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간 , 담도 및 췌장 : 악성 종양과 간경변에 동반된 복수의 Lipid 분석의 의미
차상복(Sang Bok Cha),김부성(Boo Sung Kim),박두호(Doo Ho Park),이창돈(Chang Don Lee),최상욱(Sang wook Choi),권혁호(Hyuk Ho Kwon),이종욱(Jong Wook Lee),김종진(Jong Jin Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A To evaluate the difference of ascitic lipids in liver cirrhosis and cancer, the concentrations of phosphosipids, cholesterol triglycerides and total protein were studied in 30 patients with liver cirrhosis, 22 patients with various neoplasms. The ascitic lipids, especially in phospholipids, and total protein were higher in the group with ma1ignant neoplasm (phospholipids: 21.94+-16.2 vs 48.76+-26,08 mg/dl, cholesterol: 19.24+-18.26 vs 50. 33+-36.09 mg/dl, triglycerides: 21.70+-11.76 vs 33.00+-16.50 mg/dl, total protein; 1.04+-0.45 vs 2.70+-1.47 gmjdl). The best discrimination values were 35 mg/dl for phopholipids, 28 mg/dl for cholesterol, 29.5 mg/ dl for triglycerides and 2.O gm/dl for protein. Application of these cut off points revealed on efficiency of 80.4% for phospholipids, 77.5% for cholesterol, 71.8% for triglycerides and 80.8% for protein. We conclude that ascitic lipids offers an excellent diagnostic discrimination between cirrhosis and malignant neoplasms, but further investigations are needed in tuberculosis.
Bl6 Melanoma세포에서 Protein Kinase억제제들이 Cyclic AMP 경로를 통한 멜라닌 생성에 미치는 영향
차상복(Sang Bok Cha),조남영(Nam Young Cho),윤미연(Mi Yun Yoon),임혜원(Hye Won Lim),김경원(Kyoung Won Kim),박영미(Young Mi Park),이지윤(Ji Yun Lee),이진희(Jin Hee Lee),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2003 약학회지 Vol.47 No.1
To investigate the effect of protein klnase on melanin production via CAMP-dependent pathway, we measured the melanin amount and tyrosinase activity in Bl6 melanoma cells stimulated by alpha-melanocyte stimulating hormone (MSH), forskolin and 8-Br-Camp MSH, forskolin and 8-Br-Camp significantly increased both melanin production and tyrosinase activity in Bl6 cells. Melanin production and tyrosinase activity by MSH are significantly inhibited by cyclic AMP-dependent protein kinase inhibitor (KT5720) and protein kinase C down-regulation treated with PMA. Bisindolmaleimide (1μM), protein kinase C inhibitor, significantly inhibited melanin production and tyrosinase activity stimulated by MSH, for-skolin and 8-Br-Camp with the following order of potency: MSH>forskolin>8-Br-Camp. Tyrosine kinase inhibitor, genistein and DHC, significantly inhibited both, but the inhibitory effect was more potent in 8-Br-Camp-stimulated Bl6 cells than MSH-stimulated cells. NFkB inhibitor (parthenolide) significantly inhibited melanin production and tyrosinase activity. Neither melanin production nor tyrosinase activity induced by MSH, forskolin and 8-Br-Camp were affected by KN-62 (calm-odulin-dependent protein kinase II inhibitor), PD098059 (mitogen-activated protein kinase inhibitor, MAPKK) and worthmannin (phosphatidylinositol 3-kinase inhibitor). These results suggest that both protein klnase C and tyrosine kinase are involved in melanin production by cyclic AMP-dependent pathway and NFrB pathway may play an important role in cyclic AMP-dependent melanin production in Bl6 melanoma cells.
차상복(Sang Bok Cha),송춘익(Choon Eck Song),양철우(Chul Woo Yang),최규용(Kyu Young Choi),성기열(Ki Yul Sung),이안희(Ah Hee Lee),박승만(Seung Man Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
61 year-old man with malnutrition and ascite was diagnosed to have Menetrier's disease by gastrofiberscopy and UGIS. Work-up showed classic menetriers disease with enlarged gastric rugae and hypoalbuminemia due to protein-losing gastropathy. 50 days after medical conservative treatement, total gastrectomy was performed in order to improve hypoalbuminemia. Microscopically there was a increased number of mucous cell involving the parietal and chief cell. We consider it mixed mucous-glandular cell type hyperplasia by Mings classification. The pathogenesis and pathophysiology of the disease are poorly understood. Indeed, there is sti]1 controversy regarding its classification, cause and management. A brief review of classification, etiology, pathophysiology, classical pictures and management of Menetriers disease is presented.
정규원(Kyu Won Chung),차상복(Sang Bok Cha),선희식(Hee Sik Sun),김부성(Boo Sung Kim),최규용(Kyu Yong Choi),이영석(Young Suk Lee),정욱성(Wook Sung Chung),홍영선(Young Sun Hong),박승만(Seung Man Park),이안희(Ahn Hee Lee),김진(Jin Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1
Rectal carcinoid tumor is relatively rare neoplasm orignated in Kulchitszky cell and clinicians have the difficulties in predicting their malignant potential and in proper treatrnent. The vast majority of rectal carcinoid tumors are benign and can be safely treated by local excision. Lesions larger than 2 cm and invading the muscular wall of the rectum should be considered rnalignant and treated by more radical surgery such as abdominoperineal resection. 3Ve had a case of 35-year-old male patient with a malignant rectal carcinoid tumor 2 cm in the length diagnosed by colonofiberscopy. So we present this case with a review of relevant literatures.
간장 및 담도 : 삼출성 복수증의 감별진단과 복강경 검사
정규원(Kyu Won Chung),차상복(Sang Bok Cha),선희식(Hee Sik Sun),김부성(Boo Sung Kim),정인식(In Sik Chung),안병민(Byung Min Ahn),김재광(Jae Kwang Kim),김태룡(Tae Ryong Kim),최규용(Gyu Yong Choi) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
N/A Exudative ascites should initiate an evaluation for peritoneal processes, most importantly infection and tumor. And the pathological diagnosis is required for a approapriate treatment in most cases. To assess the diagnostic accuracy and complication rates of diagnostic laparoscopy in patients with exudative ascites we studied in 73 patients with exudative ascites retrospectively. Thirty three patients had malgnancy related ascites, and peritoneal carcinomatosis was confirmed in thirty one patients. Twenty seven patients had tuberculous peritonitis, and thirteen patients had miscellaneous causes, among them eight patients had underlying liver cirrhosis and clinically spontaneous bacterial peritonitis were suspected in three patients in whom bacteria were cultivated in ascites. Pancreatic pseudocyst and leakage into peritoneal cavity was confirmed by endoscopic retrograde pancreatography in one case, but the remained four cases had not known the diagnosis. The most common primary cancer was gastric carcinoma which was diagnosed in fourteen patients, and then ovarian cancer in five patients, colon cancer in four patients, pancreatic cancer in three patients, mesothelioma in one patient and unknown origin in four patients. Cytology evaluation of the ascitic fluid was positive for tumor cells in 62% of patients with peritoneal carcinomatosis. Blind Cope needle biopsy yielded positive diagnosis of neoplastic or tuberculous in 65.4 per cent of rases. The major and minor complication rates of laparoscopy were 0% and 26.4%, respectively, with no fatalities. These findings compare favorably with general experience. We conclude that laparascopy is relatively safe and accurate diagnostic method of choice in exudative ascites, especially in cases when other non-invasive methods were failed.
간 경변증을 동반한 Neuro - Behcet 씨 증후군
정규원(Kyu Won Chung),정환국(Whan Kook Chung),차상복(Sang Bok Cha),선희식(Hee Sik Sun),정진우(Jin Wu Jeong),최규용(Kyu Yong Choi),홍현상(Hyoun sang Hong),양진모(Jin Mo Yang) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
In 1937, Behcet described a syndrome of recurrent orogenital ulcers and relapsing iritis. It is now known to be a multisystem panvasculitis of unknown etiology, which involves many other systems. Although several case reports describe many organ involvements in patients with Behcets disease, liver involvement was not observed in this syndrome. Herein we report a case of neuro-Behcet syndrome and coexistent liver cirrhosis, a previously unreported finding.
문윤기(Yoon Gi Moon),이보인(Bo In Lee),강성호(Sung Ho Kang),양영상(Young Sang Yang),채현석(Hyun Suk Chae),최규용(Gyu Yong choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
Splenic infarction is an uncommon form of splenic pathology. It occurs as a consequence of systemic thromboembolization in association with several cardiovascular disorders. Other etiologic factors include splenic vascular disease, anatomic abnormalities, collagen vascular disease, nonhematologic malignancy, and pancreatic disease in the extremely rare form. Pancreatic disease may result in splenic infarction because of constriction of the splenic vessels by the fibrotic pancreas, tortuous aneurysm, or thrombosis of splenic vein. A pseudocyst in the tail of the pancreas may dissect into the hilum, causing vascular compromise and infarction. Recently we experienced a 47-year old man cpmplaining of left upper quadrant pain, which was diagnosed as gastric variceal bleeding and splenic infarction associated with chronic fibrosing pancreatitis confirmed by ultrasonogram of abdomen, abdominal CT, angiography, and operation. Distal pancreatectomy and splenectomy were performed, and subsidence of his symptoms was observed. We report this case with a review of the relevant literature. (Korean J Gastroenterol 1995;27:611 - 616)
Helicobacter pylori에 감염된 십이지장궤양과 비궤양성 소화불량에서 ABO 혈액형과 HLA의 연관
채현석(Hiun Suk Chae),김태규(Tai Gyu Kim),한훈(Hoon Han),김성수(Sung Soo Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
N/A Background/Aims: It has been known that genetic factors, for example, blood group, non-secretor and HLA system, are associated with duodenal ulcer and that Helicobacter pylori infection is the major cause of peptic ulcer. However, Helicobacter pylori is also found in non-ulcer dyspepsia and asyrnptomatic patients without ulcer formation. But, it is still not known regarding what kind of genetic factors have an effect on ulcer formation at the time of Helicobacter pylori infection. This study was performed to make clear wbich genetic factors are re1ated with duodenal ulcers among Koreans, and what kind of genetic factors could influence on the ulcer formation in the patients with Helicobacter pylori infection according to ABO blood groups and HLA antigen.'.. Methods: The duodenal ulcer patients (36), non-ulcer dyspepsia (19) and norraal healthy controls (103) were included in this study. Helicobacter pylori infection was detected with phenol red spray method in vivo which was confirmed with Warthin-Starry silver stain. HLA antigen expression (HLA-A,B) of peripheral blood T lymphocytes was studied with microlymphocytotoxicity teclmique. Results: Tbe frequency of HLA-A 33 was higher in duodenal ulcer patients (l4/36, 38.9%) compared with the control group (21/103, 20.4%). On the contrary, no difference in HLA-B has been shown between duodenal ulcer patients and controls. Among patients with Helicobacter pylori infection, blood group 0 was significant1y more frequent in patients with duodenal ulcers (21/36, 58.3%) than in non-ulcer dyspepsia (5/19, 26.3%). In patients with HLA-A 33, blood group 0 was significantly more frequent in duodenal ulcer patients (7/)4, 50%) than in non-ulcer dyspepsia patients (0/7, 0%). Conclusions: In Helicobacter pylori-infected patients, HLA-A 33 is related with duodenal ulcers and the patients with both blood group 0 and HI.A-A 33 are more likely to have duodeual ulcers than those with HLA-A 33 and without blood groop O. (Korean J Gastrnenterol 1996; 28:623 - 631)
Bl6 Melanoma세포에서 Citrus Essential Oil이 Melanin 생성에 미치는 영향
임혜원(Hye Won Lim),조남영(Nam Young Cho),윤미연(Mi Yun Yoon),차상복(Sang Bok Cha),김경원(Kyoung Won Kim),박영미(Young Mi Park),이지윤(Ji Yun Lee),이진희(Jin Hee Lee),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2003 약학회지 Vol.47 No.1
This study is performed to investigate the effects of citrus essential oils on melanin production in Bl6 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity cell growth and cytotoxicity in Bl6 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1μM MSH-stimulated Bl6 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be development to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.