말초혈액 미토콘드리아 DNA 단위 반복수와 간기능에 미치는 영향
임채영 ( Chae Young Lim ),전대원 ( Dae Won Jun ),장성수 ( Sung Su Jang ),조원경 ( Won Kyeung Cho ),채정돈 ( Jung Don Chae ),전진현 ( Jin Hyun Jun ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.6
목적: 미토콘드리아의 기능, 구조 이상은 비알코올성 지방간염의 발생에 중요한 역할을 한다. 카르니틴은 장쇄 지방산을 미토콘드리아로 이동시켜 베타 산화를 유발하여 미토콘드리아 기능 유지에 중요한 역할을 한다. 이번 연구의 목적은 비알코올성 지방간 환자에서 카르니틴 투여가 말초혈액 미토콘드리아 수와 간기능에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 45명의 비알코올성 지방간 환자를 대상으로 카르니틴 복합체 투여군과 대조군으로 나누었다. 약물 투여 3개월 전과 후의 간기능 검사, 산화자극 및 말초혈액에서의 미토콘드리아 수의 변화를 측정하였다. 결과: 3개월 후, 대조군에서는 ALT, AST 및 빌리루빈 수치에 변화가 없었으나 카르니틴을 투여한 군에서는 의미있게 감소하였다. 카르니틴 투여군에서 말초혈액 미토콘드리아 수는 증가(158.8±69.5 copy vs. 241.6±180.6 copy, p=0.025)하였으나 대조군의 경우 말초혈액 미토콘드리아 수는 감소(205.5±142.3 copy vs. 150.0±109.7 copy)하였다. 혈청 8-oxo-dG 농도는 미토콘드리아 수와 반대로 카르니틴 군에서는 감소, 대조군에서는 증가하는 경향을 보였다(p=0.23, p=0.07). 결론: 비알코올성 지방간 환자에서 카르니틴 투여는 간기능 호전 및 말초혈액의 사립체 수를 증가시켰다. 이러한 결과를 볼 때 카르니틴은 미토콘드리아를 활성화시킴으로써 지방간의 호전에 기여를 할 수 있다는 사실을 시사한다. Background/Aims: Functional and anatomical abnormalities of mitochondria play an important role in developing steatohepatitis. Carnitine is essential for enhanced mitochondrial beta oxidation through the transfer of long-chain fatty acids into the mitochondria. We examined the impact of carnitine complex on liver function and peripheral blood mitochondria copy number in NAFLD patients. Methods: Forty-five NAFLD patients were enrolled. Patients were categorized into the carnitine complex-administered group and control group. Before and 3 months after drug administration, a liver function test and peripheral blood mitochondrial DNA and 8-oxo-dG quantitive analysis were conducted. Results: In carnitine treatment group, ALT, AST, and total bilirubin were reduced after medication. There was no difference in AST, ALT, and total bilirubin between before and after treatment in control group. In carnitine group, peripheral mitochondrial DNA copy number was significantly increased from 158.8±69.5 copy to 241.6±180.6 copy (p=0.025). While in control group the mitochondrial copy number was slightly reduced from 205.5±142.3 to 150.0±109.7. 8-oxo-dG level was also tended to decrease in carnitine group (p=0.23) and tended to increase in control group (p=0.07). Conclusions: In NAFLD, the carnitine improved liver profile and peripheral blood mitochondrial DNA copy number. This results suggest that carnitine activate the mitochondria, thereby contributing to the improvement of NAFLD. (Korean J Gastroenterol 2010;55:384-389)
급성 우하복부 통증으로 내원한 성인 환자에서 Yersinia 감염에 대한 연구
정준영 ( Jun Young Jung ),박영숙 ( Young Sook Park ),백대현 ( Dae Hyun Baek ),최정호 ( Jeoung Ho Choi ),조윤주 ( Yun Ju Jo ),김성환 ( Seong Hwan Kim ),손병관 ( Byoung Kwan Son ),채정돈 ( Jeong Don Chae ),김동희 ( Dong Hee Kim ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1
Background/Aims: Clinical manifestations of intestinal yersiniosis include enterocolitis, mesenteric adenitis, and terminal ileitis presenting with fever, right lower quadrant pain, and leukocytosis. According to a previous Korean study in 1997, Yersinia was revealed in two among 15 adult patients with mesenteric adenitis (13%). However, recent reports on the prevalence of Yersinia infection in adult patients are few. The aim of this study was to investigate the prevalence of Yersinia infection in adult patients with acute right lower quadrant pain. Methods: Adult patients (>18 years) who visited Eulji medical center, due to acute right lower quadrant pain were enrolled prospectively from December 2007 to July 2009. Abdominal CT, stool culture, serologic test for Yersinia, and Widal test were performed. Results: Among 115 patients, 5 patients were excluded due to positive Widal test or salmonella culture. In 110 patients, abdominal CT showed right colitis in 20 (18.2%), terminal ileitis in 16 (14.5%), mesenteric adenitis in 13 (11.8%), acute appendicitis in 10 (9.1%), acute diverticulitis in 7 (6.4%), non specific mucosal edema in 36 (32.7%) and no specific lesion in 8 (7.3%). Two (1.8%) of the 110 patients had antibodies to Yersinia. One patient showed acute enteritis and the other patient was diagnosed with acute appendicitis and underwent appendectomy. No Yersinia species were grown on stool or tissue culture. Conclusions: Nowadays, among adult Korean patients presenting with acute right lower quadrant pain, there have been few incidences of Yersinia infection. (Korean J Gastroenterol 2011;57:14-18)
이승엽,윤창교,민정아,이창욱,박동언,안종성,이상돈,백명재,장준영,양주연,채정호,Lee, Seung-Yup,Yoon, Chang-Gyo,Min, Jung-Ah,Lee, Chang-Uk,Park, Dong-Un,Ahn, Jong-Seong,Lee, Sang Don,Baik, Myung Jae,Jang, Jun Young,Yang, Juyoun,Chae, Jeo 대한불안의학회 2014 대한불안의학회지 Vol.10 No.1
Objective : To obtain the incidence rate of anxiety disorders among the active duty Korean military personnel, who visited the military hospitals from 2011 to 2013, this descriptive epidemiological study was performed. Methods : After acquiring the data for the anxiety disorders from Defense Medical Statistics Information System, the annual incidence rates were analyzed by forces, position status, and specific disease entities. Results : One thousand, nine hundred and thirteen (1,913) active duty male military personnel were diagnosed with any kinds of anxiety disorders in their first visit to the psychiatric outpatient department (OPD). The total OPD visit counts were 7,870 during the same period. Anxiety disorder, NOS was the most frequent disorder, followed by panic disorder. While the incidence rate for anxiety disorder, NOS decreased, panic disorder displayed increasing tendency. Stress-related disorders and obsessive-compulsive disorder were positioned third and fourth, respectively, for the number of first visit and they both showed decreasing tendency in annual incidence rates. Social anxiety disorder, specific phobias, generalized anxiety disorder (GAD) and mixed anxiety-depressive disorder followed next. The annual incidence rates for anxiety disorders showed decreasing tendency, particularly evident in army soldiers. However, naval officers showed higher anxiety disorder incidence rate compared to those of the army and the air forces. Conclusion : Comparing to general population, panic disorder was higher while specific phobias and GAD were lower in the Korean military. It is interesting to observe higher incidence rate for anxiety disorder in naval officers and warrants further evaluation.
그레이브스병 환자에서 알레르기 지표와 갑상선자극호르몬 수용체 항체의 관련성
김효정 ( Hyo Jeong Kim ),이병훈 ( Byoung Hoon Lee ),이재형 ( Jae Hyung Lee ),전재석 ( Jae Seok Jeon ),김상훈 ( Sang Hoon Kim ),안영민 ( Young Min Ahn ),채정돈 ( Jung Don Chae ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.3
Background: IgE might play a role in the pathogenesis of Graves` disease in Japanese population. Objective: We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves` disease. Method: In 406 patients with Graves` disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens. Result: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and total IgE was significantly higher in TBII ≥15 IU/L group than those of TBII <15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae ≥0.7 kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients. Conclusion: TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune response. (Korean J Asthma Allergy Clin Immunol 2010;30:195-201)