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권혁호(Hyuk-Ho Kwon),김승욱(Seung-Wook Kim),최동훈(Dong-Hoon Choi),이기천(Kichun Lee) 대한산업공학회 2016 대한산업공학회지 Vol.42 No.5
The purpose of this study is to challenge a computational regression-type problem, that is handling large-size data, in which conventional metamodeling techniques often fail in a practical sense. To solve such problems, regression-type boosting, one of ensemble model techniques, together with bootstrapping-based re-sampling is a reasonable choice. This study suggests weight updates by the amount of the residual itself and a new error decision criterion which constructs an ensemble model of models selectively chosen by rejection limits. Through these ideas, we propose AdaBoost.RMU.R as a metamodeling technique suitable for handling large-size data. To assess the performance of the proposed method in comparison to some existing methods, we used 6 mathematical problems. For each problem, we computed the average and the standard deviation of residuals between real response values and predicted response values. Results revealed that the average and the standard deviation of AdaBoost.RMU.R were improved than those of other algorithms.
간 , 담도 및 췌장 : 악성 종양과 간경변에 동반된 복수의 Lipid 분석의 의미
차상복(Sang Bok Cha),김부성(Boo Sung Kim),박두호(Doo Ho Park),이창돈(Chang Don Lee),최상욱(Sang wook Choi),권혁호(Hyuk Ho Kwon),이종욱(Jong Wook Lee),김종진(Jong Jin Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A To evaluate the difference of ascitic lipids in liver cirrhosis and cancer, the concentrations of phosphosipids, cholesterol triglycerides and total protein were studied in 30 patients with liver cirrhosis, 22 patients with various neoplasms. The ascitic lipids, especially in phospholipids, and total protein were higher in the group with ma1ignant neoplasm (phospholipids: 21.94+-16.2 vs 48.76+-26,08 mg/dl, cholesterol: 19.24+-18.26 vs 50. 33+-36.09 mg/dl, triglycerides: 21.70+-11.76 vs 33.00+-16.50 mg/dl, total protein; 1.04+-0.45 vs 2.70+-1.47 gmjdl). The best discrimination values were 35 mg/dl for phopholipids, 28 mg/dl for cholesterol, 29.5 mg/ dl for triglycerides and 2.O gm/dl for protein. Application of these cut off points revealed on efficiency of 80.4% for phospholipids, 77.5% for cholesterol, 71.8% for triglycerides and 80.8% for protein. We conclude that ascitic lipids offers an excellent diagnostic discrimination between cirrhosis and malignant neoplasms, but further investigations are needed in tuberculosis.
B 형 만성활동성간염 환자에서 합성 Interferon Alpha 2b ( INTRON A(R) ) 의 효능 및 안정성 - 제 1 보 -
이창돈(Chang Don Lee),강무일(Moo Il Kang),유혜신(Hye Sin Yu),권혁호(Hyuk Ho Kwon),김재유(Jae Yoo Kim),정진우(Jin Woo Jeong),김부성(Boo Sung Kim) 대한내과학회 1987 대한내과학회지 Vol.32 No.6
N/A To evaluate the efficacy and safety of recombinant interferon alpha-2b (INTRONA®), in eleven patients with chronic active hepatitis (CAH) type B, a course of 28-day Intron A® was given daily subcataneous injection at a dose of 1 milion unit (MU) on the first day, 3 MU on the second, 5 MU on the 3rd to 7th, 3 MU on the 8th to 28th each. In 10 patients with HBeAg positive CAH type B, DNA polymerase and transaminoferase activities were assessed and compared before, during and after INTRON A administration. The peripheral blood white blood cell (WBC), granulocyte and platelet counts were checked. The results were as follows: 1) during administration of INTRON A, DNA polymerase activities were decreased significantly within first week and sustained in spite of persistent HBe antigenemia in all patients (p<0.05). Serum alanine aminotransferase (ALT) and aspartate aminotransferase were decreased significantly from 2 and 3 weeks after therapy respectively (p<0.01). 2) After discontinuation of INTRON A, improved transaminase level lasted for 4 weeks but rebound phenomena of DNA polymerase activities were observed 7 cases (70%) within 2 weeks, 3) during follow up period, transient increase of serum ALT activities were observed 9 cases within 12 weeks. One case of seroconversion (Anti-HBe) and one case of transient loss of HBeAg were observed at 16 week during mean follow up period of 30.3 weeks (range 16-58 weeks). But transient increment of serum ALT activities were observed 9 cases (90%) within 16 weeks. 4) In all 11 patients, peripheral white blood cell, granulocyte, platelet counts were decreased significantly within first week but not decreased further during INTRON A administration and recovered within 2 weeks after discontinuation of INTRON A. 5) Myalgia and fever were noted in 10 cases (91%) and headache and high fever (>38'C) were noted in 5 cases (45%) within 4 days. Mild anorexia (36%), hair loss (27%), diarrhea (9%), nausea (9%) were noted after 2 weeks. It suggested that subcutaneous injection of 3 MU INTRON A was safe and effective in decrement of DNA polymerase and transaminase activities in patients with CAH type B transiently. Long term therapy will be nessessary for the eradication of HBe Antigenemia and clinical improvement.
김부성(Boo Sung Kim),정인식(In Sik Chung),정진우(Jin Wu Jeong),박두호(Doo Ho Park),이창돈(Chang Don Lee),권혁호(Hyuk Ho Kwon),김재유(Jae Yoo Kim),서정민(Jung Min Suh) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
Since the advent of effective antituberculous chemotherapy, the frequency and severity of intestinal tuberculosis have markedly decreased in the world. However, intestinal tuberculosis continues to be reported with impressive frequency in Korea. But the tuberculous involvement of the stomach and duodenurn is extremely rare event. Recently, we experienced a case of tuberculosis of stomach and duodenum with extensive intestinal involvement. Patient is a 27-year old female and the diagnostic confirmation was attained by histologic findings of endoscopic biopsy specimen. Administration of antituberculous agents resulted in good response. So, we report this case with review of literatures.
박동준,유재영,권혁호,심규식,허미경,김준기 대한내과학회 1987 대한내과학회지 Vol.32 No.4
Primary adenocarcinoma of the duodenum is a rare disease, accounting for about 0.3g of all gastrointestinal cancers. Its etiology is uncertain, but known to be associated with defects in immune surveillance, There are several reports of high incidence of second additional cancers in patients with small intestinal cancer in some countries. We present here a case of duodenal cacinoma who had early gastric carcinoma, type II c as a second primary neoplasm with a review of literature.
이성원,김석영,권혁호,김현,방병기,양철우,황호원,김종율,이광돈 대한내과학회 1993 대한내과학회지 Vol.45 No.1
Spontaneous perirenal hematoma is ususally associated with underlying renal cell carcinoma, angiomyolipoma and vasculr disorders. We recently experienced the spontaneous perirenal hematoma due to renal infart in a sixty-seven-year old female patient with diabetes mellitus. It was suggested that uncontrolled diabetes mellitus, hyertension and old age may be the risk factors of renal infacrt, and advanced atherosclerotic vascular change may be one of the cause of spontaneous renal rupture and perirenal hematoma.
이성원,김석영,서광선,권혁호,방병기,양철우,김종률,강문원 대한내과학회 1993 대한내과학회지 Vol.45 No.6
Extraintestinal amebiasis consists mainly of amebic liver abscess. The genitourinary amebiasis is rare and is confined to the extermal genital system. We report a 53year-old male patient with diabetes mellitus who presented with invasive amebiasis involving liver and both kidneys, which was confirmed by demonstration of trophozoite of amoeba in the drained pus. In our knowledge, this is the first report of amebiasis involving both kidneys. The patient was treated with combination therapy of repeated fine-needle aspiration, metronidazole and chloroquine with good result. Uncontrolled diabetes mellitus and poor nutrition may be the cause of systemic amebiaseis.
당뇨병성 말초혈관장애에 대한 Cilostazoe ( Pletaal ) 의 효과
강성구,이광우,손호영,차봉연,한제호,윤건호,권혁호,김용성,오현상,신순현 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1
Peripheral vascular disease is a common complication in diabetes mellitus. Accelerated atherosclerosis leading to impaired circulation in the legs is one of the most important causes of gangrene and amputation. In previous studies, a critically low systolic ankle and toe blood pressure has been shown to indicate a high probability for development of diabetic gangrene. The aim of the presint prospective study was to report the results of the treatment of 200 mg/day Cilostazol which has a vasodilating and antithrombotic action in 30 diabetic patients with peritheral vascular disease. The results were as follows: 1) The score of resting pain, numbness, cold sensation, claudication and granuloma were significantly decreased after Cilostazol treatment for 8 weeks. 2) The ankle pressure index was increased from 0.92±0.21 to 0.96±0.15, after Cilostazol treatment for 8 weeks. The score of arterial palpation and dopler wave were markely improved in both groups after Cilostazol treatment. 3) Facial flushing, headae and chest pain were noted, but geadache and chest pain were dissappeared spontaneously during Cilostazol administration 4) The assessement of overall safety of the drug evaluated by the attending-physician bases on the assessement of $quot;safe$quot; and $quot;almost safe$quot; amounted to 96.7%. The assessment of overall improvement of the deasease made by the attending physician based on the improvement of resting pain, cold sensation, claudication, numbness, ulcer and granuloma indicated that the percent improvement based on the combined assessments of $quot;markedly improved$quot;, $quot;improved$quot; and $quot;slightly improved$quot; amounted to 86.6% 5) Fasting blood sugar, postprandial 2 hour sugar and HbAlc levels were significantly decreased after Cilostazol administration. 6) Before and after Cilostazol treatment, there were no significant differences in physical findings, CBC, blood chemistry, and total cholesterol level. After Cilestazol administration, HDL·cholesterol levels were increased, and triglyceride levels were decreased, but the changes were not statistically significant. Theses results suggest that Cilostazol was useful in the treatment of diabetic peripheral vascular disease accompanied by ischemic symptoms such as resting pain, cold sensation, claudication, numbness, ulcer and granuloma in the extremities. (J Kor Endocrinol 8:78∼87. 1993)