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      • KCI등재후보

        창작무용학습을 통한 다문화가정 어린이의 사회성 변화

        양주연,이강순 韓國舞踊敎育學會 2010 韓國舞踊敎育學會誌 Vol.21 No.1

        The purpose of this study was to examine of changing sociability on creative dance program for children of multicultural family. There were one girl and one boy of multicultural families from the fifth grade class at G elementary school in Incheon. The researcher surveyed by participant observation, in-depth interview, documents, and learning reflection log(dance journal). The data were analyzed by encoding and inductive analysis and to ensure validity and reliability from every angle and in-depth technical approach. The use of reference materials, peer counseling by professionals and researchers, and research methods were utilized. The results of the study were as follows. First, through creative dance program, passive and exclusive relationships of children of multicultural family were changed positively. Second, through creative dance program, negligent of children of multicultural family diligence were changed positively. Third, through creative dance program, responsible of children of multicultural family were changed positively Fourth, through creative dance program, refusal of cooperation activities on the lack of compromise technic of children of multicultural family were changed positively obtaining pleasure by cooperation problems solving.

      • R을 이용한 결과 변수에 따른 최적의 Cut-off Point 결정

        양주연,이혜선,Juyeon Yang,Hye Sun Lee 대한소화기암연구학회 2022 Journal of digestive cancer reports Vol.10 No.2

        Clinical research ultimately aimed to promptly diagnose and prevent diseases through precise biomarker development. Finding the optimal cut-off point of a regularly measured biomarker can help its interpretation and ultimately help in disease investigation and diagnosis, more specifically in determining the presence of diseases. Therefore, this study aimed to use the characteristics of outcome variables in clinical research to explain how to determine the optimal cutoff point. The outcome variables can be divided into dichotomous, ordinal, and survival types. The optimal cut-off point can be determined by finding points that maximize the Youden index, extended Youden index, and log-rank statistics. This study will enable clinical researchers to accurately determine the optimal cut-off points for regularly measured biomarkers, thereby enabling prompt disease diagnosis for effective treatment.

      • KCI등재

        당질코르티코이드 수용체를 통한 INS-1 세포의 인슐린 분비와 합성

        양주연,김희진,강명수,송탁호,정인국,서평주 대한당뇨병학회 2006 Diabetes and Metabolism Journal Vol.30 No.6

        -Background: Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids on insulin secretion and synthesis in pancreatic beta cells are still unclear. We have investigated the direct effects of glucocorticoids on insulin secretion and synthesis in rat insulinoma (INS-1) cells.Methods: Insulin content and 11.2 mM glucose-stimulated insulin secretion (GSIS) were measured in INS-1 cells after culture with or without 1 μM dexamethasone (DEX). Preproinsulin mRNA levels were analyzed by real-time RT-PCR and normalized to the internal control. Effect of RU486 on DEX-induced inhibition of GSIS and preproinsulin mRNA synthesis was evaluated. Results: Insulin content of INS-1 cells cultured in RPMI containing 11.2 mM glucose in the presence of DEX was not different from that of control cells. After 1-h preincubation in 2.8 mM glucose, basal insulin secretion from cells treated with DEX did not differ from that of controls, but GSIS was significantly reduced in the cells treated with DEX in comparison to control cells. The expression of preproinsulin mRNA relative to beta-actin mRNA was also lower in the cells treated with DEX. Glucocorticoid receptor antagonist improved DEX-induced inhibition of GSIS and preproinsulin mRNA synthesis. Conclusion: DEX inhibited GSIS and preproinsulin mRNA synthesis in INS-1 cells. Glucocorticoid receptor antagonist ameliorated the reduced GSIS and preproinsulin mRNA synthesis induced by DEX. (J Kor Diabetes Assoc 30:428~434, 2006) 연구배경: 당질코르티코이드가 간의 포도당신합성을 증가시키며 근육과 지방조직에서 포도당 흡수를 억제하고 지방분해를 증가시키는 인슐린저항성에 대한 연구는 잘 알려져 있다. 그러나 당질코르티코이드가 췌장베타세포의 인슐린 분비와 합성에 미치는 영향에 대해서는 아직 명백히 밝혀져 있지 않다. 본 연구는 덱사메타손에 노출된 INS-1 세포에서 인슐린 함량과 포도당 자극 대한 인슐린 분비와 preproinsulin mRNA 합성을 알아보고 RU486에 의한 당질코르티코이드 수용체 억제가 덱사메타손에 의한 인슐린 분비와 합성 장애에 미치는 효과를 관찰하였다.방법: INS-1 세포를 배양한 후 덱사메타손과 vehicle을 함유한 배지에서 각각 배양한 후 세포 내 인슐린 함량과 포도당 자극에 의한 인슐린 분비를 측정하였으며 real-time역전사 중합효소 연쇄반응을 이용하여 preproinsulin mRNA 발현을 조사하였다. RU486을 이용하여 당질코르티코이드 수용체 억제제가 덱사메타손의 작용에 미치는 영향을 관찰하였다. 결과: 덱사메타손에 노출된 INS-1 세포와 대조군에서 단위세포 단백질량으로 환산한 세포 내 인슐린 함유량은 차이가 없었다. 덱사메타손에서 배양한 INS-1 세포의 2.8 mM 포도당 농도에서의 기저 인슐린 분비는 대조군과 차이가 없었으나 11.2 mM 포도당 자극에 의한 인슐린 분비는 대조군에 비하여 유의하게 감소되어 있었으며 덱사메타손에 배양한 INS-1 세포의 preproinsulin mRNA 합성이 감소되어 있었다. RU486에 의한 당질코르티코이드 수용체 억제는 덱사메타손의 포도당 자극에 의한 인슐린 분비능 저하와 preproinsulin mRNA의 합성 저하를 감소시켰다.

      • KCI등재

        남극해 인도양 해역에 위치한 콘래드 해령 지역의 마지막 빙하기 이후 생물기원 오팔 생산의 변화

        양주연,Minoru Ikehara,최혁,김부근 한국해양과학기술원 2023 Ocean and Polar Research Vol.45 No.3

        Biological pump processes generated by diatom production in the surface water of the Southern Ocean play an important role in exchanging CO2 gas between the atmosphere and ocean. In this study, the biogenic opal content of the sediments was measured to elucidate the variation in the primary production of diatoms in the surface water of the Southern Ocean since the last glacial period. A piston core (COR-1bPC) was collected from the Conrad Rise, which is located in the Indian sector of the Southern Ocean. The sediments were mainly composed of siliceous ooze, and sediment lightness increased and magnetic susceptibility decreased in an upward direction. The biogenic opal content was low (38.9%) during the last glacial period and high (73.4%) during the Holocene, showing a similar variation to that of Antarctic ice core ΔT and CO2 concentration. In addition, the variation of biogenic opal content in core COR-1bPC is consistent with previous results reported in the Antarctic Zone, south of the Antarctic Polar Front, in the Southern Ocean. The glacial-interglacial biogenic opal production was influenced by the extent of sea ice coverage and degree of water column stability. During the last glacial period, the diatom production was reduced due to the penetration of light being limited in the euphotic zone by the extended sea ice coverage caused by the lowered seawater temperature. In addition, the formation of a strong thermocline in more extensive areas of sea ice coverage led to stronger water column stability, resulting in reduced diatom production due to the reduction in the supply of nutrient-rich subsurface water caused by a decrease in upwelling intensity. Under such environmental circumstances, diatom productivity decreased in the Antarctic Zone during the last glacial period, but the biogenic opal content increased rapidly under warming conditions with the onset of deglaciation.

      • KCI등재

        R을 이용한 결과 변수에 따른 예측 모형과 시각화 - 회귀분석을 중심으로

        양주연,전소영,이혜선 한국보건정보통계학회 2022 한국보건정보통계학회지 Vol.47 No.S2

        Predictive models have recently become increasingly important across various fields. In particular, in clinical research, the main purpose is to build a model that can find risk factors and predict a specific disease. Predictive models can help clinicians make fast and accurate decisions by capturing rela- tionships between multiple factors related dependent variables. Accordingly, this paper describes a predictive model construction method and visualiza- tion that can be useful in clinical research. As dependent variables can be divided into continuous, categorical, and survival variables, the concepts and principles of linear, logistic, and cox regression analyses for building predictive models are explained in this paper. In addition, we investigated how to select variables to create an optimal model and how to evaluate the discrimination and calibration of the model. A visualization method that can help interpret according to each regression analysis model is also described. This paper will provide basic knowledge for clinical researchers to more easily build predictive models and evaluate them for practical use. .

      • KCI등재

        R을 이용한 결과 변수에 따른 예측 모형과 시각화 - 회귀분석을 중심으로

        양주연,전소영,이혜선 한국보건정보통계학회 2022 한국보건정보통계학회지 Vol.47 No.S3

        . Predictive models have recently become increasingly important across various fields. In particular, in clinical research, the main purpose is to build a model that can find risk factors and predict a specific disease. Predictive models can help clinicians make fast and accurate decisions by capturing rela- tionships between multiple factors related dependent variables. Accordingly, this paper describes a predictive model construction method and visualiza- tion that can be useful in clinical research. As dependent variables can be divided into continuous, categorical, and survival variables, the concepts and principles of linear, logistic, and cox regression analyses for building predictive models are explained in this paper. In addition, we investigated how to select variables to create an optimal model and how to evaluate the discrimination and calibration of the model. A visualization method that can help interpret according to each regression analysis model is also described. This paper will provide basic knowledge for clinical researchers to more easily build predictive models and evaluate them for practical use.

      • KCI등재

        발달장애인 가정의 가족건강성에 관한 부모 인식 연구

        양주연(Yang, Ju-yeon),조성열(Cho, Sung-yeol) 한국직업재활학회 2021 職業再活硏究 Vol.31 No.2

        본 연구는 우리나라 발달장애인들의 생활이 공적 지원체계보다는 비공식적인 가족 돌봄에 의해 이루어지고 있는 경우가 많다는 것에 주목하여, 가족 돌봄에 중요한 영향을 미치는 발달장애인 가정의 가족건강성에 관한 질적 연구를 실시하였다. 성인 발달장애인을 지원하는 보호자 7명을 대상으로 심층 면담을 실시하여 가족건강성 구성 요소인 ‘가족 간의 유대’, ‘의사소통’, ‘문제해결 능력’, ‘가족 가치체계’ 라는 하위 구성 요소를 통해 발달장애인 자녀를 양육하고 있는 부모들의 경험을 분석하여 장애가 가족건강성에 미치는 영향을 조사하였다. 연구 결과 첫째, 가족 간의 유대는 장애 자녀의 발달 단계, 장애유형, 생애주기에 따른 다양한 문제에 직면하여 구성원의 이해와 배려, 상호 노력으로 강화되는 측면이 있었다. 둘째, 의사소통은 가족건강성의 핵심요소로 가족의 문제를 해결하기 위해 서로의 의견을 자유롭게 나누며 창의적인 대안을 찾고, 의사결정을 공유하여 가족의 갈등을 해결하려는 노력을 끊임없이 해나가는 과정이라고 하였다. 셋째, 문제해결 능력에서 장애 가족은 비장애 자녀 문제, 장애수용 등 여러 위기에 맞닥뜨리지만 가족원이 공동의 노력과 책임을 가지고, 긍정적인 방법으로 대처해 나가는 경우가 많은 것을 알 수 있었다. 넷째, 발달장애 가족 구성원들의 가치체계는 고정된 것이 아니라, 인생에 있어서 중요하다고 생각하는 것이 서로 일치한다는 생각과 관심사와 취미, 규칙이나 가치관은 함께 만든다고 생각하는 것에 있었다. 연구 결과에 기초하여 실천해야 할 제언을 제시하였다. This study focuses on the health of families with developmental disabilities who have an important influence on family care, focusing on the fact that the lives of people with developmental disabilities in Korea are more informal than on the public support system. In-depth interviews with seven parents of adults with developmental disabilities were conducted to investigate the effect of disability on family health through the subcomponents of family health, such as ‘family ties’, ‘communication, problem solving’ and ‘family value system’. The results of the study show that family ties are strengthened by the understanding, consideration and mutual effort of the members in the face of various problems related to the development status, type of disability and life cycle of disabled children. Second, communication is a key element of family health, and it is a process of continuous efforts to resolve family conflicts by freely exchanging opinions, finding creative alternatives, and sharing decisions. Third, families with disabilities face a variety of crises, including children without disabilities and the disabilities acceptance of disabled people, but families often respond in a positive way with common efforts and responsibility. Fourth, the idea that the value system of the family members of the developmentally disabled is not fixed, but important to life is consistent, and that interests and hobbies, rules and values are created together. Suggestions to be put into practice based on the results of the study.

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